Common use of AGREEMENT AND MODIFICATION Clause in Contracts

AGREEMENT AND MODIFICATION. Order of Precedence Should there be any inconsistency between the Protocol and the terms of this Agreement, or any other document incorporated herein, the terms of the Protocol shall prevail to the extent of any inconsistency except insofar as the inconsistency relates to Clauses 5, 6, 7, 8, 10, 11 and 16 of this Agreement. Any change in the terms of this Agreement shall be valid only if the change is made in writing, agreed and signed by the Parties. Any amendment to the Protocol (“Protocol Amendment”) shall be managed by means of the change control procedure set out in this Clause. For the purposes of this Agreement, a “change request” is a request to change the obligations of the Parties arising from a Protocol Amendment. Where the Sponsor originates a change request, the Participating Organisation shall provide the Sponsor, within thirty-five (35) days of receiving the change request, details of the impact that the proposed Protocol Amendment will have upon the costs of carrying out the Clinical Trial and the other terms of this Agreement. A change request shall become a “change order” when the requirements of the change control procedure have been satisfied and any necessary change to this Agreement is signed by the authorised representatives of the Parties. An amended financial appendix shall be signed and appended to this Agreement according to Clause 12.2 above. This Agreement contains the entire understanding between the Parties and supersedes all other agreements, negotiations, representations and undertakings, whether written or oral, of prior date between the Parties relating to the Clinical Trial that is the subject of this Agreement.

AGREEMENT AND MODIFICATION. Order of Precedence Should there be any inconsistency between the Protocol and the terms of this Agreement, or any other document incorporated herein, the terms of the Protocol shall prevail to the extent of any inconsistency except insofar as the inconsistency relates to Clauses 5, 6, 7, 8, 10, 11 and 16 of this Agreement. Any change in the terms of this Agreement shall be valid only if the change is made in writing, agreed and signed by the Parties. Any amendment to the Protocol (“Protocol Amendment”) shall be managed by means of the change control procedure set out in this Clause. For the purposes of this Agreement, a “change request” is a request to change the obligations of the Parties arising from a Protocol Amendment. Where the Sponsor or CRO originates a change request, the Participating Organisation shall provide the SponsorSponsor or CRO, within thirty-five (35) days of receiving the change request, details of the impact that the proposed Protocol Amendment will have upon the costs of carrying out the Clinical Trial and the other terms of this Agreement. A change request shall become a “change order” when the requirements of the change control procedure have been satisfied and any necessary change to this Agreement is signed by the authorised representatives of the all Parties. An amended financial appendix shall be signed and appended to this Agreement according to Clause 12.2 above. This Agreement contains the entire understanding between the Parties and supersedes all other agreementsagreements (other than the agreement contracting the CRO to work on behalf of the Sponsor with regards to this Clinical Trial), negotiations, representations and undertakings, whether written or oral, of prior date between the Parties relating to the Clinical Trial that is the subject of this Agreement.

AGREEMENT AND MODIFICATION. Order of Precedence Should there be any inconsistency between the Protocol and the terms of this Agreement, or any other document incorporated herein, the terms of the Protocol shall prevail to the extent of any inconsistency except insofar as the inconsistency relates to Clauses 5, 6, 7, 8, 10, 11 and 16 of this Agreement, whereby the terms of this Agreement shall prevail. Any change in the terms of this Agreement shall be valid only if the change is made in writing, agreed and signed by the Parties. Any amendment to the Protocol (“Protocol Amendment”) shall be managed by means of the change control procedure set out in this Clause. For the purposes of this Agreement, a “change request” is a request to change the obligations of the Parties arising from a Protocol Amendment. Where the Sponsor originates a change request, the Participating Organisation shall provide the Sponsor, within thirty-five fourteen (3514) days of receiving the change request, details of the impact that the proposed Protocol Amendment will have upon the costs of carrying out the Clinical Trial and the other terms of this Agreement. A change request shall become a “change order” when the requirements of the change control procedure have been satisfied and any necessary change to this Agreement is signed by the authorised representatives of the Parties. An amended financial appendix shall be signed and appended to this Agreement according to Clause 12.2 above. This Agreement contains the entire understanding between the Parties and supersedes all other agreements, negotiations, representations and undertakings, whether written or oral, of prior date between the Parties relating to the Clinical Trial that is the subject of this Agreement.

AGREEMENT AND MODIFICATION. Order of Precedence Should there be any inconsistency between the Protocol and the terms of this Agreement, Agreement or any other document incorporated herein, the terms of the Protocol shall prevail to the extent of any inconsistency except insofar as the inconsistency relates to Clauses 5, 6, 7, 8, 10, 11 and 16 of this Agreement, whereby the terms of this Agreement shall prevail. Any change in the terms of this Agreement shall be valid only if the change variation is made in writing, agreed and signed by the Parties. Any amendment to the Protocol (“Protocol Amendment”) shall be managed by means of the change control procedure set out in this Clause. For the purposes of this Agreement, a “change requestChange Request” is a request to change the obligations of the Parties arising from a Protocol Amendment. Where the Sponsor originates a change requestChange Request, the Participating Organisation shall provide the Sponsor, within thirty-five fourteen (3514) days of receiving the change requestChange Request, details of the impact that the proposed Protocol Amendment will have upon the costs of carrying out the Clinical Trial Non-Interventional Study and the other terms of this Agreement. A change request Change Request shall become a “change orderChange Order” when the requirements of the change control procedure have been satisfied and any necessary change to this Agreement is signed by the authorised representatives of the Parties. An amended financial appendix shall be signed and appended to this Agreement according to Clause 12.2 above. This Agreement contains the entire understanding between the Parties and supersedes all other agreements, negotiations, representations and undertakings, whether written or oral, of prior date between the Parties relating to the Clinical Trial Non-Interventional Study that is the subject of this Agreement.

AGREEMENT AND MODIFICATION. Order of Precedence Should there be any inconsistency between the Protocol and the terms of this Agreement, or any other document incorporated herein, the terms of the Protocol shall prevail to the extent of any inconsistency except insofar as the inconsistency relates to Clauses 5, 6, 7, 8, 10, 11 and 16 of this Agreement, whereby the terms of this Agreement shall prevail. Any change in the terms of this Agreement shall be valid only if the change variation is made in writing, agreed and signed by the Parties. Any amendment to the Protocol (“Protocol Amendment”) shall be managed by means of the change control procedure set out in this Clause. For the purposes of this Agreement, a “change requestChange Request” is a request to change the obligations of the Parties arising from a Protocol Amendment. Where the Sponsor or CRO originates a change requestChange Request, the Participating Organisation Trial Site shall provide the SponsorSponsor or CRO, within thirty-five fourteen (3514) days of receiving the change requestChange Request, details of the impact that the proposed Protocol Amendment will have upon the costs of carrying out the Clinical Trial and the other terms of this Agreement. A change request Change Request shall become a “change orderChange Order” when the requirements of the change control procedure have been satisfied and any necessary change to this Agreement is signed by the authorised representatives of the all Parties. An amended financial appendix shall be signed and appended to this Agreement according to Clause 12.2 above. This Agreement contains the entire understanding between the Parties and Parties. This Agreement supersedes all other agreements, negotiations, representations and undertakings, whether written or oral, of prior date between the Parties relating to the Clinical Trial that is the subject of this Agreement, other than the agreement contracting the CRO to work on behalf of the Sponsor with regards to this Clinical Trial or where a separate Investigator Site within the Trial Site has been contracted, in which case the Agreement does not supersede that / those agreement(s).

AGREEMENT AND MODIFICATION. Order of Precedence Should there be any inconsistency between the Protocol and the terms of this Agreement, or any other document incorporated herein, the terms of the Protocol shall prevail to the extent of any inconsistency except insofar as the inconsistency relates to Clauses 5, 6, 7, 8, 10, 11 and 16 of this Agreement, whereby the terms of this Agreement shall prevail. Any change in the terms of this Agreement shall be valid only if the change is made in writing, agreed and signed by the Parties. Any amendment to the Protocol (“Protocol Amendment”) shall be managed by means of the change control procedure set out in this Clause. For the purposes of this Agreement, a “change request” is a request to change the obligations of the Parties arising from a Protocol Amendment. Where the Sponsor or CRO originates a change request, the Participating Organisation Trial Site shall provide the SponsorSponsor or CRO, within thirty-five fourteen (3514) days of receiving the change request, details of the impact that the proposed Protocol Amendment will have upon the costs of carrying out the Clinical Trial and the other terms of this Agreement. A change request shall become a “change order” when the requirements of the change control procedure have been satisfied and any necessary change to this Agreement is signed by the authorised representatives of the all Parties. An amended financial appendix shall be signed and appended to this Agreement according to Clause 12.2 above. This Agreement contains the entire understanding between the Parties and Parties. This Agreement supersedes all other agreements, negotiations, representations and undertakings, whether written or oral, of prior date between the Parties relating to the Clinical Trial that is the subject of this Agreement., other than the agreement contracting the CRO to work on behalf of the Sponsor with regards to this Clinical Trial or where a separate Investigator Site within the Trial Site has been contracted, in which case the Agreement does not supersede that/those agreement/s.