Common use of NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS Clause in Contracts

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS. This notification provides certain information about asbestos within or about the Premises at 000 Xxxxxxx Xxxx, Burlingame, CA (“Building”) in accordance with California Code of Regulations, title 8, section 1529 and Section 25915 et. seq. of the California Health and Safety Code. Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building product were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. An asbestos survey of the Building identified several ACMs in the interior of the building that were abated in August and September 2004. The remaining ACMs consist of duct tape/mastic on ventilation ducts located on the west end of the roof. Because ACMs are present and may continue to be present within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly administer the O&M Program. The O&M Program describes the risks associated with asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. The O&M Program is available for review during regular business hours at the Landlord’s office located at 0000 Xxxxx Xxxxxx, Suite 590, San Francisco, CA 94158. EXHIBIT C THIRD AMENDMENT

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS. This notification provides certain information about asbestos within or about the Premises at 000 900 Xxxxxxx Xxxx, BurlingameGaithersburg, CA Maryland (“Building”) in accordance with California Code of Regulations, title 8, section 1529 and Section 25915 et. seq. of the California Health and Safety Code). Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building product products were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. An asbestos survey Asbestos surveys of the Building identified several have determined that ACMs and/or materials that might contain asbestos, referred to as presumed asbestos-containing materials or PACMs, are present within or about the Premises. The surveys found ACMs and/or PACMs of the types, in the interior of amounts and at the following location(s) in or about the Premises: Material Description Material Location 12’ beige floor tile and mastic Janitor’s closets and stairwells Tan duct seam sealant Above ceiling, on main trunk duct Grey textured paint Roof, on air handler baffle wall Black duct seam sealant Roof, on ducts Mastic beneath 12” white with multi-colored mottle floor tile Janitor’s closet by 2nd floor former Intronn Suite Bxxxx expansion joint caulk Throughout building that were abated in August and September 2004. The remaining ACMs consist of duct tape/mastic on ventilation ducts located on the west end of the roof. Because ACMs and PACMs are present and may continue to be present within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly administer the O&M Program. , The O&M Program describes the risks associated with asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. The O&M Program is available for review during regular business hours at the Landlord’s office located at 0000 Xxxxx Xxxxxx900 Xxxxxxx Xxxx, Suite 590Gaithersburg, San Francisco, CA 94158. EXHIBIT C THIRD AMENDMENTMaryland 20878.

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS. This notification provides certain information about asbestos within or about the Premises at 000 00 Xxxxxxx XxxxXxx, BurlingameCambridge, CA MA (“Building”) in accordance with California Code of Regulations, title 8, section 1529 and Section 25915 et. seq. of the California Health and Safety Code). Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building product products were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. An asbestos survey of the Building identified several has determined that ACMs in and/or materials that might contain asbestos, referred to as presumed asbestos-containing materials or PACMs, are present within or about the interior of the building that were abated in August and September 2004Premises. The remaining surveys found ACMs consist of duct tape/mastic on ventilation ducts located on and/or PACMs at the west end of following location(s) in or about the roofPremises: The ACMs and PACMs listed above were in good condition and may be managed in place. Because ACMs are and PACMs may be present and may continue to be present within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly administer the O&M Program. The O&M Program describes the risks associated with asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. The O&M Program is available for review during regular business hours at the LandlordLicensor’s office located at 0000 Xxxxx 000 Xxxxxxxxxx Xxxxxx, Suite 590Xxxxx 000, San FranciscoXxxxxxxxx, CA 94158. EXHIBIT C THIRD AMENDMENTXX 00000.

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS. This notification provides certain information about asbestos within or about the Premises at 000 Xxxxxxx XxxxArsenal on the Cxxxxxx, BurlingameWatertown, CA Massachusetts (“Building”) in accordance with California Code of Regulations, title 8, section 1529 and Section 25915 et. seq. of the California Health and Safety Code). Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building product products were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. An The Buildings at the site were constructed prior to 1981 and an asbestos survey of the Building identified several ACMs buildings conducted in 2019 confirmed the interior presence of the building that were abated in August and September 2004Asbestos Containing Materials (ACMs). The remaining asbestos survey has determined that ACMs consist of duct tape/mastic on ventilation ducts located on and/or materials that might contain ACMs, referred to as presumed asbestos-containing materials or PACMs, are present within or about the west end of the roof. Premises as follows: Bxxxxxxx 00 Xxxxxxxx 00 Xxxxxxxx 000 Xxxxxxxx 118 Building 311 Building 312 Building 313 Because ACMs are present and PACMs may continue to be present within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly administer the O&M Program. The O&M Program describes the risks associated with asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. The O&M Program is available for review during regular business hours at the Landlord’s office located at 0000 Xxxxx 400 Xxxxxxxxxx Xxxxxx, Suite 590Xxxxx 000, San FranciscoXxxxxxxxx, CA 94158. EXHIBIT C THIRD AMENDMENTXX 00000.

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS. This notification provides certain information about asbestos within or about the Premises at 000 Xxxxxxx 0000 Xxxxxx Xxxxxx Xxxx., Xxxxxxxx Xxxx, Burlingame, CA XX (“Building”) in accordance with California Code of Regulations, title 8, section 1529 and Section 25915 et. seq. of the California Health and Safety Code. Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building product products were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. An According to a historical environmental site assessment report, an asbestos survey of the 1280 Building conducted in 2006 identified several ACMs in the interior approximately 400-square feet of the building that were abated in August xxxx and September 2004. The remaining ACMs consist of duct tape/black patching mastic on ventilation ducts located the roof was identified as ACM. Based on the west end available information and the date of construction for the roofBuilding, as well as the absence of an asbestos abatement report, it is likely that ACMs are present in some building materials at the site. Because ACMs are present and may continue to be present within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly administer the O&M Program. The O&M Program describes the risks associated with asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. The O&M Program is available for review during regular business hours at the Landlord’s office located at 0000 00 Xxxxx Xxxxxx Xxxxxx, Suite 590Xxxxxxxx, San Francisco, CA 94158XX 00000. 739800997.11739800997.11 EXHIBIT C THIRD AMENDMENTH TO LEASE

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS. This notification provides certain information about asbestos within or about the Premises at 000 Xxxxxxx XxxxXxxxx Xxxxxx, BurlingameXxxxxxxxx, CA XX (“Building”) in accordance with California Code of Regulations, title 8, section 1529 and Section 25915 et. seq. of the California Health and Safety Code). Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building product products were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. An No ACMs were identified in an asbestos survey of the Building identified building conducted in 2007. However, to avoid damage, several ACMs materials were not sampled and are presumed asbestos-containing materials or PACMs as listed in the interior of the building that following table: Material Description Material Location Ceramic tile adhesive and grout Throughout restrooms; ground floor hallways; first floor lobby and hallways Built-up roofing beneath rubber Throughout roof Flashing cement Roof Flex connectors on HVAC units Roof The PACMs described above were abated observed to be in August good condition and September 2004. The remaining ACMs consist of duct tape/mastic on ventilation ducts located on the west end of the roofmay be managed in place. Because ACMs are present and may continue to be present within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly administer the O&M Program. The O&M Program describes the risks associated with asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. The O&M Program is available for review during regular business hours at the Landlord’s office located at 0000 Xxxxx 000 Xxxxxxxxxx Xxxxxx, Suite 590Xxxxx 000, San FranciscoXxxxxxxxx, CA 94158XX 00000. EXHIBIT C THIRD AMENDMENTK TO LEASE FURNITURE Open office area:

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS. This notification provides certain information about asbestos within or about the Premises at 000 0000 Xxxxxxx XxxxXxxxxxx Xxxxx, BurlingameXxx Xxxxx, CA Xxxxxxxxxx (“Building”) in accordance with California Code of Regulations, title 8, section 1529 and Section 25915 et. seq. of the California Health and Safety Code. Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building product products were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. An ACMs were not identified in the materials sampled as part of an asbestos survey of the Building identified several ACMs in the interior of the building that Building. However, roofing materials were abated in August not sampled and September 2004are considered presumed asbestos-containing materials or PACMs. The remaining ACMs consist of duct tape/mastic on ventilation ducts located on the west end of the roofroofing materials were observed in good condition and may be managed in place. Because ACMs and/or PACMs are present and may continue to be present within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly administer the O&M Program. The O&M Program describes the risks associated with asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. The O&M Program is available for review during regular business hours at the Landlord’s our office located at 0000 Xx Xxxxx XxxxxxXxxxxxx Xxxxx, Suite 590Xxxxx 000, San FranciscoXxx Xxxxx, CA 94158. EXHIBIT C THIRD AMENDMENTXX 00000.

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS. This notification provides certain information about asbestos within or about the Premises at 000 Xxxxxxx XxxxXxxxx Xxxxxx, BurlingameXxxxxxxxx, CA XX (“Building”) in accordance with California Code of Regulations, title 8, section 1529 and Section 25915 et. seq. of the California Health and Safety Code). Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building product products were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. An No ACMs were identified in an asbestos survey of the Building identified building conducted in 2007. However, to avoid damage, several ACMs materials were not sampled and are presumed asbestos-containing materials or PACMs as listed in the interior of the building that following table: Material Description Material Location Ceramic tile adhesive and grout Throughout restrooms; ground floor hallways; first floor lobby and hallways Built-up roofing beneath rubber Throughout roof Flashing cement Roof Flex connectors on HVAC units Roof The PACMs described above were abated observed to be in August good condition and September 2004. The remaining ACMs consist of duct tape/mastic on ventilation ducts located on the west end of the roofmay be managed in place. Because ACMs are present and may continue to be present within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly administer the O&M Program. The O&M Program describes the risks associated with asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. The O&M Program is available for review during regular business hours at the Landlord’s office located at 0000 Xxxxx 000 Xxxxxxxxxx Xxxxxx, Suite 590Xxxxx 000, San FranciscoXxxxxxxxx, CA 94158XX 00000. EXHIBIT C THIRD AMENDMENTK TO LEASE SPACE PLAN FIRST AMENDMENT TO LEASE THIS FIRST AMENDMENT TO LEASE (this “First Amendment”) is made as of October 26, 2012, by and between ARE-MA REGION NO. 38, LLC, a Delaware limited liability company (“Landlord”), and SAGE THERAPEUTICS, INC., a Delaware corporation (“Tenant”).

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS. This notification provides certain information about asbestos within or about the Premises at 000 Building 000/000 Xxx Xxxxxxx XxxxXxxxxx, BurlingameBoston, CA Massachusetts (“Building”) in accordance with California Code of Regulations, title 8, section 1529 and Section 25915 et. seq. of the California Health and Safety Code). Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building product products were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. An asbestos survey of the Building identified several ACMs building conducted in 2017 confirmed the presence of asbestos on the floor tile mastic in a janitor’s closet, duct sealant in the interior of the building that 1st floor vacant space, and residual black mastic below carpet/floor in Suite 7-102. However, roofing materials and fire rated doors were abated in August not sampled to avoid damage and September 2004. The remaining ACMs consist of duct tape/mastic on ventilation ducts located on the west end of the roofare considered presumed asbestos-containing materials or PACMS. Because ACMs are present and PACMs may continue to be present within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly administer the O&M Program. The O&M Program describes the risks associated with asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. The O&M Program is available for review during regular business hours at the Landlord’s office located at 0000 Xxxxx 000 Xxxxxxxxxx Xxxxxx, Suite 590Xxxxx 000, San FranciscoXxxxxxxxx, CA 94158XX 00000. EXHIBIT C THIRD AMENDMENTFIRST AMENDMENT TO LEASE THIS FIRST AMENDMENT TO LEASE (this “First Amendment”) is made as of March 2, 2021 (the “Amendment Date”), by and between ARE-MA REGION NO. 59, LLC, a Delaware limited liability company (“Landlord”), and KORRO BIO, INC., a Delaware corporation (“Tenant”).

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS. This notification provides certain information about asbestos within or about the Premises at 000 Xxxxxxx XxxxXxxxx Xxxxxx, BurlingameXxxxxxxxx, CA XX (“Building”) in accordance with California Code of Regulations, title 8, section 1529 and Section 25915 et. seq. of the California Health and Safety Code). Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building product products were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. An No ACMs were identified in an asbestos survey of the Building identified building conducted in 2007. However, to avoid damage, several ACMs materials were not sampled and are presumed asbestos-containing materials or PACMs as listed in the interior of the building that following table: Material Description Material Location Ceramic tile adhesive and grout Throughout restrooms; ground floor hallways; first floor lobby and hallways Built-up roofing beneath rubber Throughout roof Flashing cement Roof Flex connectors on HVAC units Roof The PACMs described above were abated observed to be in August good condition and September 2004. The remaining ACMs consist of duct tape/mastic on ventilation ducts located on the west end of the roofmay be managed in place. Because ACMs are present and may continue to be present within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly administer the O&M Program. The O&M Program describes the risks associated with asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. The O&M Program is available for review during regular business hours at the Landlord’s office located at 0000 Xxxxx 000 Xxxxxxxxxx Xxxxxx, Suite 590Xxxxx 000, San FranciscoXxxxxxxxx, CA 94158XX 00000. EXHIBIT C THIRD AMENDMENTK TO LEASE AVAILABLE SPACE EXHIBIT L 000 Xxxxx Xxxxxx 2011 Estimated Oper. & Tax Exp. Based on 366,719 SF Real Estate Taxes - $ 4.21 PSF Building Operating Payroll $ 493,500 Insurance $ 44,627 Utilities $ 884,000 Contract Service $ 567,500 Repairs $ 279,500 Admin Exp & MGR Fee $ 30,000 Subtotal $ 2,299,127 Building Operating Expense - $ 6.27 PSF Science Area Operating Expenses Rentable Square feet 85,069 Added HVAC Equipment Service $ 84,000 Utilities (Natural Gas for Science Area) $ 182,000 Pure Water $ 16,250 Generator Contract $ 2,750 Janitorial $ 10,000 Misc. Contract $ 42,000 Subtotal $ 337,000 Subtotal Science Area 3.96 PSF Total Tax and Operating Expense $ 14.44 PSF FIRST AMENDMENT TO LEASE THIS FIRST AMENDMENT TO LEASE (this “First Amendment”) is made as of September 6, 2011, by and between ARE-MA REGION NO. 38, LLC, a Delaware limited liability company (“Landlord”), and BLUEPRINT MEDICINES CORPORATION, a Delaware corporation (“Tenant”).