Guide RNA definition

Guide RNA means one or more synthetic, short ribonucleic acid sequences composed of a scaffold sequence that binds to the Genome Editing Protein Target and a sequence complementary to the site on the Human Genome at which the Genome Editing Protein Target is intended to Genome Edit.
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Guide RNA means a modified or unmodified RNA sequence intended to direct a DNA Editing Protein to a specific DNA Target.
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Guide RNA means any single- or double-stranded polynucleotide (including any analogue, variant, or mimic thereof) used for genome sequence site-specific targeting of a Gene Editing protein.
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Examples of Guide RNA in a sentence

  • Guide RNA for the Mbait target sequence in the donor plasmids was created using the sgM vector described previously (Kimura et al., 2014) (a gift from Shinichi Higashijima).

  • Guide RNA vectors were created using pDR274 (Hwang et al., 2013) and following a protocol described previously (Kimura, Hisano, Kawahara, & Higashijima, 2014).

  • Guide RNA expression cassettes were integrated using vectors from the EasyClone 2.0 toolkit for yeast genomic integration (64).

  • For purposes of this Section 12.2.2, “licensed systems” mean a Gene Editing protein and a Guide RNA that is designed to modulate a target.

  • Guide RNA expression was then induced by injecting concentrated anyhydrotetracycline into both the growth chamber and turbidostat media reservoir to obtain a final concentration of 250 ng/ml of anyhydrotetracycline.

  • Large-Scale Single Guide RNA Library Construction and Use for CRISPR-Cas9-Based Genetic Screens.

  • Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.

  • Guide RNA engineering in CRISPR-Cas9 technology, on the other hand, is far more rapid and less expensive (on the order of tens of US dollars), offering a significant ad- vantage over other existing forms of genetic modification.

  • Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 Endonuclease.

  • Guide RNA format CRISPR/Cas9 systems can function with guide RNAs having a variety of modifications, such as changes to the physical guide RNA structure or chemical modifications of nucleotides.


More Definitions of Guide RNA

Guide RNA means, for the purpose of this Amendment Agreement only, [*****]
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Guide RNA means one or more [***].
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