Common use of INVESTMENT PARTNERSHIP Clause in Contracts

INVESTMENT PARTNERSHIP. By: Pacific Rim Life Science No.1/2 Investment Partnership, its general partner By: /s/ Masahiro Michishita -------------------------------- Masahiro Michishita, M.D., Ph.D., Xxxxxxxg General Partner MONTAGU NEWHALL GLOBAL PARTNERS LP By: /s/ C. Ashton Newhall -------------------------------- Name: C. Ashton Newhall ------------------------------ Title: General Partner ----------------------------- FIRST AMENDMENT TO THE MYOGEN, INC. THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 5. HUNT VENTURES By: /s/ Chxxxxopher W. Kleinert -------------------------------- Name: Christopher W. Kleinert ------------------------------ Title: Managing Director ----------------------------- SILICON VALLEY BANCVENTURES By: Silicon Valley BancVentures, L.P. Its General Partner By: /s/ Aaron Gershenberg -------------------------------- Name: Aaron Gershenberg ------------------------------ Title: Managing Director ----------------------------- HFM CHARITABLE REMAINDER TRUST By: -------------------------------- Roy M. Jones, Authorized Agent ----------------------------------- DAVID N. LOW, JR. ----------------------------------- JIM F. ZANZE ----------------------------------- PHILIPPE MCAULIFFE ----------------------------------- MIKE GAITO PACIFIC RIM CAXXXXX, XXX By: -------------------------------- T. Chester Wang FIRST AMENDMENT TO THE MYOGEN, IXX. THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT

INVESTMENT PARTNERSHIP. By: Pacific Rim Life Science No.1/2 No. 1/2 Investment Partnership, its general partner By: /s/ Masahiro Michishita -------------------------------- ------------------------------ Masahiro Michishita, M.D., Ph.D.Xx.X., Xxxxxxxg Xxxxging General Partner MONTAGU CMEA LIFE SCIENCES FUND, L.P. By: /s/ Thomas R. Baruch ------------------------------ General Partner HFM CHARITABLE REMAINDER TRUST By: /s/ Roy M. Jones ------------------------------ Roy M. Jones, Authorized Agent XXNTAGU NEWHALL GLOBAL PARTNERS LP By: /s/ C. Ashton Newhall -------------------------------- ------------------------------ Name: C. Ashton Newhall ------------------------------ ---------------------------- Title: General Partner ----------------------------- FIRST AMENDMENT TO THE MYOGEN--------------------------- STOCK PURCHASE AGREEMENT /s/ David N. Low, Jr. ---------------------------------- David N. Low, Jr. /s/ Xxx X. Zanse ---------------------------------- Jim F. Zanze /s/ Philixxx XxXxxxxxe ---------------------------------- Philippe McAuliffe /s/ Xxxx Xxxxx ---------------------------------- Mike Gaito STOCK PURCHASE AGREEMENT CHINA DEVELOPMENT INDUSTRIAL BANK INC. THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 5. HUNT VENTURES By: /s/ Chxxxxopher W. Kleinert -------------------------------- Tai-ying Liu ------------------------------ Name: Christopher W. Kleinert Tai-ying Liu ---------------------------- Title: Chairman and CEO --------------------------- STOCK PURCHASE AGREEMENT PERSEUS-SOROS BIOPHARMACEUTICAL XXXX, LP By: Perseus-Soros Partners, LLC, Xxxeral Partner By: SFM Participation, LP, Member By: SFM AH, Inc., General Partner /s/ Richard D. Holahan, Jr. ------------------------------ By: Richard D. Holahan, Jr. Xxxxx: Xxxxxxxxx STOCK PURCHASE AGREEMENT HUNT VENTURES, L.P. Bx: /s/ Fulton Murray III ------------------------------ Name: J. Fulton Murray, III ---------------------------- Title: Managing Director ----------------------------- --------------------------- SILICON VALLEY BANCVENTURES BANCVENTURES, L.P. By: Silicon Valley BancVentures, L.P. Inc., Its General Partner By: /s/ Aaron Gershenberg -------------------------------- Greg Becker ------------------------------ Name: Aaron Gershenberg ------------------------------ Greg Becker ---------------------------- Title: Managing Director ----------------------------- HFM CHARITABLE REMAINDER TRUST By: -------------------------------- Roy M. JonesInvestment Manager --------------------------- STOCK PURCHASE AGREEMENT PACIFIC CAPITAL, Authorized Agent ----------------------------------- DAVID N. LOW, JR. ----------------------------------- JIM F. ZANZE ----------------------------------- PHILIPPE MCAULIFFE ----------------------------------- MIKE GAITO PACIFIC RIM CAXXXXX, XXX By: -------------------------------- LLC /s/ T. Chester Wang ------------------------------ T. Chester Wang /s/ Xxxxx Xxxxxxis ------------------------------ James Margolis, MD XXXXXX X. XXY & CONSTANCE X. TOY, JXXXXX /x/ Xhomas J. Toy ------------------------------ Thomas J. Toy /s/ Xxxxxxxxx K. Toy ------------------------------ Constance K. Toy /x/ Xxxxxx X. Narajowski ------------------------------ Walter M. Narajowski XXXXX-XXXXXX XXX ASSOCIATES, XX By: /s/ Ronald Dieck -------------------------- Ronald Dieck, General Partner /s/ Daniel Rubin ------------------------------ Daniel Ruben /s/ Xxxxx Xxxxxxer ------------------------------ David Pflueger /s/ Xxxxx Xxxxxxk ------------------------------ James Larrick STOCK PURCHASE AGREEMENT EXHIBIT A SCHEDULE OF PURCHASERS FIRST AMENDMENT TO THE MYOGENCLOSING NAME AND ADDRESS SHARES PRICE ---------------- ------ ----- J.P. Morgan Partners (SBIC), IXX. THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENTLLC 14,545,454 $00,099,999.25 50 California Street, Suite 2940 San Francisco, CA 94111 Attn: Rod Fxxxxxxx

INVESTMENT PARTNERSHIP. By: Pacific Rim Life Science No.1/2 No. 1/2 Investment Partnership, its general partner By: /s/ Masahiro Michishita -------------------------------- ------------------------------ Masahiro Michishita, M.D., Ph.D.Xx.X., Xxxxxxxg Xxxxging General Partner HFM CHARITABLE REMAINDER TRUST By: /s/ Roy M. Jones ------------------------------ Roy M. Jones, Authorized Agent STOCKHOXXXXX XXXXXXENT MONTAGU NEWHALL GLOBAL PARTNERS LP By: /s/ C. Ashton Newhall -------------------------------- ------------------------------ Name: C. Ashton Newhall ------------------------------ ---------------------------- Title: General Partner ----------------------------- FIRST AMENDMENT TO THE MYOGEN--------------------------- /s/ David N. Low, Jr. ---------------------------------- David N. Low, Jr. /s/ Xxx X. Zanze ---------------------------------- Jim F. Zanze /s/ Philixxx XxXxxxxxe ---------------------------------- Philippe McAuliffe /s/ Xxxx Xxxxx ---------------------------------- Mike Gaito STOCKHOLDERS AGREEMENT CHINA DEVELOPMENT INDUSTRIAL BANK INC. THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 5By: CHINA DEVELOPMENT INDUSTRIAL BANK INC. HUNT VENTURES By: /s/ Chxxxxopher W. Kleinert -------------------------------- Tai-ying Liu ------------------------------ Tai-ying Liu, Chairman & CEO STOCKHOLDERS XXXXXXXXT PERSEUS-SOROS BIOPHARMACEUTICAL XXXX, LP By: Perseus-Soros Partners, LLC, Xxxeral Partner By: SFM Participation, LP, Member By: SFM AH, Inc., General Partner /s/ Richard D. Holahan, Jr. ------------------------------ By: Richard D. Holahan, Jr. Xxxxx: Xxxxxxxxx HUNT VENTURES, L.P. Bx: /s/ J. Fulton Murray III ------------------------------ Name: Christopher W. Kleinert ------------------------------ J. Fulton Murray, III ---------------------------- Title: Managing Director ----------------------------- SILICON VALLEY BANCVENTURES BANCVENTURES, L.P. By: Silicon Valley BancVentures, L.P. Inc., Its General Partner By: /s/ Aaron Gershenberg -------------------------------- Greg Becker ------------------------------ Name: Aaron Gershenberg ------------------------------ Greg Becker ---------------------------- Title: Managing Director ----------------------------- HFM CHARITABLE REMAINDER TRUST By: -------------------------------- Roy M. Jones, Authorized Agent ----------------------------------- DAVID N. LOW, JR. ----------------------------------- JIM F. ZANZE ----------------------------------- PHILIPPE MCAULIFFE ----------------------------------- MIKE GAITO PACIFIC RIM CAXXXXX, XXX By: -------------------------------- Investment Manager --------------------------- STOCKHOLDERS AGREEMENT Pacific Rim Capital LLC /s/ T. Chester Wang FIRST AMENDMENT TO THE MYOGEN---------------------------------- T. Chester Wang, IXXManager /x/ Xxxxx Xargolis, MD ---------------------------------- James Margolis, MD THXXXX X. XXX & CONSTANCE K. TOY, JTWROX /s/ Thomas J. Toy ---------------------------------- Thomas J. Toy /s/ Consxxxxx X. Toy ---------------------------------- Constance K. Toy /s/ Xxxxxx X. Xxrajowski ---------------------------------- Walter M. Narajowski DXXXX-XXXXXX XXX XXXXCIATES, LP Xy: /s/ Ronald Dieck ---------------------------------- Ronald Dieck, General Partner /x/ Daniel Ruben ---------------------------------- Daniel Ruben /s/ Davix Xxxxxxxx ---------------------------------- David Pflueger /s/ Jaxxx Xxxxxxx ---------------------------------- James Larrick EXHIBIT A LIST OF KEY STOCKHOLDERS Michael R. Bristow Savacor Trust InvestoCor Trust Michael Juliano Xxxxxx Xxxxx Xxxlie A. Leinward M. Benjamin Perrymxx Xxxxx Xxxxxrt X. Xxxxxxx Fxxxxxx Xxxxxx X. Turnex Xxxx X. Xxxxxx Xxxxx Xxxxx Xurtin Xxxxxxx X. Xxrcxxxxxx Xxxxxx Xan Xxxxx Xxxx X. Xxxxx XXXXXXX X LIST OF INVESTORS Sequel Limited Partnership 4430 Arapahoe Avenue, Suite 220 Boulder, CO 80303 Sequel Euro Limitex Xxxxxxxxxxx 0000 Xxxxxxxx Xxxxxx, Xxxxx 000 Xxxlder, CO 80303 Crosspoint Venture Xxxxxxxx 0000 00000 XxxXxxxxx Xxxx., Xxxxx 000 Xrvine, CA 92612 InterWest Partners XX, X.X. 0000 Xxxx Xxxx Xxxx Xxxxxxxx 0, Xxxxx 055 Menlo Park, CA 94025 InterXxxx Xxxxxxxxx XX, X.X. 0000 Xxxx Xxxx Xxxx Xxxxxxxx 0, Xxxxx 255 Menlo Park, CA 94025 New Exxxxxxxxx Xxxxxxxxxx 0, Xxxxxxx Xxxxxxxxxxx 0000 Xx. THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENTXxxx Xxxxet Baltimore, MD 21202 Attn: Gene Trainor NEA Presxxxxxx Xxxx, X.P. 1119 St. Paul Street Baltimorx, XX 00000 Attn: Gene Trainor NEA Ventxxxx 0000, Xxxxxxx Xxxxxxxxxxx 1119 St. Paul Stxxxx Xxxxxxxre, MD 21202 Attn: Gene Trainor New Ventxxx Xxxxxxxx XX L.P. 1119 St. Paul Street Baltixxxx, XX 00002 CMEA Life Sciences Fund, L.X. Xxx Xxxxxxxxxxx Xxxxxx, Suite 3250 San Francisco, CA 94111 Attn: Merxx X. Xxxxxxxxxxxx

INVESTMENT PARTNERSHIP. By: Pacific Rim Life Science No.1/2 Investment Partnership, its general partner By: /s/ Masahiro Michishita -------------------------------- ------------------------------ Masahiro Michishita, M.D., Ph.D.Xx.X., Xxxxxxxg Xxxxging General Partner MONTAGU HFM CHARITABLE REMAINDER TRUST By: /s/ Roy M. Jones ------------------------------ Roy M. Jones, Authorized Agent XXNTAGU NEWHALL GLOBAL PARTNERS LP By: /s/ C. Ashton Newhall -------------------------------- ------------------------------ Name: C. Ashton Newhall ------------------------------ ---------------------------- Title: General Partner ----------------------------- FIRST AMENDMENT TO THE MYOGEN, INC. --------------------------- THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 5/s/ David N. Low, Jr. ------------------------------ David N. Low, Jr. /x/ Xxx F. Zanze ------------------------------ Jim F. Zanze /s/ Pxxxxxxx XxXxliffe ----------------------------- Philippe McAuliffe /x/ Xxxx Xxxxx ------------------------------ Mike Gaito THIRD AMENDED AND RESTATED INVESTOR RIGHTS XXXXXXXXX CHINA DEVELOPMENT INDUSTRIAL BANK INC. HUNT VENTURES By: CHINA DEVELOPMENT INDUSTRIAL BANK INC. By: /s/ Chxxxxopher W. Kleinert -------------------------------- Tai-ying Liu ------------------------------ Tai-ying Liu, Chairman & CEO THIRD AMENDED AND RESTATED IXXXXXXX RIGHTS AGREEMENT PERSEUS-SOROS BIOPHARMACEUTICAL FUND, XX By: Perseus-Soros Partners, LLC, Genxxxx Partner By: SFM Participation, LP, Member By: SFM AH, Inc., General Partner /s/ Richard D. Holahan, Jr. ------------------------------ By: Richard D. Holahan, Jr. Xxxxx: Xxxxxxxxx THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT HUNT VENTURES, L.P. Bx: /s/ J. Fulton Murray, III ------------------------------ Name: Christopher W. Kleinert ------------------------------ J. Fulton Murray, III ---------------------------- Title: Managing Director ----------------------------- SILICON VALLEY BANCVENTURES BANCVENTURES, L.P. By: Silicon Valley BancVentures, L.P. Inc., Its General Partner By: /s/ Aaron Gershenberg -------------------------------- Greg Becker ------------------------------ Name: Aaron Gershenberg ------------------------------ Greg Becker ---------------------------- Title: Managing Director ----------------------------- HFM CHARITABLE REMAINDER TRUST By: -------------------------------- Roy M. Jones, Authorized Agent ----------------------------------- DAVID N. LOW, JR. ----------------------------------- JIM F. ZANZE ----------------------------------- PHILIPPE MCAULIFFE ----------------------------------- MIKE GAITO PACIFIC RIM CAXXXXX, XXX By: -------------------------------- T. Chester Wang FIRST AMENDMENT TO THE MYOGEN, IXX. Investment Manager --------------------------- THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENTAGREEMENT PACIFIC RIM CAPITAL, LLC /s/ T. Chester Wang ---------------------------------- T. Chester Wang /s/ Jamex Xxxxxxxx ---------------------------------- James Margolis, MD THXXXX X. XXX & CONSTANCE K. TOY, JTWROX /s/ Thomas J. Toy ---------------------------------- Thomas J. Toy /s/ Consxxxxx X. Toy ---------------------------------- Constance K. Toy /s/ Xxxxxx X. Xxrajowski ---------------------------------- Walter M. Narajowski DXXXX-XXXXXX XXX XXXXCIATES, LP Xy: /s/ Ronald Dieck ------------------------------ Ronald Dieck, General Partner /x/ Daniel Ruben ---------------------------------- Daniel Ruben /s/ Davix Xxxxxxxx ---------------------------------- David Pflueger /s/ Jaxxx Xxxxxxx ---------------------------------- James Larrick THIRD AMENDED AND RESTATED INVESTOR RIGXXX XXXXXXXXX EXHIBIT A SCHEDULE OF COMMON STOCKHOLDERS Michael R. Bristow 654,000 Savacor Trust 136,000 InvestoCor Trust 453,333 Michael Juliano 544,000 Leslie A. Leinwand 204,000 Milton Levin 544,000 M. Benjamin Perryman 204,000 Frank Stewart 01,000 J. William Freytag 629,535 Joseph Turner 15,000 John R. Julian 0 Ellen Leigh Curtin 0 Richard J. Gorzynski 52,708 Gordon Van Dusen 01,770 Eric N. Olson 141,667 EXHIBIT B SCHEDULE OF INVESTORS INVESTOR: CLASS OF SHARES PURCHASED: --------- -------------------------- Sequel Limited Partnership Series A, Series C and Series D 4430 Arapahoe Avenue, Suite 220 Boulder, CO 80303

INVESTMENT PARTNERSHIP. By: Pacific Rim Life Science No.1/2 Investment Partnership, its general partner By: /s/ Masahiro Michishita -------------------------------- --------------------------------- Masahiro Michishita, M.D., Ph.D., Xxxxxxxg General Partner STOCK PURCHASE AGREEMENT CMEA LIFE SCIENCES FUND, L.P. By: Thomas R. Baruch -------------------------------- General Partner HUNT VENTURES, L.P. Bx: /s/ Christopher W. Kleinert -------------------------------- Name: Christopher W. Kleinert ------------------------------ Title: Managing Director ----------------------------- BVCF IV, L.P. By: J.W. Puth Associates, LLC, its General Partner By: Brinson Venture Management, LLC, it's Attorney-in-fact By: Adams Street Partners, LLC, as its Administrative Member By: /s/ Craig S. Taylor -------------------------------- Craig S. Taylor Partnxx SILICON VALLEY BANCVENTURES L.P. By: /s/ Aaron Gershenberg -------------------------------- Name: Aaron Gershenberg ------------------------------ Title: Managing Director ----------------------------- MONTAGU NEWHALL GLOBAL PARTNERS LP By: /s/ C. Ashton Newhall -------------------------------- Name: C. Ashton Newhall ------------------------------ Title: General Partner ----------------------------- FIRST AMENDMENT TO THE MYOGEN, INC. THIRD AMENDED STOCK PURCHASE AGREEMENT EXHIBIT A SCHEDULE OF PURCHASERS NAME AND RESTATED INVESTOR RIGHTS AGREEMENT 5. HUNT VENTURES By: /s/ Chxxxxopher W. Kleinert -------------------------------- Name: Christopher W. Kleinert ------------------------------ Title: Managing Director ----------------------------- SILICON VALLEY BANCVENTURES By: Silicon Valley BancVentures, L.P. Its General Partner By: /s/ Aaron Gershenberg -------------------------------- Name: Aaron Gershenberg ------------------------------ Title: Managing Director ----------------------------- HFM CHARITABLE REMAINDER TRUST By: -------------------------------- Roy M. Jones, Authorized Agent ----------------------------------- DAVID N. LOW, JR. ----------------------------------- JIM F. ZANZE ----------------------------------- PHILIPPE MCAULIFFE ----------------------------------- MIKE GAITO PACIFIC RIM CAXXXXX, XXX By: -------------------------------- T. Chester Wang FIRST AMENDMENT TO THE MYOGEN, IXX. THIRD AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENTADDRESS SHARES PRICE ---------------- -------------- --------------