Common use of Cumulative Effect of Royalty Reductions Clause in Contracts

Cumulative Effect of Royalty Reductions. On a country-by-country basis, in no event will the royalty reductions for Products that Modulate a given Target permitted under Section 11.7.2(a) (Lack of Valid Claims), Section 11.7.2(b) (Loss of Market Exclusivity), or Section 11.7.2(c)(i) (Third Party Licenses), alone or together, reduce the Royalties due to HMI for Products that Modulate such Target pursuant to Section 11.7.1 (Royalty Rates) in a country in a given Calendar Quarter to less than the applicable royalty floor set forth in Table 11.7.1 in such country in such Confidential Portions of this Exhibit marked as [***] have been omitted pursuant to a request for confidential treatment and have been filed separately with the Securities and Exchange Commission. Confidential Treatment Requested by Homology Medicines, Inc. Calendar Quarter (the “Royalty Floor”). [***] Notwithstanding the Royalty Floor or any other limitations set forth in this Section 11.7.3 (Cumulative Effect of Royalty Reductions) and without limiting HMI’s obligations hereunder, if a Third Party threatens to either terminate or diminish the scope or exclusivity of the licenses granted to NVS under any HMI Licensed Technology under a Third Party License to which HMI or its Affiliates is a party, then [***]