Background and Significance Introduction Sample Clauses

Background and Significance Introduction. Proper function of skeletal muscle tissue is critical for survival and quality of life. As in any tissue, proper function relies on correct gene expression. Unlike other tissues, the primary cell type in skeletal muscle is multinucleated. This plurality of nuclei adds a layer of complication to regulating gene expression Thousands of nuclei sharing a common cytoplasm introduces new variables like nuclear position, age of a nucleus, and interaction with other nuclei that could affect nuclear activity. Whether nuclear activity is coordinated among nuclei or is regulated by each nucleus independently is unknown as is the effect of factors like nuclear position and age. By extension, how different states like growth, regeneration, exercise, or aging affect muscle nuclei is largely unknown. Nucleocytoplasmic transport regulates which proteins enter and leave the nucleus and thereby broadly modulates nuclear activity. This dissertation will examine nuclear import in multinucleated skeletal muscle cells and changes to the myonuclear proteome that occur in aging. This chapter highlights the basic properties of skeletal muscle, nucleocytoplasmic transport, and multinucleated cells. First, skeletal muscle and its properties in development and aging are examined. Second, the primary components of nucleocytoplasmic transport are presented with particular emphasis on nuclear import. Third, the basic properties of multinucleated cells, how they are formed, and any differences among nuclei within a single cell are reviewed.
Sample 1
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Related to Background and Significance Introduction

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