AMBIT BIOSCIENCES CORPORATION SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT

Exhibit 10.18

SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT

THIS SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the “Agreement”) is entered into as of October 25, 2012 by and among AMBIT BIOSCIENCES CORPORATION, a Delaware corporation (the “Company”) and the investors listed on Exhibit A hereto, referred to hereinafter as the “Investors” and each individually as an “Investor.”

RECITALS

WHEREAS, the Company previously entered into a Fifth Amended and Restated Investor Rights Agreement dated as of May 9, 2011 (the “Prior Agreement”) with certain purchasers (the “Prior Investors”) of Series A Preferred Stock of the Company (the “Series A Preferred”), Series B Preferred Stock of the Company (the “Series B Preferred”), Series C Preferred Stock of the Company (the “Series C Preferred”), Series D Preferred Stock of the Company (the “Series D Preferred”) and Series D-2 Preferred Stock of the Company (the “Series D-2 Preferred”);

WHEREAS, certain of the Investors are purchasing shares of Series E Preferred Stock of the Company (the “Series E Preferred”) pursuant to that certain Series E Preferred Stock, Common Stock and Warrant Purchase Agreement dated as of October 25, 2012, as may be amended from time to time (the “Purchase Agreement” and the transactions contemplated thereby, the “Financing”);

WHEREAS, the obligations in the Purchase Agreement are conditioned upon the execution and delivery of this Agreement;

WHEREAS, the Company and the Prior Investors desire to amend and restate the Prior Agreement as set forth below; and

WHEREAS, in connection with the consummation of the Financing, the parties desire to enter into this Agreement in order to grant registration, information rights and other rights to the Investors as set forth below.

NOW, THEREFORE, in consideration of the premises and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties agree hereto as follows:

SECTION 1. GENERAL.

1.1 Definitions. As used in this Agreement the following terms shall have the following respective meanings:

“Charter” means the Amended and Restated Certificate of Incorporation of the Company filed with the Secretary of State of the State of Delaware on or about the date hereof, as the same may be amended from time to time.

“Control” or “Controlled” means, for purposes of Section 2.1, holding 50% or more of the voting power of an entity and/or having the right to appoint at least a majority of the members of an entity’s Board of Directors.

“Control Group” means any company that (i) a Holder directly or indirectly holds Control of, (ii) the Holder is directly or indirectly Controlled by, or (iii) is directly or indirectly under common Control with the Holder. In addition, “Control Group” means any company or Investment Fund which manages any of the aforementioned companies or is managed by any of the aforementioned companies or a general partner, officer, director or manager of such Person and any venture capital fund now or hereafter existing that is controlled by one or more general partners or managing members of, or shares the same management company with, such Person.

“Exchange Act” means the Securities Exchange Act of 1934, as amended.

“Form S-3” means such form under the Securities Act as in effect on the date hereof or any successor or similar registration form under the Securities Act subsequently adopted by the SEC which permits inclusion or incorporation of substantial information by reference to other documents filed by the Company with the SEC.

“Holder” means any person owning of record Registrable Securities that have not been sold to the public or any assignee of record of such Registrable Securities in accordance with Section 2.10 hereof.

“Initial Offering” means a firmly underwritten public offering pursuant to an effective registration statement under the Securities Act covering the offer and sale of Common Stock of the Company for the account of the Company in which the per share price is at least an amount that reflects a pre-money valuation (calculated on a fully-diluted basis and including the shares of capital stock reserved for future issuance under the Company’s 2011 Equity Incentive Plan (the “Option Plan”)) for the Company of not less than $125,000,000, and (ii) the net cash proceeds to the Company (after deducting underwriting discounts, commissions and fees) are at least $50,000,000.

“Investment Fund” means any Person holding Shares for investment purposes.

“Member of the same Group” means (a) if the Person concerned is a body corporate, any holding company or parent undertaking or subsidiary or subsidiary undertaking or subsidiary or subsidiary undertaking of any such holding company or parent undertaking of such person where “subsidiary” and “holding company” shall have the meanings given to them in section 736 of the Companies Xxx 0000, or (b) if the Person concerned is a firm or other unincorporated body, any corporation directly or indirectly controlled (as defined in section 840 of the Income and Corporation Taxes Act 1988) by such Person.

“Key Employee” means the president, chief executive officer, chief financial officer, chief operating officer, chief technology officer, vice presidents of operations, research, development, sales or marketing, or any other individual who performs a significant role in the leadership and operations of the Company or a subsidiary or in the development or conception of any material intellectual property of the Company as may be reasonably designated by the Board of Directors of the Company.

“Permitted Transfer” means a transfer of shares by a Holder to a Control Group.

“Person” means an individual, a partnership, a corporation, a limited liability company, an association, a joint stock company, a trust, a fund, a joint venture, an unincorporated organization and a governmental entity or any department, agency or political subdivision thereof.

“Register,” “registered,” and “registration” refer to a registration effected by preparing and filing a registration statement in compliance with the Securities Act, and the declaration or ordering of effectiveness of such registration statement or document.

“Registrable Securities” means (a) Common Stock of the Company issued or issuable upon conversion of the Shares, (b) Common Stock of the Company issued upon the exercise of the warrants issued pursuant to the Note and Warrant Purchase Agreement dated September 30, 2010 (the “2010 Note Purchase Agreement”), (c) Common Stock issued upon the exercise of warrants issued pursuant to the Note and Warrant Purchase Agreement dated September 30, 2010 by and among the Company, Ambit Biosciences (Canada) Corporation and GrowthWorks Canadian Fund Ltd. (the “2010 Canadian Note Purchase Agreement”), (d) Common Stock of the Company issued upon the exercise of warrants issued pursuant to the Note and Warrant Purchase Agreement dated June 4, 2009 (the “2009 Note Purchase Agreement”), (e) Common Stock of the Company issued upon the exercise of warrants issued pursuant to the Note and Warrant Purchase Agreement dated July 8, 2009 by and among the Company, Ambit Biosciences (Canada) Corporation and GrowthWorks Canadian Fund Ltd. (the “2009 Canadian Note Purchase Agreement”), (f) Common Stock of the Company issued upon the exercise of warrants issued pursuant to the Purchase Agreement (including the warrants issued in connection with the exchange of Prior Warrants (as defined in the Purchase Agreement) pursuant to the Purchase Agreement, (g) any Common Stock of the Company issued as (or issuable upon the conversion or exercise of any warrant, right or other security which is issued as) a dividend or other distribution with respect to, or in exchange for or in replacement of, such above-described securities, and (h) any Common Stock issued or issuable to MedImmune Ventures, Inc. (“MedImmune”) pursuant to Section 3.10 hereof. Notwithstanding the foregoing, Registrable Securities shall not include any securities sold by a person to the public either pursuant to a registration statement or Rule 144 or sold in a private transaction in which the transferor’s rights under Section 2 of this Agreement are not assigned.

“Registrable Securities then outstanding” shall be the number of shares determined by calculating the total number of shares of the Company’s Common Stock that are Registrable Securities and either (a) are then issued and outstanding or (b) are issuable pursuant to then exercisable or convertible securities.

“Registration Expenses” shall mean all expenses incurred by the Company in complying with Sections 2.2, 2.3 and 2.4 hereof, including, without limitation, all registration and filing fees, printing expenses, fees and disbursements of counsel for the Company, reasonable fees and disbursements of a single special counsel for the Holders, blue sky fees and expenses and the expense of any special audits incident to or required by any such registration (but excluding the compensation of regular employees of the Company which shall be paid in any event by the Company).

“SEC” or “Commission” means the Securities and Exchange Commission.

“Securities Act” shall mean the Securities Act of 1933, as amended.

“Selling Expenses” shall mean all underwriting discounts and selling commissions applicable to the sale.

“Shares” shall mean the Company’s (i) Series A Preferred issued pursuant to the Stock Purchase Agreement dated as of December 5, 2000, (ii) Series B Preferred issued pursuant to the Series B Preferred Stock Purchase Agreement dated as of June 26, 2001 and Second Series B Preferred Stock Purchase Agreement dated as of May 29, 2002, (iii) Series C Preferred issued pursuant to the Series C Preferred Stock Purchase Agreement dated August 13, 2004 and the Series C Preferred Stock Purchase Agreement dated December 9, 2005 by and between the Company and Xxxxxxx-Xxxxx Squibb Company, (iv) shares of the Company’s Series C-2 Preferred Stock (the “Series C-2 Preferred”), Series D Preferred, Series D-2 Preferred and Series E Preferred if and when issued pursuant to the Amended and Restated Put Agreement among the Company, GrowthWorks Canadian Fund Ltd. (“GrowthWorks”) and Ambit Biosciences (Canada) Corporation (“Ambit Canada”) dated May 11, 2011, as the same may be amended from time to time (the “Put Agreement”), (v) Series D Preferred issued pursuant to the Series D Preferred Stock Purchase Agreement dated October 30, 2007, as amended, (vi) shares of Series D-2 Preferred issued pursuant to the Series D-2 and Series D-3 Preferred Stock and Warrant Purchase Agreement dated May 9, 2011, as amended (the “Series D-2 Purchase Agreement”), (vii) shares of Series D-2 Preferred issued upon the exercise of warrants issued pursuant to the Series D-2 Purchase Agreement, in each case as held by certain of the Investors listed on Exhibit A hereto and their permitted assigns, (viii) shares of Series E Preferred issued pursuant to the Purchase Agreement, and (ix) any of the foregoing shares of the Company’s capital stock acquired by any of the Investors from any other Investor or Person in connection with the exercise of such Investor’s rights pursuant to that certain Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement by and among the Company and the other parties thereto.

“Special Registration Statement” shall mean (i) a registration statement relating to any employee benefit plan or (ii) with respect to any corporate reorganization or other transaction under Rule 145 of the Securities Act, including any registration statements related to the resale of securities issued in such a transaction or (iii) a registration related to stock issued upon conversion of debt securities.

SECTION 2. REGISTRATION; RESTRICTIONS ON TRANSFER.

2.1 Restrictions on Transfer.

(a) Each Holder agrees not to make any disposition of all or any portion of the Shares or Registrable Securities unless and until:

(i) There is then in effect a registration statement under the Securities Act covering such proposed disposition and such disposition is made in accordance with such registration statement; or

(ii) (A) The transferee has agreed in writing to be bound by the terms of this Agreement, (B) such Holder shall have notified the Company of the proposed disposition and shall have furnished the Company with a detailed statement of the circumstances surrounding the proposed disposition, and (C) if reasonably requested by the Company, such Holder shall have furnished the Company with an opinion of counsel, reasonably satisfactory to the Company, that such disposition will not require registration of such shares under the Securities Act. It is agreed that the Company will not require opinions of counsel for transactions made pursuant to Rule 144, except in unusual circumstances. After its Initial Offering, the Company will not require the transferee to be bound by the terms of this Agreement.

(iii) Notwithstanding the provisions of paragraphs (i) and (ii) above, no such registration statement or opinion of counsel shall be necessary for a transfer by a Holder that is (A) a partnership transferring to its partners, former partners or a subsidiary Controlled by any such partner or former partner in accordance with partnership interests, (B) an Investment Fund or its trustee, custodian or nominee to (1) the beneficial owner or owners in respect of which the transferor is a nominee or custodian, (2) any trustee, nominee, subsidiary, subsidiary undertaking or custodian for such Investment Fund and vice versa, (3) any unitholder, shareholder, partner, participant in, manager or adviser (or an employee of such manager or adviser) of the Investment Fund including any person to whom such partner may have assigned its interest or any interest therein, (4) any other Investment Fund, or its trustee, nominee, subsidiary, subsidiary undertaking or custodian, managed or advised by the same manager or adviser or whose general partner is the same general partner as the Investment Fund, (5) in the case of Apposite Healthcare Fund LP (“Apposite”), Mizuho Financial Group or any of its subsidiaries, and (6) trustee, nominee, custodian or to a Member of the same Group of any of the Persons referred to in sub-clauses (1)-(5) of clause (B) of this Section 2.1(a)(iii) (collectively referred to herein as an “Investor Group”), (C) a corporation transferring to a wholly-owned subsidiary or a parent corporation that owns all of the capital stock of the Holder, (D) a limited liability company transferring to its members or former members in accordance with their interest in the limited liability company, (E) an individual transferring to the Holder’s family member or trust for the benefit of an individual Holder or (F) a Permitted Transfer; provided that in each case the transferee will be subject to the terms of this Agreement to the same extent as if such transferee were an original Holder hereunder, and such transfer complies with state, federal and foreign securities laws.

(b) Each certificate representing Shares or Registrable Securities shall (unless otherwise permitted by the provisions of the Agreement) be stamped or otherwise imprinted with a legend substantially similar to the following (in addition to any legend required under applicable state securities laws):

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE “ACT”) AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED.

(c) The Company shall be obligated to reissue promptly unlegended certificates at the request of any Holder thereof if the Holder shall have obtained an opinion of counsel (which counsel may be counsel to the Company) reasonably acceptable to the Company to the effect that the securities proposed to be disposed of may lawfully be so disposed of without registration, qualification or legend.

(d) Any legend endorsed on an instrument pursuant to applicable state securities laws and the stop-transfer instructions with respect to such securities shall be removed upon receipt by the Company of an order of the appropriate blue sky authority authorizing such removal.

2.2 Demand Registration.

(a) Subject to the conditions of this Section 2.2, if the Company shall receive a written request from the Holders of at least a majority of the Registrable Securities (the “Initiating Holders”) that the Company file a registration statement under the Securities Act covering the registration of Registrable Securities having an aggregate offering price, net of underwriting discounts and commissions, exceeding $25,000,000, then the Company shall, within 30 days of the receipt thereof, give written notice of such request to all Holders, and subject to the limitations of this Section 2.2, effect, as expeditiously as reasonably possible, the registration under the Securities Act of all Registrable Securities that the Holders request to be registered.

(b) If the Initiating Holders intend to distribute the Registrable Securities covered by their request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to this Section 2.2 or any request pursuant to Section 2.4 and the Company shall include such information in the written notice referred to in Section 2.2(a) or Section 2.4(a), as applicable. In such event, the right of any Holder to include its Registrable Securities in such registration shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities through such underwriting shall enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by at least 67% in interest of the Initiating Holders (which underwriter or underwriters shall be reasonably acceptable to the Company). Notwithstanding any other provision of this Section 2.2 or Section 2.4, if the underwriter advises

the Company that marketing factors require a limitation of the number of securities to be underwritten (including Registrable Securities) then the Company shall so advise all Holders of Registrable Securities which would otherwise be underwritten pursuant hereto, and the number of shares that may be included in the underwriting shall be allocated to the Holders of such Registrable Securities on a pro rata basis based on the number of Registrable Securities held by all such Holders (including the Initiating Holders); provided, however, that the number of shares of Registrable Securities to be included in such underwriting shall not be reduced unless all other securities are first entirely excluded from the underwriting). Any Registrable Securities excluded or withdrawn from such underwriting shall be withdrawn from the registration.

(c) The Company shall not be required to effect a registration pursuant to this Section 2.2:

(i) prior to the earlier of (A) the third anniversary of the date of this Agreement or (B) 180 days following the effective date of the registration statement pertaining to the Initial Offering;

(ii) after the Company has effected three registrations pursuant to this Section 2.2, and such registrations have been declared or ordered effective;

(iii) during the period starting with the date of filing of, and ending on the date 180 days following the effective date of the registration statement pertaining to the Initial Offering; provided that the Company is actively employing in good faith all reasonable efforts to cause such registration statement to become effective;

(iv) if within 30 days of receipt of a written request from Initiating Holders pursuant to Section 2.2(a), the Company gives notice to the Holders of the Company’s intention to file a registration statement for its Initial Offering within 90 days;

(v) if the Company shall furnish to Holders requesting a registration statement pursuant to this Section 2.2, a certificate signed by the Chairman of the Board stating that in the good faith judgment of the Board of Directors of the Company, it would be seriously detrimental to the Company and its stockholders for such registration statement to be effected at such time, in which event the Company shall have the right to defer such filing for a period of not more than 90 days after receipt of the request of the Initiating Holders; provided that such right to delay a request shall be exercised by the Company not more than once in any 12 month period; or

(vi) if the Initiating Holders propose to dispose of shares of Registrable Securities that may be immediately registered on Form S-3 pursuant to a request made pursuant to Section 2.4 below.

2.3 Piggyback Registrations. The Company shall notify all Holders of Registrable Securities in writing at least 15 days prior to the filing of any registration statement under the Securities Act for purposes of registering securities of the Company (including, but not limited to, registration statements relating to secondary offerings of securities of the Company, but excluding Special Registration Statements) and will afford each such Holder an opportunity to

include in such registration statement all or part of such Registrable Securities held by such Holder. Each Holder desiring to include in any such registration statement all or any part of the Registrable Securities held by it shall, within 15 days after the above-described notice from the Company, so notify the Company in writing. Such notice shall state the intended method of disposition of the Registrable Securities by such Holder. If a Holder decides not to include all of its Registrable Securities in any registration statement thereafter filed by the Company, such Holder shall nevertheless continue to have the right to include any Registrable Securities in any subsequent registration statement or registration statements as may be filed by the Company with respect to offerings of its securities, all upon the terms and conditions set forth herein.

(a) Underwriting. If the registration statement under which the Company gives notice under this Section 2.3 is for an underwritten offering, the Company shall so advise the Holders of Registrable Securities. In such event, the right of any such Holder to be included in a registration pursuant to this Section 2.3 shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their Registrable Securities through such underwriting shall enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by the Company. Notwithstanding any other provision of this Agreement, if the underwriter determines in good faith that marketing factors require a limitation of the number of shares to be underwritten, the number of shares that may be included in the underwriting shall be allocated, first, to the Company; second, to the Holders on a pro rata basis according to the total number of shares of the Registrable Securities requested for inclusion by the Holders, or in such other proportions as shall mutually be agreed to among the Holders of at least a majority of the Registrable Securities proposed to be included in the registration; and third, to any stockholder of the Company (other than a Holder) on a pro rata basis. No such reduction shall reduce the amount of securities of the selling Holders included in the registration below 25% of the total amount of securities included in such registration, unless such offering is the Initial Offering and such registration does not include shares of any other selling stockholders, in which event any or all of the Registrable Securities of the Holders may be excluded in accordance with the immediately preceding sentence. If any Holder disapproves of the terms of any such underwriting, such Holder may elect to withdraw therefrom by written notice to the Company and the underwriter, delivered at least 10 business days prior to the effective date of the registration statement. Any Registrable Securities excluded or withdrawn from such underwriting shall be excluded and withdrawn from the registration. For any Holder which is a partnership or corporation, the partners, retired partners and shareholders of such Holder, or the estates and family members of any such partners and retired partners and any trusts for the benefit of any of the foregoing person shall be deemed to be a single “Holder,” and any pro rata reduction with respect to such “Holder” shall be based upon the aggregate amount of shares carrying registration rights owned by all entities and individuals included in such “Holder,” as defined in this sentence.

(b) Right to Terminate Registration. The Company shall have the right to terminate or withdraw any registration initiated by it under this Section 2.3 prior to the effectiveness of such registration whether or not any Holder has elected to include securities in such registration. The Registration Expenses of such withdrawn registration shall be borne by the Company in accordance with Section 2.5 hereof.

2.4 Form S-3 Registration. In case the Company shall receive from any Holder or Holders of Registrable Securities a written request or requests that the Company effect a registration on Form S-3 (or any successor to Form S-3) or any similar short-form registration statement and any related qualification or compliance with respect to all or a part of the Registrable Securities owned by such Holder or Holders, the Company will:

(a) promptly give written notice of the proposed registration, and any related qualification or compliance, to all other Holders of Registrable Securities; and

(b) as soon as practicable, effect such registration and all such qualifications and compliances as may be so requested and as would permit or facilitate the sale and distribution of all or such portion of such Holder’s or Holders’ Registrable Securities as are specified in such request, together with all or such portion of the Registrable Securities of any other Holder or Holders joining in such request as are specified in a written request given within 15 days after receipt of such written notice from the Company; provided, however, that the Company shall not be obligated to effect any such registration, qualification or compliance pursuant to this Section 2.4:

(i) if Form S-3 is not available for such offering by the Holders;

(ii) if the Holders, together with the holders of any other securities of the Company entitled to inclusion in such registration, propose to sell Registrable Securities and such other securities (if any) at an aggregate price to the public, net of underwriting discounts and commissions, of less than $1,000,000;

(iii) if within 30 days of receipt of a written request from any Holder or Holders pursuant to this Section 2.4, the Company gives notice to such Holder or Holders of the Company’s intention to make a public offering within 90 days, other than pursuant to a Special Registration Statement;

(iv) if the Company shall furnish to the Holders a certificate signed by the Chairman of the Board of Directors of the Company stating that in the good faith judgment of the Board of Directors of the Company, it would be seriously detrimental to the Company and its stockholders for such Form S-3 registration to be effected at such time, in which event the Company shall have the right to defer the filing of the Form S-3 registration statement for a period of not more than 90 days after receipt of the request of the Holder or Holders under this Section 2.4; provided, that such right to delay a request shall be exercised by the Company not more than once in any 12 month period;

(v) if the Company has, within the six month period preceding the date of such request, already effected a registration on Form S-3 for the Holders pursuant to this Section 2.4;

(vi) after the Company has effected six registrations on Form S-3 for the Holders pursuant to this Section 2.4, and such registrations have been declared or ordered effective; or

(vii) in any particular jurisdiction in which the Company would be required to qualify to do business or to execute a general consent to service of process in effecting such registration, qualification or compliance.

(c) Subject to the foregoing, the Company shall file a Form S-3 registration statement covering the Registrable Securities and other securities so requested to be registered as soon as practicable after receipt of the requests of the Holders. Registrations effected pursuant to this Section 2.4 shall not be counted as demands for registration or registrations effected pursuant to Sections 2.2 or 2.3, respectively.

2.5 Expenses of Registration. Except as specifically provided in this Section 2.5, all Registration Expenses incurred in connection with any registration, qualification or compliance pursuant to Section 2.2 or any registration under Section 2.3 or Section 2.4 herein shall be borne by the Company. All Selling Expenses incurred in connection with any registrations hereunder, shall be borne by the holders of the securities so registered pro rata on the basis of the number of shares so registered. The Company shall not, however, be required to pay for expenses of any registration proceeding begun pursuant to Section 2.2 or 2.4, the request of which has been subsequently withdrawn by the Initiating Holders unless (a) the withdrawal is based upon material adverse information concerning the Company of which the Initiating Holders were not aware at the time of such request or (b) the Holders of at least 67% of Registrable Securities agree to forfeit their right to one requested registration pursuant to Section 2.2 or Section 2.4, as applicable, in which event such right shall be forfeited by all Holders. If the Holders are required to pay the Registration Expenses, such expenses shall be borne by the holders of securities (including Registrable Securities) requesting such registration in proportion to the number of shares for which registration was requested. If the Company is required to pay the Registration Expenses of a withdrawn offering pursuant to clause (a) above, then the Holders shall not forfeit their rights pursuant to Section 2.2 or Section 2.4 to a demand registration.

2.6 Obligations of the Company. Whenever required to effect the registration of any Registrable Securities, the Company shall, as expeditiously as reasonably possible:

(a) Prepare and file with the SEC a registration statement with respect to such Registrable Securities and use its best efforts to cause such registration statement to become effective provided, that before filing a registration statement or prospectus or any amendments or supplements thereto, the Company shall furnish to counsel representing the Holders selling Registrable Securities in connection with such registration copies of all documents proposed to be filed, which documents shall be subject to the review and reasonable comments of such counsel; and keep such registration statement effective for up to 90 days or, if earlier, until the Holder or Holders have completed the distribution related thereto provided, however, that (i) such 90-day period shall be extended for a period of time equal to the period the Holder refrains from selling any securities included in such registration at the request of an underwriter of Common Stock (or other securities) of the Company; and (ii) in the case of any registration of Registrable Securities on Form S-3 which are intended to be offered on a continuous or delayed

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basis, such 90-day period shall be extended, if necessary, to keep the registration statement effective until all such Registrable Securities are sold, provided that Rule 415, or any successor rule under the Securities Act, permits an offering on a continuous or delayed basis, and provided further that applicable rules under the Securities Act governing the obligation to file a post-effective amendment permit, in lieu of filing a post-effective amendment which (I) includes any prospectus required by Section 10(a)(3) of the Securities Act or (II) reflects facts or events representing a material or fundamental change in the information set forth in the registration statement, the incorporation by reference of information required to be included in (I) and (II) above to be contained in periodic reports filed pursuant to Section 13 or 15(d) of the Exchange Act in the registration statement.

(b) Prepare and file with the SEC such amendments and supplements to such registration statement and the prospectus used in connection with such registration statement as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such registration statement for the period set forth in paragraph (a) above; and promptly incorporate in a prospectus supplement or post–effective amendment such information as the underwriter(s) or the Holders reasonably request to be included therein relating to the plan of distribution with respect to such Registrable Securities; and make all required filings of such prospectus supplements or post–effective amendments as soon as practical after being notified of the matters to be incorporated in such supplement or amendment.

(c) Furnish to the Holders of the Registrable Securities covered by the registration statement such number of copies of a prospectus, including a preliminary prospectus, in conformity with the requirements of the Securities Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them.

(d) Furnish to the Holders of the Registrable Securities covered by the registration statement or to their counsel copies of all material communications between the Company and the SEC related to such registration statement, including any and all SEC comment letters and the Company’s responses thereto.

(e) Use its best efforts to register and qualify the securities covered by such registration statement under such other securities or Blue Sky laws of such jurisdictions as shall be reasonably requested by the Holders of the Registrable Securities covered by the registration statement; provided that the Company shall not be required in connection therewith or as a condition thereto to qualify to do business or to file a general consent to service of process in any such states or jurisdictions, unless the Company is already subject to service in such jurisdiction and except as may be required by the Securities Act.

(f) Within a reasonable time before each filing of the registration statement or prospectus or amendments or supplements thereto with the SEC, furnish to counsel selected by Holders of a majority in interest of the Registrable Securities participating in such registration copies of such documents proposed to be filed, which documents shall be subject to review and comment by such counsel.

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(g) In the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and customary form, with the managing underwriter(s) of such offering. Each Holder participating in such underwriting shall also enter into and perform its obligations under such an agreement.

(h) Promptly make available for inspection by the selling Holders, any managing underwriters participating in any disposition pursuant to such registration statement, and any attorney or accountant or other agent retained by any such underwriter or selected by the selling Holders, all financial and other records, pertinent corporate documents, and properties of the Company, and cause the Company’s officers, directors, employees and independent accountants to supply all information reasonably requested by any such seller, underwriter, attorney, accountant or agent, in each case, as necessary or advisable to verify the accuracy of the information in such registration statement and to conduct appropriate due diligence in connection therewith.

(i) Notify each Holder of Registrable Securities covered by such registration statement at any time when a prospectus relating thereto is required to be delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such registration statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing. The Company will use reasonable efforts to amend or supplement such prospectus in order to cause such prospectus not to include any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing.

(j) Use its best efforts to furnish, on the date that such Registrable Securities are delivered to the underwriters for sale, if such securities are being sold through underwriters, or, if such securities are not being sold through underwriters, on the date that the registration statement with respect to such securities becomes effective, (i) an opinion, dated as of such date, of the counsel representing the Company for the purposes of such registration, in form and substance as is customarily given to underwriters in an underwritten public offering, addressed to the underwriters, if any, and to the Holders requesting registration of Registrable Securities and (ii) a letter, dated as of such date, from the independent certified public accountants of the Company, in form and substance as is customarily given by independent certified public accountants to underwriters in an underwritten public offering addressed to the underwriters, if any.

(k) Provide a CUSIP number for all Registrable Securities no later than the effective date of the registration and provide the applicable transfer agent and registrar for all such Registrable Securities with printed certificates representing the Registrable Securities that are in a form eligible for deposit with The Depositary Trust Company not later than the effective date of the registration statement.

2.7 Termination of Registration Rights. All registration rights granted under this Section 2 shall terminate and be of no further force and effect five years after the date of the Company’s Initial Offering. In addition, a Holder’s registration rights shall expire if all Registrable Securities held by and issuable to such Holder (and its affiliates) may be sold under Rule 144 during any 90 day period.

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2.8 Delay of Registration; Furnishing Information.

(a) No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any such registration as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2.

(b) It shall be a condition precedent to the obligations of the Company to take any action pursuant to Section 2.2, 2.3 or 2.4 that the selling Holders shall furnish to the Company such information regarding themselves, the Registrable Securities held by them and the intended method of disposition of such securities as shall be required to effect the registration of their Registrable Securities.

(c) The Company shall have no obligation with respect to any registration requested pursuant to Section 2.2 or Section 2.4 if, due to the operation of subsection 2.2(b), the number of shares or the anticipated aggregate offering price of the Registrable Securities to be included in the registration does not equal or exceed the number of shares or the anticipated aggregate offering price required to originally trigger the Company’s obligation to initiate such registration as specified in Section 2.2 or Section 2.4, whichever is applicable.

2.9 Indemnification. In the event any Registrable Securities are included in a registration statement under Sections 2.2, 2.3 or 2.4:

(a) To the extent permitted by law, the Company will indemnify and hold harmless each Holder, the partners, officers and directors of each Holder, any underwriter (as defined in the Securities Act) for such Holder and each person, if any, who controls such Holder or underwriter within the meaning of the Securities Act or the Exchange Act, against any losses, claims, damages, or liabilities (joint or several) to which they may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any of the following statements, omissions or violations (collectively a “Violation”) by the Company: (i) any untrue statement or alleged untrue statement of a material fact contained in such registration statement, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the Securities Act, the Exchange Act, any state securities law or any rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities law in connection with the offering covered by such registration statement; and the Company will pay as incurred to each such Holder, partner, officer, director, underwriter or controlling person for any legal or other expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action; provided however, that the indemnity agreement contained in this Section 2.9(a) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Company, which consent shall not be unreasonably withheld, nor shall the Company be liable in any such case for

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any such loss, claim, damage, liability or action to the extent that it arises out of or is based upon a Violation which occurs in reliance upon and in conformity with written information furnished expressly for use in connection with such registration by such Holder, partner, officer, director, underwriter or controlling person of such Holder.

(b) To the extent permitted by law, each Holder will, if Registrable Securities held by such Holder are included in the securities as to which such registration qualifications or compliance is being effected, indemnify and hold harmless the Company, each of its directors, its officers and each person, if any, who controls the Company within the meaning of the Securities Act, any underwriter and any other Holder selling securities under such registration statement or any of such other Holder’s partners, directors or officers or any person who controls such Holder, against any losses, claims, damages or liabilities (joint or several) to which the Company or any such director, officer, controlling person, underwriter or other such Holder, or partner, director, officer or controlling person of such other Holder may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities (or actions in respect thereto) arise out of or are based upon any Violation, in each case to the extent (and only to the extent) that such Violation occurs in reliance upon and in conformity with written information furnished by such Holder under an instrument duly executed by such Holder and stated to be specifically for use in connection with such registration; and each such Holder will pay as incurred any legal or other expenses reasonably incurred by the Company or any such director, officer, controlling person, underwriter or other Holder, or partner, officer, director or controlling person of such other Holder in connection with investigating or defending any such loss, claim, damage, liability or action if it is judicially determined that there was such a Violation; provided, however, that the indemnity agreement contained in this Section 2.9(b) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Holder, which consent shall not be unreasonably withheld; provided further, that in no event shall any indemnity under this Section 2.9 exceed the net proceeds from the offering received by such Holder.

(c) Promptly after receipt by an indemnified party under this Section 2.9 of notice of the commencement of any action (including any governmental action), such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 2.9, deliver to the indemnifying party a written notice of the commencement thereof and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other indemnifying party similarly noticed, to assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an indemnified party shall have the right to retain its own counsel, with the fees and expenses to be paid by the indemnifying party, if representation of such indemnified party by the counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such proceeding. The failure to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action, if materially prejudicial to its ability to defend such action, shall relieve such indemnifying party of any liability to the indemnified party under this Section 2.9, but the omission so to deliver written notice to the indemnifying party will not relieve it of any liability that it may have to any indemnified party otherwise than under this Section 2.9.

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(d) If the indemnification provided for in this Section 2.9 is held by a court of competent jurisdiction to be unavailable to an indemnified party with respect to any losses, claims, damages or liabilities referred to herein, the indemnifying party, in lieu of indemnifying such indemnified party thereunder, shall to the extent permitted by applicable law contribute to the amount paid or payable by such indemnified party as a result of such loss, claim, damage or liability in such proportion as is appropriate to reflect the relative fault of the indemnifying party on the one hand and of the indemnified party on the other in connection with the Violation(s) that resulted in such loss, claim, damage or liability, as well as any other relevant equitable considerations. The relative fault of the indemnifying party and of the indemnified party shall be determined by a court of law by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission to state a material fact relates to information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission; provided, that in no event shall any contribution by a Holder hereunder exceed the net proceeds from the offering received by such Holder.

(e) The obligations of the Company and Holders under this Section 2.9 shall survive completion of any offering of Registrable Securities in a registration statement and the termination of this Agreement. No indemnifying party, in the defense of any such claim or litigation, shall, except with the consent of each indemnified party, consent to entry of any judgment or enter into any settlement which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such Indemnified Party of a release from all liability in respect to such claim or litigation.

2.10 Assignment of Registration Rights. The rights to cause the Company to register Registrable Securities pursuant to this Section 2 may be assigned by a Holder to a transferee or assignee of Registrable Securities that (a) is an Investor Group or Control Group member, subsidiary, affiliate, parent, general partner, limited partner, retired partner, member or retired member of a Holder, (b) is a Holder’s family member or trust for the benefit of an individual Holder, or (c) acquires at least 100,000 shares of Registrable Securities (as adjusted for stock splits and combinations); provided, however, (i) the transferor shall, within 10 days after such transfer, furnish to the Company written notice of the name and address of such transferee or assignee and the securities with respect to which such registration rights are being assigned and (ii) such transferee shall agree to be subject to all restrictions set forth in this Agreement.

2.11 Amendment of Registration Rights. Any provision of this Section 2 may be amended and the observance thereof may be waived (either generally or in a particular instance and either retroactively or prospectively), only with the written consent of the Company and the Holders of at least 67% of the Registrable Securities then outstanding. Any amendment or waiver effected in accordance with this Section 2.11 shall be binding upon each Holder and the Company. By acceptance of any benefits under this Section 2, Holders of Registrable Securities hereby agree to be bound by the provisions hereunder.

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2.12 Limitation on Subsequent Registration Rights. After the date of this Agreement, the Company shall not, without the prior written consent of the Holders of at least 67% of the Registrable Securities then outstanding, enter into any agreement with any holder or prospective holder of any securities of the Company that would grant such holder any registration rights.

2.13 “Market Stand-Off” Agreement; Agreement to Furnish Information. Each Holder hereby agrees that such Holder shall not sell, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale, any Common Stock (or other securities) of the Company held by such Holder (other than those included in the registration or acquired following the Company’s Initial Offering) for a period specified by the representative of the underwriters of Common Stock (or other securities) of the Company not to exceed (i) 180 days following the effective date of a registration statement of the Company filed under the Securities Act for the Initial Offering or (ii) 90 days following the effective date of a registration statement of the Company filed under the Securities Act for any other offering of the Company’s securities (or, in either case, such longer period as necessary to permit compliance with FINRA Rule 2711(f)(4) and similar or successor regulatory rules and regulations) (the “Lock-Up Period”); provided that unless otherwise determined by the holders of at least 60% of the outstanding shares of Series E Preferred, all officers and directors of the Company and holders of at least 1% of the Company’s voting securities enter into similar agreements.

Each Holder agrees to execute and deliver such other agreements as may be reasonably requested by the Company and the managing underwriter that are consistent with the Holder’s obligations under this Section 2.13 or that are necessary to give further effect thereto. In addition, if requested by the Company or the representative of the underwriters of Common Stock (or other securities) of the Company, each Holder shall provide, within 10 days of such request, such information as may be required by the Company or such representative in connection with the completion of any public offering of the Company’s securities pursuant to a registration statement filed under the Securities Act. The obligations described in this Section 2.13 shall not apply to a Special Registration Statement. The Company may impose stop-transfer instructions with respect to the shares of Common Stock (or other securities) subject to the foregoing restriction until the end of the Lock-Up Period. Each Holder agrees that any transferee of any shares of Registrable Securities shall be bound by this Section 2.13. The underwriters of the Company’s stock are intended third party beneficiaries of this Section 2.13 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto.

2.14 Rule 144 Reporting. With a view to making available to the Holders the benefits of certain rules and regulations of the SEC which may permit the sale of the Registrable Securities to the public without registration or pursuant to a registration on Form S-3, the Company agrees to use its best efforts to:

(a) Make and keep public information available, as those terms are understood and defined in SEC Rule 144 or any similar or analogous rule promulgated under the Securities Act, at all times after the effective date of the first registration filed by the Company for an offering of its securities to the general public;

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(b) Take such action, including the voluntary registration of its Common Stock under Section 12 of the Exchange Act, as is necessary to enable the Holders to utilize Form S-3 for the sale of their Registrable Securities, such action to be taken as soon as practicable after the end of the fiscal year in which the first registration statement filed by the Company for the offering of its securities to the general public is declared effective;

(c) File with the SEC, in a timely manner, all reports and other documents required of the Company under the Exchange Act; and

(d) So long as a Holder owns any Registrable Securities, furnish to such Holder forthwith upon request: a written statement by the Company as to its compliance with the reporting requirements of said Rule 144 of the Securities Act, and of the Exchange Act (at any time after it has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Form S-3 (at any time after it so qualifies); a copy of the most recent annual or quarterly report of the Company; and such other information, reports and documents as a Holder may reasonably request in availing itself of any rule or regulation of the SEC allowing it to sell any such securities without registration or pursuant to such form.

2.15 Pledges Pursuant to Margin Agreements. After the effectiveness of a registration statement under the Securities Act covering the registration of Registrable Securities and only at times that are outside of a lock-up period (i) set forth in Section 2.13 of this Agreement or (ii) as otherwise agreed to between the applicable Holder and the Company and/or the underwriters of the Company’s stock in the applicable lock-up agreements entered into by such parties in connection with an underwritten offering, the Company acknowledges and agrees that a Holder may from time to time pledge pursuant to a bona fide margin agreement with a registered broker dealer or grant a security interest in some or all of such Registrable Securities to a financial institution that is an “accredited investor” as defined in Rule 501(a) under the Securities Act and, if required under the terms of such arrangement, such Holder may transfer such pledged or secured Registrable Securities to the pledgees or secured parties. Such a pledge or transfer shall not be subject to approval of the Company nor shall any notice be required of such pledge. The Company will execute and deliver such documentation as a pledgee or secured party of Registrable Securities pursuant to this Section 2.15 may reasonably request in connection with such pledge or transfer, including the preparation and filing of any required prospectus supplement under Rule 424(b)(3) of the Securities Act or other applicable provision of the Securities Act to appropriately amend the list of selling stockholders thereunder, provided that the Company may first require a legal opinion of legal counsel of the pledgee, secured party or pledgor in connection therewith and that states the exemption from registration under the Securities Act that is applicable to such transfer or pledge. Notwithstanding anything to the contrary set forth herein, the rights set forth in this Section 2.15 shall not be applicable to the extent such application would violate any window-period, xxxxxxx xxxxxxx or similar policy of the Company as may be in effect from time to time.

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SECTION 3. COVENANTS OF THE COMPANY.

3.1 Basic Financial Information and Reporting.

(a) The Company will maintain true books and records of account in which full and correct entries will be made of all its business transactions pursuant to a system of accounting established and administered in accordance with generally accepted accounting principles consistently applied, and will set aside on its books all such proper accruals and reserves as shall be required under generally accepted accounting principles consistently applied.

(b) As soon as practicable after the end of each fiscal year of the Company, and in any event within 180 days thereafter, the Company will furnish each Investor, together with its Affiliates (as such term is defined in the Charter), holding at least five percent (5%) of the issued and outstanding shares of Preferred Stock of the Company (on an as-converted to Common Stock basis) (a “Major Investor”) a balance sheet of the Company, as at the end of such fiscal year, and a statement of income and a statement of cash flows of the Company, for such year, all prepared in accordance with generally accepted accounting principles consistently applied and setting forth in each case in comparative form the figures for the previous fiscal year, all in reasonable detail. Such financial statements referred to in this Section 3.1(b) shall be accompanied by a report and opinion thereon by such independent public accountants of national standing selected by the Company’s Board of Directors.

(c) The Company will furnish each Major Investor, as soon as practicable after the end of the first, second and third quarterly accounting periods in each fiscal year of the Company, and in any event within 45 days thereafter, a balance sheet of the Company as of the end of each such quarterly period, and a statement of income and a statement of cash flows of the Company for such period and for the current fiscal year to date, prepared in accordance with generally accepted accounting principles, with the exception that such statements shall be unaudited, no notes need be attached to such statements and year-end audit adjustments may not have been made.

(d) The Company will furnish each Major Investor, as soon as practicable after the end of the first, second, fourth, fifth, seventh, eighth, tenth and eleventh monthly accounting periods in each fiscal year of the Company, and in any event within 30 days thereafter, a balance sheet of the Company as of the end of each such monthly period, and a statement of income and a statement of cash flows of the Company for such period and for the current fiscal year to date, prepared in accordance with generally accepted accounting principles, with the exception that such statements shall be unaudited, no notes need be attached to such statements and year-end audit adjustments may not have been made.

(e) Without limiting the foregoing, the Company will furnish to each Major Investor, simultaneously with or prior to the delivery of the financial information set forth in Sections 3.1(b), (c) and (d) above, a monthly financial and operations “dash board” report in a form reasonably acceptable to the Major Investors.

(f) The Company will furnish to each Major Investor at least 30 days prior to the beginning of each fiscal year an annual budget and operating plans for such fiscal year forecasting, on a monthly basis, the Company’s revenues, expenses and cash position for such fiscal year (and as soon as available, any subsequent revisions thereto).

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3.2 Inspection Rights. Each Major Investor shall have the right to visit and inspect any of the properties of the Company or any of its subsidiaries, and to discuss the affairs, finances and accounts of the Company or any of its subsidiaries with its officers, and to review such information as is reasonably requested all at such reasonable times and as often as may be reasonably requested; provided, however, that the Company shall not be obligated under this Section 3.2: (a) with respect to a competitor of the Company (as determined by the Company’s Board of Directors in good faith), (b) with respect to information that is subject to attorney-client privilege or (c) with respect to proprietary information, the disclosure of which the Company’s Board of Directors determines in good faith is reasonably likely to have a material adverse effect on the Company and should not, therefore, be disclosed.

3.3 Reservation of Common Stock. The Company will at all times reserve and keep available, solely for issuance and delivery upon the conversion of the Preferred Stock, all Common Stock issuable from time to time upon such conversion.

3.4 Stockholder Meeting. At the request of at least 60% of the outstanding shares of Series E Preferred, the Company will conduct at any time a meeting of the stockholders (or initiate a corporate proceeding) to elect directors to serve until the next annual meeting of the stockholders or until the director’s successor is duly elected and has been qualified provided, however, that the Company is only required to conduct such meeting (or initiate such corporate proceeding) once within any twelve month period.

3.5 Observation Rights.

(a) Provided that (i) the respective Investor (other than Avalon Ventures (“Avalon”)) holds at least 3% of the outstanding Preferred Stock of the Company (on an as-converted basis), and (ii) such Investor (other than Avalon) is not a Non-participating Holder or Non-participating Purchaser (each as defined in the Charter), the Company shall allow one representative designated by GIMV NV, one representative designated by Roche Finance Ltd (“Roche”), one representative designated by Apposite, one representative designated by MedImmune, one representative designated by Avalon, one representative designated by Radius Venture Partners III, LLC (“Radius”) and one representative designated by OrbiMed Advisors, LLC (“OrbiMed”) to attend all meetings of the Company’s Board of Directors in a nonvoting capacity, and in connection therewith, the Company shall give such representatives copies of all notices, minutes, consents and other materials, financial or otherwise, which the Company provides to its Board of Directors at the same time it provides such materials to the Board of Directors; provided, however, that the Company reserves the right to exclude such representative from access to any material or meeting or portion thereof if the Company believes upon advice of counsel that such exclusion is reasonably necessary to preserve the attorney-client privilege, to protect confidential proprietary information or for other similar reasons. Each of GIMV NV, Roche, Apposite, MedImmune, Avalon, Radius and OrbiMed agrees, and any representatives of GIMV NV, Roche, Apposite, MedImmune, Avalon, Radius and OrbiMed will agree, to hold in confidence and trust and not use or disclose any confidential information provided to or learned by it in connection with the rights set forth in this Section 3.5. The Company shall not be responsible for reimbursement of any expenses incurred by such representatives in connection with attending meetings of the Company’s Board of Directors.

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(b) Five Percent Investor Observer Rights. For so long as an Investor entitled to designate a representative pursuant to Section 3.5(a) (each such representative an “Observer”), together with its Affiliates (as such term is defined in the Charter), holds 5% or more of the outstanding capital stock of the Company (calculated on a fully-diluted basis and including the shares of capital stock reserved for future issuance under the Option Plan) (each a “Five Percent Investor”), the Company shall, in addition to the rights set forth in Section 3.5(a), provide such Five Percent Investor’s Observer with notice of and opportunity to be present at all meetings of the Board and at all meetings of the compensation committee of the Board, and each other committee of the Board, as well as the boards of directors or other similar managing bodies (and any committee thereof) of each of the subsidiaries of the Company, and the Five Percent Investor’s Observer shall be notified of any such meetings, including such meetings’ time and place, in the same manner as the members of the Board or committees thereof, as applicable. The Company shall provide the Five Percent Investor’s Observer with the same access to information concerning the business and operations of the Company and at the same time as the directors of the Company and its subsidiaries and the members of the various committees thereof, including the compensation committee of the Board, as applicable, and shall allow such Five Percent Investor’s Observer to participate in discussions and consult with, and make proposals and furnish advice to, the Board, the board of directors of the subsidiaries of the Company, and the various committees thereof, including the compensation committee of the Board, but such Five Percent Investor’s Observer shall not have the right to vote. Notwithstanding the foregoing, the Company reserves the right to exclude such Five Percent Investor’s Observer from access to any material or meeting or portion thereof if the Company believes upon advice of counsel that such exclusion is reasonably necessary to preserve the attorney-client privilege, to protect confidential proprietary information or for other similar reasons; provided, however, that the Company shall, prior to the occurrence of the meeting, communicate to the excluded Five Percent Investor’s Observer of the occurrence of the meeting and the reason for exclusion, via email, voicemail, or telephone. If the Company excludes any such Five Percent Investor’s Observer from a meeting of the Board or any committee of the Board or any portion thereof in accordance with the preceding sentence, the Company will, following such scheduled meeting, promptly inform such excluded Five Percent Investor’s Observer of any resolutions passed or recommendations made; provided that, the Company reserves the right to withhold such information in order to preserve the attorney-client privilege, to protect confidential proprietary information or for other similar reasons. Each Five Percent Investor agrees, and such Five Percent Investor’s Observer will agree, to hold in confidence and trust and not use or disclose any confidential information provided to or learned by it in connection with the rights set forth in this Section 3.5(b). The Company shall not be responsible for reimbursement of any expenses incurred by each Five Percent Investor’s Observer in connection with their exercise of the rights set forth herein. In addition, should any other Investor not listed above have an individual not a board member attend a Board or committee meeting, then such person will agree to hold in confidence and trust and not use or disclose any confidential information provided to or learned by it in connection with attending such meeting.

3.6 Option Pool Increases. In connection with the Rights Offering Closing and Second Tranche Closing (each as defined in the Purchase Agreement), the Company shall increase the number of shares of Common Stock reserved for issuance to officers, directors,

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employees and consultants of the Company under the Option Plan (the “Option Share Reserve”) so that the Option Share Reserve will represent 11.33% of the capital stock of the Company (calculated on a fully-diluted basis and including the shares of capital stock reserved for future issuance under the Option Plan).

3.7 Compensation Committee. The Company acknowledges and agrees that any grant of stock options granted under the Option Plan to, and/or increase in salary and/or benefits of, any Key Employee or any member of the Board of Directors of the Company shall be approved by the Compensation Committee of the Board of Directors of the Company (the “Compensation Committee”). The Series D Representative (as defined in the Charter) that is designated by Apposite pursuant to the terms of that certain Second Amended and Restated Voting Agreement, dated as of even date herewith, among the Company and the individuals and entities listed as Founders and Investors thereunder (the “Voting Agreement”) shall be appointed to the Compensation Committee and as the Chairman of such Compensation Committee; provided, however that such Series D Representative may decline to serve on the Compensation Committee in his or her discretion. The Series E Representative (as defined in the Charter) that is designated by OrbiMed pursuant to the terms of the Voting Agreement (or another director specified at the election of OrbiMed) shall be appointed to the Compensation Committee, provided however that such director may decline to serve on the Compensation Committee in his or her discretion.

3.8 The Company’s Board of Directors shall continue to consist of an Audit Committee of the Board of Directors of the Company (the “Audit Committee”), which is responsible for the quality and integrity of the accounting, auditing and reporting practices of the Company, a Nominating and Corporate Governance Committee of the Board of Directors (the “Nominating and Corporate Governance Committee”) and a Pricing Committee of the Board of Directors (the “Pricing Committee”). The members of the Audit Committee, Nominating and Corporate Governance Committee and Pricing Committee shall be acceptable to the Major Investors holding a majority of the Registrable Securities held by the Major Investors; provided, however, that the Pricing Committee shall be chaired by the Chairman of the Board of Directors and shall include a Series B Representative (as defined in the Charter) that is designated by Perseus-Xxxxx Biopharmaceutical Fund, L.P. pursuant to the terms of the Voting Agreement, who shall initially be Xxxxxx Xxxx, and a Series D Representative (as defined in the Charter) that is designated by Apposite pursuant to the terms of the Voting Agreement, who shall initially be Xxxxx Xxxxxxxxxxx; provided further, that the Series E Representative that is designated by OrbiMed pursuant to the terms of the Voting Agreement (or another director specified at the election of OrbiMed) shall be appointed to each such committee, provided however that such director may decline to serve on any such committee in his or her discretion. Notwithstanding the foregoing, with respect to the Pricing Committee (or other similar committee that has been delegated the authority to approve the public offering price for the Company’s Common Stock) for an initial public offering of the Company’s Common Stock that occurs concurrently with any Closing pursuant to Section 2.4(c) or 2.5 of the Purchase Agreement, if, in the reasonable determination of the Board of Directors upon advice of counsel, membership by any individual director on such committee in connection with the issuance of securities in, or at the time of, the initial public offering violates any securities or other law or regulation, the rights set forth in this Section 3.8 shall be deemed to be waived with respect to any membership on such committee, and the parties shall work in good faith with the Company to identify suitable replacements.

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3.9 Director and Officer Insurance. The Company shall maintain in full force and effect its director and officer liability insurance in an amount to be determined by the Board of Directors of the Company.

3.10 Director Compensation and Expense Reimbursement. In the event that the Company pays any compensation to any member of the Board of Directors of the Company that is designated by MedImmune (each a “MedImmune Designee”) in recognition of his or her service on the Board of Directors of the Company, such compensation (including any equity compensation) otherwise payable to the MedImmune Designee shall, upon the direction of such MedImmune Designee, be paid directly to MedImmune. Nothing in this Section 3.10 shall create an obligation on the part of the Company to pay any compensation to the MedImmune Designee. The Company shall promptly reimburse each non-employee director of the Company for all of his or her reasonable out-of-pocket expenses (including travel expenses) incurred in attending each meeting of the Board or a committee thereof or otherwise incurred in the course of performing his or her duties as a director of the Company, subject at all times to the Company’s standard travel and reimbursement policies, including the requirement that all expenses over $1,000 be pre-approved by the Company.

3.11 Ambit Canada Actions.

(a) The Company shall not, in its capacity as a shareholder of Ambit Canada or as a party to the applicable agreement, amend or waive, or agree to amend or waive, any provision of (i) the Amended and Restated Articles of Incorporation of Ambit Canada, (ii) the Put Agreement, (iii) the Amended and Restated Shareholders Agreement among the Company, GrowthWorks, Ambit Canada and Osler, Xxxxxx & Harcourt LLP, dated May 11, 2011, as the same may be amended from time to time (the “Shareholders Agreement”), (iv) the Co-Development, Distribution and Licence Agreement dated February 23, 2005 by and between the Company and Ambit Canada, as amended, or (v) the Research and Development Cost Sharing Agreement dated February 23, 2005 by and between the Company and Ambit Canada, without the approval of the Company’s Board of Directors (including, for the avoidance of doubt, at least two-thirds of the Preferred Representatives (as defined in the Charter) then serving on the Company’s Board of Directors).

(b) In addition to the foregoing, the Company shall not, in its capacity as a shareholder of Ambit Canada, approve or give its consent to any of the matters identified in Schedule 3.8 of the Shareholders Agreement without the approval of the Company’s Board of Directors (including, for the avoidance of doubt, at least two-thirds of the Preferred Representatives then serving on the Company’s Board of Directors).

3.12 Termination of Covenants. All covenants of the Company contained in Section 3 of this Agreement shall expire and terminate as to each Investor upon the earlier of (i) the effective date of the registration statement pertaining to the Initial Offering or (ii) upon an Acquisition or Asset Transfer (each as defined in the Charter); provided, that the Company’s obligation to maintain director and officer liability insurance under Section 3.9 hereof shall not terminate upon the effective date of the registration statement pertaining to the Initial Offering.

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3.13 Special Stockholder Committee. If the Company fails to redeem all shares of Series E Preferred, Series D-2 Preferred, Series D Preferred, Series C-2 Preferred Stock of the Company and Series C Preferred (together, the “Redeemable Shares”) to be redeemed at any one or more Redemption Dates (as defined in the Charter) pursuant to Article IV, Section E.5 of the Charter for any reason, the Major Investors shall be entitled to form a special committee of representatives of such Major Investors for the purposes of soliciting and negotiating an Acquisition or Asset Transfer. Such committee shall have reasonable access to Company management, shall be entitled to engage outside consultants, including legal and investment advisors and shall have the right to present any proposed Acquisition or Asset Transfer to the Company’s Board of Directors for consideration. Any rights under this Section 3.13 shall terminate upon the earlier of (a) the date on which the Company is current on its redemption obligations under the Charter (provided, that such rights shall be reinstated in the event of any subsequent default by the Company with respect to its redemption obligations at a later Redemption Date), or (b) the date on which the holders of at least 60% of the then outstanding shares of Series E Preferred irrevocably withdraw their demand for redemption.

SECTION 4. RIGHTS OF FIRST REFUSAL.

4.1 Subsequent Offerings. Each Major Investor shall have a right of first refusal to purchase its pro rata share of all Equity Securities, as defined below, that the Company may, from time to time, propose to sell and issue after the date of this Agreement, other than the Equity Securities excluded by Section 4.6 hereof. Each Major Investor’s pro rata share is equal to the ratio of (a) the number of shares of the Company’s Common Stock (including all shares of Common Stock issued or issuable upon conversion of the Shares) of which such Investor is deemed to be a holder immediately prior to the issuance of such Equity Securities to (b) the total number of shares of the Company’s outstanding Common Stock (including all shares of Common Stock issued or issuable upon conversion of the Shares or, to the extent not included within the meaning of “Shares,” upon the exercise of any outstanding warrants or options) immediately prior to the issuance of the Equity Securities; provided, however, that if the price per share of such Equity Securities is less than $0.70 per share (as adjusted for stock splits, dividends, recapitalizations and the like after the date hereof), each Major Investor’s pro rata share shall be equal to the ratio of (a) the number of shares of the Company’s Series Preferred (as defined in the Charter) of which such Major Investor is deemed to be a holder immediately prior to the issuance of such Equity Securities to (b) the total number of shares of the Company’s issued and outstanding Series Preferred (as defined in the Charter) immediately prior to the issuance of such Equity Securities. The term “Equity Securities” shall mean (i) any Common Stock, Preferred Stock or other security of the Company, (ii) any security convertible, exchangeable or exercisable, with or without consideration, into or for any Common Stock, Preferred Stock or other security (including any option to purchase such a convertible security), (iii) any security carrying any warrant or right to subscribe to or purchase any Common Stock, Preferred Stock or other security or (iv) any such warrant or right.

4.2 Exercise of Rights. If the Company proposes to issue any Equity Securities, it shall give each Major Investor written notice of its intention, describing the Equity Securities, the

23.

price and the terms and conditions upon which the Company proposes to issue the same. Each Major Investor shall have 20 days from the giving of such notice to agree to purchase up to its pro rata share of the Equity Securities for the price and upon the terms and conditions specified in the notice by giving written notice to the Company and stating therein the quantity of Equity Securities to be purchased. Notwithstanding the foregoing, the Company shall not be required to offer or sell such Equity Securities to any Major Investor who would cause the Company to be in violation of applicable federal securities laws by virtue of such offer or sale.

4.3 Issuance of Equity Securities to Other Persons. If not all of the Major Investors elect to purchase their pro rata share (determined in accordance with Section 4.1 above) of the Equity Securities, then the Company shall promptly notify in writing the Major Investors who do so elect (the “Fully-Exercising Investors”) of the number of Equity Securities remaining unsubscribed (the “Unsubscribed Shares”) and shall offer such Fully-Exercising Investors the right to acquire such Unsubscribed Shares. The Fully-Exercising Investors shall have 10 days after receipt of such notice to notify the Company of its election to purchase all or a portion of the Unsubscribed Shares. In the event that the number of shares subscribed for by the Fully-Exercising Investors pursuant to the immediately preceding sentence exceeds the total number of Unsubscribed Shares, then the Unsubscribed Shares shall be allocated among such Fully-Exercising Investors so electing on a pro rata basis. For purposes of this Section 4.3, Each Fully-Exercising Investor’s pro rata share shall be equal to the ratio of (a) the number of shares of the Company’s Common Stock (including all shares of Common Stock issued or issuable upon conversion of the Shares) of which such Investor is deemed to be a holder immediately prior to the issuance of such Equity Securities to (b) the number of shares of the Company’s Common Stock (including all shares of Common Stock issued or issuable upon conversion of the Shares) of which the Fully-Exercising Investors electing to purchase Unsubscribed Shares under this Section 4.3 are deemed to hold immediately prior to the issuance of such Equity Securities. If the Fully-Exercising Investors fail to exercise in full the rights of first refusal, the Company shall have 90 days thereafter to sell the Equity Securities in respect of which the Major Investors’ rights were not exercised, at a price and upon general terms and conditions materially no more favorable to the purchasers thereof than specified in the Company’s notice to the Major Investors pursuant to Section 4.2 hereof. If the Company has not sold such Equity Securities within 90 days of the notice provided pursuant to Section 4.2, the Company shall not thereafter issue or sell any Equity Securities, without first offering such securities to the Major Investors in the manner provided above.

4.4 Termination and Waiver of Rights of First Refusal. The rights of first refusal established by this Section 4 shall not apply to, and shall terminate upon the earliest of (i) the effective date of the registration statement pertaining to the Company’s Initial Offering, (ii) an Acquisition or (iii) an Asset Transfer. The rights of first refusal established by this Section 4 may be amended or waived with the written consent of the Company and the holders of at least 60% of the then outstanding shares of Series E Preferred then held by the Major Investors.

4.5 Transfer of Rights of First Refusal. The rights of first refusal of each Investor under this Section 4 may be transferred to the same parties, subject to the same restrictions as any transfer of registration rights pursuant to Section 2.10.

24.

4.6 Excluded Securities. The rights of first refusal established by this Section 4 shall have no application to any of the following Equity Securities:

(a) shares of Common Stock issued upon conversion of any then outstanding Preferred Stock of the Company;

(b) shares of Common Stock and/or options, warrants or other Common Stock purchase rights (in each case as adjusted for stock splits, dividends, recapitalizations and the like after the date hereof) and the Common Stock issued pursuant to such options, warrants or other rights to employees, officers or directors of, or consultants or advisors to, the Company or any subsidiary pursuant to stock purchase or stock option plans or other arrangements approved by the Company’s Board of Directors;

(c) any Equity Securities issued upon the exercise of options, warrants or convertible securities outstanding as of the date hereof;

(d) any Equity Securities issued pursuant to any commercial transaction, licensing arrangement, equipment loan or leasing arrangement, real property leasing arrangement or debt financing transaction, in each case which has been unanimously approved by the Company’s Board of Directors and the holders of at least 60% of the outstanding shares of Series E Preferred;

(e) shares of Common Stock, Preferred Stock of the Company and/or other Equity Securities issued in connection with transactions involving the Company and other entities, the principal purpose of which is other than for the raising of capital through the sale of equity securities, including (i) joint ventures, manufacturing, marketing or distribution agreements, (ii) technology transfer or development arrangements and (iii) merger, consolidation, acquisition, strategic alliance or similar business combination, in each case which has been unanimously approved by the Board of Directors and the holders of at least 60% of the outstanding shares of Series E Preferred;

(f) shares of Common Stock issued in an Initial Offering;

(g) shares of Common Stock issued in connection with any stock split, stock dividend or recapitalization by the Company;

(h) shares of Preferred Stock of the Company issued pursuant to the Put Agreement; and

(i) shares of Common Stock, Series E Preferred and/or other Equity Securities issued pursuant to the Purchase Agreement.

25.

SECTION 5. MISCELLANEOUS.

5.1 Governing Law. This Agreement shall be governed by and construed under the laws of the State of California as applied to agreements among California residents entered into and to be performed entirely within California.

5.2 Survival. The representations, warranties, covenants, and agreements made herein shall survive any investigation made by any Holder and the closing of the transactions contemplated hereby. All statements as to factual matters contained in any certificate or other instrument delivered by or on behalf of the Company pursuant hereto in connection with the transactions contemplated hereby shall be deemed to be representations and warranties by the Company hereunder solely as of the date of such certificate or instrument.

5.3 Successors and Assigns. Except as otherwise expressly provided herein, the provisions hereof shall inure to the benefit of, and be binding upon, the successors, assigns, heirs, executors, and administrators of the parties hereto and shall inure to the benefit of and be enforceable by each person who shall be a holder of Registrable Securities from time to time; provided, however, that prior to the receipt by the Company of adequate written notice of the transfer of any Registrable Securities specifying the full name and address of the transferee, the Company may deem and treat the person listed as the holder of such shares in its records as the absolute owner and holder of such shares for all purposes, including the payment of dividends or any redemption price. Notwithstanding anything to the contrary set forth herein, the rights set forth in Section 3.1(b) through (f) and Section 3.2 of this Agreement shall only be transferable to other Major Investors.

5.4 Entire Agreement. This Agreement, the Exhibits and Schedules hereto, the Purchase Agreement and the other documents delivered pursuant thereto constitute the full and entire understanding and agreement between the parties with regard to the subjects hereof and no party shall be liable or bound to any other in any manner by any representations, warranties, covenants and agreements except as specifically set forth herein and therein. The Company and holders of at least 67% of the Registrable Securities held by the Prior Investors and, with respect to Section 4 of the Prior Agreement, by the Major Investors (as defined in the Prior Agreement) hereby agree, as evidenced by their signatures hereto, that all rights granted and covenants made under the Prior Agreement are hereby waived, released and terminated in their entirety and shall have no further force or effect whatsoever, including the right of first offer set forth in Section 4 of the Prior Agreement, and such holders hereby further agree and acknowledge that the right of first offer set forth in Section 4 of the Prior Agreement did not apply to and is hereby waived with respect to the Common Stock, Series E Preferred and other Equity Securities issued pursuant to the Purchase Agreement. The rights and covenants provided herein set forth the sole and entire agreement between the parties hereto with respect to the subject matter hereof.

5.5 Severability. In the event one or more of the provisions of this Agreement should, for any reason, be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provisions of this Agreement, and this Agreement shall be construed as if such invalid, illegal or unenforceable provision had never been contained herein.

26.

5.6 Amendment and Waiver.

(a) Except as otherwise expressly provided, this Agreement may be amended or modified only upon the written consent of the Company and the holders of at least 60% of the then outstanding shares of Series E Preferred and the obligations of the Company and the rights of the Holders under this Agreement may be waived only with the written consent of the holders of at least 60% of the then outstanding shares of Series E Preferred; provided that this Agreement may not be amended and/or modified and the obligations of the Company and the rights of the Holders under this Agreement may not be waived, in each case with respect to any Investor without the written consent of such Investor unless such amendment, termination or waiver applies to all Investors in the same fashion and does not otherwise materially adversely affect the rights of such Investor in a manner that is different from the effect on the rights of the other Investors.

(b) Notwithstanding the foregoing, until the earlier of (i) the effective date of the registration statement pertaining to the Initial Offering or (ii) upon an Acquisition or Asset Transfer (each as defined in the Charter), (A) Section 3.5 of this Agreement shall not be amended or waived to alter any of the rights of GIMV NV, Roche, Apposite, MedImmune, Avalon, Radius or OrbiMed as set forth therein without the written consent of GIMV NV, Roche, Apposite, MedImmune, Avalon, Radius or OrbiMed, as applicable, so long as (x) the respective Investor (other than Avalon) continues to hold at least 3% of the outstanding Preferred Stock of the Company (on an as-converted to Common Stock basis), and (y) such Investor (other than Avalon) is not a Non-participating Holder or Non-participating Purchaser, and (B) Sections 3.7 and 3.8 shall not be amended or waived to alter any of the rights of Apposite or OrbiMed as set forth therein without the written consent of Apposite or OrbiMed, as applicable, so long as, with respect to Apposite, Apposite or any member of its Investor Group continues to hold shares of Series D-2 Preferred, and with respect to OrbiMed, OrbiMed or any member of its Investor Group continues to hold shares of Series E Preferred.

(c) For the purposes of determining the number of Holder or Investors entitled to vote or exercise any rights hereunder, the Company shall be entitled to rely solely on the list of record holders of its stock as maintained by or on behalf of the Company.

5.7 Delays or Omissions. It is agreed that no delay or omission to exercise any right, power, or remedy accruing to any Holder, upon any breach, default or noncompliance of the Company under this Agreement shall impair any such right, power, or remedy, nor shall it be construed to be a waiver of any such breach, default or noncompliance, or any acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent, or approval of any kind or character on any Holder’s part of any breach, default or noncompliance under the Agreement or any waiver on such Holder’s part of any provisions or conditions of this Agreement must be in writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either under this Agreement, by law, or otherwise afforded to Holders, shall be cumulative and not alternative.

5.8 Notices. All notices required or permitted hereunder shall be in writing and shall be deemed effectively given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient; if

27.

not, then on the next business day, (c) five days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. All communications shall be sent to the party to be notified at the address as set forth on the signature pages hereof or Exhibit A hereto or at such other address as such party may designate by 10 days advance written notice to the other parties hereto.

5.9 Attorneys’ Fees. In the event that any suit or action is instituted to enforce any provision in this Agreement, the prevailing party in such dispute shall be entitled to recover from the losing party all fees, costs and expenses of enforcing any right of such prevailing party under or with respect to this Agreement, including without limitation, such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs and expenses of appeals.

5.10 Titles and Subtitles. The titles of the sections and subsections of this Agreement are for convenience of reference only and are not to be considered in construing this Agreement.

5.11 Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be an original, but all of which together shall constitute one instrument.

[Signature Pages Follow]

28.

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.

COMPANY:


AMBIT BIOSCIENCES CORPORATION

By:		/s/ Xxxxxxx X. Xxxxxxx

Name:		Xxxxxxx X. Xxxxxxx

Title:		President and CEO

Address:		0000 Xxxxxxxx Xxxxxx Xxxxxxxxx
		Xxx Xxxxx, XX 00000

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.


INVESTORS:

APPOSITE HEALTHCARE FUND LP ACTING BY ITS MANAGER, APPOSITE CAPITAL

By:		/s/ X X Xxxxxxxxxxx

Name:		X X Xxxxxxxxxxx

Title:		Partner

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.


INVESTORS:

FORWARD VENTURES IV, L.P.
BY: FORWARD IV ASSOCIATES LLC
AS: GENERAL PARTNER

By:		/s/ Xxxxxxxx Xxxxxxx

Name:		Xxxxxxxx Xxxxxxx

Title:		Managing Member

FORWARD VENTURES IV B, L.P.
BY: FORWARD IV ASSOCIATES LLC
AS: GENERAL PARTNER

By:		/s/ Xxxxxxxx Xxxxxxx

Name:		Xxxxxxxx Xxxxxxx

Title:		Managing Member

FORWARD VENTURES IV-C, L.P.
BY: FORWARD IV ASSOCIATES LLC
AS: GENERAL PARTNER

By:		/s/ Xxxxxxxx Xxxxxxx

Name:		Xxxxxxxx Xxxxxxx

Title:		Managing Member

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.


INVESTORS:

GENECHEM THERAPEUTICS VENTURE FUND L.P.

By:		/s/ Xxxxx Xxxxxxx

Name:		Xxxxx Xxxxxxx

Title:		President

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.


INVESTORS:

GIMV NV

By:		/s/ Xxxxxx Bastijns

Name:		Xxxxxx Bastijns

Title:		GIMV Partner

By:		/s/ Koen Dejonckheere

Name:		Koen Dejonckheere

Title:		CEO

ADVIESBEHEER GIMV LIFE SCIENCES 2004 NV

By:		/s/ Xxxxxx Bastijns

Name:		Xxxxxx Bastijns

Title:		GIMV Partner

By:		/s/ Koen Dejonckheere

Name:		Koen Dejonckheere

Title:		CEO

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.


INVESTORS:

GROWTHWORKS CANADIAN FUND LTD. by its manager, GrowthWorks WV Management Ltd.

PER:		/s/ Xxx Xxx

TITLE:		SVP Investments

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.


INVESTORS:

HORIZON TECHNOLOGY FUNDING COMPANY II LLC

By:		/s/ Xxxxxx X. Xxxxxxx, Xx.
Name:		Xxxxxx X. Xxxxxxx, Xx.
Title:		Chief Executive Officer

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.


INVESTORS:

MEDIMMUNE VENTURES, INC.

By:		/s/ Xxx Xxxxxx
Name:		Xxx Xxxxxx
Title:		SR. Managing Director

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.


INVESTORS:

ORBIMED PRIVATE INVESTMENTS III, LP BY: ORBIMED CAPITAL GP III LLC, ITS GENERAL PARTNER

By:		/s/ Xxxxxxxx Xxxxxxxxxxx
Name:		Xxxxxxxx Xxxxxxxxxxx
Title:		Member

ORBIMED ASSOCIATES III, LP BY: ORBIMED CAPITAL GP III LLC, ITS GENERAL PARTNER

By:		/s/ Xxxxxxxx Xxxxxxxxxxx
Name:		Xxxxxxxx Xxxxxxxxxxx
Title:		Member

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.


INVESTORS:

PERSEUS-XXXXX BIOPHARMACEUTICAL FUND, LP

By:		/s/ Xxxxx Xxxxx
Name:		Xxxxx Xxxxx
Title:		CFO

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.


INVESTORS:

PHARMABIO DEVELOPMENT INC.

By:		/s/ Xxxxxxx Xxxxxxxx
Name:		Xxxxxxx Xxxxxxxx
Title:		President

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.


INVESTORS:

RADIUS VENTURE PARTNERS III, L.P.

By:		/s/ Jordan X. Xxxxx

Name:		Jordan X. Xxxxx

Title:		Managing Member

RADIUS VENTURE PARTNERS III QP, L.P.

By:		/s/ Jordan X. Xxxxx

Name:		Jordan X. Xxxxx

Title:		Managing Member

RADIUS VENTURE PARTNERS III (OHIO), L.P.

By:		/s/ Jordan X. Xxxxx

Name:		Jordan X. Xxxxx

Title:		Managing Member

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

IN WITNESS WHEREOF, the parties hereto have executed this SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.


INVESTORS:

ROCHE FINANCE LTD

By:		/s/ Xxxxxx Xxxxxxxxxxxx

Name:		Xxxxxx Xxxxxxxxxxxx

Title:		Authorized Signatory

By:		/s/ Andreas Knierzinger

Name:		Andreas Knierzinger

Title:		Authorized Signatory

[Signature Page to Sixth Amended and Restated Investor Rights Agreement]

EXHIBIT A

LIST OF INVESTORS

Name and Address

APPOSITE HEALTHCARE FUND LP

Xxxxxxxxxx Xxxxx

Xxxxx Xxxxxx Xxxxxx

PO Box 1234

Xxxxxx Town, Grand Cayman, Cayman Islands

FORWARD VENTURES IV, L.P.

0000 Xxxxx Xxxxxx Xxxxx, Xxxxx 000

Xxx Xxxxx, XX 00000

Attn: Xxxxxxxx X. Xxxxxxx

(000) 000-0000

FORWARD VENTURES IV B, L.P.

0000 Xxxxx Xxxxxx Xxxxx, Xxxxx 000

Xxx Xxxxx, XX 00000

Attn: Xxxxxxxx X. Xxxxxxx

(000) 000-0000

FORWARD VENTURES IV-C, L.P.

0000 Xxxxx Xxxxxx Xxxxx, Xxxxx 000

Xxx Xxxxx, XX 00000

Attn: Xxxxxxxx X. Xxxxxxx

(000) 000-0000

GENECHEM THERAPEUTICS VENTURE FUND L.P.

0000 Xx Xxxxxxxxxxx Xxxx, Xxxx

Xxxxx 000

Xxxxxxxx, Xxxxxx X0X 0X0

GIMV NV

Xxxxx Xxxxxxxxxx 00

0000 Xxxxxxx, Xxxxxxx

ADVIESBEHEER GIMV LIFE SCIENCES 2004 NV

Xxxxx Xxxxxxxxxx 00

0000 Xxxxxxx, Xxxxxxx

GROWTHWORKS CANADIAN FUND LTD.

Attn: Xxxxxx Xxxxx

000 Xxxx Xxxxxx Xxxx, Xxxxx 0000

Xxxxxxx, Xxxxxxx X0X 0X0

Xxxxxx

Name and Address

HORIZON TECHNOLOGY FUNDING

COMPANY II LLC

000 Xxxxxxxxxx Xxxxxx

Xxxxxxxxxx, XX 00000

Attention: Legal Department

MEDIMMUNE VENTURES, INC.

Xxx XxxXxxxxx Xxx

Xxxxxxxxxxxx, XX 00000

ORBIMED PRIVATE INVESTMENTS III, LP

c/o OrbiMed Advisors, LLC

Attn: Xxxx Xxxxxx

000 Xxxxxxxxx Xxxxxx, 00xx Xxxxx

Xxx Xxxx, XX 00000

ORBIMED ASSOCIATES III, LP

c/o OrbiMed Advisors, LLC

Attn: Xxxx Xxxxxx

000 Xxxxxxxxx Xxxxxx, 00xx Xxxxx

Xxx Xxxx, XX 00000

PERSEUS-XXXXX BIOPHARMACEUTICAL FUND, L.P.

000 Xxxxxxx Xxxxxx, 00^xx Xxxxx

Xxx Xxxx, XX 00000

Attn: Xxxxx Xxxx

PHARMABIO DEVELOPMENT INC.

Attn: Xxxx Xxxxxxx

0000 Xxx Xxxxx Xxxx

Xxxxxxx, XX 00000

RADIUS VENTURE PARTNERS III, L.P.

Attn: Xxxxxx Xxxxx

000 Xxxxxxx Xxxxxx, 0xx Xxxxx

Xxx Xxxx, XX 00000

RADIUS VENTURE PARTNERS III QP, L.P.

Attn: Xxxxxx Xxxxx

000 Xxxxxxx Xxxxxx, 0xx Xxxxx

Xxx Xxxx, XX 00000

RADIUS VENTURE PARTNERS III (OHIO), L.P.

Attn: Xxxxxx Xxxxx

000 Xxxxxxx Xxxxxx, 0xx Xxxxx

Xxx Xxxx, XX 00000

ROCHE FINANCE LTD

Xxxxxxxxxxxxxxxxx 000

0000 Xxxxx

Name and Address

ALEXANDRIA EQUITIES, LLC

Attn: Xx. Xxxx Xxxxxx

000 X. Xxx Xxxxxx Xxxxxx, #000

Xxxxxxxx, XX 00000

ALEXANDRIA REAL ESTATE EQUITIES, L.P.

Attn: Xx. Xxxx Xxxxxx

000 X. Xxx Xxxxxx Xxxxxx, #000

Xxxxxxxx, XX 00000

THE XXXXX X. XXXXXXXX RE-STATED TRUST DECEMBER 7, 2000

000 Xxxxxxxx Xxxxxx, Xxxxx 000

Xx Xxxxx, XX 00000

MR. XXXX XXXXXXX

00000 X. Xxxxxx Xxxxx Xx.

Xx Xxxxx, XX 00000

XXXXX X. XXXX AND XXXXXXXX XXXX

0000 Xxxxxx xx xx Xxxxx

Xx Xxxxx, XX 00000

(858) 454-6752

XXXXX X. XXXX

000 Xxxxx Xxxxxx, 0^xx Xxxxx

Xxx Xxxx, XX 00000

TANG CAPITAL PARTNERS, LP

0000 Xxxxxxxx Xxxx

Xxx Xxxxx, XX 00000

GRANTOR TRUST FOR XXXXX X. XXXX

Attn: Xxxxx X. Xxxx, Trustee

000 Xxxxx Xxxxxx, 0^xx Xxxxx

Xxx Xxxx, XX 00000

GRANTOR TRUST FOR XXXX X. XXXX

Attn: Xxxxx X. Xxxx, Trustee

000 Xxxxx Xxxxxx, 0^xx Xxxxx

Xxx Xxxx, XX 00000

GRANTOR TRUST FOR XXXXXXX X. XXXX

Attn: Xxxxx X. Xxxx, Trustee

000 Xxxxx Xxxxxx, 0^xx Xxxxx

Xxx Xxxx, XX 00000

XXXXX XXXXXXXXX

00 Xxxxx Xxxxxx Xxxx, XX

Xxx Xxxx, XX 00000

Name and Address

XXXXX XXXXX

0000 Xxxx Xxxxxxxx Xxxxx

Xxxxxxxxx, XX 00000

XXXX S & XXXX X. XXX FAMILY TRUST

Attn: Xx. Xxxx X. Xxx, Trustee

00 Xxxxxx Xxxxx Xxxxx

Xxxxxxx Xxxxx, XX 00000

ZUKER FAMILY TRUST, DATED 3/15/00

Attn: Xxxxxxx X. and Xxxxxxxx X. Xxxxx, Co-Trustees

0000 Xxxxxxxx Xxxxx

Xxx Xxxxx, XX 00000

XXXXXXXX XXXXX IRREVOCABLE TRUST, DATED

11/29/99

Attn: Xxxxxxx X. & Xxxxxxxx X. Xxxxx, Co-Trustees

0000 Xxxxxxxx Xxxxx

Xxx Xxxxx, XX 00000

XXXXXX XXX XXXXX IRREVOCABLE TRUST, DATED 11/29/99

Attn: Xxxxxxx X. & Xxxxxxxx X. Xxxxx, Co-Trustees

0000 Xxxxxxxx Xxxxx

Xxx Xxxxx, XX 00000

XXXXXXX XXXX XXX III REVOCABLE TRUST, DATED

DECEMBER 28, 1998

Attn: Xxxxxxx Xxxx Xxx III, Trustee

0000 Xxxxxxxxxx Xxxxxx Xxxx, #000

Xxx Xxxxx, XX 00000

THE STRYER REVOCABLE TRUST,

DATED AUGUST 11, 2000

Attn: Xxxxxx Xxxxxx & Xxxxxx Xxxxxx,

Co-Trustees

000 Xxxxxx Xxxxxxx

Xxxxxxxx, XX 00000

XX. XXXXXX XXXXXXXXX

000 Xxxxxx Xxxx

Xxxxxxxxxx, XX 00000

(631) 537-1334

XX. XXXX XXXXXXXX

i/c/o Avalon Ventures VI, L.P.

000 Xxxxxxxx Xxxxxx, Xxxxx 000

Xxx Xxxxx, XX 00000

Attn: Xxxxx X. Xxxxxxxx

Name and Address

THE XXXXXX FAMILY TRUST

DATED JUNE 1, 1999

000 Xxxxxxxx Xxxxxx, Xxxxx 000

Xx Xxxxx, XX 00000

(858) 546-2460 Ext. 203

THE XXXXXX CHILDREN’S 2002 IRREVOCABLE TRUST

X/X/X XXXXX 0, 0000-XXXXX XXXXXX XXXXXXXXX

SHARES

000 Xxxxxxxx Xxxxxx, Xxxxx 000

Xx Xxxxx, XX 00000

(858) 546-2460 Ext. 203

THE XXXXXX CHILDREN’S 2002 IRREVOCABLE TRUST

X/X/X XXXXX 0, 0000-XXXXXX XXXXXX XXXXXXXXX

SHARES

000 Xxxxxxxx Xxxxxx, Xxxxx 000

Xx Xxxxx, XX 00000

(858) 546-2460 Ext. 203

FOUR PARTNERS

Attn: Xxxxxx Xxxxx

000 Xxxxxxx Xxxxxx, 00xx Xxxxx

00^xx Xxxxx

Xxx Xxxx, XX 00000

XXXXX-XXXXX INVESTMENTS

Attn: Xxxxxx Xxxxx

000 Xxxxxxx Xxxxxx, 00xx Xxxxx

00^xx Xxxxx

Xxx Xxxx, XX 00000

XXXXX BROS. INVESTMENTS II

Attn: Xxxxxx Xxxxx

000 Xxxxxxx Xxxxxx, 00xx Xxxxx

00^xx Xxxxx

Xxx Xxxx, XX 00000

667, L.P.

(F/K/A XXXXX BIOTECH FUND I)

Attn: Xxxxxx Xxxxx

000 Xxxxxxx Xxxxxx, 00xx Xxxxx

00^xx Xxxxx

Xxx Xxxx, XX 00000

GC&H INVESTMENTS

000 Xxxxxxxxxx Xxxxxx, 0xx Xxxxx

Xxx Xxxxxxxxx, XX 00000

XXXXXX XXXXXXXX

0000 Xxxxxxxxxx Xx.

Xx Xxxxx, XX 00000-0000

Name and Address

XX. XXXX XXXX

0000 Xxxx Xxxxxx Xxxxx

Xxx Xxxxx, XX 00000

(858) 587-4290 Ext. 228

XXXX XXXX LIVING TRUST

0000 Xxxx Xxxxxx Xxxxx

Xxx Xxxxx, XX 00000

(858) 587-4290 Ext. 228

XXXX X. XXXXXXXX

0000 Xxxx Xxxxxx

Xx Xxxxx, XX 00000

(858) 646-8303

XXXXXX XXXXXXX

00 Xxxxx Xxxx

Xxxxx Xxxxx, XX 00000

XXXX XXXXXXX

Chesapeake Management Group

0000 00^xx Xx. X.X.

Xxxxxxxxxx, XX 00000

XXXX XXXXX

00, Xxxxxxxxx Xxxxxx

Xxxxxxx

Xxxxx XX0 0XX

Xxxxxx Xxxxxxx

XX. XXXX X. XXXXXX

i/c/o Forward Ventures IV, L.P.

0000 Xxxxx Xxxxxx Xxxxx, Xxxxx 000

Xxx Xxxxx, XX 00000

Attn: Xxxxxxxx X. Xxxxxxx

(000) 000-0000

XXXXXXX XXXXXX

0000 Xxxxxxx Xxxxx Xxxx

Xxxxxxxxx, XX 00000.

XXXX X. XXX

00 Xxxxxx Xxxxx

Xxxxxxx Xxxxx, XX 00000

MEDAREX, INC.

000 Xxxxx Xxxx, Xxxxx 000

Xxxxxxxxx, XX 00000-0000

Attn: Xxxxxxxxx X. Xxxxxxxx

AVALON VENTURES VI, L.P.

000 Xxxxxxxx Xxxxxx, Xxxxx 000

Xx Xxxxx, XX 00000

Attn: Xxxxx X. Xxxxxxxx

Name and Address

AVALON GP FUND, LLC

000 Xxxxxxxx Xxxxxx, Xxxxx 000

Xx Xxxxx, XX 00000

Attn: Xxxxx X. Xxxxxxxx

AVALON VENTURES VI GP FUND, LLC

000 Xxxxxxxx Xxxxxx, Xxxxx 000

Xx Xxxxx, XX 00000

Attn: Xxxxx X. Xxxxxxxx

XXXXXXX, XXXXXXX & XXXXXXXX LLP

Out of business; no contact information

XXXXXX XXXXXXX

000 Xxxxxxxx Xxxxxx, Xxxxx 000

Xx Xxxxx, XX 00000

WS INVESTMENT COMPANY, LLC (2004A)

0000 Xxxx Xxxxxxxx Xxx, Xxx 000

Xxxxxxxxx, XX 00000

WS INVESTMENT COMPANY, LLC (2004C)

0000 Xxxx Xxxxxxxx Xxx, Xxx 000

Xxxxxxxxx, XX 00000

XXXXXXXX XXXXXXXX

c/x Xxxxx and Company, Inc.

0000 Xxxxxxx Xxxx Xxxx, Xxxxx 000

Xxx Xxxxxxx, XX 00000

XXXX XXXXXX

c/x Xxxxx & Company, Inc.,

000 Xxxxxx Xxxxxx, Xxxxx 0000

Xxx Xxxxxxxxx, XX 00000

XXXXXXX-XXXXX SQUIBB COMPANY

Attn: Xxxxxxxxx Xxxxx, VP and Assistant General

Counsel

000 Xxxx Xxx.

Xxx Xxxx, XX 00000

XXXXXXX XXXXXXXXX

00000 Xxxxxxxx Xxxx Xx

Xxx Xxxxx, XX 00000

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AMBIT BIOSCIENCES CORPORATION SIXTH AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT

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