0001019155-03-000221 Sample Contracts

THE RIGHTS OF OWNERS OF RECEIPTS TO DIRECT THE VOTING OF SHARES MAY BE RESTRICTED AS DESCRIBED IN ARTICLES 16 AND 23 BELOW Exhibit A to Deposit Agreement
American Depositary Receipt • April 23rd, 2003 • British Biotech PLC • Pharmaceutical preparations

The Bank of New York as depositary (hereinafter called the "Depositary"), hereby certifies that ____________________________________________________ _____________________________________, or registered assigns IS THE OWNER OF ____________________________________ AMERICAN DEPOSITARY SHARES representing deposited Ordinary Shares of 5p nominal value per share (herein called "Shares") of British Biotech plc, an English public limited company (herein called the "Company"). At the date hereof, each American Depositary Share represents forty Shares deposited or subject to deposit under the deposit agreement at the London office of The Bank of New York, as custodian (herein called the "Custodian"). The Depositary's Corporate Trust Office is located at a different address than its principal executive office. Its Corporate Trust Office is located at 101 Barclay Street, New York, N.Y. 10286, and its principal executive office is located at One Wall Street, New York, N.Y. 10286.

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