Common use of Trade Date Clause in Contracts

Trade Date. June 2, 2022 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMD”) Number of Warrants: 137,620. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 Premium Payment Date: June 6, 2022 Exchange: New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2February 5, 2022 2020 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDIART”) Number of Warrants: 137,620203,609. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275113.3400. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7957.83, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 1,162,500 Premium Payment Date: June 6February 7, 2022 2020 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 21, 2022 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMD”) Number of Warrants: 137,620963,340. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 12,600,000 Premium Payment Date: June 6, 2022 Exchange: New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2January 24, 2022 2019 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMD”) Number of Warrants: 137,620506,736. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275114.9225. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7969.6500, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 3,987,000.00 Premium Payment Date: June 6January 29, 2022 2019 Exchange: New York Stock Exchange NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 2January 25, 2022 2019 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMD”) Number of Warrants: 137,62076,010. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275114.9225. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7969.6500, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 598,050.00 Premium Payment Date: June 6January 29, 2022 2019 Exchange: New York Stock Exchange NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 2, 2022 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMD”) Number of Warrants: 137,62068,810. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 900,000 Premium Payment Date: June 6, 2022 Exchange: New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2December 12, 2022 2016 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The Class A common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDWWE”) Number of Warrants: 137,6203,612,645. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527531.8880. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7919.93, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 8,757,000 Premium Payment Date: June 6December 16, 2022 2016 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2May 11, 2022 2016 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDKN”) Number of Warrants: 137,620610,584. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527521.1050. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7913.06, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 2,548,125 Premium Payment Date: June 6May 13, 2022 2016 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2March 4, 2022 2016 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Date, subject to Section 9(w). Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock shares of Company, without par value USD 0.01 per share (Exchange symbol “CNMDIVC”) Number of Warrants: 137,620240,197. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527522.4175. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7914.22, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 330,000 Premium Payment Date: June 6Xxxxx 0, 2022 Exchange0000 Xxxxxxxx: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2December 12, 2022 2016 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The Class A common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDWWE”) Number of Warrants: 137,620802,810. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527531.8880. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7919.93, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 1,946,000 Premium Payment Date: June 6December 16, 2022 2016 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2, 2022 2015 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDON”) Number of Warrants: 137,620[ ]. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527525.9600. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7912.98, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 [ ] Premium Payment Date: June 68, 2022 2015 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 21, 2022 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMD”) Number of Warrants: 137,620481,670. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 6,300,000 Premium Payment Date: June 6, 2022 Exchange: New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 28, 2022 2016 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 0.001 per share (Exchange symbol “CNMDNVRO”) Number of Warrants: 137,62070,045. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275127.2775. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7972.73, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 1,296,000 Premium Payment Date: June 613, 2022 2016 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 214, 2022 2013 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share Share (Exchange symbol “CNMDMDRX”) Number of Warrants: 137,620654,603. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527523.1350. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to 13.22 (the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization“Strike Price Floor”). Premium: USD 1,800,000 1,670,625 Premium Payment Date: June 618, 2022 2013 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 28, 2022 2016 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 0.001 per share (Exchange symbol “CNMDNVRO”) Number of Warrants: 137,620116,741. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275127.2775. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7972.73, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 2,160,000 Premium Payment Date: June 613, 2022 2016 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 214, 2022 2013 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share Share (Exchange symbol “CNMDMDRX”) Number of Warrants: 137,6201,309,205. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527523.1350. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to 13.22 (the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization“Strike Price Floor”). Premium: USD 1,800,000 3,341,250.00 Premium Payment Date: June 618, 2022 2013 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 2May 28, 2022 2015 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share Share (Exchange symbol “CNMDAAWW”) Number of Warrants: 137,620945,252. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275. 95.0130 Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7957.86, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 11,315,500 Premium Payment Date: June 63, 2022 2015 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 2May 28, 2022 2015 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share Share (Exchange symbol “CNMDAAWW”) Number of Warrants: 137,6201,755,468. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275. 95.0130 Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7957.86, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 21,014,500 Premium Payment Date: June 63, 2022 2015 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 26, 2022 2018 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Date. Warrants: Equity call warrantsoptions, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDAVYA”) Number of Warrants: 137,6205,404,425. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike PriceMaximum Number of Shares: USD 251.5275For any day, 10,924,836 Shares, minus the aggregate number of Shares delivered prior to such day pursuant to (i) this Confirmation and (ii) any other substantially similar confirmation for Warrants sold by Company to Dealer with a trade date within 30 days of the Trade Date and with expiration dates the same as the Expiration Dates (the “Maximum Number of Shares”). Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price Maximum Number of Shares be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes a Potential Adjustment Event (as defined in Section 11.2(e) of the Equity Definitions and without any amendment thereto pursuant to Company’s capitalizationthe terms of this Confirmation). Strike Price: USD 37.3625 Premium: USD 1,800,000 24,945,000 Premium Payment Date: June 611, 2022 2018 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 214, 2022 2013 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share Share (Exchange symbol “CNMDMDRX”) Number of Warrants: 137,620654,603. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527523.1350. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to 13.22 (the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization“Strike Price Floor”). Premium: USD 1,800,000 1,670,625.00 Premium Payment Date: June 618, 2022 2013 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 212, 2022 2013 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share Share (Exchange symbol “CNMDMDRX”) Number of Warrants: 137,6208,728,034. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527523.1350. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to 13.22 (the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization“Strike Price Floor”). Premium: USD 1,800,000 22,275,000.00 Premium Payment Date: June 618, 2022 2013 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 212, 2022 2013 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share Share (Exchange symbol “CNMDMDRX”) Number of Warrants: 137,6204,364,018. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527523.1350. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to 13.22 (the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization“Strike Price Floor”). Premium: USD 1,800,000 11,137,500.00 Premium Payment Date: June 618, 2022 2013 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 2August 23, 2022 2012 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share Share (Exchange symbol “CNMDWMGI”) ). Number of Warrants: 137,6203,066,492. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527529.9250. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7919.95, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s 's capitalization. Premium: USD 1,800,000 8,994,750 Premium Payment Date: June 6August 31, 2022 2012 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 27, 2022 2016 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 0.001 per share (Exchange symbol “CNMDNVRO”) Number of Warrants: 137,620778,275. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275127.2775. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7972.73, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 14,400,000 Premium Payment Date: June 613, 2022 2016 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 26, 2022 2018 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Date. Warrants: Equity call warrantsoptions, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDAVYA”) Number of Warrants: 137,6202,161,770. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike PriceMaximum Number of Shares: USD 251.5275For any day, 4,369,934 Shares, minus the aggregate number of Shares delivered prior to such day pursuant to (i) this Confirmation and (ii) any other substantially similar confirmation for Warrants sold by Company to Dealer with a trade date within 30 days of the Trade Date and with expiration dates the same as the Expiration Dates (the “Maximum Number of Shares”). Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price Maximum Number of Shares be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes a Potential Adjustment Event (as defined in Section 11.2(e) of the Equity Definitions and without any amendment thereto pursuant to Company’s capitalizationthe terms of this Confirmation). Strike Price: USD 37.3625 Premium: USD 1,800,000 9,978,000 Premium Payment Date: June 611, 2022 2018 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2May 18, 2022 2017 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share Share (Exchange symbol “CNMDAAWW”) Number of Warrants: 137,620237,384. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275. 92.20 Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7959.85, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 1,914,000.00 Premium Payment Date: June 6May 23, 2022 2017 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 212, 2022 2014 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer JPMorgan Shares: The common stock of Company, par value USD 0.01 0.001 per share (Exchange symbol “CNMDARIA”) Number of Warrants: 137,62021,501,900. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527512.00. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.797.02, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 27,580,000 Premium Payment Date: June 617, 2022 2014 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 2January 11, 2022 2017 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The Class A common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDWWE”) Number of Warrants: 137,62060,211. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527531.8880. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7918.99, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 145,950 Premium Payment Date: June 6January 17, 2022 2017 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2April 1, 2022 2020 Effective Date: The second Exchange Business Day immediately prior With respect to Section 9(w) of this Confirmation, the Trade Date; otherwise, the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 0.001 per share (Exchange symbol “CNMDNVRO”) Number of Warrants: 137,6201,099,999. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275147.0000. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7984.00, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 21,263,550 Premium Payment Date: June April 6, 2022 2020 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2January 26, 2022 2017 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDHZN”) Number of Warrants: 137,6201,761,760. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527529.6000. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7918.76, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 7,554,800 Premium Payment Date: June 6February 1, 2022 2017 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2January 27, 2022 2017 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDHZN”) Number of Warrants: 137,620180,180. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527529.6000. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7919.44, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 772,650 Premium Payment Date: June 6February 1, 2022 2017 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2April 28, 2022 2016 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDKN”) Number of Warrants: 137,6202,442,335. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527521.1050. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7913.40, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 10,192,500 Premium Payment Date: June 6May 4, 2022 2016 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 226, 2022 2018 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Date. Warrants: Equity call warrantsoptions, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDAVYA”) Number of Warrants: 137,620540,443. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike PriceMaximum Number of Shares: USD 251.5275For any day, 6,554,902 Shares, minus the aggregate number of Shares delivered prior to such day pursuant to (i) this Confirmation and (ii) any other substantially similar confirmation for Warrants sold by Company to Dealer with a trade date within 30 days of the Trade Date and with expiration dates the same as the Expiration Dates (the “Maximum Number of Shares”). Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price Maximum Number of Shares be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes a Potential Adjustment Event (as defined in Section 11.2(e) of the Equity Definitions and without any amendment thereto pursuant to Company’s capitalizationthe terms of this Confirmation). Strike Price: USD 37.3625 Premium: USD 1,800,000 2,494,500 Premium Payment Date: June 628, 2022 2018 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2May 18, 2022 2017 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share Share (Exchange symbol “CNMDAAWW”) Number of Warrants: 137,620142,430. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275. 92.20 Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7959.85, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 1,148,400.00 Premium Payment Date: June 6May 23, 2022 2017 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 2December 5, 2022 2014 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Nomura Shares: The common stock of Company, par value USD 0.01 0.0001 per share (Exchange symbol “CNMDANIP”) Number of Warrants: 137,620269,843. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527596.21. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7953.28, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 2,693,399.74 Premium Payment Date: June 6December 10, 2022 2014 Exchange: New York Stock Exchange The NASDAQ Global Market Related Exchange(s): All Exchanges

Trade Date. June 21, 2022 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMD”) Number of Warrants: 137,620. 481,670 For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 6,300,000 Premium Payment Date: June 6, 2022 Exchange: New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2May 11, 2022 2016 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDKN”) Number of Warrants: 137,620366,350. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527521.1050. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7913.06, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 1,528,875 Premium Payment Date: June 6May 13, 2022 2016 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2May 18, 2022 2017 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share Share (Exchange symbol “CNMDAAWW”) Number of Warrants: 137,62094,954. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275. 92.20 Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7959.85, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 765,600.00 Premium Payment Date: June 6May 23, 2022 2017 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 2January 27, 2022 2017 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDHZN”) Number of Warrants: 137,620240,240. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527529.6000. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7919.44, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 1,030,200 Premium Payment Date: June 6February 1, 2022 2017 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2May 11, 2022 2016 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDKN”) Number of Warrants: 137,620244,233. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527521.1050. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7913.06, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 1,019,250 Premium Payment Date: June 6May 13, 2022 2016 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2May 17, 2022 2017 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 0.001 per share (Exchange symbol “CNMDRP”) Number of Warrants: 137,6203,575,895. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527557.5750. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7932.90, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 13,695,000.00 Premium Payment Date: June 6May 23, 2022 2017 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 2January 26, 2022 2017 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDHZN”) Number of Warrants: 137,6201,321,320. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527529.6000. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7918.76, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 5,666,100 Premium Payment Date: June 6February 1, 2022 2017 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2February 17, 2022 2016 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Date, subject to Section 9(w). Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock shares of Company, without par value USD 0.01 per share (Exchange symbol “CNMDIVC”) Number of Warrants: 137,6201,561,279. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527522.4175. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7914.22, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 2,145,000 Premium Payment Date: June 6February 23, 2022 2016 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2February 4, 2022 2020 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDIART”) Number of Warrants: 137,6201,357,390. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275113.3400. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7956.67, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 7,750,000 Premium Payment Date: June 6February 7, 2022 2020 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges

Trade Date. June 2January 11, 2022 2017 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The Class A common stock of Company, par value USD 0.01 per share (Exchange symbol “CNMDWWE”) Number of Warrants: 137,620270,948. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.527531.8880. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7918.99, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 656,775 Premium Payment Date: June 6January 17, 2022 2017 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 219, 2022 2017 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 0.001 per share Share (Exchange symbol “CNMDNOW”) Number of Warrants: 137,620[ ]. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275203.40. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.79103.60, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 [ ] Premium Payment Date: June 622, 2022 2017 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 27, 2022 2016 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 0.001 per share (Exchange symbol “CNMDNVRO”) Number of Warrants: 137,620466,965. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275127.2775. Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7972.73, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 8,640,000 Premium Payment Date: June 613, 2022 2016 Exchange: The New York Stock Exchange Related Exchange(s): All Exchanges

Trade Date. June 2May 17, 2022 2017 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Warrants: Equity call warrants, each giving the holder the right to purchase a number of Shares equal to the Warrant Entitlement at a price per Share equal to the Strike Price, subject to the terms set forth under the caption “Settlement Terms” below. For the purposes of the Equity Definitions, each reference to a Warrant herein shall be deemed to be a reference to a Call Option. Warrant Style: European Seller: Company Buyer: Dealer Shares: The common stock of Company, par value USD 0.01 per share Share (Exchange symbol “CNMDAAWW”) Number of Warrants: 137,620851,308. For the avoidance of doubt, the Number of Warrants shall be reduced by any Warrants exercised or deemed exercised hereunder. In no event will the Number of Warrants be less than zero. Warrant Entitlement: One Share per Warrant Strike Price: USD 251.5275. 92.20 Notwithstanding anything to the contrary in the Agreement, this Confirmation or the Equity Definitions, in no event shall the Strike Price be subject to adjustment to the extent that, after giving effect to such adjustment, the Strike Price would be less than USD 111.7959.85, except for any adjustment pursuant to the terms of this Confirmation and the Equity Definitions in connection with stock splits or similar changes to Company’s capitalization. Premium: USD 1,800,000 6,864,000.00 Premium Payment Date: June 6May 23, 2022 2017 Exchange: New York Stock Exchange The NASDAQ Global Select Market Related Exchange(s): All Exchanges