Validated Target definition

Validated Target means a Target that has been validated in vitro ---------------- or in vivo as part of a TVD program by ATUGEN or its Collaborator.

Validated Target means a biological drug target against which any drug has received Marketing Authorization Approval.

Validated Target means any one or more of the following: (i) NMDA channels, (ii) sodium channels, and/or (iii) both NMDA and sodium channels, if so designated by the Research Management Committee pursuant to Section 4.1, or other glutamate-activated channels that the Research Management Committee determines from time to time.

Examples of Validated Target in a sentence

• Novartis shall have the right to initiate Compound Screening with each Novel Validated Target upon notice to Rigel any time during the Exclusivity Term with respect to such Novel Validated Target.

• The date on which Rigel has delivered the notice described in this Section 4.1.4, provided Novartis has not within ten (10) business days of receipt of said notice informed Rigel that in Novartis' opinion, the CMC-predetermined validation cirteria have not been met, shall be considered the "Notice Date" of such Novel Validated Target.

• Rigel shall notify the CMC in writing of each Novel Validated Target identified by Rigel during the Research Period of each Joint Project promptly after its identification.

• At any time during the Exclusivity Term with respect to a Novel Validated Target, Novartis shall on a not less than quarterly basis provide documentation to the reasonable satisfaction of Rigel that Novartis is maintaining a diligent, continuous program with respect to the Novel Validated Target.

• At any time during the Exclusivity Term with respect to a Novel Validated Target, Novartis, at its sole discretion, may request in writing that Rigel conduct Compound Screening of Rigel's small-molecule compound library against such Novel Validated Target.

More Definitions of Validated Target

Validated Target means a Target which has been shown to meet all of the following criteria approved by the PC: (a) the Target is well characterized (i.e., its biochemical and physiological actions are reasonably well understood); (b) agents, ligands, or intracellular molecules that interact with the Target demonstrate a desired effect on a biological process in relationship to a disease state or disorder; and (c) the Target is shown to be present in human tissue with the disease state or condition.

Validated Target means the *** .

Validated Target means a Target which has been shown to meet all of the following criteria approved by the PC: (a) the Target is well characterized (i.e., its biochemical and physiological actions are reasonably well understood); (b) agents, ligands, or intracellular molecules that interact with the Target demonstrate a desired effect on a biological process in relationship to a disease state or disorder; and (c) the Target is shown to be present in human tissue with the disease state or condition. ARTICLE II -

Validated Target means, for a Target Validation Program, a Target that successfully achieves the Validated Target Criteria for such Target Validation Program.

Validated Target means a signal transduction target, selected from the group of tyrosine kinases and tyrosine phosphatases and serine-threonine kinases, that has been determined by the RMC to be [ ] where inhibition of target function in in vitro and in vivo models lead to effective inhibition of pathophysiology.

Validated Target has the meaning forth in Section 2.1.3.

Validated Target means a biological target which, based on demonstrating relevant IN VITRO and IN VIVO activity, is appropriate for [**] , and which has been [**]. A Validated Target may be a Candidate Gene, a Protein encoded by a Candidate Gene or other qualifying biological molecule in a relevant biochemical pathway, the identification of which or the linkage with a disease is based upon the identification of a Candidate Gene.