0001636282-24-000083 Sample Contracts

September 20, 2024 Dr. Sheldon Sloan, M.D. Re: Offer of Employment Dear Sheldon:
Spyre Therapeutics, Inc. • November 7th, 2024 • Pharmaceutical preparations

On behalf of Spyre Therapeutics, Inc. (the “Company”), I am very pleased to offer you a position as Chief Medical Officer (the “Role”) pursuant to this letter agreement (the “Agreement”), provided you accept such offer as indicated by your signature below.

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