Close Observation Clause Samples
Close Observation. Watch refers to a Mental Health Watch status where a staff member maintains visual contact with a prisoner periodically, typically every 15 minutes, and is a status used if a prisoner is not seen as acutely at risk but still demonstrates behavior that indicates the potential for self-injurious behavior.
Close Observation. Upon detection and confirmation of early signs of possible DILI (see Section 7.7.1), close observation should be initiated immediately. Close observation will include the following: • Repeating liver enzyme and serum bilirubin tests 2 or 3-times weekly. The frequency of retesting can decrease to once a week or less if abnormalities stabilize or the trial drug has been discontinued and the subject is asymptomatic; • Obtaining a more detailed history of symptoms and prior or concurrent diseases; • Obtaining a history of concomitant drug use including non-prescription medications and herbal and dietary supplement preparations, alcohol use, recreational drug use, and special diets; • Ruling out acute viral hepatitis types A, B, C, D, and E, autoimmune or alcoholic hepatitis, hypoxic/ischemic hepatopathy, and biliary tract disease; • Obtaining a history of exposure to environmental chemical agents; • Obtaining additional tests to evaluate liver function, as appropriate (e.g., INR, direct bilirubin); • Consider gastroenterology or hepatology consultations; • Consider liver biopsy.