BIOTECHNOLOGY Clause Samples

BIOTECHNOLOGY. This Patent and Technology License Agreement (“Agreement”) is between The Board of Regents (“Board”) of The University of Texas System (“System”), an agency of the State of Texas whose address is 2▇▇ ▇▇▇▇ ▇▇▇ ▇▇▇▇▇▇, ▇▇▇▇▇▇, ▇▇▇▇▇ ▇▇▇▇▇ on behalf of The University of Texas Southwestern Medical Center (“UT Southwestern”), a component institution of System, whose address is 5▇▇▇ ▇▇▇▇▇ ▇▇▇▇▇ Boulevard, Dallas, Texas 75390-9094 (“Licensor”) and MAIA Biotechnology, Inc., a Delaware corporation, with its principal place of business at 4▇▇ ▇▇▇▇ ▇▇▇▇ ▇▇▇▇▇▇, ▇▇▇▇▇ ▇▇▇▇, ▇▇▇▇▇▇▇, ▇▇ ▇▇▇▇▇ (“Licensee”) (collectively, “Parties”, or singly, “Party”). This Agreement has an “Effective Date” of the date of the last signature hereto. Licensor and Licensee have previously entered into “Patent & Technology License Agreement Agt. No. L2664-MAIA Biotechnology,” as amended, which was executed December 8, 2020. This agreement and all of its exhibits and schedules and including any and all amendments to any of the foregoing will be referred to collectively in this agreement as the “Original Agreement.” As set forth in the Original Agreement, Licensee had the option to obtain additional licenses to technology developed by the Licensor. The instant Agreement between the Licensor and Licensee is directed to granting Licensee such additional license rights. In that regard, Licensor owns or controls Licensed Subject Matter (defined below). Licensee desires to secure the right and license to use, develop, manufacture, market, and commercialize the Licensed Subject Matter. Licensor has determined that such use, development, and commercialization of the Licensed Subject Matter is in the public’s best interest and is consistent with Licensor’s educational and research missions and goals. Licensor desires to have the Licensed Subject Matter developed and used for the benefit of Licensee, the inventors, Licensor, and the public.

BIOTECHNOLOGY. (a) The Parties appreciate that marine environment is a source of unique chemical compounds with vast potential for industrial and commercial development as pharmaceuticals, cosmetics, nutritional supplements, molecular probes, enzymes, fine chemicals and agrichemicals. (b) The Parties agree to have a collaborative framework between the Mauritius Oceanography Institute/Mauritius Research and Innovation Council and the CSIR- National Environmental Engineering Research Institute/CSIR-Central Salt and Marine Chemicals Research Institute from India on biotechnology for technology transfer, capacity building, joint research, sharing of scientific expertise and knowledge exchange in technical and research fields. These include collaboration on: (i) sharing of modern technologies to accelerate the development and expansion of the marine biotechnology sector; (ii) research and development in food products and ingredients from marine resources, renewable and sustainable energy supply, marine environmental health monitoring, bioremediation of effluents, enzymes and biopolymers from macroalgae; (iii) research in marine biotechnology and pharmacology as well as in various fields including medicinal plant, forest and forest products; (iv) development of marine pharmaceuticals including sharing of experience on the use of analytical instruments, data analysis and results interpretation to support identification and structural characterization of biomolecules from marine natural product, bioassay techniques used for biological testing of bioactive extracts and compounds; (v) setting up marine biotechnology parks with facilities for commercial exploitation in pharmaceuticals, food supplements and cosmetics; (vi) the production of marine derived compounds of commercial and environmental importance; (vii) the development of demonstration-scale facilities (mass cultivation methods, pond systems design) of marine microalgae for biotechnological application; (viii) For culture of non-traditional species, diseases detection and feed production and including technology transfer and joint research.

BIOTECHNOLOGY. Biotechnology for agriculture, aquaculture, forestry and biomass production;

BIOTECHNOLOGY. Biohydrometallurgy is a branch of extractive metallurgy which describes biotechnological processes that involve interactions between microorganisms and metal-bearing minerals. Bioleaching and bioremediation are two of the most studied branches in this field and are employed worldwide at commercial scale. Bioleaching involves the use of naturally occurring microorganisms to recover gold, base metals and uranium from mineral ores, concentrates and a range of waste materials. Mintek has established an internationally recognised position for the treatment of sulphide ores and concentrates bearing gold and base metals. The tank bioleaching technologies developed by Mintek typically find application in niche areas for treatment of refractory gold concentrates as well as complex polymetallic concentrates which contain impurities that attract smelting penalties. The organisation has the ability to take processes from amenability test work through to piloting, flowsheet design, techno-economic studies and commercial implementation. With the depletion of higher grade resources, Mintek’s biotechnology processes have shifted focus to include heap ▇▇▇▇▇ applications where metals are extracted into solution from minerals contained in dumps or stacked heaps of low- grade ores. The learnings from biological heap leaching have been expanded to also include acid, alkaline and chloride heap leaching in the division’s portfolio. In addition, Mintek has the unique ability to combine percolation ▇▇▇▇▇ test work with geomechanical (hydraulic / hydrodynamic) testing of such ores and their ▇▇▇▇▇ residues. This allows Mintek to offer clients a combination of metallurgical performance results and geomechanical/hydrodynamic information from which engineering can be done based on quantified specifications provided. Mintek’s activities in this area range from a suite of various bench-scale tests to integrated pilot and demonstration tests at Pre-Feasibility Study or Process Selection Phase level, enabling commercial clients to determine ideal flowsheet design and operating conditions for optimizing value. There is a global trend to move the mining industry towards participating in a circular economy by promoting and investing in sustainable solutions and green technologies. Mintek is uniquely positioned to contribute to this drive through its multi-disciplinary capabilities, which include bioprocessing, chemical and environmental engineering and biological sciences expertise. The focus...

BIOTECHNOLOGY. 1. Biotechnology for agriculture, aquaculture, forestry and biomass production; 2. Industrial and food biotechnology; 3. Biotechnology for health, medicine and related industries; 4. Integrated environmental biotechnology. ✓Project Promoter (PP): Research organizations, as defined in the Community Framework for State Aid for RDI (2014/C 198/01), established in RO ✓Project Partners (pp): Research organizations and companies (SMS and large enterprises) established in RO or NO (at least one from NO) ✓Principal Investigator (PI): • Project coordinator • PI (of any nationality) could be PI for one single submitted proposal • A researcher who is PI of an ongoing project funded under EEA Grants Call 2018 cannot be in the same time a PI of a new project Working together for a green, competitive and inclusive Europe Useful documents ▇▇▇▇▇://▇▇▇▇▇▇▇▇.▇▇▇.▇▇/eea-grants- collaborative-research-projects ✓ One single stage ✓ Proposals must be in English language ✓ Respect the deadline date and time (16th of December 2019, 4:00 PM RO time) ✓ Only the PP is authorised to submit a proposal ✓ Online submission system only: ▇▇▇.▇▇▇▇▇▇▇▇-▇▇▇▇▇▇.▇▇ (no paper support, email/fax); ✓ Acknowledgement of receipt: • proposal title, acronym and unique proposal identifier (proposal number) • date and time of receipt • name of the Programme and/or thematic area and call identifier Only for RO applicants for NO applicants also Working together for a green, competitive and inclusive Europe

BIOTECHNOLOGY. Any technique that uses living organisms or sub- stances from those organisms to make or modify a product, to improve plants or animals, or to devel- op microorganisms for specific uses. These tech- niques include the use of novel DNA, cell fusion, and other bioprocesses. A formal agreement between a federal laboratory and a nonfederal party (individual, university, or private firm) in which the nonfederal party pro- vides resources in exchange for exclusive rights to license patents that result from collaboration. Congress gave federal laboratories the authority to enter into CRADAs as part of the Federal Technology Transfer Act of 1986 (Public Law 99-502). The molecule that encodes genetic information. DNA is a double-stranded helix held together by weak bonds between base pairs of nucleotides. See deoxyribonucleic acid.

BIOTECHNOLOGY. We see a great opportunity for Germany to increase its competitiveness as a centre of business and science in biotechnological research, development and application. We will continue to develop the potential of responsible innovations in biotechnology and genetic engineering to secure Germany’s position as a business centre and to meet our global responsibilities. We will work together with the Bioeconomy Council to draft and implement an internationally competitive strategy for a knowledge-based bioeconomy. The scientific, business and agricultural communities require clear signals regarding research into and the use of genetically modified plants based on current law. Green genetic engineering can contribute to the fight against global famine. Prevention is better than cure. We will strengthen prevention research. New findings produced by research must benefit people more quickly. We are paving the way for individualised medicine and therapies that are more effective and better tolerated by patients. This must be accompanied by new concepts in health system and health care research. With “German Centres for Health Research” that bring together research institutions, universities, university clinics and clinics in equal and long-term partnership we will create the necessary conditions for combating the rapid increase in common diseases. Stem cell research offers great opportunities for the health sector. We want to ensure that these opportunities can be realised in Germany. At the same time, ethically sensitive research must take place within the framework of current law and involve all the key players in society. We are investigating the establishment of a platform for dialogue called the “German Stem Cell Network”. Page 77

BIOTECHNOLOGY. Mintek’s Biotechnology programme is a branch of extractive metallurgy, which describes biotechnological processes that involve interactions between microorganisms and metal-bearing minerals. Bioleaching and bioremediation are two of the most studied branches in this field and are employed worldwide at commercial scale. Bioleaching involves the use of naturally occurring microorganisms to recover gold, base metals and uranium from mineral ores, concentrates and a range of waste materials. It is a well-established programme of Mintek that is internationally recognised for the treatment of sulphide ores and concentrates bearing gold and base metals. GOAL 1 CONDUCT RELEVANT, APPLIED RESEARCH AND TECHNOLOGICAL INNOVATION Objective Build capacity to support innovation and technology development in the environmental sector. Objective statement In line with evolving industry dynamics which are increasingly being driven by the environmental, social and corporate governance (ESG) aspects of mining operations and the increasing push for the development and implementation of green technologies that are capable of delivering on ener- gy, water and carbon efficiency targets, the division aims to increase its capability to provide tech- nology solutions to the water, waste and energy sector as they are applied to the minerals industry. Baseline Development of a client-directed sustainable technology strategy for the Biotechnology Division. Produce value-added products from waste effluents, jointly funded by the Water Research Com- mission and Mintek. GOAL 2 ▇▇▇▇▇▇ INDUSTRY ESTABLISHMENT AND EXPANSION Objective 1 Unlocking Value from South Africa’s Precious Metals Mine Tailings by Heap ▇▇▇▇▇ Technology Objective statement Commercialisation of heap leaching as a viable option for the treatment of small to large tonnages of South African precious metal bearing low-grade ores and waste rock. Baseline Concept of alkaline gold heap ▇▇▇▇▇ technology has been proven to treat sulphide refractory gold ore and waste rock through simultaneous sulphide oxidation and gold dissolution in the heap, elim- inating the need for neutralisation stages prior to gold cyanidation. Interest from commercial clients in treatment of PGM tailings using heap leaching. Discovery filed. PhD in progress. Objective 2 Transfer of mining and process-impacted water treatment technology to the mining and related industries. Objective statement Demonstrate Mintek’s biological sulphate reduction process (cloSU...

BIOTECHNOLOGY. TAGs may be written in Biotechnology for students who meet the TAG criteria for the College of Agricultural and Environmental Sciences [Section III)A)1)] and who meet the following additional criteria: ▪ Mathematics 16A/B or Mathematics 17A/B or Mathematics 21A/B Students must have a GPA of at least 2.50 for this group of courses. Courses must be taken for a letter grade, with no grade less than "C." ▪ Chemistry 2A/B/C Students must have a GPA of at least 2.50 for this group of courses. Courses must be taken for a letter grade, with no grade less than "C." ▪ Biological Sciences 1A or 1B or 1C OR Biological Sciences 2A or 2B or 2C (Series completion highly recommended) o A minimum of one course equivalent to a UC ▇▇▇▇▇ Biological Sciences course must be competed with a "B" grade or higher for admission. o If two courses or the entire series are completed, a group GPA of 2.50 or higher is required. Courses must be taken for a letter grade, with no grade less than "C." We strongly encourage students to complete an entire biological sciences series, either Biological Sciences 1A/B/C or Biological Sciences 2A/B/C before matriculating to UC ▇▇▇▇▇. Students may wish to consider completing the series during summer session at their current school or at UC ▇▇▇▇▇ before enrolling for the fall term as this will allow for a smoother transition and reduce time to degree.‌‌ ▪ It is strongly recommended that students complete courses comparable to the following UC ▇▇▇▇▇ courses with a GPA of at least 2.50 for the group. Completion of these courses will help the student move more efficiently toward graduation. Courses should be taken for a letter grade, with no grade less than "C": Organic Chemistry 8A/B or 118A/B/C