Common use of Final Exercise Date Clause in Contracts

Final Exercise Date. 00 pm Eastern time on Date: [Date is ten years minus one day from Grant Date] This Agreement includes this Notice of Grant and the following Exhibits, which are expressly incorporated by reference in their entirety herein: Exhibit A – General Terms and Conditions Exhibit B – Notice of Stock Option Exercise Exhibit C – Tvardi Therapeutics, Inc. 2018 Stock Incentive Plan

Final Exercise Date. 00 5:00 pm Eastern time on Date: [Date is ten years minus one day from Grant Date] This Agreement includes this Notice of Grant and the following Exhibits, which are expressly incorporated by reference in their entirety herein: Exhibit A – General Terms and Conditions Exhibit B – Notice of Stock Option Exercise Exhibit C – Tvardi TherapeuticsInozyme Pharma, Inc. 2018 Stock Amended and Restated 2017 Equity Incentive Plan

Final Exercise Date. 00 5:00 pm Eastern time on Date: [Date is ten years minus one day from Grant Date] This Agreement includes this Notice of Grant and the following Exhibits, which are expressly incorporated by reference in their entirety herein: Exhibit A – General Terms and Conditions Exhibit B – Notice of Stock Option Exercise Exhibit C – Tvardi Xilio Therapeutics, Inc. 2018 2020 Stock Incentive PlanPlan 1 Vesting Table to reflect vesting schedule approved by Board of Directors.

Final Exercise Date. 00 5:00 pm Eastern time on Date: [Date is ten years minus one day from Grant Date] This Agreement includes this Notice of Grant and the following Exhibits, which are expressly incorporated by reference in their entirety herein: Exhibit A – General Terms and Conditions Exhibit B – Notice of Stock Option Exercise Exhibit C – Tvardi Werewolf Therapeutics, Inc. 2018 2017 Stock Incentive Plan