JOINT FILING AGREEMENT
EXHIBIT 1
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JOINT FILING AGREEMENT
Each of the undersigned hereby acknowledges and agrees, in
compliance with the provisions of Rule 13d-1(k)(1) promulgated under the
Securities Exchange Act of 1934, as amended, that the Schedule 13D to which this
Agreement is attached as an Exhibit (the "Schedule 13D"), and any amendments
thereto, will be filed with the Securities and Exchange Commission jointly on
behalf of the undersigned. This Agreement may be executed in one or more
counterparts.
Dated: August 9, 2004
PERSEUS-XXXXX BIOPHARMACEUTICAL FUND, LP
By: Perseus-Xxxxx Partners, LLC,
General Partner
By: SFM Participation, L.P.,
Managing Member
By: SFM AH LLC
General Partner
By: Xxxxx Fund Management LLC,
Managing Member
By: /s/ Xxxxx X. Xxxxxxxxx
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Name: Xxxxx X. Xxxxxxxxx
Title: Assistant General Counsel
PERSEUS-XXXXX PARTNERS, LLC
By: SFM Participation, L.P.
Managing Member
By: SFM AH LLC
General Partner
By: Xxxxx Fund Management LLC,
Managing Member
By: /s/ Xxxxx X. Xxxxxxxxx
---------------------------------------
Name: Xxxxx X. Xxxxxxxxx
Title: Assistant General Counsel
PERSEUS BIOTECH FUND PARTNERS, LLC
By: Perseuspur EC, L.L.C.
Managing Member
By: Perseuspur, L.L.C.
Member
By: /s/ Xxxx Xxxxxxx
---------------------------------------
Name: Xxxx Xxxxxxx
Title: Secretary and Treasurer
PERSEUS EC, L.L.C.
By: Perseuspur, L.L.C.
Member
By: /s/ Xxxx Xxxxxxx
---------------------------------------
Name: Xxxx Xxxxxxx
Title: Secretary and Treasurer
PERSEUSPUR, L.L.C.
By: /s/ Xxxx Xxxxxxx
---------------------------------------
Name: Xxxx Xxxxxxx
Title: Secretary and Treasurer
XX. XXXXX X. XXXXX
By: /s/ Xxxx Xxxxxxx
----------------------------------------
Name: Xxxx Xxxxxxx
Title: Attorney-in-Fact
SFM PARTICIPATION, L.P.
By: SFM AH LLC
General Partner
By: Xxxxx Fund Management LLC,
Managing Member
By: /s/ Xxxxx X. Xxxxxxxxx
---------------------------------------
Name: Xxxxx X. Xxxxxxxxx
Title: Assistant General Counsel
SFM AH LLC
By: Xxxxx Fund Management LLC,
Managing Member
By: /s/ Xxxxx X. Xxxxxxxxx
---------------------------------------
Name: Xxxxx X. Xxxxxxxxx
Title: Assistant General Counsel
MR. XXXXXX XXXXX
By: /s/ Xxxxx X. Xxxxxxxxx
---------------------------------------
Name: Xxxxx X. Xxxxxxxxx
Title: Attorney-in-Fact
XXXXX FUND MANAGEMENT LLC
By: /s/ Xxxxx X. Xxxxxxxxx
---------------------------------------
Name: Xxxxx X. Xxxxxxxxx
Title: Assistant General Counsel
