0001193125-17-257407 Sample Contracts

RADIUS HEALTH, INC. AND WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee FIRST SUPPLEMENTAL INDENTURE Dated as of August 14, 2017 to Indenture Dated as of August 14, 2017 3.00% Convertible Senior Notes due 2024
First Supplemental Indenture • August 14th, 2017 • Radius Health, Inc. • Pharmaceutical preparations • New York

FIRST SUPPLEMENTAL INDENTURE dated as of August 14, 2017 (this “Supplemental Indenture”) between RADIUS HEALTH, INC., a Delaware corporation, as issuer (the “Company,” as more fully set forth in Section 1.01) and WILMINGTON TRUST, NATIONAL ASSOCIATION, a national banking association, as trustee (the “Trustee,” as more fully set forth in Section 1.01), supplementing the Indenture dated as of August 14, 2017 between the Company and the Trustee (the “Base Indenture” and the Base Indenture, as amended and supplemented by this Supplemental Indenture, and as it may be further amended or supplemented from time to time with respect to the Notes, the “Indenture”).

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