Common use of Settlement Upon Conversion Clause in Contracts

Settlement Upon Conversion. 40 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 Section 5.05. Adjustments to the Conversion Rate. 42 Section 5.06. Voluntary Adjustments. 52 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 Section 5.08. Exchange in Lieu of Conversion. 54 Section 5.09. Effect of Common Stock Change Event. 54 Article 6. Successors 56 Section 6.01. When the Company May Merge, Etc. 56 Section 6.02. Successor Corporation Substituted. 57 Article 7. Defaults and Remedies 57 Section 7.01. Events of Default. 57 Section 7.02. Acceleration. 59 Section 7.03. Sole Remedy for a Failure to Report. 59 Section 7.04. Other Remedies. 60 Section 7.05. Waiver of Past Defaults. 61 Section 7.06. Control by Majority. 61 Section 7.07. Limitation on Suits. 61 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 Section 7.09. Collection Suit by Trustee. 62 Section 7.10. Trustee May File Proofs of Claim. 62 Section 7.11. Priorities. 63 Section 7.12. Undertaking for Costs. 63 Article 8. Amendments, Supplements and Waivers 64 Section 8.01. Without the Consent of Holders. 64 Section 8.02. With the Consent of Holders. 64 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 Section 8.05. Notations and Exchanges. 66 Section 8.06. Trustee to Execute Supplemental Indentures. 67 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Section 9.01. Termination of Company’s Obligations. 67 Section 9.02. Repayment to Company. 68 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 Article 10. Trustee 69 Section 10.01. Duties of the Trustee. 69 Section 10.02. Rights of the Trustee. 70 Section 10.03. Individual Rights of the Trustee. 71 Section 10.04. Trustee’s Disclaimer. 72 Section 10.05. Notice of Defaults. 72 Section 10.06. Compensation and Indemnity. 72 Section 10.07. Replacement of the Trustee. 73 Section 10.08. Successor Trustee by Merger, Etc. 74 Section 10.09. Eligibility; Disqualification. 74 Article 11. Miscellaneous 74 Section 11.01. Notices. 74 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).

Settlement Upon Conversion. 40 45 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 49 Section 5.05. Adjustments to the Conversion Rate. 42 50 Section 5.06. Voluntary Adjustments. 52 60 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 61 Section 5.08. Exchange in Lieu of Conversion. 54 62 Section 5.09. Effect of Common Stock Change Event. 54 63 Section 5.10. Responsibility of Trustee. 65 Article 6. Successors 56 65 Section 6.01. When the Company May Merge, Etc. 56 65 Section 6.02. Successor Corporation Entity Substituted. 57 66 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 66 Article 7. Defaults and Remedies 57 66 Section 7.01. Events of Default. 57 66 Section 7.02. Acceleration. 59 68 Section 7.03. Sole Remedy for a Failure to Report. 59 69 Section 7.04. Other Remedies. 60 70 Section 7.05. Waiver of Past Defaults. 61 70 Section 7.06. Control by Majority. 61 70 Section 7.07. Limitation on Suits. 61 71 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 71 Section 7.09. Collection Suit by Trustee. 62 71 Section 7.10. Trustee May File Proofs of Claim. 62 72 Section 7.11. Priorities. 63 72 Section 7.12. Undertaking for Costs. 63 73 Article 8. Amendments, Supplements and Waivers 64 73 Section 8.01. Without the Consent of Holders. 64 73 Section 8.02. With the Consent of Holders. 64 74 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 75 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 75 Section 8.05. Notations and Exchanges. 66 76 Section 8.06. Trustee to Execute Supplemental Indentures. 67 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Section 9.01. Termination of Company’s Obligations. 67 Section 9.02. Repayment to Company. 68 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 Article 10. Trustee 69 Section 10.01. Duties of the Trustee. 69 Section 10.02. Rights of the Trustee. 70 Section 10.03. Individual Rights of the Trustee. 71 Section 10.04. Trustee’s Disclaimer. 72 Section 10.05. Notice of Defaults. 72 Section 10.06. Compensation and Indemnity. 72 Section 10.07. Replacement of the Trustee. 73 Section 10.08. Successor Trustee by Merger, Etc. 74 Section 10.09. Eligibility; Disqualification. 74 Article 11. Miscellaneous 74 Section 11.01. Notices. 74 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).76

Settlement Upon Conversion. 40 48 Section 5.04. Reserve and Status of Common Stock Ordinary Shares Issued Upon upon Conversion. 41 50 Section 5.05. Adjustments to the Conversion Rate. 42 51 Section 5.06. Voluntary Adjustments. 52 61 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 61 Section 5.08. Exchange in Lieu of ConversionRestriction on Conversions. 54 63 Section 5.09. Effect of Common Stock Ordinary Share Change Event. 54 63 Article 6. Successors 56 65 Section 6.01. When the Company May Merge, Etc. 56 65 Section 6.02. Successor Corporation Substituted. 57 66 Article 7. Defaults and Remedies 57 66 Section 7.01. Events of Default. 57 66 Section 7.02. Acceleration. 59 68 Section 7.03. Sole Remedy for a Failure to Report. 59 69 Section 7.04. Other Remedies. 60 70 Section 7.05. Waiver of Past Defaults. 61 70 Section 7.06. Control by Majority. 61 70 Section 7.07. Limitation on Suits. 61 71 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 71 Section 7.09. Collection Suit by Trustee. 62 71 Section 7.10. Trustee May File Proofs of Claim. 62 72 Section 7.11. Priorities. 63 72 Section 7.12. Undertaking for Costs. 63 73 Article 8. Amendments, Supplements and Waivers 64 73 Section 8.01. Without the Consent of Holders. 64 73 Section 8.02. With the Consent of Holders. 64 74 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 75 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 75 Section 8.05. Notations and Exchanges. 66 76 Section 8.06. Trustee to Execute Supplemental Indentures. 67 76 Article 9. Guarantees 76 Section 9.01. Guarantees. 76 Section 9.02. Limitation on Guarantor Liability. 78 Section 9.03. Execution and Delivery of Guarantee. 78 Section 9.04. When Guarantors May Merge, Etc. 78 Section 9.05. Future Guarantors. 79 Section 9.06. Application of Certain Provisions to the Guarantors. 79 Article 10. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 80 Section 9.0110.01. Termination of Company’s Obligations. 67 80 Section 9.0210.02. Repayment to Company. 68 80 Section 9.0310.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 80 Article 1011. Trustee 69 81 Section 10.0111.01. Duties of the Trustee. 69 81 Section 10.0211.02. Rights of the Trustee. 70 82 Section 10.0311.03. Individual Rights of the Trustee. 71 83 Section 10.0411.04. Trustee’s Disclaimer. 72 83 Section 10.0511.05. Notice of Defaults. 72 83 Section 10.0611.06. Compensation and Indemnity. 72 83 Section 10.0711.07. Replacement of the Trustee. 73 84 Section 10.0811.08. Successor Trustee by Merger, Etc. 74 85 Section 10.0911.09. Eligibility; Disqualification. 74 85 Article 1112. Miscellaneous 74 85 Section 11.0112.01. Notices. 74 85 Section 11.0212.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 87 Section 11.0312.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 87 Section 11.0412.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 87 Section 11.0512.05. No Personal Liability of Directors, Officers, Employees and StockholdersShareholders. 77 88 Section 11.0612.06. Governing Law; Waiver of Jury Trial. 77 88 Section 11.0712.07. Submission to Jurisdiction. 77 88 Section 11.0812.08. No Adverse Interpretation of Other Agreements. 77 88 Section 11.0912.09. Successors. 77 89 Section 11.1012.10. Force Majeure. 78 89 Section 11.1112.11. U.S.A. PATRIOT Act. 78 89 Section 11.1212.12. Calculations. 78 89 Section 11.1312.13. Severability. 78 89 Section 11.1412.14. Counterparts. 78 89 Section 11.1512.15. Table of Contents, Headings, Etc. 78 90 Section 11.1612.16. Withholding Taxes. 79 90 Section 12.17. Trust Indenture Act Controls. 90 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2B: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents B-1 INDENTURE, dated as of December 7[closing date], 2020, between Progenityamong Aegerion Pharmaceuticals, Inc., a Delaware corporation, as issuer (the “Company”), [New Parent], a company incorporated in England and The Bank of New York Mellon Trust CompanyWales (the “Parent”), N.A.Amryt Pharma plc, a company incorporated in England and Wales (“Old Parent”), the additional guarantors listed on the signature pages hereto, as guarantors (together with the Parent and Old Parent, the “Guarantors”), and [trustee’s legal name], as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.255.00% Convertible Senior Notes due 2025 [maturity year] (the “Notes”).

Settlement Upon Conversion. 40 49 Section 5.04. Reserve and Status of Common Stock Ordinary Shares Issued Upon upon Conversion. 41 52 Section 5.05. Adjustments to the Conversion Rate. 42 52 Section 5.06. Voluntary Adjustments. 52 63 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Make- Whole Fundamental Change. 53 63 Section 5.08. Exchange in Lieu of Conversion. 54 65 Section 5.09. Effect of Common Stock Ordinary Share Change Event. 54 65 Article 6. Successors 56 67 Section 6.01. When the Company May Merge, Etc. 56 67 Section 6.02. Successor Corporation Entity Substituted. 57 68 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 68 Article 7. Defaults and Remedies 57 68 Section 7.01. Events of Default. 57 68 Section 7.02. Acceleration. 59 70 Section 7.03. Sole Remedy for a Failure to Report. 59 71 Section 7.04. Other Remedies. 60 72 Section 7.05. Waiver of Past Defaults. 61 72 Section 7.06. Control by Majority. 61 72 Section 7.07. Limitation on Suits. 61 73 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 73 Section 7.09. Collection Suit by Trustee. 62 73 Section 7.10. Trustee May File Proofs of Claim. 62 74 Section 7.11. Priorities. 63 74 Section 7.12. Undertaking for Costs. 63 75 Article 8. Amendments, Supplements and Waivers 64 75 Section 8.01. Without the Consent of Holders. 64 75 Section 8.02. With the Consent of Holders. 64 76 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 77 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 77 Section 8.05. Notations and Exchanges. 66 78 Section 8.06. Trustee to Execute Supplemental Indentures. 67 78 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 78 Section 9.01. Termination of Company’s Obligations. 67 78 Section 9.02. Repayment to Company. 68 79 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 79 Article 10. Trustee 69 79 Section 10.01. Duties of the Trustee. 69 79 Section 10.02. Rights of the Trustee. 70 81 Section 10.03. Individual Rights of the Trustee. 71 82 Section 10.04. Trustee’s Disclaimer. 72 82 Section 10.05. Notice of Defaults. 72 83 Section 10.06. Compensation and Indemnity. 72 83 Section 10.07. Replacement of the Trustee. 73 84 Section 10.08. Successor Trustee by Merger, Etc. 74 85 Section 10.09. Eligibility; Disqualification. 74 85 Article 11. Miscellaneous 74 85 Section 11.01. Notices. 74 85 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 87 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 88 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 88 Section 11.05. No Personal Liability of Directors, Officers, Employees and StockholdersShareholders. 77 88 Section 11.06. Governing Law; Waiver of Jury Trial. 77 88 Section 11.07. Submission to Jurisdiction. 77 88 Section 11.08. No Adverse Interpretation of Other Agreements. 77 89 Section 11.09. Successors. 77 89 Section 11.10. Force Majeure. 78 89 Section 11.11. U.S.A. PATRIOT Act. 78 89 Section 11.12. Calculations. 78 89 Section 11.13. Severability. 78 90 Section 11.14. Counterparts. 78 90 Section 11.15. Table of Contents, Headings, Etc. 78 90 Section 11.16. Withholding Taxes[Reserved]. 79 90 Section 11.17. Foreign Account Tax Compliance Act (FATCA). 91 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1AB-1: Form of Restricted Note Legend (NonB1-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7August 6, 20202024, between ProgenitySMART Global Holdings, Inc., a Delaware corporationCayman Islands exempted company, as issuer (the “Company”), and The U.S. Bank of New York Mellon Trust Company, N.A.National Association, as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”as defined below).

Settlement Upon Conversion. 40 45 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 48 Section 5.05. Adjustments to the Conversion Rate. 42 49 Section 5.06. Voluntary Adjustments. 52 60 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 61 Section 5.08. Exchange in Lieu of Conversion. 54 62 Section 5.09. Effect of Common Stock Change Event. 54 63 Article 6. Successors 56 65 Section 6.01. When the Company May Merge, Etc. 56 65 Section 6.02. Successor Corporation Substituted. 57 65 Article 7. Defaults and Remedies 57 66 Section 7.01. Events of Default. 57 66 Section 7.02. Acceleration. 59 68 Section 7.03. Sole Remedy for a Failure to Report. 59 68 Section 7.04. Other Remedies. 60 69 Section 7.05. Waiver of Past Defaults. 61 70 Section 7.06. Control by Majority. 61 70 Section 7.07. Limitation on Suits. 61 70 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 71 Section 7.09. Collection Suit by Trustee. 62 71 Section 7.10. Trustee May File Proofs of Claim. 62 71 Section 7.11. Priorities. 63 72 Section 7.12. Undertaking for Costs. 63 72 Article 8. Amendments, Supplements and Waivers 64 73 Section 8.01. Without the Consent of Holders. 64 73 Section 8.02. With the Consent of Holders. 64 74 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 75 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 75 Section 8.05. Notations and Exchanges. 66 76 Section 8.06. Trustee to Execute Supplemental Indentures. 67 76 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 76 Section 9.01. Termination of Company’s Obligations. 67 76 Section 9.02. Repayment to Company. 68 77 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 77 Article 10. Trustee 69 77 Section 10.01. Duties of the Trustee. 69 77 Section 10.02. Rights of the Trustee. 70 79 Section 10.03. Individual Rights of the Trustee. 71 80 Section 10.04. Trustee’s Disclaimer. 72 80 Section 10.05. Notice of Defaults. 72 81 Section 10.06. Compensation and Indemnity. 72 81 Section 10.07. Replacement of the Trustee. 73 82 Section 10.08. Successor Trustee by Merger, Etc. 74 83 Section 10.09. Eligibility; Disqualification. 74 83 Article 11. Miscellaneous 74 83 Section 11.01. Notices. 74 83 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 85 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 86 Section 11.04. Rules by the Trustee, the Registrar and Registrar, the Paying Agent and Conversion Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).86

Settlement Upon Conversion. 40 45 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 49 Section 5.05. Adjustments to the Conversion Rate. 42 49 Section 5.06. Voluntary Adjustments. 52 60 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 60 Section 5.08. Exchange in Lieu of Conversion. 54 61 Section 5.09. Effect of Common Stock Change Event. 54 62 Article 6. Successors 56 64 Section 6.01. When the Company May Merge, Etc. 56 64 Section 6.02. Successor Corporation Entity Substituted. 57 65 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 65 Article 7. Defaults and Remedies 57 65 Section 7.01. Events of Default. 57 65 Section 7.02. Acceleration. 59 67 Section 7.03. Sole Remedy for a Failure to Report. 59 68 Section 7.04. Other Remedies. 60 69 Section 7.05. Waiver of Past Defaults. 61 69 Section 7.06. Control by Majority. 61 69 Section 7.07. Limitation on Suits. 61 69 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 70 Section 7.09. Collection Suit by Trustee. 62 70 Section 7.10. Trustee May File Proofs of Claim. 62 70 Section 7.11. Priorities. 63 71 Section 7.12. Undertaking for Costs. 63 71 Article 8. Amendments, Supplements and Waivers 64 72 Section 8.01. Without the Consent of Holders. 64 72 Section 8.02. With the Consent of Holders. 64 73 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 74 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 74 Section 8.05. Notations and Exchanges. 66 75 Section 8.06. Trustee to Execute Supplemental Indentures. 67 75 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 75 Section 9.01. Termination of Company’s Obligations. 67 75 Section 9.02. Repayment to Company. 68 76 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 76 Article 10. Trustee 69 76 Section 10.01. Duties of the Trustee. 69 76 Section 10.02. Rights of the Trustee. 70 78 Section 10.03. Individual Rights of the Trustee. 71 78 Section 10.04. Trustee’s Disclaimer. 72 79 Section 10.05. Notice of Defaults. 72 79 Section 10.06. Compensation and Indemnity. 72 79 Section 10.07. Replacement of the Trustee. 73 80 Section 10.08. Successor Trustee by MergerXxxxxx, Etc. 74 81 Section 10.09. Eligibility; Disqualification. 74 81 Article 11. Miscellaneous 74 82 Section 11.01. Notices. 74 82 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 84 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 84 Section 11.04. Rules by the Trustee, the Registrar Registrar, the Paying Agent and the Paying Conversion Agent. 76 84 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 84 Section 11.06. Governing Law; Waiver of Jury Trial. 77 85 Section 11.07. Submission to Jurisdiction. 77 85 Section 11.08. No Adverse Interpretation of Other Agreements. 77 85 Section 11.09. Successors. 77 85 Section 11.10. Force Majeure. 78 85 Section 11.11. U.S.A. PATRIOT Act. 78 86 Section 11.12. Calculations. 78 86 Section 11.13. Severability. 78 86 Section 11.14. Counterparts. 78 86 Section 11.15. Table of Contents, Headings, Etc. 78 86 Section 11.16. Withholding Taxes. 79 87 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1AB-1: Form of Restricted Note Legend (NonB1-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7October 11, 20202023, between ProgenityRivian Automotive, Inc., a Delaware corporation, as issuer (the “Company”), and The U.S. Bank of New York Mellon Trust Company, N.A.National Association, as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.253.625% Green Convertible Senior Notes due 2025 2030 (the “Notes”).

Settlement Upon Conversion. 40 77 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 Conversion 79 Section 5.05. Adjustments to the Conversion Rate. 42 Rate 79 Section 5.06. Voluntary Adjustments. 52 Adjustments 90 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 Requisite Stockholder Approval 90 Section 5.08. Exchange in Lieu of Conversion. 54 Conversion 90 Section 5.09. Effect of Common Stock Change EventEvent 91 Section 5.10. 54 Trustee and the Note Agents 92 Article 6. Successors 56 94 Section 6.01. When the Company May Merge, Etc. 56 94 Section 6.02. Successor Corporation Substituted. 57 Substituted 94 Article 7. Defaults and Remedies 57 94 Section 7.01. Events of Default. 57 Default 94 Section 7.02. Acceleration. 59 Acceleration 97 Section 7.03. Sole Remedy for a Failure to Report. 59 Report 97 Section 7.04. Other Remedies. 60 Remedies 98 Section 7.05. Waiver of Past Defaults. 61 Defaults 99 Section 7.06. Control by Majority. 61 Required Holders 99 Section 7.07. Limitation on Suits. 61 Suits 99 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 Consideration 100 Section 7.09. Collection Suit by Trustee. 62 Trustee 100 Section 7.10. Trustee May File Proofs of Claim. 62 Claim 100 Section 7.11. Priorities. 63 Priorities 101 Section 7.12. Undertaking for Costs. 63 Costs 101 Article 8. Amendments, Supplements and Waivers 64 102 Section 8.01. Without the Consent of Holders. 64 Holders 102 TABLE OF CONTENTS (continued) Page Section 8.02. With the Consent of Holders. 64 Holders 103 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 Waivers 105 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 105 Section 8.05. Notations and Exchanges. 66 Exchanges 105 Section 8.06. Trustee and Collateral Agent to Execute Supplemental Indentures. 67 Indentures 106 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents 106 Section 9.01. Termination of Company’s Obligations. 67 Obligations 106 Section 9.02. Repayment to Company. 68 Company 107 Section 9.03. Reinstatement. 68 Reinstatement 107 Section 9.04. Defeasance of Restrictive Covenants. 68 Covenants 107 Article 10. Trustee 69 109 Section 10.01. Duties of the Trustee. 69 Trustee 109 Section 10.02. Rights of the Trustee. 70 Trustee 110 Section 10.03. Individual Rights of the Trustee. 71 Trustee 112 Section 10.04. Trustee’s Disclaimer. 72 Disclaimer 112 Section 10.05. Notice of Defaults. 72 Defaults 113 Section 10.06. Compensation and Indemnity. 72 Indemnity 113 Section 10.07. Replacement of the Trustee. 73 Trustee 114 Section 10.08. Successor Trustee by Merger, Etc. 74 115 Section 10.09. Eligibility; Disqualification. 74 Disqualification 115 Article 11. Miscellaneous 74 115 Section 11.01. Notices. 74 Notices 115 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 Precedent 117 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 Counsel 117 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 Agent 117 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Stockholders 117 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Trial 118 Section 11.07. Submission to Jurisdiction. 77 Jurisdiction 118 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Agreements 118 Section 11.09. Successors. 77 Successors 118 Section 11.10. Force Majeure. 78 Majeure 118 Section 11.11. U.S.A. PATRIOT Act. 78 Act 119 Section 11.12. Calculations. 78 Calculations 119 Section 11.13. Severability. 78 Severability 119 Section 11.14. Counterparts. 78 Counterparts 119 Section 11.15. Table of Contents, Headings, Etc. 78 120 Section 11.16. Withholding TaxesTaxes 120 Section 11.17. 79 Sanctions 120 TABLE OF CONTENTS (continued) Page Article 12. Collateral 120 Section 12.01. Collateral Documents 120 Section 12.02. Collateral Agent 121 Section 12.03. Release of Collateral; Non-Disturbance 125 Section 12.04. Suits to Protect the Collateral 126 Section 12.05. Authorization of Action to be Taken 126 Section 12.06. Purchaser Protection 127 Section 12.07. Powers Exercisable by Receiver or Trustee 127 Section 12.08. Release Upon Termination of the Company’s Obligations 128 Section 12.09. Collateral Agent; Collateral Documents 128 Section 12.10. Replacement of Collateral Agent 129 Section 12.11. Acceptance by Collateral Agent 130 Article 13. Guarantees 130 Section 13.01. Guarantees 130 Section 13.02. Limitation on Guarantor Liability 132 Section 13.03. Execution of Guarantees 133 Section 13.04. When Guarantors May Merge, etc. 133 Section 13.05. Application of Certain Provisions of the Guarantors 133 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table Exhibit C: Form of Contents Supplemental Indenture C-1 THIS AMENDED AND RESTATED INDENTURE, dated as of December 7August 15, 20202024, between Progenityamong Biora Therapeutics, Inc., a Delaware corporation, as issuer (the “Company”), the Guarantors party hereto from time to time (as defined herein), and The Bank of New York Mellon GLAS Trust Company, N.A.Company LLC, as trustee (in such capacity, the “Trustee”) and as collateral agent (in such capacity, the “Collateral Agent”), is an amendment and restatement of the indenture dated December 19, 2023, as amended by the supplemental indenture thereto dated March 12, 2024. Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party Trustee, the Collateral Agent and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.2511.00% / 13.00% Convertible Senior Secured Notes due 2025 2028 (the “Notes”).

Settlement Upon Conversion. 40 39 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 42 Section 5.05. Adjustments to the Conversion Rate. 42 43 Section 5.06. Voluntary Adjustments. 52 53 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 Section 5.08. Exchange in Lieu of Conversion. 54 Section 5.09. Effect of Common Stock Change Event. 54 55 Article 6. Successors 56 57 Section 6.01. When the Company May Merge, Etc. 56 57 Section 6.02. Successor Corporation Substituted. 57 Section 6.03. Exclusion for Certain Asset Transfers. 57 Article 7. Defaults and Remedies 57 Section 7.01. Events of Default. 57 Section 7.02. Acceleration. 59 Section 7.03. Sole Remedy for a Failure to Report. 59 60 Section 7.04. Other Remedies. 60 61 Section 7.05. Waiver of Past Defaults. 61 Section 7.06. Control by Majority. 61 Section 7.07. Limitation on Suits. 61 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 Section 7.09. Collection Suit by Trustee. 62 Section 7.10. Trustee May File Proofs of Claim. 62 Section 7.11. Priorities. 63 Section 7.12. Undertaking for Costs. 63 Article 8. Amendments, Supplements and Waivers 64 63 Section 8.01. Without the Consent of Holders. 64 63 Section 8.02. With the Consent of Holders. 64 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 65 Section 8.05. Notations and Exchanges. 66 Section 8.06. Trustee to Execute Supplemental Indentures. 67 66 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 66 Section 9.01. Termination of Company’s Obligations. 67 66 Section 9.02. Repayment to Company. 68 67 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 67 Article 10. Trustee 69 67 Section 10.01. Duties of the Trustee. 69 67 Section 10.02. Rights of the Trustee. 70 69 Section 10.03. Individual Rights of the Trustee. 71 69 Section 10.04. Trustee’s Disclaimer. 72 69 Section 10.05. Notice of Defaults. 72 70 Section 10.06. Compensation and Indemnity. 72 70 Section 10.07. Replacement of the Trustee. 73 71 Section 10.08. Successor Trustee by Merger, Etc. 74 72 Section 10.09. Eligibility; Disqualification. 74 72 Article 11. Miscellaneous 74 72 Section 11.01. Notices. 74 72 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 73 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 74 Section 11.04. Rules by the Trustee, the Registrar and Registrar, the Paying Agent and Conversion Agent. 76 74 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 74 Section 11.06. Governing Law; Waiver of Jury Trial. 77 74 Section 11.07. Submission to Jurisdiction. 77 74 Section 11.08. No Adverse Interpretation of Other Agreements. 77 75 Section 11.09. Successors. 77 75 Section 11.10. Force Majeure. 78 75 Section 11.11. U.S.A. PATRIOT Act. 78 75 Section 11.12. Calculations. 78 75 Section 11.13. Severability. 78 76 Section 11.14. Counterparts. 78 76 Section 11.15. Table of Contents, Headings, Etc. 78 76 Section 11.16. Withholding Taxes. 79 76 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1AX-0 Xxxxxxx X-0: Form of Restricted Note Legend (NonB1-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7January 19, 20202022, between ProgenityVirgin Galactic Holdings, Inc., a Delaware corporation, as issuer (the “Company”), and The U.S. Bank of New York Mellon Trust Company, N.A.National Association, as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.252.50% Convertible Senior Notes due 2025 (the “Notes”)2027.

Settlement Upon Conversion. 40 54 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 58 Section 5.05. Adjustments to the Conversion Rate. 42 58 Section 5.06. Voluntary Adjustments. 52 69 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 69 Section 5.08. Exchange in Lieu of Conversion. 54 70 Section 5.09. Effect of Common Stock Change Event. 54 71 Section 5.10. Limits Upon Issuances of Shares of Common Stock upon Conversion. 73 Article 6. Successors 56 75 Section 6.01. When the Company May Merge, Etc. 56 75 Section 6.02. Successor Corporation Entity Substituted. 57 75 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 76 Article 7. Defaults and Remedies 57 76 Section 7.01. Events of Default. 57 76 Section 7.02. Acceleration. 59 79 Section 7.03. Sole Remedy for a Failure to Report. 59 79 Section 7.04. Other Remedies. 60 80 Section 7.05. Waiver of Past Defaults. 61 81 Section 7.06. Control by Majority. 61 81 Section 7.07. Limitation on Suits. 61 81 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 82 Section 7.09. Collection Suit by Trustee. 62 82 Section 7.10. Trustee May File Proofs of Claim. 62 82 Section 7.11. Priorities. 63 83 Section 7.12. Undertaking for Costs. 63 83 Article 8. Amendments, Supplements and Waivers 64 83 Section 8.01. Without the Consent of Holders. 64 83 Section 8.02. With the Consent of Holders. 64 84 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 85 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 86 Section 8.05. Notations and Exchanges. 66 86 Section 8.06. Trustee to Execute Supplemental Indentures. 67 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Section 9.01. Termination of Company’s Obligations. 67 Section 9.02. Repayment to Company. 68 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 Article 10. Trustee 69 Section 10.01. Duties of the Trustee. 69 Section 10.02. Rights of the Trustee. 70 Section 10.03. Individual Rights of the Trustee. 71 Section 10.04. Trustee’s Disclaimer. 72 Section 10.05. Notice of Defaults. 72 Section 10.06. Compensation and Indemnity. 72 Section 10.07. Replacement of the Trustee. 73 Section 10.08. Successor Trustee by Merger, Etc. 74 Section 10.09. Eligibility; Disqualification. 74 Article 11. Miscellaneous 74 Section 11.01. Notices. 74 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).87

Settlement Upon Conversion. 40 39 Section 5.04. Reserve and Status of Common Stock Issued Upon upon Conversion. 41 42 Section 5.05. Adjustments to the Conversion Rate. 42 43 Section 5.06. Voluntary Adjustments. 52 54 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 54 Section 5.08. Exchange in Lieu of Conversion. 54 55 Section 5.09. Effect of Common Stock Change Event. 54 56 Article 6. Successors 56 57 Section 6.01. When the Company May Merge, Etc. 56 57 Section 6.02. Successor Corporation Substituted. 57 58 Article 7. Defaults and Remedies 57 58 Section 7.01. Events of Default. 57 58 Section 7.02. Acceleration. 59 60 Section 7.03. Sole Remedy for a Failure to Report. 59 61 Section 7.04. Other Remedies. 60 62 Section 7.05. Waiver of Past Defaults. 61 62 Section 7.06. Control by Majority. 61 62 Section 7.07. Limitation on Suits. 61 63 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 63 Section 7.09. Collection Suit by Trustee. 62 63 Section 7.10. Trustee May File Proofs of Claim. 62 64 Section 7.11. Priorities. 63 64 Section 7.12. Undertaking for Costs. 63 65 Article 8. Amendments, Supplements and Waivers 64 65 Section 8.01. Without the Consent of Holders. 64 65 Section 8.02. With the Consent of Holders. 64 66 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 67 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 67 Section 8.05. Notations and Exchanges. 66 68 Section 8.06. Trustee to Execute Supplemental Indentures. 67 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Section 9.01. Termination of Company’s Obligations. 67 Section 9.02. Repayment to Company. 68 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 Article 10. Trustee 69 Section 10.01. Duties of the Trustee. 69 Section 10.02. Rights of the Trustee. 70 Section 10.03. Individual Rights of the Trustee. 71 Section 10.04. Trustee’s Disclaimer. 72 Section 10.05. Notice of Defaults. 72 Section 10.06. Compensation and Indemnity. 72 Section 10.07. Replacement of the Trustee. 73 Section 10.08. Successor Trustee by Merger, Etc. 74 Section 10.09. Eligibility; Disqualification. 74 Article 11. Miscellaneous 74 Section 11.01. Notices. 74 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).68

Settlement Upon Conversion. 40 ‌ 46 Section 5.04. Reserve and Status of Common Stock Issued Upon upon Conversion. 41 ‌ 49 Section 5.05. Adjustments to the Conversion Rate. 42 ‌ 49 Section 5.06. Voluntary Adjustments. 52 ‌ 59 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 ‌ 59 Section 5.08. Exchange in Lieu of Conversion. 54 ‌ 61 Section 5.09. Effect of Common Stock Change Event. 54 ‌ 61 Article 6. 6 Successors 56 ‌ 63 Section 6.01. When the Company May Merge, Etc. 56 ‌ 63 Section 6.02. Successor Corporation Substituted. 57 ‌ 64 Article 7. 7 Defaults and Remedies 57 ‌ 64 Section 7.01. Events of Default. 57 ‌ 64 Section 7.02. Acceleration. 59 ‌ 66 Section 7.03. Sole Remedy for a Failure to Report. 59 ‌ 67 Section 7.04. Other Remedies. 60 ‌ 68 Section 7.05. Waiver of Past Defaults. 61 ‌ 68 Section 7.06. Control by Majority. 61 ‌ 68 Section 7.07. Limitation on Suits. 61 ‌ 69 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 ‌ 69 Section 7.09. Collection Suit by Trustee. 62 ‌ 69 Section 7.10. Trustee May File Proofs of Claim. 62 ‌ 70 Section 7.11. Priorities. 63 ‌ 70 Section 7.12. Undertaking for Costs. 63 ‌ 71 Article 8. 8 Amendments, Supplements and Waivers 64 ‌ 71 Section 8.01. Without the Consent of Holders. 64 ‌ 71 Section 8.02. With the Consent of Holders. 64 ‌ 72 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 ‌ 73 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 ‌ 73 Section 8.05. Notations and Exchanges. 66 ‌ 74 Section 8.06. Trustee to Execute Supplemental Indentures. 67 ‌ 74 Article 9. 9 Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge ‌ 74 Section 9.01. Termination of Company’s Obligations. 67 ‌ 74 Section 9.02. Repayment to Company. 68 ‌ 75 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 ‌ 75 - ii - ‌ ​ ​ ​ Article 10. 10 Trustee 69 ‌ 75 Section 10.01. Duties of the Trustee. 69 ‌ 75 Section 10.02. Rights of the Trustee. 70 ‌ 76 Section 10.03. Individual Rights of the Trustee. 71 ‌ 78 Section 10.04. Trustee’s Disclaimer. 72 ‌ 78 Section 10.05. Notice of Defaults. 72 ‌ 78 Section 10.06. Compensation and Indemnity. 72 ‌ 78 Section 10.07. Replacement of the Trustee. 73 ‌ 79 Section 10.08. Successor Trustee by MergerXxxxxx, Etc. 74 ‌ 80 Section 10.09. Eligibility; Disqualification. 74 ‌ 80 Article 11. 11 Miscellaneous 74 ‌ 80 Section 11.01. Notices. 74 ‌ 80 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 Section 11.04. Rules by the Trustee, the Registrar and the Paying Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).‌ 82

Settlement Upon Conversion. 40 44 Section 5.04. Reserve and Status of Common Stock Issued Upon Conversion. 41 48 Section 5.05. Adjustments to the Conversion Rate. 42 48 Section 5.06. Voluntary Adjustments. 52 59 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 59 Section 5.08. Exchange in Lieu of Conversion. 54 61 Section 5.09. Effect of Common Stock Change Event. 54 61 Article 6. Successors 56 63 Section 6.01. When the Company May Merge, Etc. 56 63 Section 6.02. Successor Corporation Entity Substituted. 57 64 Section 6.03. Exclusion for Asset Transfers with Wholly Owned Subsidiaries. 64 Article 7. Defaults and Remedies 57 64 Section 7.01. Events of Default. 57 64 Section 7.02. Acceleration. 59 66 Section 7.03. Sole Remedy for a Failure to Report. 59 67 Section 7.04. Other Remedies. 60 68 Section 7.05. Waiver of Past Defaults. 61 68 Section 7.06. Control by Majority. 61 68 Section 7.07. Limitation on Suits. 61 68 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 69 Section 7.09. Collection Suit by Trustee. 62 69 Section 7.10. Trustee May File Proofs of Claim. 62 69 Section 7.11. Priorities. 63 70 Section 7.12. Undertaking for Costs. 63 70 Article 8. Amendments, Supplements and Waivers 64 71 Section 8.01. Without the Consent of Holders. 64 71 Section 8.02. With the Consent of Holders. 64 72 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 73 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 73 Section 8.05. Notations and Exchanges. 66 74 Section 8.06. Trustee to Execute Supplemental Indentures. 67 74 Article 9. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 74 Section 9.01. Termination of Company’s Obligations. 67 74 Section 9.02. Repayment to Company. 68 75 Section 9.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 75 Article 10. Trustee 69 75 Section 10.01. Duties of the Trustee. 69 75 Section 10.02. Rights of the Trustee. 70 76 Section 10.03. Individual Rights of the Trustee. 71 77 Section 10.04. Trustee’s Disclaimer. 72 78 Section 10.05. Notice of Defaults. 72 78 Section 10.06. Compensation and Indemnity. 72 78 Section 10.07. Replacement of the Trustee. 73 79 Section 10.08. Successor Trustee by MergerXxxxxx, Etc. 74 80 Section 10.09. Eligibility; Disqualification. 74 80 Article 11. Miscellaneous 74 81 Section 11.01. Notices. 74 81 Section 11.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 83 Section 11.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 83 Section 11.04. Rules by the Trustee, the Registrar Registrar, the Paying Agent and the Paying Conversion Agent. 76 83 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 83 Section 11.06. Governing Law; Waiver of Jury Trial. 77 84 Section 11.07. Submission to Jurisdiction. 77 84 Section 11.08. No Adverse Interpretation of Other Agreements. 77 84 Section 11.09. Successors. 77 84 Section 11.10. Force Majeure. 78 84 Section 11.11. U.S.A. PATRIOT Act. 78 85 Section 11.12. Calculations. 78 85 Section 11.13. Severability. 78 85 Section 11.14. Counterparts. 78 85 Section 11.15. Table of Contents, Headings, Etc. 78 85 Section 11.16. Withholding Taxes. 79 86 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1AB-1: Form of Restricted Note Legend (NonB1-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Resale Legend B3-1 Table of Contents iii INDENTURE, dated as of December 7March 20, 20202023, between ProgenityFreshpet, Inc., a Delaware corporation, as issuer (the “Company”), and The U.S. Bank of New York Mellon Trust Company, N.A.National Association, as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.253.00% Convertible Senior Notes due 2025 2028 (the “Notes”).

Settlement Upon Conversion. 40 45 Section 5.04. Reserve and Status of Common Stock Shares Issued Upon Conversion. 41 48 Section 5.05. Adjustments to the Conversion Rate. 42 49 Section 5.06. Voluntary Adjustments. 52 59 Section 5.07. Adjustments to the Conversion Rate in Connection with a Make-Whole Fundamental Change. 53 59 Section 5.08. Exchange in Lieu of Conversion. 54 61 Section 5.09. Effect of Common Stock Share Change Event. 54 61 ​ ​ Article 6. Successors 56 63 ​ ​ ​ Section 6.01. When the Company May Merge, Etc. 56 63 Section 6.02. Successor Corporation Substituted. 57 64 ​ ​ Article 7. Defaults and Remedies 57 64 ​ ​ ​ Section 7.01. Events of Default. 57 64 Section 7.02. Acceleration. 59 66 Section 7.03. Sole Remedy for a Failure to Report. 59 67 Section 7.04. Other Remedies. 60 68 Section 7.05. Waiver of Past Defaults. 61 68 Section 7.06. Control by Majority. 61 68 Section 7.07. Limitation on Suits. 61 69 Section 7.08. Absolute Right of Holders to Institute Suit for the Enforcement of the Right to Receive Payment and Conversion Consideration. 62 69 Section 7.09. Collection Suit by Trustee. 62 69 Section 7.10. Trustee May File Proofs of Claim. 62 70 Section 7.11. Priorities. 63 70 Section 7.12. Undertaking for Costs. 63 71 ​ ​ Article 8. Amendments, Supplements and Waivers 64 71 ​ ​ ​ Section 8.01. Without the Consent of Holders. 64 71 Section 8.02. With the Consent of Holders. 64 72 Section 8.03. Notice of Amendments, Supplements and Waivers. 65 73 Section 8.04. Revocation, Effect and Solicitation of Consents; Special Record Dates; Etc. 66 73 Section 8.05. Notations and Exchanges. 66 74 Section 8.06. Trustee to Execute Supplemental Indentures. 67 74 ​ ​ Article 9. Guarantees 74 ​ - ii - ​ ​ Section 9.01. Guarantees. 74 Section 9.02. Limitation on Guarantor Liability. 76 Section 9.03. Execution and Delivery of Guarantee. 76 Section 9.04. When the Guarantor May Merge, Etc. 76 Section 9.05. Application of Certain Provisions to the Guarantor. 77 ​ ​ Article 10. Satisfaction and Discharge; Defeasance of Certain Covenants 67 Table of Contents Discharge 77 ​ ​ ​ Section 9.0110.01. Termination of Company’s Obligations. 67 77 Section 9.0210.02. Repayment to Company. 68 78 Section 9.0310.03. Reinstatement. 68 Section 9.04. Defeasance of Restrictive Covenants. 68 78 ​ ​ Article 1011. Trustee 69 79 ​ ​ ​ Section 10.0111.01. Duties of the Trustee. 69 79 Section 10.0211.02. Rights of the Trustee. 70 80 Section 10.0311.03. Individual Rights of the Trustee. 71 81 Section 10.0411.04. Trustee’s Disclaimer. 72 81 Section 10.0511.05. Notice of Defaults. 72 81 Section 10.0611.06. Compensation and Indemnity. 72 81 Section 10.0711.07. Replacement of the Trustee. 73 82 Section 10.0811.08. Successor Trustee by Merger, Etc. 74 83 Section 10.0911.09. Eligibility; Disqualification. 74 83 ​ ​ Article 1112. Miscellaneous 74 83 ​ ​ ​ Section 11.0112.01. Notices. 74 83 Section 11.0212.02. Delivery of Officer’s Certificate and Opinion of Counsel as to Conditions Precedent. 76 85 Section 11.0312.03. Statements Required in Officer’s Certificate and Opinion of Counsel. 76 86 Section 11.0412.04. Rules by the Trustee, the Registrar Registrar, the Paying Agent and the Paying Conversion Agent. 76 Section 11.05. No Personal Liability of Directors, Officers, Employees and Stockholders. 77 Section 11.06. Governing Law; Waiver of Jury Trial. 77 Section 11.07. Submission to Jurisdiction. 77 Section 11.08. No Adverse Interpretation of Other Agreements. 77 Section 11.09. Successors. 77 Section 11.10. Force Majeure. 78 Section 11.11. U.S.A. PATRIOT Act. 78 Section 11.12. Calculations. 78 Section 11.13. Severability. 78 Section 11.14. Counterparts. 78 Section 11.15. Table of Contents, Headings, Etc. 78 Section 11.16. Withholding Taxes. 79 Exhibits Exhibit A: Form of Note A-1 Exhibit B-1A: Form of Restricted Note Legend (Non-Affiliate Note) B1A-1 Exhibit B-1B: Form of Restricted Note Legend (Affiliate Note) B1B-1 Exhibit B-2: Form of Global Note Legend B2-1 Exhibit B-3: Form of Non-Affiliate Legend B3-1 Table of Contents INDENTURE, dated as of December 7, 2020, between Progenity, Inc., a Delaware corporation, as issuer (the “Company”), and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”). Each party to this Indenture (as defined below) agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 7.25% Convertible Senior Notes due 2025 (the “Notes”).86