Application to real data Sample Clauses

Application to real data. To illustrate the score test with real data we used data obtained from a pub- lished study on association between the collagen type II gene(COL2A1) and radiographic osteoarthritis (ROA) (Meulenbelt et al., 1999). Osteoarthritis is a degenerative disease of the joints. The VNTR marker next to COL2A1 was typed in 820 subjects aged 50-70 years from a population-based cohort study, the Rotterdam study. Radiographs of knees, hips, hands, and spine were scored for the presence of XXX. 123 cases had ROA in at least 3 joints groups. 697 remaining subjects were used as controls. Five variants had frequencies
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