Common use of Form of Global Security Clause in Contracts

Form of Global Security. [Insert any legend required by the Internal Revenue Code and the regulations thereunder.] No. _______________ XXXXX & NEPHEW PLC, a public limited company incorporated under the laws of England and Wales (herein called the “Issuer”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to _____________________ [If applicable – insert – as nominee for [insert name]], or registered assigns upon presentation and surrender of this Security the principal sum of _________________ on ______________________ [if the Security is to bear interest prior to Maturity, insert -, and to pay interest thereon from _____________, 20__ or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semiannually in arrears on ____________ and _____________ in each year] [annually in arrears on __________________ in each year], commencing ______________, 20__, at the rate of ___% per annum, until the principal hereof is paid or made available for payment [if applicable, insert -; provided that any principal and premium, and any such instalment of interest, which is overdue shall bear interest at the rate of __% per annum (to the extent that the payment of such interest shall be legally enforceable), from the dates such amounts are due until they are paid or made available for payment, and such interest shall be payable on demand]. [If the Security is not to bear interest prior to Maturity, insert - The principal of this Security shall not bear interest except in the case of a default in payment of principal upon acceleration, upon redemption or at Stated Maturity, and in such case the overdue principal and any overdue premium shall bear interest at the rate of __% per annum (to the extent that the payment of such interest shall be legally enforceable), from the date such amounts are due until they are paid or made available for payment. Interest on any overdue principal shall be payable on demand. Any such interest on any overdue principal or premium which is not so paid on demand shall bear interest at the rate of __% per annum (to the extent that the payment of such interest on interest shall be legally enforceable), from the date of such demand until the amount so demanded is paid or made available for payment. Interest on overdue interest shall be payable on demand.] [The Trustee shall act as Paying Agent with respect to the Securities of this series.] [Title to this Security shall pass by delivery.] Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. [All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.] Unless the certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof, directly or through an Authenticating Agent, by manual or pdf or other electronically-imaged (including, without limitation, DocuSign or Adobe Sign) signature of an authorized signatory, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.

Form of Global Security. [Form of Face of Global Security] [Insert any legend required by the Internal Revenue Code and the regulations thereunder.] DIAGEO FINANCE B.V. [Title of Security] Payment of Principal[, Premium, if any,] and Interest Fully and Unconditionally Guaranteed by DIAGEO PLC No.______________ CUSIP NO. _______________ XXXXX & NEPHEW PLCDIAGEO FINANCE B.V., a public private company with limited company liability (besloten vennootschap met beperkte aansprakelijkheid) incorporated under the laws of England Dutch law and Wales having its corporate seat in Amsterdam, The Netherlands (herein called the “"Issuer”", which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to _____________________ [If applicable – insert – as nominee for [insert name]], or registered assigns bearer upon presentation and surrender of this Security the principal sum of of______________________ on ________________________________________ [if the Security is to bear interest prior to Maturity, insert ---, and to pay interest thereon from _____________, 20___ or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semiannually semi-annually in arrears on ____________ and _____________ in each year] [annually in arrears on __________________ in each year], commencing ______________, 20___, at the rate of ____% per annum, until the principal hereof is paid or made available for payment [if applicable, insert -; --, provided that any principal and premium, and any such instalment of interest, which is overdue shall bear interest at the rate of __% per annum (to the extent that the payment of such interest shall be legally enforceable), from the dates such amounts are due until they are paid or made available for payment, and such interest shall be payable on demand]. .] [If the Security is not to bear interest prior to Maturity, insert - -- The principal of this Security shall not bear interest except in the case of a default in payment of principal upon acceleration, upon redemption or at Stated Maturity, and in such case the overdue principal and any overdue premium shall bear interest at the rate of ____% per annum (to the extent that the payment of such interest shall be legally enforceable), from the date such amounts are due until they are paid or made available for payment. Interest on any overdue principal shall be payable on demand. Any such interest on any overdue principal or premium which is not so paid on demand shall bear interest at the rate of ____% per annum (to the extent that the payment of such interest on interest shall be legally enforceable), from the date of such demand until the amount so demanded is paid or made available for payment. Interest on overdue interest shall be payable on demand.] [The Trustee shall act as Paying Agent with respect to the Securities of this series.] [The Issuer, the Guarantor, the Trustee and any agent of the Issuer, the Guarantor or the Trustee may treat the bearer hereof as the owner of this Security for all purposes, whether or not this Security shall be overdue, and none of the Issuer, the Guarantor, the Trustee nor any such agent shall be affected by notice to the contrary.] [Title to this Security shall pass by delivery.] Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. [All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.] Unless the certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof, directly or through an Authenticating Agent, by manual or pdf or other electronically-imaged (including, without limitation, DocuSign or Adobe Sign) signature of an authorized signatory, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.

Form of Global Security. [Form of Face of Global Security] [Insert any legend required by the Internal Revenue Code and the regulations thereunder.] No. _______________ XXXXX & NEPHEW CUSIP NO. AstraZeneca PLC, a public limited company incorporated under the laws of England and Wales (herein called the “Issuer”, ,” which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to _____________________ [If applicable – insert – as nominee for [insert name]], or registered assigns bearer upon presentation and surrender of this Security the principal sum of ____________________ on ______________________ [if the Security is to bear interest prior to Maturity, insert -, and to pay interest thereon from ____________________, 20__ or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semiannually semi-annually in arrears on ____________ and _____________ in each year] [annually in arrears on __________________ in each year], commencing ____________________, 20__, at the rate of ___% per annum, until the principal hereof is paid or made available for payment [if applicable, insert -; provided that any principal and premium, and any such instalment of interest, which is overdue shall bear interest at the rate of __% per annum (to the extent that the payment of such interest shall be legally enforceable), from the dates such amounts are due until they are paid or made available for payment, and such interest shall be payable on demand]. [If the Security is not to bear interest prior to Maturity, insert - The principal of this Security shall not bear interest except in the case of a default in payment of principal upon acceleration, upon redemption or at Stated Maturity, and in such case the overdue principal and any overdue premium shall bear interest at the rate of __% per annum (to the extent that the payment of such interest shall be legally enforceable), from the date such amounts are due until they are paid or made available for payment. Interest on any overdue principal shall be payable on demand. Any such interest on any overdue principal or premium which is not so paid on demand shall bear interest at the rate of __% per annum (to the extent that the payment of such interest on interest shall be legally enforceable), from the date of such demand until the amount so demanded is paid or made available for payment. Interest on overdue interest shall be payable on demand.] [The Trustee shall act as Paying Agent with respect to the Securities of this series.] [The Issuer, the Trustee and any agent of the Issuer or the Trustee may treat the bearer hereof as the owner of this Security for all purposes, whether or not this Security shall be overdue, and none of the Issuer, the Trustee nor any such agent shall be affected by notice to the contrary.] [Title to this Security shall pass by delivery.] Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. [All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.] Unless the certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof, directly or through an Authenticating Agent, by manual or pdf or other electronically-imaged electronic image scan signature of the Trustee created on an electronic platform (including, without limitation, DocuSign such as DocuSign) or by digital signing (such as Adobe Sign) signature of an authorized signatory, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.

Form of Global Security. [Form of Face of Global Security] [Insert any legend required by the Internal Revenue Code and the regulations thereunder.] ASTRAZENECA PLC [Title of Security] No. _______________ XXXXX & NEPHEW CUSIP NO. --------- ASTRAZENECA PLC, a public limited company incorporated under the laws of England and Wales (herein called the “"Issuer”", which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to _____________________ [If applicable – insert – as nominee for [insert name]], or registered assigns bearer upon presentation and surrender of this Security the principal sum of _________________ on ______________________ [if the Security is to bear interest prior to Maturity, insert -, and to pay interest thereon from _____________, 20__ or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semiannually in arrears on ____________ and _____________ in each year] [annually in arrears on __________________ in each year], commencing ______________, 20__, at the rate of ___% per annum, until the principal hereof is paid or made available for payment [if applicable, insert -; provided that any principal and premium, and any such instalment of interest, which is overdue shall bear interest at the rate of __% per annum (to the extent that the payment of such interest shall be legally enforceable), from the dates such amounts are due until they are paid or made available for payment, and such interest shall be payable on demand]. .] [If the Security is not to bear interest prior to Maturity, insert - The principal of this Security shall not bear interest except in the case of a default in payment of principal upon acceleration, upon redemption or at Stated Maturity, and in such case the overdue principal and any overdue premium shall bear interest at the rate of __% per annum (to the extent that the payment of such interest shall be legally enforceable), from the date such amounts are due until they are paid or made available for payment. Interest on any overdue principal shall be payable on demand. Any such interest on any overdue principal or premium which is not so paid on demand shall bear interest at the rate of __% per annum (to the extent that the payment of such interest on interest shall be legally enforceable), from the date of such demand until the amount so demanded is paid or made available for payment. Interest on overdue interest shall be payable on demand.] [The Trustee shall act as Paying Agent with respect to the Securities of this series.] [The Issuer, the Trustee and any agent of the Issuer or the Trustee may treat the bearer hereof as the owner of this Security for all purposes, whether or not this Security shall be overdue, and none of the Issuer, the Trustee nor any such agent shall be affected by notice to the contrary.] [Title to this Security shall pass by delivery.] Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. [All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.] Unless the certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof, directly or through an Authenticating Agent, by manual or pdf or other electronically-imaged (including, without limitation, DocuSign or Adobe Sign) signature of an authorized signatory, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.

Form of Global Security. [Form of Face of Global Security] [Insert any legend required by the Internal Revenue Code and the regulations thereunder.] DIAGEO FINANCE B.V. [Title of Security] Payment of Principal[, Premium, if any,] and Interest Fully and Unconditionally Guaranteed by DIAGEO PLC No.______________ CUSIP NO. _______________ XXXXX & NEPHEW PLCDIAGEO FINANCE B.V., a public private company with limited company liability (besloten vennootschap met beperkte aansprakelijkheid) incorporated under Dutch law and having its corporate seat in Amsterdam, the laws of England and Wales Netherlands (herein called the “"Issuer”", which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to _____________________ [If applicable – insert – as nominee for [insert name]], or registered assigns bearer upon presentation and surrender of this Security the principal sum of of______________________ on ________________________________________ [if the Security is to bear interest prior to Maturity, insert ---, and to pay interest thereon from _____________, 20___ or from the most recent Interest Payment Date to which interest has been paid or duly provided for, semiannually semi-annually in arrears on ____________ and _____________ in each year] [annually in arrears on __________________ in each year], commencing ______________, 20___, at the rate of ____% per annum, until the principal hereof is paid or made available for payment [if applicable, insert -; --, provided that any principal and premium, and any such instalment of interest, which is overdue shall bear interest at the rate of __% per annum (to the extent that the payment of such interest shall be legally enforceable), from the dates such amounts are due until they are paid or made available for payment, and such interest shall be payable on demand]. .] [If the Security is not to bear interest prior to Maturity, insert - -- The principal of this Security shall not bear interest except in the case of a default in payment of principal upon acceleration, upon redemption or at Stated Maturity, and in such case the overdue principal and any overdue premium shall bear interest at the rate of ____% per annum (to the extent that the payment of such interest shall be legally enforceable), from the date such amounts are due until they are paid or made available for payment. Interest on any overdue principal shall be payable on demand. Any such interest on any overdue principal or premium which is not so paid on demand shall bear interest at the rate of ____% per annum (to the extent that the payment of such interest on interest shall be legally enforceable), from the date of such demand until the amount so demanded is paid or made available for payment. Interest on overdue interest shall be payable on demand.] [The Trustee shall act as Paying Agent with respect to the Securities of this series.] [The Issuer, the Guarantor, the Trustee and any agent of the Issuer, the Guarantor or the Trustee may treat the bearer hereof as the owner of this Security for all purposes, whether or not this Security shall be overdue, and none of the Issuer, the Guarantor, the Trustee nor any such agent shall be affected by notice to the contrary.] [Title to this Security shall pass by delivery.] Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. [All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.] Unless the certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof, directly or through an Authenticating Agent, by manual or pdf or other electronically-imaged (including, without limitation, DocuSign or Adobe Sign) signature of an authorized signatory, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.