In Vivo Studies Sample Clauses
In Vivo Studies. If Company wishes to conduct any in vivo study (preclinical or clinical, in animals or in humans, each a “Study”) of the Licensed Product utilizing Captisol, the following provisions shall apply:
In Vivo Studies. If Company wishes to conduct any in vivo study (preclinical or clinical, in animals or in humans, each a “Study”) of the Licensed Product utilizing Captisol, then Company shall notify CyDex of any such Study and the name of the protocol therefor in writing at least fourteen (14) days prior to commencing such Study for pre-clinical studies, and at least thirty (30) days prior to commencing such Study for clinical studies, and the following provisions shall apply:
In Vivo Studies. If Company wishes to conduct any in vivo study (preclinical or clinical, in animals or in humans, each a “Study”) of the Licensed Product utilizing Captisol, then Company shall notify CyDex of any such Study and of the protocol therefore in writing at least **** prior to commencing such Study for pre-clinical studies, and at least **** prior to commencing such Study for clinical studies, and the following provisions shall apply:
In Vivo Studies. If Sage wishes to conduct any in vivo study ([…***…], each a “Study”) […***…], then Sage shall notify CyDex of any such Study and of the protocol therefor in writing at least […***…] days before commencing such Study, and the following provisions shall apply:
In Vivo Studies. If Seelos wishes to conduct any in vivo study (preclinical or clinical, in animals or in humans, each a “Study”) of a CEA Licensed Product utilizing Captisol, the following provisions shall apply:
In Vivo Studies. If Sage wishes to conduct any in vivo study (preclinical or clinical, in animals or in humans, each a “Study”) of the Combination Product combined with or formulated using Captisol, then Sage shall notify CyDex of any such Study and of the protocol therefor in writing at least [***] before commencing such Study, and the following provisions shall apply:
In Vivo Studies. The effect of TCAP-l using intravenous administration under a variety of conditions will be used to determine the efficacy of TCAP-1 on the inhibition of cocaine seeking reinstatement in rats. These studies are currently underway in the laboratory of Xx. Xxxxxxx Xxx. Further studies will be aimed at determining the molecular and neural pathways by which this mechanism occurs. Based on previous data, we hypothesize that TCAP-1 regulates cocaine addiction by altering the dopaminergic pathway associated with reward. Thus these new studies are aimed at determining the co-localization of the TCAP-1 system with that of the dopaminergic pathway.
In Vivo Studies. If Gilead wishes to conduct any in vivo study (preclinical or clinical, in animals or in humans, each a “Study”) of a Licensed Product, the following provisions shall apply:
In Vivo Studies. If Company wishes to conduct any in vivo study (preclinical or clinical, in animals or in humans, each a “Study”) of a Licensed Product, the following provisions shall apply:
In Vivo Studies. On the basis of these optimized protocols for ex vivo imaging of zebrafish, we extended our studies to image living adult zebrafish using μMRI. Although in vivo MRI has become an approved tool in medicine and pharmacologic research, very few studies have used this method to uncover physiology in aquatic organisms (21). Aquatic animals require special setups and several precautions for supporting in vivo imaging. For example, fish need a continuous flow of aerated water to irrigate their gills during the MRI measurements. This requires a special watertight flow- through chamber to support the fish and to prevent any contact of water with the RF coil and gradient insert. The fish needs to be immobilized to prevent motion artifacts, either by restraining or using anesthetic. In addition, imaging artifacts due to the surrounding water flow should be minimized. In vivoMRI studies in a few aquatic animals such as teleosts (e.g., carp), eelpout, and Gadus morhua have been successfully demonstrated (21-24). Due to the small size of zebrafish, additional precautions are needed for in vivo imaging. For example, a high-resolution microimaging magnet, needed to get good resolution with small fish, has limited space for a flow-through chamber. The small flow-through chamber cannot support a high flow of water that would be needed if unwanted signal from surrounding water is to be avoided. It has been shown that unwanted signal from surrounded water