Dosage Schedule Clause Samples

Dosage Schedule. Use of snus (or placebo) within the trial is ad libitum. When participants feel an urge to smoke, they are instructed to try their allocated study product for at least 20-30 minutes. If they still feel an urge to smoke, they can do so. Participants will be informed that one 1 g snus sachet typically can replace one cigarette. They will also be informed that nicotine overdosage may occur with excessive use of the product, particularly with concomitant smoking, but those symptoms (typically nausea, tachycardia, etc) quickly subside upon cessation of smoking or use of the product. The participants will be instructed to replace as many cigarettes as possible with their allocated study product. Those who achieve “smoking reduction” at 24 weeks will be encouraged to quit smoking totally. The average snus consumption among snus users in Sweden who do not smoke is about 10-15 sachets per day.