1
EXHIBIT 10.59
Synthelabo
January 14, ▇▇▇▇
▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇
▇▇▇▇▇ BIOTECHNOLOGY CORPORATION
▇▇▇▇ ▇▇▇▇▇▇, ▇▇▇▇▇ ▇▇▇▇
▇▇▇▇▇▇▇, ▇▇▇▇▇ ▇▇▇▇▇
(VIA COURIER)
re: License and Research Development Agreement dated October 11, 1994
Dear ▇▇▇▇▇,
I refer to the License and Research Development Agreement between Texas
Biotechnology Corporation ("TBC") and Synthelabo S.A. ("Synthelabo") dated
October 11, 1994, as amended (hereinafter the "Research Agreement"). Any
capitalized terms not defined herein shall have the meanings attributed to them
in the Research Agreement.
This letter will serve as the agreement of TBC and Synthelabo to amend the
provisions of Section 4.2(c) of the Research Agreement by deleting the
requirement that Synthelabo make research payments of $750,000 on each of
January 31, April 30, July 31 and October 31, 1997. TBC further agrees that
the last research payment which has been made by Synthelabo in the amount of
$750,000 for the quarter ended January 31, 1997 fully satisfies any and all
obligations of Synthelabo to make any research payments under Section 4.2(c) of
the Research Agreement.
TBC and Synthelabo further agree that Section 3.1 of the Research Agreement is
amended by deleting the third and fourth sentences of Section 3.1, and
inserting in lieu thereof the following: "TBC shall conduct the research
relating to the FGF Program in a manner reflecting the reduced research
payments provided by Synthelabo, which research will be conducted by
approximately four scientists working on a full-time basis.
Additionally, TBC and Synthelabo agree that the third sentence of Section 10.2
of the Research Agreement is amended to provide that the date of October 15,
1996 set forth therein is hereby changed to October 15, 1997.
Except as set forth in this letter agreement and any prior amendments, the
Research Agreement otherwise remains in full force and effect.
2
If the above accurately reflects your agreement please execute the two
originals of this letter and return one to the undersigned.
SYNTHELABO
By: ▇▇▇▇ ▇▇▇▇▇▇▇, Ph.D.
---------------------------------------
Title: Executive Vice President
------------------------------------
Date: January 16, 1996
----------------
Accepted and Agreed to:
TEXAS BIOTECHNOLOGY CORPORATION
By: /s/ ▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇
-----------------------------------
Title: President
--------------------------------
Date: 02/19/97
--------------------------------
