ST&B DRAFT 10/23/97 2,500,000 Shares of Common Stock SYNAPTIC PHARMACEUTICAL CORPORATION UNDERWRITING AGREEMENT ____________, 1997Underwriting Agreement • October 30th, 1997 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research • New York
EXHIBIT 10.45 ------------- FIRST AMENDMENT TO LEASE THIS FIRST AMENDMENT TO LEASE (this "Amendment") is entered into as of November 25, 1998, by and between AREB215 COLLEGE ROAD, LLC, a Delaware limited liability company ("Landlord"), and SYNAPTIC...Lease • March 25th, 1999 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research
ISO Plan Option NONTRANSFERABLE INCENTIVE STOCK OPTION AGREEMENTIncentive Stock Option Agreement • November 14th, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • New Jersey
Non-Plan Option NONTRANSFERABLE NONQUALIFIED STOCK OPTION AGREEMENTNonqualified Stock Option Agreement • November 14th, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • New Jersey
AGREEMENT BETWEENSublease Agreement • March 27th, 1998 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research
EMPLOYMENT AGREEMENT dated as of September 9, 2002, between SYNAPTIC PHARMACEUTICAL CORPORATION, a Delaware corporation (the "Company"), and Errol de Souza (the "Employee"). Effective as of the Start Date (as defined below), the Employee is hereby...Employment Agreement • November 14th, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • New Jersey
Exhibit 4.2 ----------- FIRST AMENDMENT TO RIGHTS AGREEMENT FIRST AMENDMENT, dated October 19, 2001 (this "Amendment"), between Synaptic Pharmaceutical Corporation, a Delaware corporation (the "Company") and Mellon Investor Services LLC, a New Jersey...Rights Agreement • February 13th, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • Delaware
EMPLOYMENT AGREEMENT dated as of April 1, 1998 (the "Effective Date"), between SYNAPTIC PHARMACEUTICAL CORPORATION, a Delaware corporation (the "Company"), and THERESA A. BRANCHEK (the "Employee"). Immediately prior to the Effective Date, the Employee...Employment Agreement • May 8th, 1998 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research • New Jersey
This Executive Employment Agreement (the "Agreement") is entered into effective as of October 1, 1997 (the "Effective Date"), between Synaptic Pharmaceutical Corporation (the "Company"), a Delaware corporation, and Dr. Kathleen P. Mullinix (the...Executive Employment Agreement • March 27th, 1998 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research • New Jersey
SUBLEASESublease • May 11th, 2000 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research • New Jersey
AMENDMENT NO. 1 TO COOPERATION AGREEMENT ---------------------Cooperation Agreement • November 6th, 1998 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research
COLLABORATIVE RESEARCH AND LICENSE AGREEMENTCollaborative Research and License Agreement • November 7th, 1997 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research • New Jersey
EXHIBIT 10.40 ------------- AMENDMENT NO. 4 TO RESEARCH COLLABORATION AND LICENSE AGREEMENTResearch Collaboration and License Agreement • March 27th, 1998 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research
Exhibit 10.33 ------------- SEPARATION AGREEMENT This Separation Agreement (the "Agreement") is entered into effective as of November 26, 2001 (the "Effective Date"), by and between Synaptic Pharmaceutical Corporation (the "Company"), a Delaware...Separation Agreement • April 1st, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • New Jersey
OPTION AND LICENSE AGREEMENTOption and License Agreement • March 27th, 1998 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research • New Jersey
RESEARCH AND LICENSE AGREEMENTResearch & License Agreement • February 10th, 1997 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research • New York
ANDResearch, Option and License Agreement • March 25th, 1999 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research
EXHIBIT 10.46 ------------- AMENDMENT NO. 5 AND SUPPLEMENT TO RESEARCH COLLABORATION AND LICENSE AGREEMENTResearch Collaboration and License Agreement • March 25th, 1999 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research
EXHIBIT 10.36 ------------- AMENDMENT NO. 3 AND SUPPLEMENT TO RESEARCH COLLABORATION AND LICENSE AGREEMENTResearch Collaboration and License Agreement • March 27th, 1998 • Synaptic Pharmaceutical Corp • Services-commercial physical & biological research
AGREEMENT AND PLAN OF MERGER Dated as of November 21, 2002, Among H. LUNDBECK A/S, VIKING SUB CORPORATION And SYNAPTIC PHARMACEUTICAL CORPORATIONMerger Agreement • November 22nd, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • Delaware
SECOND AMENDMENT TO RIGHTS AGREEMENTRights Agreement • November 22nd, 2002 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • Delaware
SECOND AMENDMENT, dated as of November 21, 2002 (the "Amendment"), to the Rights Agreement, dated as of December 11, 1995 and amended on October 19, 2001 (as amended, the "Rights Agreement"), between Synaptic Pharmaceutical Corporation, a Delaware corporation (the "Company"), and Mellon Investor Services LLC (formerly known as Chemical Mellon Shareholder Services), as rights agent (the "Rights Agent").
Exhibit No. 10.1 ---------------- STOCK PURCHASE AGREEMENT This STOCK PURCHASE AGREEMENT is dated as of the 2nd day of August, 2001 by and among Synaptic Pharmaceutical Corporation, a Delaware corporation with its principal office at 215 College Road,...Stock Purchase Agreement • August 6th, 2001 • Synaptic Pharmaceutical Corp • Biological products, (no disgnostic substances) • Delaware
