Re: Amendment to the Second Amendment of August 22, 2006 to the License Agreement between Accentia Specialty Biopharmaceuticals, Inc., Accentia Specialty Pharmacy and Mayo Foundation for Medical Education and Research of February 10, 2004, as amended...

Exhibit 10.3

August 22, 2006

Xxxxx X. X’Xxxxxxx, Xx. MD

Chairman and CEO

Accentia Biopharmaceuticals, Inc

0000 Xxxxxxx Xxxxxx Xxxxx, Xxxxx 000

Xxxxx, Xxxxxxx, 00000

Re: Amendment to the Second Amendment of August 22, 2006 to the License Agreement between Accentia Specialty Biopharmaceuticals, Inc., Accentia Specialty Pharmacy and Mayo Foundation for Medical Education and Research of February 10, 2004, as amended (“Agreement”)

Dear Xx. X’Xxxxxxx:

This letter memorializes an amendment to the Second Amendment between the parties regarding the interpretation of the Second Amendment that:

1. Paragraph 4.03 of the Agreement is not applicable to NPP Products (as that term is defined in the Second Amendment); and

2. The reference to new Paragraph 4.11 in the Second Amendment is understood to be the addition of Paragraph 4.13 to the Agreement.

As you are authorized to make this Amendment to the Second Amendment on behalf of Accentia Specialty Biopharmaceuticals, Inc. and Accentia Specialty Pharmacy, please memorialize this agreement by signing below.

Sincerely,

/s/ Xxxxxx X. XxxXxxxxx
Mayo Foundation for Medical Education and Research
Name:		Xxxxxx X. XxxXxxxxx
Title:		Assistant Treasurer
Accepted and Agreed by:
Accentia Biopharmaceuticals and Accentia Specialty Pharmacy
/s/ Xxxxx X. X’Xxxxxxx, Xx., M.D.
Xxxxx X. X’Xxxxxxx, Xx. MD
Chairman and CEO