0001193125-19-199075 Sample Contracts

REPLIGEN CORPORATION, Issuer AND WILMINGTON TRUST, NATIONAL ASSOCIATION, Trustee INDENTURE Dated as of July 19, 2019 Senior Debt Securities
Indenture • July 22nd, 2019 • Repligen Corp • Biological products, (no disgnostic substances) • New York

INDENTURE, dated as of July 19, 2019, among REPLIGEN CORPORATION, a Delaware corporation (the “Company”), and WILMINGTON TRUST, NATIONAL ASSOCIATION, a national banking association as trustee (the “Trustee”):

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REPLIGEN CORPORATION AND WILMINGTON TRUST, NATIONAL ASSOCIATION, as Trustee FIRST SUPPLEMENTAL INDENTURE Dated as of July 19, 2019 to Indenture for Senior Debt Securities Dated as of July 19, 2019 0.375% Convertible Senior Notes due 2024
First Supplemental Indenture • July 22nd, 2019 • Repligen Corp • Biological products, (no disgnostic substances) • New York

FIRST SUPPLEMENTAL INDENTURE dated as of July 19, 2019 (this “Supplemental Indenture”), between REPLIGEN CORPORATION, a Delaware corporation, as issuer (the “Company,” as more fully set forth in Section 1.01) and WILMINGTON TRUST, NATIONAL ASSOCIATION, a national banking association, as trustee (the “Trustee,” as more fully set forth in Section 1.01), supplementing the Indenture for Senior Debt Securities dated as of July 19, 2019, between the Company and the Trustee (the “Base Indenture” and the Base Indenture, as amended and supplemented by this Supplemental Indenture, and as it may be further amended or supplemented from time to time with respect to the Notes, the “Indenture”).

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