Common use of Stockholder Obligation Several and Not Joint Clause in Contracts

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX AND COMPANY By: /s/ Xxxx Xxxxxxxx Name: Xxxx Xxxxxxxx Title: Senior Vice President, Immunology Development MERGER SUB: RAINIER ACQUISITION CORPORATION By: /s/ Xxxxxxx X. Xxxxxxxx Name: Xxxxxxx X. Xxxxxxxx Title: President and Treasurer The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERS: XXXX XXXXXX By: /s/ Xxxx Xxxxxx Name: Xxxx Xxxxxx POLARIS PARTNERS VII, L.P. By: /s/ Xxxxxx Xxxxxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS FUND VII, L.P. By: /s/ Xxxxxx Xxxxxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact [Signature Page to Tender and Support Agreement] Schedule A Name of Stockholder Shares of Company Common Stock Company Stock Options Company RSUs Xxxx Xxxxxx 145 99,163 0 Polaris Partners VII, L.P. 1,860,498 0 0

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Merger Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX AND COMPANY ByCOMPANY, as Parent by: /s/ Xxxx Xxxxxxxx Xxxxx X. Xxxxx Name: Xxxx Xxxxxxxx Xxxxx X. Xxxxx Title: Senior Vice PresidentChairman, Immunology Development MERGER SUB: RAINIER President and Chief Executive Officer BOWFIN ACQUISITION CORPORATION ByCORPORATION, as Merger Sub by: /s/ Xxxxxx X. Xxxxxxx X. Xxxxxxxx Name: Xxxxxx X. Xxxxxxx X. Xxxxxxxx Title: President [Signature Page to Tender and Treasurer Support Agreement] The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERS: XXXX XXXXXX By: /s/ Xxxx Xxxxxx Name: Xxxx Xxxxxx POLARIS PARTNERS VIIAISLING CAPITAL III, L.P. LP By: /s/ Xxxxxx Xxxxxxxx Xxxxxx Name: Xxxxxx Xxxxxxxx Xxxxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS FUND VIIChief Financial Officer Aisling Capital III, L.P. By000 Xxxxxxx Xxxxxx, 00xx Xxxxx Xxx Xxxx, XX 00000 Attn: /s/ Xxxxx Xxxx Fax: 000 000 0000 Email: xxxxx@xxxxxxxxxxxxxx.xxx and Aisling Capital III, L.P. 000 Xxxxxxx Xxxxxx, 00xx Xxxxx Xxx Xxxx, XX 00000 Attn: Chief Financial Officer Fax: 000 000 0000 Email: xxxxxxx@xxxxxxxxxxxxxx.xxx with a copy (which does not constitute notice) to: XxXxxxxxx Will & Xxxxx LLP 000 Xxxxxxx Xxxxxx Xxxxxxxx NameXxx Xxxx, XX 00000-0000 Attn: Xxxxxx Xxxxxxxx TitleXxxx Finger Fax: Attorney-in-fact 000 000 0000 Email: xxxxxxx@xxx.xxx [Signature Page to Tender and Support Agreement] Schedule A Name of Stockholder Stockholders Shares of Company Common Stock Company Stock Options Company RSUs Xxxx Xxxxxx 145 99,163 0 Polaris Partners VIIAisling Capital III, L.P. 1,860,498 0 0LP 2,038,920 N/A

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Sub Purchaser agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties Parties are executing this Tender and Support Agreement on as of the date set forth in the introductory clausepreamble. PARENTALLIANCE ACQUISITION SUB, INC. By: XXX XXXXX AND COMPANY /s/ Xxxxx Xxxxxxx Name: Xxxxx Xxxxxxx Title: Director ALLIANCE HOLDCO LIMITED By: /s/ Xx. Xxxxxxxxxxx Xxxxxxxxx Name: Xx. Xxxxxxxxxxx Xxxxxxxxx Title: President [Signature Page to Tender and Support Agreement] By: /s/ Xxxxx X. Xxxxxx Name: Xxxxx X. Xxxxxx Title: Director, President and Chief Executive Officer [Signature Page to Tender and Support Agreement] By: /s/ Hope D’Oyley-Gay Name: Xxxx X’Xxxxx-Xxx Title: General Counsel [Signature Page to Tender and Support Agreement] By: /s/ Xxxxx Xxxxxxxx Name: Xxxxx Xxxxxxxx Title: Director [Signature Page to Tender and Support Agreement] By: /s/ Xxxxx Xxxxxxxxx Name: Xxxxx Xxxxxxxxx Title: Chief Medical Officer [Signature Page to Tender and Support Agreement] By: /s/ Xxxxxxx Xxxxxx Name: Xxxxxxx Xxxxxx Title: Chief Business Officer [Signature Page to Tender and Support Agreement] By: /s/ Xxxxxxx Xxxxxx Name: Xxxxxxx Xxxxxx Title: Chief Scientific Officer [Signature Page to Tender and Support Agreement] By: /s/ Xxxxxxxx X. Xxxxxx Name: Xxxxxxxx X. Xxxxxx Title: Chief Financial Officer [Signature Page to Tender and Support Agreement] By: /s/ Xxxx Xxxxxxxx XxxXxxx Name: Xxxx Xxxxxxxx XxxXxxx Title: Senior Vice President, Immunology Development MERGER SUBDirector [Signature Page to Tender and Support Agreement] By: RAINIER ACQUISITION CORPORATION /s/ Xxxxx Xxxxx Name: Xxxxx Xxxxx Title: Director [Signature Page to Tender and Support Agreement] By: /s/ Xxxxxxx X. Xxxxxxxx Xxxxxx Name: Xxxxxxx X. Xxxxxxxx Xxxxxx Title: President Director [Signature Page to Tender and Treasurer The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERS: XXXX XXXXXX By: /s/ Xxxx Xxxxxx Name: Xxxx Xxxxxx POLARIS PARTNERS VII, L.P. Support Agreement] By: /s/ Xxxxxx Xxxxxxxx Xxxxxxx Name: Xxxxxx Xxxxxxxx Xxxxxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS FUND VII, L.P. Director [Signature Page to Tender and Support Agreement] By: /s/ Xxxxx Xxxxxx Xxxxxxxx Name: Xxxxx Xxxxxx Xxxxxxxx Title: Attorney-in-fact Director [Signature Page to Tender and Support Agreement] By: /s/ Xxxxx Xxxxxx Name: Xxxxx Xxxxxx Title: Director [Signature Page to Tender and Support Agreement] Schedule A Name of Stockholder Beneficial Owner Number of Shares Number of RSUs Company Common Stock Company Stock Options Company RSUs Xxxx Warrants Xxxxx X. Xxxxxx 145 99,163 143,021 0 Polaris Partners VII1,640,936 0 Xxxxxxxx X. Xxxxxx 0 0 356,700 0 Xxxxx Xxxxxxxxx, L.P. 1,860,498 M.D. 0 0 322,300 0 Hope D’Oyley-Gay 0 0 327,900 0 Xxxxxxx Xxxxxx 47,133 8,750 662,149 0 Xxxxxxx Xxxxxx 0 0 344,500 0 Xxxxxxx Xxxxxx, MPA 8,500 0 71,000 0 Xxxxx Xxxxxx, M.D. 0 0 39,000 0 Xx Xxxxxxx 27,472 0 80,000 0 Xxxxx Xxxxxx, M.D., Ph.D. 34,246 0 98,548 0 Xxxxx Xxxxxxxx 0 0 25,000 0 Xxxxx Xxxxx 1,000 0 84,263 0

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. Parent and Xxxxxx Sub agree that no Stockholder shall be liable in his, her or its capacity as a stockholder of the Company for claims, losses, damages, expenses, liabilities or obligations arising under the Merger Agreement. Notwithstanding anything to the contrary in this Agreement, this Agreement may only be enforced against, and any claim or cause of action based upon, or arising under, this Agreement may only be brought against, the persons that are expressly named as parties hereto and their respective successors and assigns. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX AND COMPANY VIENNA PARENT CORPORATION, an Indiana corporation By: /s/ Xxxx Xxxxxxxx Xxxxxx Xxxxxxxxx Name: Xxxx Xxxxxxxx TitleXxxxxx Xxxxxxxxx Xxxxx: Senior Vice President, Immunology Development Chief Executive Officer MERGER SUB: RAINIER VIENNA ACQUISITION CORPORATION CORPORATION, a Delaware corporation By: /s/ Xxxxxxx X. Xxxxxxxx Xxxxxx Xxxxxxxxx Name: Xxxxxxx X. Xxxxxxxx TitleXxxxxx Xxxxxxxxx Xxxxx: President and Treasurer Chief Executive Officer The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERS: XXXX XXXXXX BySTOCKHOLDER: /s/ Xxxx Xxxxxx NameXxxxxxxxxx Xxxxxx Xxxxxxxxxx The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDER: Xxxx Xxxxxx POLARIS PARTNERS VIIQAR INDUSTRIES, L.P. INC. By: /s/ Xxxxxx Xxxxxxxx Xxxxxxxxxx Name: Xxxxxx Xxxxxxxx Xxxxxxxxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS FUND VII, L.P. By: /s/ Xxxxxx Xxxxxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact [Signature Page to Tender and Support Agreement] Schedule President SCHEDULE A Name of Stockholder Shares of Company Common Stock Vested Restricted Shares Company Stock Options QAR Industries, Inc. 498,884 0 0 Xxxxxx Xxxxxxxxxx 61,615 * 51,615 0 * Includes unvested shares of Company RSUs Xxxx Xxxxxx 145 99,163 0 Polaris Partners VII, L.P. 1,860,498 0 0Common Stock that are not eligible to be tendered. Schedule A

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX AND COMPANY By: /s/ Xxxx Xxxxxxxx Name: Xxxx Xxxxxxxx Title: Senior Vice President, Immunology Development MERGER SUB: RAINIER ACQUISITION CORPORATION By: /s/ Xxxxxxx X. Xxxxxxxx Name: Xxxxxxx X. Xxxxxxxx Title: President and Treasurer The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERS: XXXX XXXXXX XXXXXXX XXXXXXXX and TAS Partners, LLC By: /s/ Xxxx Xxxxxx Name: Xxxx Xxxxxx POLARIS PARTNERS VII, L.P. By: /s/ Xxxxxx Xxxxxxx Xxxxxxxx Name: Xxxxxx Xxxxxxx Xxxxxxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS FUND VIIHimself, L.P. By: /s/ Xxxxxx Xxxxxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact and Manager, TAS Partners LLC [Signature Page to Tender and Support Agreement] XXXXXX XX By: /s/ Xxxxxx Xx Name: Xxxxxx Xx [Signature Page to Tender and Support Agreement] XXXXXXXX-XX FAMILY 2004 IRREVOCABLE TRUST DATED MARCH 29, 2004 FBO – XXXXX By: Fiduciary Trust Company of New England LLC, its Trustee By: /s/ Xxxxxxx X. Xxxxx Name: Xxxxxxx X. Xxxxx Title: President & CEO XXXXXXXX-XX FAMILY 2004 IRREVOCABLE TRUST DATED MARCH 29, 2004 FBO – XXXXXXX By: Fiduciary Trust Company of New England LLC, its Trustee By: /s/ Xxxxxxx X. Xxxxx Name: Xxxxxxx X. Xxxxx Title: President & CEO Schedule A Name of Stockholder Shares of Company Common Stock Company Stock Options Company RSUs Xxxx Xxxxxxx Xxxxxxxx 4,608,052 193,537 0 Xxxxxx 145 99,163 Xx 42,873 0 Polaris Partners VII0 Xxxxxxxx-Xx Family 2004 Irrevocable Trust dated March 29, L.P. 1,860,498 2004 FBO – Kayla 107,183 0 0 Xxxxxxxx-Xx Family 2004 Irrevocable Trust dated March 29, 2004 FBO – Xxxxxxx 107,183 0 0

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Mxxxxx Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX EXX LXXXX AND COMPANY By: /s/ Xxxx Xxxxxxxx Dxxxx X. Xxxxx Name: Xxxx Xxxxxxxx Dxxxx X. Xxxxx Title: Senior Vice President, Immunology Development Chair and Chief Executive Officer MERGER SUB: RAINIER YOSEMITE FALLS ACQUISITION CORPORATION By: /s/ Pxxxxx X. Xxxxxxx X. Xxxxxxxx Name: Pxxxxx X. Xxxxxxx X. Xxxxxxxx Title: President and Treasurer The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERS: XXXX AXXXX XXXXXXX XXXXXX By: /s/ Xxxx Axxxx Xxxxxxx Xxxxxx MANOR DREW INVESTMENTS INC. By: /s/ Axxxx Xxxxxxx Xxxxxx Name: Xxxx Axxxx Xxxxxxx Xxxxxx POLARIS PARTNERS VII, L.P. HXXXX XXXXXX By: /s/ Hxxxx Xxxxxx Xxxxxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS FUND VII, L.P. AXXXX XXXXXX IN TRUST By: /s/ Axxxx Xxxxxxx Xxxxxx Xxxxxxxx Name: Axxxx Xxxxxxx Xxxxxx Xxxxxxxx TitleSXXXXX HOLDINGS INC. By: Attorney-in-fact [Signature Page to Tender and Support Agreement] /s/ Axxxx Xxxxxxx Xxxxxx Name: Axxxx Xxxxxxx Xxxxxx ANGLIAN HOLDINGS, LLC By: /s/ Axxxx Xxxxxxx Xxxxxx Name: Axxxx Xxxxxxx Xxxxxx Schedule A Name of Stockholder Shares of Company Common Stock Company PSUs Company Stock Options Company RSUs Xxxx Manor Drew Investments Inc. 4,268,605 0 0 Hxxxx Xxxxxx 145 99,163 313,884 0 Polaris Partners VII0 Sxxxxx Holdings Inc. 4,035,655 0 0 Anglian Holdings, L.P. 1,860,498 LLC 71,744 0 00 Axxxx Xxxxxxx Xxxxxx 0 33,469 876,585

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Merger Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX AND COMPANY By: /s/ Xxxx Xxxxxxxx Xxxxx X. Xxxxx Name: Xxxx Xxxxxxxx Xxxxx X. Xxxxx Title: Senior Vice PresidentChairman, Immunology Development MERGER SUB: RAINIER President and Chief Executive Officer BLUEGILL ACQUISITION CORPORATION By: /s/ Xxxxxxx Xxxxxx X. Xxxxxxxx Xxxxxx Name: Xxxxxxx Xxxxxx X. Xxxxxxxx Xxxxxx Title: President KPCB Holdings, Inc., as Nominee By: /s/ Xxxxx X Xxxxx Name: Xxxxx X. Xxxxx Title: President and Treasurer The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERSChairman Address: XXXX XXXXXX By: /s/ 0000 Xxxx Xxxxxx Name: Xxxx Xxxxxx POLARIS PARTNERS VIIXxxx Xxxxx Xxxx, L.P. By: /s/ Xxxxxx Xxxxxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS FUND VII, L.P. By: /s/ Xxxxxx Xxxxxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact Xxxxxxxxxx 00000 [Signature Page to Tender and Support Agreement] Schedule A Name of Stockholder Shares of Company Common Stock Company Stock Options Company RSUs OrbiMed Private Investments IV, LP By: OrbiMed Capital XX XX LLC. its General Partner By: OrbiMed Advisors LLC, its Managing Member By: /s/ Xxxx X. Xxxxxx 145 99,163 0 Polaris Partners VIIName: Xxxx X. Xxxxxx Title: Member OrbiMed Private Investments V, LP By: OrbiMed Capital GP V LLC. its General Partner By: OrbiMed Advisors LLC, its Managing Member By: /s/ Xxxx X. Xxxxxx Name: Xxxx X. Xxxxxx Title: Member Address: 000 Xxxxxxxxx Xxxxxx, 00xx Xxxxx Xxx Xxxx, XX 00000 [Signature Page to Tender and Support Agreement] QUAN VENTURE FUND I, L.P. 1,860,498 0 By: Quan Venture Partners I, L.L.C. Its: General Partner By: /s/ Xxxxxx Xx Name: Xxxxxx Xx Title: Managing Director Address: Jinchuang Plaza 4560 Jinke Rd., Bldg. 1N, Suite 000 Xxxxxxxxxx Xx-xxxx Xxxx, Xxxxxx Xxx Xxxx Xxxxxxxx, Xxxxx 000000 DECHENG CAPITAL CHINA LIFE SCIENCES USD FUND II, L.P. By: its General Partner, Decheng Capital Management II (Cayman), LLC By: /s/ Xxxxxxxx Xxx Xxxxxxxx Xxx Managing Director Address: 0000 Xxxx Xxxx Xxxx, Xxxxxxxx 0, Xxxxx 000 Xxxxx Xxxx, XX 00000 [Signature Page to Tender and Support Agreement] /s/ Xxxxx Van Vlasselaer, Ph.D. Xxxxx Van Vlasselaer, Ph.D. Address: 0000 Xxxxxxxx Xxxx Xxxxxxxx, XX 00000 EXHIBIT A

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Mxxxxx Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX EXX LXXXX AND COMPANY By: /s/ Xxxx Xxxxxxxx Dxxxx X. Xxxxx Name: Xxxx Xxxxxxxx Dxxxx X. Xxxxx Title: Senior Vice President, Immunology Development Chair and Chief Executive Officer MERGER SUB: RAINIER YOSEMITE FALLS ACQUISITION CORPORATION By: /s/ Pxxxxx X. Xxxxxxx X. Xxxxxxxx Name: Pxxxxx X. Xxxxxxx X. Xxxxxxxx Title: President and Treasurer The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERS: XXXX XXXXXX NXXX X. XXXXXXXX By: /s/ Xxxx Xxxxxx Nxxx X. Xxxxxxxx Name: Xxxx Xxxxxx POLARIS PARTNERS VII, L.P. Nxxx X. Xxxxxxxx 1510789 ONTARIO INC. By: /s/ Xxxxxx Nxxx X. Xxxxxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS FUND VII, L.P. Nxxx X. Fxxxxxxx XXXXXXXX XXXXX IN TRUST By: /s/ Xxxxxx Xxxxxxxx Pxxxxxxx Xxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact Pxxxxxxx Xxxxx [Signature Page to Tender and Support Agreement] Schedule A Name of Stockholder Shares of Company Common Stock Company PSUs Company Stock Options Company RSUs Xxxx Xxxxxx 145 99,163 1510789 Ontario Inc. 233,171 0 Polaris Partners VII, L.P. 1,860,498 0 0Pxxxxxxx Xxxxx in Trust 358 0 0 Nxxx X. Xxxxxxxx 3,023,045 6,062 169,491

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Merger Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX AND COMPANY By: /s/ Xxxx Xxxxxxxx Xxxxx X. Xxxxx Name: Xxxx Xxxxxxxx Xxxxx X. Xxxxx Title: Senior Vice President, Immunology Development Chairman and Chief Executive Officer MERGER SUB: RAINIER BALD EAGLE ACQUISITION CORPORATION By: /s/ Xxxxxxx X. Xxxxxxxx Xxxxxxxxx Name: Xxxxxxx X. Xxxxxxxx Xxxxxxxxx Title: President and Treasurer The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERSSTOCKHOLDER: XXXX XXXXXX NEW ENTERPRISE ASSOCIATES 13, L.P. By: /s/ Xxxx Xxxxxx NameNEA Partners 13, L.P. By: Xxxx Xxxxxx POLARIS PARTNERS VIINEA 13 GP, L.P. By: /s/ Xxxxx X. Xxxxxx Xxxxxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS FUND VIINEA VENTURES 2011, L.P. LIMITED PARTNERSHIP By: /s/ Xxxxx X. Xxxxxx Xxxxxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact [Signature Page to Tender and Support Agreement] Vice President Schedule A Name of Stockholder Stockholders Shares of Company Common Stock Company Stock Options Company RSUs Xxxx Xxxxxx 145 99,163 0 Polaris Partners VIINew Enterprise Associates 13, L.P. 1,860,498 0 03,502,922 N/A N/A NEA Ventures 2011, Limited Partnership 3,727 N/A N/A

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Merger Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. [Remainder of Page Intentionally Left Blank. Signature Pages Follow.] The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX AND COMPANY By: /s/ Xxxx Xxxxxxxx Xxxxx X. Xxxxx Name: Xxxx Xxxxxxxx Xxxxx X. Xxxxx Title: Senior Vice PresidentChairman, Immunology Development MERGER SUB: RAINIER President and Chief Executive Officer BLUEGILL ACQUISITION CORPORATION By: /s/ Xxxxxxx Xxxxxx X. Xxxxxxxx Xxxxxx Name: Xxxxxxx Xxxxxx X. Xxxxxxxx Xxxxxx Title: President [Signature Page to Tender and Support Agreement] KPCB Holdings, Inc., as Nominee By: /s/ Xxxxx X Xxxxx Name: Xxxxx X. Xxxxx Title: President and Treasurer The parties are executing this Agreement on the date set forth in the introductory clauseChairman Address: 0000 Xxxx Xxxx Xxxx Xxxxx Xxxx, Xxxxxxxxxx 00000 [Signature Page to Tender and Support Agreement] OrbiMed Private Investments IV, LP By: OrbiMed Capital XX XX LLC. STOCKHOLDERSits General Partner By: XXXX XXXXXX OrbiMed Advisors LLC, its Managing Member By: /s/ Xxxx X. Xxxxxx Name: Xxxx X. Xxxxxx POLARIS PARTNERS VIITitle: Member OrbiMed Private Investments V, LP By: OrbiMed Capital GP V LLC. its General Partner By: OrbiMed Advisors LLC, its Managing Member By: /s/ Xxxx X. Xxxxxx Name: Xxxx X. Xxxxxx Title: Member Address: 000 Xxxxxxxxx Xxxxxx, 00xx Xxxxx Xxx Xxxx, XX 00000 [Signature Page to Tender and Support Agreement] QUAN VENTURE FUND I, L.P. By: Quan Venture Partners I, L.L.C. Its: General Partner By: /s/ Xxxxxx Xxxxxxxx Xx Name: Xxxxxx Xxxxxxxx Xx Title: AttorneyManaging Director Address: Jinchuang Plaza 4560 Jinke Rd., Bldg. 1N, Suite 000 Xxxxxxxxxx Xx-in-fact POLARIS ENTREPRENEURS xxxx Xxxx, Xxxxxx Xxx Xxxx Xxxxxxxx, Xxxxx 000000 [Signature Page to Tender and Support Agreement] DECHENG CAPITAL CHINA LIFE SCIENCES USD FUND VIIII, L.P. By: its General Partner, Decheng Capital Management II (Cayman), LLC By: /s/ Xxxxxx Xxxxxxxx NameXxx Xxxxxxxx Xxx Managing Director Address: Xxxxxx 0000 Xxxx Xxxx Xxxx, Xxxxxxxx Title0, Xxxxx 000 Xxxxx Xxxx, XX 00000 [Signature Page to Tender and Support Agreement] /s/ Xxxxx Van Vlasselaer, Ph.D. Xxxxx Van Vlasselaer, Ph.D. Address: Attorney0000 Xxxxxxxx Xxxx Xxxxxxxx, XX 00000 [Signature Page to Tender and Support Agreement] EXHIBIT A FORM OF SPOUSAL CONSENT The undersigned represents that the undersigned is the spouse of Stockholder and that the undersigned is familiar with the terms of the Tender and Support Agreement (the “Agreement”), entered into as of May 9, 2018, by and among Xxx Xxxxx and Company, an Indiana corporation (“Parent”), Bluegill Acquisition Corporation, a Delaware corporation and a wholly-in-fact owned subsidiary of Parent (“Merger Sub”), and the undersigned’s spouse (the “Stockholder”). All capitalized terms that are used but not defined herein shall have the respective meanings ascribed to them in the Agreement. The undersigned hereby agrees that the interest of Stockholder in all property which is the subject of such Agreement shall be irrevocably bound by the terms of such Agreement and by any amendment, modification, waiver or termination signed by Stockholder. The undersigned further agrees that the undersigned’s community property interest in all property which is the subject of such Agreement shall be irrevocably bound by the terms of such Agreement, and that such Agreement shall be binding on the executors, administrators, heirs and assigns of the undersigned. The undersigned further authorizes Stockholder to amend, modify or terminate such Agreement, or waive any rights thereunder, and that each such amendment, modification, waiver or termination signed by Stockholder shall be binding on the community property interest of undersigned in all property which is the subject of such Agreement and on the executors, administrators, heirs and assigns of the undersigned, each as fully as if the undersigned had signed such amendment, modification, waiver or termination. Dated: May 9, 2018 SPOUSE: Signature: /s/ Xxxx Xxx Xxxx Print name: Xxxx Xxx Xxxx [Signature Page to Tender and Support Agreement] Schedule A Name of Stockholder Number of Shares of Company Common Stock Company Stock Options Company RSUs Xxxx Xxxxxx 145 99,163 0 Polaris Partners VIIXxxxxxx Xxxxxxx Xxxxxxxx & Xxxxx XIV, LLC (signed for by KPCB Holdings, Inc., as Nominee) 3,475,576 — KPCB XIV Founders Fund, LLC (signed for by KPCB Holdings, Inc., as Nominee) 294,029 — Xxxxxxx Xxxxxxx Xxxxxxxx & Xxxxx XVI, LLC (signed for by KPCB Holdings, Inc., as Nominee) 480,625 — KPCB XVI Founders Fund, LLC (signed for by KPCB Holdings, Inc., as Nominee) 16,453 — OrbiMed Private Investments IV, LP 3,709,356 — OrbiMed Private Investments V, LP 409,547 — Decheng Capital China Life Sciences USD Fund II, L.P. 1,860,498 0 01,214,700 — Quan Venture Fund I, L.P. 404,900 — Xxxxx Van Vlasselaer, Ph.D. 809,865 1,025,528 [Schedule A to Tender and Support Agreement] EXHIBIT A FORM OF SPOUSAL CONSENT The undersigned represents that the undersigned is the spouse of Stockholder and that the undersigned is familiar with the terms of the Tender and Support Agreement (the “Agreement”), entered into as of May 9, 2018, by and among Xxx Lilly and Company, an Indiana corporation (“Parent”), Bluegill Acquisition Corporation, a Delaware corporation and a wholly-owned subsidiary of Parent (“Merger Sub”), and the undersigned’s spouse (the “Stockholder”). All capitalized terms that are used but not defined herein shall have the respective meanings ascribed to them in the Agreement. The undersigned hereby agrees that the interest of Stockholder in all property which is the subject of such Agreement shall be irrevocably bound by the terms of such Agreement and by any amendment, modification, waiver or termination signed by Stockholder. The undersigned further agrees that the undersigned’s community property interest in all property which is the subject of such Agreement shall be irrevocably bound by the terms of such Agreement, and that such Agreement shall be binding on the executors, administrators, heirs and assigns of the undersigned. The undersigned further authorizes Stockholder to amend, modify or terminate such Agreement, or waive any rights thereunder, and that each such amendment, modification, waiver or termination signed by Stockholder shall be binding on the community property interest of undersigned in all property which is the subject of such Agreement and on the executors, administrators, heirs and assigns of the undersigned, each as fully as if the undersigned had signed such amendment, modification, waiver or termination. Dated: [•] SPOUSE: Signature:

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Merger Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX AND COMPANY ByCOMPANY, as Parent by: /s/ Xxxx Xxxxxxxx Xxxxx X. Xxxxx Name: Xxxx Xxxxxxxx Xxxxx X. Xxxxx Title: Senior Vice PresidentChairman, Immunology Development MERGER SUB: RAINIER President and Chief Executive Officer BOWFIN ACQUISITION CORPORATION ByCORPORATION, as Merger Sub by: /s/ Xxxxxx X. Xxxxxxx X. Xxxxxxxx Name: Xxxxxx X. Xxxxxxx X. Xxxxxxxx Title: President and Treasurer The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERS: XXXX XXXXXX By: /s/ Xxxx Xxxxxx Name: Xxxx Xxxxxx POLARIS PARTNERS VIIAISLING CAPITAL III, L.P. LP By: /s/ Xxxxxx Xxxxxxxx Xxxxxx Name: Xxxxxx Xxxxxxxx Xxxxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS FUND VIIChief Financial Officer Aisling Capital III, L.P. By000 Xxxxxxx Xxxxxx, 00xx Xxxxx Xxx Xxxx, XX 00000 Attn: /s/ Xxxxx Xxxx Fax: 000 000 0000 Email: xxxxx@xxxxxxxxxxxxxx.xxx and Aisling Capital III, L.P. 000 Xxxxxxx Xxxxxx, 00xx Xxxxx Xxx Xxxx, XX 00000 Attn: Chief Financial Officer Fax: 000 000 0000 Email: xxxxxxx@xxxxxxxxxxxxxx.xxx with a copy (which does not constitute notice) to: XxXxxxxxx Will & Xxxxx LLP 000 Xxxxxxx Xxxxxx Xxxxxxxx NameXxx Xxxx, XX 00000-0000 Attn: Xxxxxx Xxxxxxxx TitleXxxx Finger Fax: Attorney-in-fact [Signature Page to Tender and Support Agreement] 000 000 0000 Email: xxxxxxx@xxx.xxx Schedule A Name of Stockholder Stockholders Shares of Company Common Stock Company Stock Options Company RSUs Xxxx Xxxxxx 145 99,163 0 Polaris Partners VIIAisling Capital III, L.P. 1,860,498 0 0LP 2,038,920 N/A

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Merger Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX AND COMPANY Byby: /s/ Xxxx Xxxxxxxx Name: Xxxx Xxxxxxxx Xxxxx X. Xxxxx Title: Senior Vice President, Immunology Development Chairman and Chief Executive Officer MERGER SUB: RAINIER BALD EAGLE ACQUISITION CORPORATION Byby: /s/ Xxxxxxx X. Xxxxxxxx Name: Xxxxxxx X. Xxxxxxxx Xxxxxxxxx Title: President [Signature Page to Tender and Treasurer Support Agreement] The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERSSTOCKHOLDER: XXXX XXXXXX By: /s/ Xxxx Xxxxxx Name: Xxxx Xxxxxx POLARIS PARTNERS VIIBAY CITY CAPITAL FUND V, L.P. By: /s/ Xxxxxx Xxxxxxxx Its Bay City Capital Management V LLC, General Partner By: Its Bay City Capital LLC, Manager By: Name: Xxxxxx Xxxxxxxx Xxxx Craves Title: AttorneyManaging Director Address: 000 Xxxxxxx Xxxxxx, Xxxxx 000 Xxx Xxxxxxxxx, XX 00000 BAY CITY CAPITAL FUND V CO-in-fact POLARIS ENTREPRENEURS FUND VIIINVESTMENT FUND, L.P. By: /s/ Xxxxxx Xxxxxxxx Its Bay City Capital Management V LLC, General Partner By: Its Bay City Capital LLC, Manager By: Name: Xxxxxx Xxxxxxxx Xxxx Craves Title: Attorney-in-fact Managing Director Address: 000 Xxxxxxx Xxxxxx, Xxxxx 000 Xxx Xxxxxxxxx, XX 00000 BAY CITY CAPITAL, LLC By: Xxxx Craves, Manager Address: 000 Xxxxxxx Xxxxxx, Xxxxx 000 Xxx Xxxxxxxxx, XX 00000 [Signature Page to Tender and Support Agreement] Schedule A Name of Stockholder Stockholders Shares of Company Common Stock Company Stock Options Company RSUs Xxxx Xxxxxx 145 99,163 0 Polaris Partners VIIBay City Capital Fund V, L.P. 1,860,498 0 03,441,075 N/A N/A Bay City Capital Fund V Co-Investment Fund, L.P. 65,572 N/A N/A Bay City Capital LLC 6,000 38,688 3,000

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX AND COMPANY By: /s/ Xxxx Xxxxxxxx Xxxxx X. Xxxxx Name: Xxxx Xxxxxxxx Xxxxx X. Xxxxx Title: Senior Vice President, Immunology Development Chair and Chief Executive Officer MERGER SUB: RAINIER XXXXXXX ACQUISITION CORPORATION By: /s/ Xxxxxx X. Xxxxxxx X. Xxxxxxxx Name: Xxxxxx X. Xxxxxxx X. Xxxxxxxx Title: President and Treasurer The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERSSTOCKHOLDER: XXXX XXXXXX By: /s/ Xxxx Xxxxxx Name: Xxxx Xxxxxx POLARIS PARTNERS VIIRA CAPITAL HEALTHCARE FUND, L.P. By: RA Capital Healthcare Fund GP, LLC Its: General Partner By: /s/ Xxxxxx Xxxxxxxx Xxxx Name: Xxxxxx Xxxxxxxx Xxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS Manager The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDER: RA CAPITAL NEXUS FUND VIIII, L.P. By: RA Capital Nexus Fund II GP, LLC Its: General Partner By: /s/ Xxxxxx Xxxxxxxx Xxxx Name: Xxxxxx Xxxxxxxx Xxxx Title: Attorney-in-fact [Signature Page to Tender and Support Agreement] Manager Schedule A Name of Stockholder Shares of Company Common Stock Company Stock Options Company RSUs Xxxx Xxxxxx 145 99,163 0 Polaris Partners VIIRA Capital Healthcare Fund, L.P. 1,860,498 0 07,070,205 RA Capital Nexus Fund II, L.P. 786,407

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX AND COMPANY XXXXXX RESTAURANTS, INC. By: /s/ Xxxx Xxxxxxx Xxxxxxxx Name: Xxxx Xxxxxxx Xxxxxxxx Title: Senior Vice President, Immunology Development President and Chief Executive Officer MERGER SUB: RAINIER RUBY ACQUISITION CORPORATION By: /s/ Xxxxxxx X. Xxxxxxxx Xxxxx Name: Xxxxxxx X. Xxxxxxxx Xxxxx Title: President COMPANY: RUTH’S HOSPITALITY GROUP, INC. By: /s/ Xxxxxx Xxxxx Name: Xxxxxx Xxxxx Title: President and Treasurer The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERSChief Executive Officer STOCKHOLDERS By: XXXX XXXXXX /s/ Xxxxxx Xxxxx Name: Xxxxxx Xxxxx Address or E-mail: [**] By: /s/ Xxxxxxxxx Xxxxxxx Name: Xxxxxxxxx Xxxxxxx Address or E-mail: [**] By: /s/ Xxxx Xxxxxx Xxxxxxx Name: Xxxx Xxxxxx POLARIS PARTNERS VII, L.P. ByXxxxxxx Address or E-mail: /s/ Xxxxxx Xxxxxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS FUND VII, L.P. By: /s/ Xxxxxx Xxxxxxxx Name: Xxxxxx Xxxxxxxx Title: Attorney-in-fact [**] [Signature Page to Tender and Support Agreement] Schedule A Name of Stockholder Shares of Company Common Stock Company Stock Options Company RSUs By: /s/ Xxxxx X. Xxxxxx Name: Xxxxx X. Xxxxxx Address or E-mail: [**] By: /s/ Xxxxxxx X. Xxxx Name: Xxxxxxx X. Xxxx Address or E-mail: [**] By: /s/ Xxxxxxx X’Xxxxxxx Name: Xxxxxxx X’Xxxxxxx Address or E-mail: [**] By: /s/ Xxxxx X. Xxxxxx 145 99,163 0 Polaris Partners VII, L.P. 1,860,498 0 0Name: Xxxxx X. Xxxxxx Address or E-mail: [**] By: /s/ Xxxxx X. Xxxxx Name: Xxxxx X. Xxxxx Address or E-mail: [**] By: /s/ Xxxxxx Xxxxxxx Name: Xxxxxx Xxxxxxx Address or E-mail: [**] By: /s/ Xxxxx X. Xxxxx Name: Xxxxx X. Xxxxx Address or E-mail: [**] By: /s/ Xxxxx X. Xxxxx Name: Xxxxx X. Xxxxx Address or E-mail: [**]

Stockholder Obligation Several and Not Joint. The obligations of each Stockholder hereunder shall be several and not joint, and no Stockholder shall be liable for any breach of the terms of this Agreement by any other Stockholder. Further, Parent and Xxxxxx Merger Sub agree that no Stockholder will be liable for claims, losses, damages, liabilities or other obligations of, or incurred by, the Company resulting from the Company’s breach of the Merger Agreement except to the extent that breach of such Stockholder’s obligations hereunder was also involved in such breach by the Company. The parties are executing this Agreement on the date set forth in the introductory clause. PARENT: XXX XXXXX AND COMPANY By: /s/ Xxxx Xxxxxxxx Xxxxx X. Xxxxx Name: Xxxx Xxxxxxxx Xxxxx X. Xxxxx Title: Senior Vice President, Immunology Development Chairman and Chief Executive Officer MERGER SUB: RAINIER BALD EAGLE ACQUISITION CORPORATION By: /s/ Xxxxxxx X. Xxxxxxxx Xxxxxxxxx Name: Xxxxxxx X. Xxxxxxxx Xxxxxxxxx Title: President and Treasurer The parties are executing this Agreement on the date set forth in the introductory clause. STOCKHOLDERSSTOCKHOLDER: XXXX XXXXXX BAY CITY CAPITAL FUND V, L.P. By: Bay City Capital Management V LLC, Its General Partner By: Bay City Capital LLC, Its Manager By: /s/ Xxxx Xxxxxx Craves Name: Xxxx Xxxxxx POLARIS PARTNERS VIICraves Title: Managing Director Address: 000 Xxxxxxx Xxxxxx, Xxxxx 000 Xxx Xxxxxxxxx, XX 00000 BAY CITY CAPITAL FUND V CO-INVESTMENT FUND, L.P. By: /s/ Xxxxxx Xxxxxxxx NameBay City Capital Management V LLC, Its General Partner By: Xxxxxx Xxxxxxxx Title: Attorney-in-fact POLARIS ENTREPRENEURS FUND VIIBay City Capital LLC, L.P. Its Manager By: /s/ Xxxxxx Xxxxxxxx Xxxx Craves Name: Xxxxxx Xxxxxxxx Xxxx Craves Title: Attorney-in-fact [Signature Page to Tender and Support Agreement] Managing Director Address: 000 Xxxxxxx Xxxxxx, Xxxxx 000 Xxx Xxxxxxxxx, XX 00000 BAY CITY CAPITAL, LLC By: /s/ Xxxx Craves Xxxx Craves, Manager Address: 000 Xxxxxxx Xxxxxx, Xxxxx 000 Xxx Xxxxxxxxx, XX 00000 Schedule A Name of Stockholder Stockholders Shares of Company Common Stock Company Stock Options Company RSUs Xxxx Xxxxxx 145 99,163 0 Polaris Partners VIIBay City Capital Fund V, L.P. 1,860,498 0 03,441,075 N/A N/A Bay City Capital Fund V Co-Investment Fund, L.P. 65,572 N/A N/A Bay City Capital LLC 6,000 38,688 3,000