Reconstituted HDL(rHDL Sample Clauses

Reconstituted HDL(rHDL infusion In a small study of healthy subjects, these intravenous infusions promoted reverse cho- lesterol transport168. Based on that a randomized placebo-controlled trial was conducted, ERASE101, which showed that short-term infusions of reconstituted HDL (CSL 111) in patients with recent onset acute coronary syndromes showed no significant reduction in coronary atheroma volume, nonetheless, it induced a possibly favorable change in the quality of coro- nary atheroma. There was a high incidence of liver function test abnormalities with the high doses of HDL infusions, these were however self-limiting without any clinical consequence or intervention. Recently published results from a first-in-man randomized controlled study evaluating the safety and feasibility of autologous delipidated HDL plasma infusions (Plasma selective delipidation converts αHDL to preβ-like HDL, the most effective form of HDL for lipid removal from arterial plaques) in patients with ACS showed promising results regarding regression in the atheroma volume. Two ongoing phase I/II trials are testing the safety and efficacy of single intravenous infusions of rHDL in healthy volunteers169, 170.
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Related to Reconstituted HDL(rHDL

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  • Dissolution and Liquidation (Check One)

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