Common use of Xxxxx Xxxx Clause in Contracts

Xxxxx Xxxx. Xxxxxx Xxxarek -------------------------------------- Tel: 000-000-0000 Print Name: Sven H. Borho Fax: 000-000-0000 Print Title: Xxxxxxx; XxxiMed Advisors LLC Subscriptiox Xxxxxx: $07,768 ------------------- Shares Purchased: 5,600 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE INTEGRATED HOLDINGS II LIMITED ------------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue, 30th Floor Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Xxxarek Xanarek -------------------------------------- TelTxx: 000-000-0000 0006 Print Name: Sven H. Borho Fax: 000-000-0000 0044 Print TitleTitlx: Xxxxxxx; XxxiMed XrbiMed Advisors LLC Subscriptiox Xxxxxx: $07,768 001,962 ------------------- Shares Purchased: 5,600 35,400 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE INTEGRATED HOLDINGS II LIMITED ------------------------------------------- IV POST VENTURE, LP ---------------------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue, 30th Floor Avenue 00xx Xxxxx Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Xxxarek Kanarek -------------------------------------- TelXxx: 000-000-0000 6406 Print Name: Sven H. Borho FaxFxx: 000-000-0000 6444 Print TitleTixxx: Xxxxxxx; XxxiMed OrbiMed Advisors LLC Subscriptiox Xxxxxx: $07,768 007,080 ------------------- Shares Purchased: 5,600 36,000 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE INTEGRATED HOLDINGS II LIMITED ------------------------------------------- NETHERLANDS II, L.P. ----------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue, 30th Floor Avenue 00xx Xxxxx Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Xxxarek Kanarek -------------------------------------- TelXxx: 000-000-0000 6406 Print Name: Sven H. Borho FaxFxx: 000-000-0000 6444 Print TitleTixxx: Xxxxxxx; XxxiMed OrbiMed Advisors LLC Subscriptiox Xxxxxx: $07,768 019,477 ------------------- Shares Purchased: 5,600 60,900 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE INTEGRATED HOLDINGS II LIMITED ------------------------------------------- VENTURE CAPITAL III LP --------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue, 30th Floor Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Xxxarek Kanarek -------------------------------------- TelXxx: 000-000-0000 6406 Print Name: Sven H. Borho FaxFxx: 000-000-0000 6444 Print TitleTixxx: Xxxxxxx; XxxiMed OrbiMed Advisors LLC Subscriptiox Xxxxxx: $07,768 023,710.69 ------------------- Shares Purchased: 5,600 49,673 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE INTEGRATED HOLDINGS II LIMITED ------------------------------------------- POST VENTURE IV L.P. --------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue, 30th Floor Avenue 00xx Xxxxx Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Xxxarek -------------------------------------- Tel: 000-000-0000 Print Name: Sven H. Borho Fax: 000-000-0000 Print Title: Xxxxxxx; XxxiMed Advisors LLC Subscriptiox Xxxxxx: $07,768 00,472 ------------------- Shares Purchased: 5,600 2,400 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE INTEGRATED HOLDINGS II LIMITED ------------------------------------------- VENTURE CAPITAL IV L.P. --------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue, 30th Floor Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Xxxarek -------------------------------------- Tel: 000-000-0000 Print Name: Sven H. Borho Fax: 000-000-0000 Print Title: Xxxxxxx; XxxiMed Advisors LLC Subscriptiox Xxxxxx: $07,768 021,581 ------------------- Shares Purchased: 5,600 37,700 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE INTEGRATED HOLDINGS II LIMITED NETHERLANDS III - LP ------------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue, 30th Floor Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Xxxarek Kanarek -------------------------------------- TelXxx: 000-000-0000 6406 Print Name: Sven H. Borho FaxFxx: 000-000-0000 6444 Print TitleTixxx: Xxxxxxx; XxxiMed OrbiMed Advisors LLC Subscriptiox Xxxxxx: $07,768 068,041 ------------------- Shares Purchased: 5,600 19,700 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE INTEGRATED HOLDINGS II LIMITED ------------------------------------------- HOLDINGS, V, LP ----------------------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue, 30th Floor Avenue 00xx Xxxxx Xxx Xxxx, XX 00000

Xxxxx Xxxx. Xxxxxx Xxxarek -------------------------------------- Tel: 000-000-0000 Print Name: Sven H. Borho Fax: 000-000-0000 Print Title: Xxxxxxx; XxxiMed Advisors LLC Subscriptiox Xxxxxx: $07,768 ------------------- Shares Purchased: 5,600 ----------------------- SECURITY DELIVERY INSTRUCTIONS (IF DIFFERENT THAN NOTICE ADDRESS) [PURCHASER SIGNATURE PAGES TO SECURITIES PURCHASE AGREEMENT] KNIGHTSBRIDGE INTEGRATED HOLDINGS II LIMITED ------------------------------------------- NETHERLAND I LP ----------------------------- Address for Notice: Print Entity Name ------------------ OrbiMed Advisors LLC 767 Third Avenue, 30th Floor Xxx Xxxx, XX 00000