Common use of Terms Defined Elsewhere in the Agreement Clause in Contracts

Terms Defined Elsewhere in the Agreement. For purposes of this Agreement, the following terms have the meaning set forth in the Section indicated: Term Section A&R Agreement Recitals Act Recitals Additional Consideration 11.03(d) Additional Units 12.02 Affiliate 12.02 Agreement Preamble Available Units 10.04(a) Bad Actor Disqualification Event 2.14 Baupost Director 3.02 Board of Directors 3.01 Capital Account 12.02 Capital Contribution 12.02 Capital Transaction 12.02 Capital Transaction Proceeds 12.02 Capital Units 2.10(a) Certificate 1.01 CEO 3.02(b)(iii) CEO Director 3.02(b)(iii) Change of Control 12.02 Code 12.02 Common Units 2.10(a) Company Preamble Company Distributions 12.02 Company Notice 12.02 Company Undersubscription Notice 10.03(d) Confidential Information 12.02 Control 12.02 Corporate Conversion 10.09(a) Co-Sale Per Unit Liquidation Value 10.04(b) Co-Sale Purchase Price 10.04(b) Covered Persons 3.11(b) Designated Affiliate 12.02 Designated Affiliate License Agreements 12.02 Designated Affiliate Sale 8.01(d) DGCL 5.01 Director 12.02 Economic Capital Account 12.02 Exercising Preferred Members 10.03(d) Expenses 5.06(b) Fair Market Value 12.02 Fiscal Year 1.04 Fully Exercising Preferred Member 10.07(b) F2 3.02(b)(ii) Foresite 12.02 Holding 10.09(a) Imputed Underpayment Amount 13.01(b) Indemnified Person 5.06(a) Initial Consideration 11.03(d) IPO 10.10 Investor Business Opportunity 3.11(b) Majority Interest 2.03(a) Member Preamble New Securities 12.02 Non-Voting Incentive Units 2.10(a) OIF 3.02(b)(i) Offer Notice 10.07(a) Officer 4.01 Other Indemnitors 5.02 Participating Preferred Member 10.04(a) Partnership Representative 3.03(a)(viii) Permitted Transfer 10.01(a) Permitted Transferee 10.01(a) Person 12.02 Preferred Director 3.02(b)(iii) Preferred Member 12.02 Preferred Member Notice 12.02 Preferred Member Notice Period 10.03(d) Preferred Units 2.10(a) Preferred Unit Preference Amount 12.02 President 4.01 Prior Agreement Recitals Proceeding 5.06(c) Proceeds Available for Distribution 12.02 Prohibited Transfer 10.05(c) Proposed Sale 10.06(c) Proposed Transfer 12.02 Proposed Transfer Notice 12.02 Proposed Transferee 12.02 Purchase Agreement 12.02 QPO 10.09 Original Issue Date 12.02 Released Securities 10.10 Required Reserve 12.02 Requisite Preferred Holders 12.02 Revised Audit Procedures 12.02 Right of Co-Sale 12.02 Right of First Refusal 12.02 Rule 506(d) Related Party 12.02 Sale Event 11.03(a) Sale of the Company 10.06(a) Secondary Notice 12.02 Secondary Refusal Right 12.02 Secretary 4.01 Securities Act 2.02 Selling Investors Series Seed Preferred Units 10.06(b) 2.10(a) Series A Preferred Units 2.10(a) Series A Preferred Director 3.02 Series B Accrued Dividend 12.02 Series B Preferred Units 2.10(a) Series B Original Issue Price 12.02 Series B Vote 12.02 Series C Original Issue Price 12.02 Series C Vote 12.02 Series A1 Accrued Dividend 12.02 Series Seed Accrued Dividend 12.02 Series A1 Original Issue Price 12.02 Series Seed Original Issue Price 12.02 Strike Price 2.10(e) Target Balance 12.02 Tax Distribution 8.02 Tax Liability 8.02 Tax Rate 8.02 Transfer 10.02(a) Transferring Member 12.02 Transfer Notice 12.02 Transfer Units 12.02 Treasurer 4.01 Treasury Regulation 12.02 Unit Certificate 2.10(g) Unit Sale 10.06(a) Units 2.10(a) Units Deemed Outstanding 12.02 Unpaid Preferred Cap 12.02 Unpaid Preferred Unit Preference Amount 12.02 Withholding Payment 13.01(a)

Terms Defined Elsewhere in the Agreement. For purposes of this Agreement, the following terms have the meaning set forth in the Section indicated: Term Section A&R Agreement Recitals Act Recitals Additional Consideration 11.03(dDirectors 3.2(b)(iv) Additional Units 12.02 Adjusted Capital Account 12.2 Affiliate 12.02 12.2 Agreement Preamble Assignee 10.2(c) Approved Sale 10.5(a) Approved Sale Notice 10.5(c) Available Units 10.04(a10.4(a) Bad Actor Disqualification Event 2.14 Baupost Director 3.02 Board of Directors 3.01 3.1 (a) Capital Account 12.02 12.2 Capital Contribution 12.02 12.2 Capital Transaction 12.02 12.2 Capital Transaction Proceeds 12.02 Capital 12.2 Articles 1.1 Articles of Organization Preamble CEO 4.1 Closing Notice 10.3(e) Co-Sale Election Period 10.4(b) Co-Sale Notice 10.4(a) Co-Sale Participant 10.4(b) Co-Sale Right 10.4(a) Co-Sale Right Units 2.10(a10.4(b) Certificate 1.01 CEO 3.02(b)(iii) CEO Director 3.02(b)(iii) Change of Control 12.02 Code 12.02 Common Units 2.10(a12.2 Collateral Action 10.1(c) Company Preamble Company Distributions 12.02 Acceptance Period 10.3 (b) Company Purchase Notice 12.02 Company Undersubscription Notice 10.03(d10.3 (b) Confidential Information 12.02 12.2 Continuing Company 10.7 Control 12.02 Corporate Conversion 10.09(a) Co-Sale Per Unit Liquidation Value 10.04(b) Co-Sale Purchase Price 10.04(b) 12.2 COO 4.1 Covered Persons 3.11(b3.11 (b) Designated Affiliate 12.02 Designated Affiliate License Agreements 12.02 Designated Affiliate Sale 8.01(dDirector; Directors 3.2(a) DGCL 5.01 Director 12.02 Economic Capital Account 12.02 Exercising Preferred Members 10.03(dEligible Member 10.3(a) Eligible Member Acceptance Period 10.3(c) Eligible Member Purchase Notice 10.3(c) Expenses 5.06(b5.5(b) Fair Market Value 12.02 12.2 Fiscal Year 1.04 Fully Exercising Preferred Member 10.07(b1.4 Incentive Units 2.10(b) F2 3.02(b)(ii) Foresite 12.02 Holding 10.09(a) Imputed Underpayment Amount 13.01(bInclusion Notice 10.4(b) Indemnified Person 5.06(a5.5(a) Initial Consideration 11.03(dInventions 2.11(b) IPO 10.10 Investor Business Opportunity 3.11(b) Key Person 5.6(b) Key Person Policy 5.6(b) Key Person Policy Payout Event (KPPPE) 5.6(b) KPPPE Appraiser 5.6(b) KPPPE Units 5.6(b) KPPPE Units Purchase Price 5.6(b) Major Member 12.2 Majority Interest 2.03(a) 12.2 Member Preamble Membership Interest 7.1 New Securities 12.02 Non-Voting Incentive Units 2.10(a) OIF 3.02(b)(i) Offer Notice 10.07(a) 12.2 Officer 4.01 Other Indemnitors 5.02 Participating Preferred 4.1 Oversubscribing Member 10.04(a10.3(d) Partnership Representative 3.03(a)(viii3.4(f) Permitted Transfer 10.01(a10.1(a) Permitted Transferee 10.01(a10.1(a) Person 12.02 Preferred Director 3.02(b)(iii) Preferred Member 12.02 Preferred Member Notice 12.02 Preferred Member Notice Period 10.03(d) Preferred Units 2.10(a) Preferred Unit Preference Amount 12.02 12.2 Plan 12.2 President 4.01 4.1 Prior Agreement Recitals Preamble Proceeding 5.06(c5.5(c) Proceeds Available for Distribution 12.02 Prohibited Transfer 10.05(c12.2 Proposed Acquirer 10.5(c) Proposed Sale 10.06(cTransferee 10.3(a) Proposed Purchase Right 10.6(c) Purchaser 10.3(e) Remaining Transfer 12.02 Proposed Transfer Notice 12.02 Proposed Transferee 12.02 Purchase Agreement 12.02 QPO 10.09 Original Issue Date 12.02 Released Securities 10.10 Required Reserve 12.02 Requisite Preferred Holders 12.02 Revised Audit Procedures 12.02 Right Units 10.3(b) Restructuring 10.7 Secretary 4.1 Secretary of Co-Sale 12.02 Right of First Refusal 12.02 Rule 506(dState Preamble Service Provider NDA 2.9(a) Related Party 12.02 Sale Event 11.03(a) Sale of the Company 10.06(a) Secondary Notice 12.02 Secondary Refusal Right 12.02 Secretary 4.01 Securities Act 2.02 Selling Investors Series Seed Preferred Units 10.06(b) 2.10(a) Series A Preferred Units 2.10(a) Series A Preferred Director 3.02 Series B Accrued Dividend 12.02 Series B Preferred Units 2.10(a) Series B Original Issue Price 12.02 Series B Vote 12.02 Series C Original Issue Price 12.02 Series C Vote 12.02 Series A1 Accrued Dividend 12.02 Series Seed Accrued Dividend 12.02 Series A1 Original Issue Price 12.02 Series Seed Original Issue Price 12.02 Strike Price 2.10(e2.10(d) Target Balance 12.02 Subsequent Owner 10.1(c) Subsidiaries 1.2 Tax Distribution 8.02 Tax Liability 8.02 Tax Rate 8.02 8.3 Total and Permanent Disability 5.6(b) Transfer 10.02(a10.1(a) Transferring Member 12.02 10.3(a) Transfer Notice 12.02 10.3(a) Transfer Notice Date 10.3(b) Transfer Purchase Price Per Unit 10.3(a) Transfer Units 12.02 Treasurer 4.01 10.3(a) Transfer 10.1(a) Treasury Regulation 12.02 Unit Certificate 2.10(g12.2 UCC 2.10(b) Unit Sale 10.06(aUnsubscribed Units 10.3(d) Units 2.10(a) Units Deemed Outstanding 12.02 Unpaid Preferred Cap 12.02 Unpaid Preferred Unit Preference Amount 12.02 Withholding Payment 13.01(aVesting Agreement 2.10(c)

Terms Defined Elsewhere in the Agreement. For purposes of this Agreement, the following terms have the meaning set forth in the Section indicated: Term Section A&R Agreement Recitals Acceptance Period 10.03(d) Act Recitals Preamble Additional Consideration 11.03(d) Additional Units 12.02 Adjustment Price 12.02 Adjustment Ratio 12.02 Affiliate 12.02 Agreement Preamble Available Units 10.04(a) Bad Actor Disqualification Event 2.14 Baupost Director 3.02 As Adjusted Voting Basis 12.02 Board of Directors 3.01 Managers 1.01 Board Observers 3.02(f) Budget 2.08(a)(iv) Capital Account 12.02 Capital Contribution 12.02 Capital Transaction 12.02 Capital Transaction Proceeds 12.02 Capital Units 2.10(a) CEO 4.01 CEO Manager 3.02(b)(iii Certificate 1.01 CEO 3.02(b)(iii) CEO Director 3.02(b)(iii) Change of Control 12.02 Code 12.02 Common Units 2.10(a) Company Preamble Company Distributions 12.02 Company Notice 12.02 Company Refusal Period 10.03(c) Company Undersubscription Notice 10.03(d10.03(e) Confidential Information 12.02 Company’s Expiration Notice 10.03(c) Control 12.02 Convertible Securities 8.06(e)(i) Corporate Conversion 10.09(a) Co-Sale Per Unit Liquidation Value 10.04(b) Co-Sale Purchase Price 10.04(b10.11(a) Covered Persons 3.11(b3.10(b) Designated Affiliate Deep Track 12.02 Designated Affiliate License Agreements 12.02 Designated Affiliate Sale 8.01(dDeep Track Board Observer 3.02(f) DGCL 5.01 Director 12.02 Disqualification Event 2.02 Disqualified Designee 2.02 Economic Capital Account 12.02 Exercising Preferred Members 10.03(d) Exchange Act 12.02 Exempted Securities 12.02 Existing Agreement Preamble Expenses 5.06(b) Fair Market Value 12.02 Fairmount Managers 3.02(b)(ii) Fairmount Members 12.02 FCPA 5.13 Fidelity Member 12.02 Fiscal Year 1.04 Fully Exercising Preferred Member 10.07(bInvestors 10.03(e) F2 3.02(b)(iiHoldings 10.11(a) Foresite 12.02 Holding 10.09(aHoldings Reduced Equity 10.11(a) Imputed Underpayment Amount 13.01(b) Incentive Units 2.10(a) Indemnified Person 5.06(a) Initial Consideration 11.03(d) IPO 10.10 Initial Equity Allocation 10.11(a) Investor Business Opportunity 3.11(b3.10(b) Majority Interest 2.03(aInvestor Counsel 5.11 Investor Notice Period 10.03(e) IPO 12.02 Major Investor 12.02 Manager 12.02 Mandatory Conversion Time 8.12(a) Member Preamble Member Representative 10.07(b)(vii) New Securities 12.02 Non-Voting Incentive Units 2.10(a) OIF 3.02(b)(i) Offer Notice 10.07(a10.12(a) Options 8.06(e)(i) Officer 4.01 OrbiMed 12.02 Other Indemnitors 5.02 Paragon Member 12.02 Participating Preferred Member 10.04(a) Partnership Representative 3.03(a)(viii3.04(h) Pass -Through Entities 9.08 Percentage Interest 12.02 Permitted Transfer 10.01(a) Permitted Transferee 10.01(a) Person 12.02 Preferred Director 3.02(b)(iii) Preferred Member 12.02 Preferred Member Notice 12.02 Preferred Member Notice Period 10.03(d) Preferred Units 2.10(a) Preferred Unit Preference Amount 12.02 President 4.01 Prior Agreement Recitals Proceeding 5.06(c) Proceeds 8.01(b) Proceeds Available for Distribution 12.02 Prohibited Transfer 10.05(c) Proposed Sale Prohibited Transferees 10.06(c) Proposed Transfer 12.02 Sale 10.07(c) Proposed Transfer Notice 12.02 Proposed Transferee 12.02 Purchase Agreement 12.02 QPO 10.09 Original Issue Date Preamble Purchase Notice 10.03(d) Qualified IPO 8.12(a) RA Capital 12.02 Released Securities 10.10 Required Reserve 12.02 10.13(b) Requisite Preferred Holders 12.02 Revised Audit Procedures Requisite Series A Preferred Holders 12.02 Requisite Series B Preferred Holders 12.02 Right of Co-Sale 12.02 Right of First Refusal 12.02 ROFR Subject 10.03(a) RTW Funds 12.02 RTW Board Observer 3.02(f) Rule 506(d) Related Party 12.02 Sale Event 11.03(a) Sale of the Company 10.06(a10.07(a) Secondary Offer Notice 12.02 Secondary Refusal Right 12.02 10.12(b) Secretary 4.01 Securities Act 2.02 Selling Investors Holders 10.07(b) Series Seed Preferred Units 10.06(b) A Adjustment Price 12.02 Series A Adjustment Ratio 12.02 Series A As Adjusted Voting Basis 2.10(a) Series A Original Issuance Price 12.02 Series A Preferred Units 12.02 Series B Adjustment Price 12.02 Series B Adjustment Ratio 12.02 Series B As Adjusted Voting Basis 2.10(a) Series A Preferred Director 3.02 Series B Accrued Dividend Original Issuance Price 12.02 Series B Preferred Units 2.10(a) Series B Original Issue Price 12.02 Series B Vote 12.02 Series C Original Issue Price 12.02 Series C Vote 12.02 Series A1 Accrued Dividend 12.02 Series Seed Accrued Dividend 12.02 Series A1 Original Issue Price 12.02 Series Seed Original Issue Price 12.02 Preamble Strike Price 2.10(e2.10(f) Target Balance 12.02 Tax Distribution 8.02 8.02(a) Tax Liability 8.02 8.02(a) Tax Rate 8.02 8.02(a) Transfer 10.02(a10.01(a) Trade Secrets 12.02 Transferring Member 12.02 Transfer Notice 12.02 Transfer Units 12.02 Transferor’s Owner 10.02(b)(iv) Treasurer 4.01 Treasury Regulation 12.02 Unit Certificate 2.10(g) Unit Sale 10.06(a10.07(a) Units 2.10(a) Units Deemed Outstanding 12.02 United States Person 10.02(b)(iv) Unpaid Preferred Cap 12.02 Unpaid Series A Preferred Unit Preference Amount 12.02 Unpaid Series B Preferred Unit Preference Amount 12.02 USRPHC 9.07 Venrock Managers 3.02(b)(i) Voting Majority 2.03(b) Wellington Investors 12.02 Withholding Payment 13.01(a)) Xontogeny 12.02

Terms Defined Elsewhere in the Agreement. For purposes of this Agreement, the following terms have the meaning set forth in the Section indicated: Term Section A&R Agreement Recitals Act Recitals Additional Consideration 11.03(d) Additional Units 12.02 Affiliate 12.02 Agreement Preamble Available Units 10.04(a) Bad Actor Disqualification Event 2.14 Baupost Director 3.02 Board of Directors 3.01 Capital Account 12.02 Capital Contribution 12.02 Capital Transaction 12.02 Capital Transaction Proceeds 12.02 Capital Units 2.10(a) Certificate 1.01 CEO 3.02(b)(iii) CEO Director 3.02(b)(iii) Change of Control 12.02 Code 12.02 Common Units 2.10(a) Company Preamble Company Distributions 12.02 Company Notice 12.02 Company Undersubscription Notice 10.03(d) Confidential Information 12.02 Control 12.02 Corporate Conversion 10.09(a) Co-Sale Per Unit Liquidation Value 10.04(b) Co-Sale Purchase Price 10.04(b) Covered Persons 3.11(b) Designated Affiliate 12.02 Designated Affiliate License Agreements 12.02 Designated Affiliate Sale 8.01(d) DGCL 5.01 Director 12.02 Economic Capital Account 12.02 Exercising Preferred Members 10.03(d) Expenses 5.06(b) Fair Market Value 12.02 Fiscal Year 1.04 Fully Exercising Preferred Member 10.07(b) F2 3.02(b)(ii) Foresite 12.02 Holding 10.09(a) Imputed Underpayment Amount 13.01(b) Indemnified Person 5.06(a) Initial Consideration 11.03(d) IPO 10.10 Investor Business Opportunity 3.11(b) Majority Interest 2.03(a) Member Preamble New Securities 12.02 Non-Voting Incentive Units 2.10(a) OIF 3.02(b)(i) Offer Notice 10.07(a) Officer 4.01 Other Indemnitors 5.02 Participating Preferred Member 10.04(a) Partnership Representative 3.03(a)(viii) Permitted Transfer 10.01(a) Permitted Transferee 10.01(a) Person 12.02 Preferred Director 3.02(b)(iii) Preferred Member 12.02 Preferred Member Notice 12.02 Preferred Member Notice Period 10.03(d) Preferred Units 2.10(a) Preferred Unit Preference Amount 12.02 President 4.01 Prior Agreement Recitals Proceeding 5.06(c) Proceeds Available for Distribution 12.02 Prohibited Transfer 10.05(c) Proposed Sale 10.06(c) Proposed Transfer 12.02 Proposed Transfer Notice 12.02 Proposed Transferee 12.02 Purchase Agreement 12.02 QPO 10.09 Original Issue Date 12.02 Released Securities 10.10 Required Reserve 12.02 Requisite Preferred Holders 12.02 Revised Audit Procedures 12.02 Right of Co-Sale 12.02 Right of First Refusal 12.02 Rule 506(d) Related Party 12.02 Sale Event 11.03(a) Sale of the Company 10.06(a) Secondary Notice 12.02 Secondary Refusal Right 12.02 Secretary 4.01 Securities Act 2.02 Selling Investors Series Seed Preferred Units 10.06(b) 2.10(a) Series A Preferred Units 2.10(a) Series A Preferred Director 3.02 Series B Accrued Dividend 12.02 Series B Preferred Units 2.10(a) Series B Original Issue Price 12.02 Series B Vote 12.02 Series C Original Issue Price 12.02 Series C Vote 12.02 Series A1 Accrued Dividend 12.02 Series Seed Accrued Dividend 12.02 Series A1 Original Issue Price 12.02 Series Seed Original Issue Price 12.02 Strike Price 2.10(e) Target Balance 12.02 Tax Distribution 8.02 Tax Liability 8.02 Tax Matters Partner 3.03(a)(viii) Tax Rate 8.02 Transfer 10.02(a) Transferring Member 12.02 Transfer Notice 12.02 Transfer Units 12.02 Treasurer 4.01 Treasury Regulation 12.02 Unit Certificate 2.10(g) Unit Sale 10.06(a) Units 2.10(a) Units Deemed Outstanding 12.02 Unpaid Preferred Cap 12.02 Unpaid Preferred Unit Preference Amount 12.02 Withholding Payment 13.01(a)