Common use of Trade Date Clause in Contracts

Trade Date. February 5, 2020 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IART”). Number of Options: 75,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 20% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.5739. Strike Price: USD 73.6708 Premium: USD 2,719,500 Premium Payment Date: February 7, 2020 Exchange: The NASDAQ Global Select Market Related Exchange(s): All Exchanges Excluded Provisions: Section 14.04(h) and Section 14.03 of the Indenture.

Trade Date. February 5June 1, 2020 2022 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTCNMD”). Number of Options: 75,000700,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 20% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.57396.8810. Strike Price: USD 73.6708 145.3277 Premium: USD 2,719,500 32,830,000 Premium Payment Date: February 7June 6, 2020 2022 Exchange: The NASDAQ Global Select Market New York Stock Exchange Related Exchange(s): All Exchanges Excluded Provisions: Section 14.03 and Section 14.04(h) and Section 14.03 of the Indenture.

Trade Date. February 5June 2, 2020 2022 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTCNMD”). Number of Options: 75,000100,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 20% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.57396.8810. Strike Price: USD 73.6708 145.3277 Premium: USD 2,719,500 4,690,000 Premium Payment Date: February 7June 6, 2020 2022 Exchange: The NASDAQ Global Select Market New York Stock Exchange Related Exchange(s): All Exchanges Excluded Provisions: Section 14.03 and Section 14.04(h) and Section 14.03 of the Indenture.

Trade Date. February 5June 2, 2020 2022 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTCNMD”). Number of Options: 75,000100,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 2010% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.57396.8810. Strike Price: USD 73.6708 145.3277 Premium: USD 2,719,500 2,345,000 Premium Payment Date: February 7June 6, 2020 2022 Exchange: The NASDAQ Global Select Market New York Stock Exchange Related Exchange(s): All Exchanges Excluded Provisions: Section 14.03 and Section 14.04(h) and Section 14.03 of the Indenture.

Trade Date. February 5June 1, 2020 2022 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTCNMD”). Number of Options: 75,000700,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 2010% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.57396.8810. Strike Price: USD 73.6708 145.3277 Premium: USD 2,719,500 16,415,000 Premium Payment Date: February 7June 6, 2020 2022 Exchange: The NASDAQ Global Select Market New York Stock Exchange Related Exchange(s): All Exchanges Excluded Provisions: Section 14.03 and Section 14.04(h) and Section 14.03 of the Indenture.

Trade Date. February 5January 24, 2020 2019 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTCNMD”). Number of Options: 75,000300,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 2015% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.573911.2608. Strike Price: USD 73.6708 88.8036 Premium: USD 2,719,500 6,678,000.00 Premium Payment Date: February 7January 29, 2020 2019 Exchange: The NASDAQ Global Select Market Related Exchange(s): All Exchanges Excluded Provisions: Section 14.03 and Section 14.04(h) and Section 14.03 of the Indenture.

Trade Date. February 54, 2020 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IART”). Number of Options: 75,000500,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 20% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.5739. Strike Price: USD 73.6708 Premium: USD 2,719,500 18,130,000 Premium Payment Date: February 7, 2020 Exchange: The NASDAQ Global Select Market Related Exchange(s): All Exchanges Excluded Provisions: Section 14.04(h) and Section 14.03 of the Indenture.

Trade Date. February 5June 26, 2020 2018 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTAVYA”). Number of Options: 75,00050,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 2030% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.573936.0295. Strike Price: USD 73.6708 27.76 Premium: USD 2,719,500 3,615,000 Premium Payment Date: February 7June 28, 2020 2018 Exchange: The NASDAQ Global Select Market New York Stock Exchange Related Exchange(s): All Exchanges Excluded Provisions: Section 14.04(h) 14.03 and Section 14.03 14.04(i) of the Indenture.

Trade Date. February 5August 12, 2020 2021 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The Class A common stock of Counterparty, par value USD 0.01 0.00001 per share (Exchange symbol “IARTFSR”). Number of Options: 75,000625,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 20% [***] Option Entitlement: A number equal to the product of the Applicable Percentage and 13.573950.7743. Strike Price: USD 73.6708 19.6950 Cap Price: USD 32.5725 Premium: USD 2,719,500 [***] Premium Payment Date: February 7August 17, 2020 2021 Exchange: The NASDAQ Global Select Market New York Stock Exchange Related Exchange(s): All Exchanges Excluded Provisions: Section 14.03 and Section 14.04(h) and Section 14.03 of the Indenture.

Trade Date. February 5June 26, 2020 2018 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTAVYA”). Number of Options: 75,00050,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 20% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.573936.0295. Strike Price: USD 73.6708 27.76 Premium: USD 2,719,500 2,410,000 Premium Payment Date: February 7June 28, 2020 2018 Exchange: The NASDAQ Global Select Market New York Stock Exchange Related Exchange(s): All Exchanges Excluded Provisions: Section 14.04(h) 14.03 and Section 14.03 14.04(i) of the Indenture.

Trade Date. February 5June 6, 2020 2018 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTAVYA”). Number of Options: 75,000300,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 2050% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.573936.0295. Strike Price: USD 73.6708 27.76 Premium: USD 2,719,500 36,150,000 Premium Payment Date: February 7June 11, 2020 2018 Exchange: The NASDAQ Global Select Market New York Stock Exchange Related Exchange(s): All Exchanges Excluded Provisions: Section 14.04(h) 14.03 and Section 14.03 14.04(i) of the Indenture.

Trade Date. February 5June 12, 2020 2013 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTMDRX”). Number of Options: 75,000300,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 2025% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.573958.1869. Strike Price: USD 73.6708 17.1860 Premium: USD 2,719,500 18,000,000.00 Premium Payment Date: February 7June 18, 2020 2013 Exchange: The NASDAQ Global Select Market Related Exchange(s): All Exchanges Excluded Provisions: Section 14.04(h14.04(g) and Section 14.03 of the Indenture.

Trade Date. February 5June 6, 2020 2018 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTAVYA”). Number of Options: 75,000300,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 2030% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.573936.0295. Strike Price: USD 73.6708 27.76 Premium: USD 2,719,500 21,690,000 Premium Payment Date: February 7June 11, 2020 2018 Exchange: The NASDAQ Global Select Market New York Stock Exchange Related Exchange(s): All Exchanges Excluded Provisions: Section 14.04(h) 14.03 and Section 14.03 14.04(i) of the Indenture.

Trade Date. February 5, 2020 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IART”). Number of Options: 75,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 2040% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.5739. Strike Price: USD 73.6708 Premium: USD 2,719,500 5,439,000 Premium Payment Date: February 7, 2020 Exchange: The NASDAQ Global Select Market Related Exchange(s): All Exchanges Excluded Provisions: Section 14.04(h) and Section 14.03 of the Indenture.

Trade Date. February 5June 12, 2020 2013 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTMDRX”). Number of Options: 75,000300,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 2050% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.573958.1869. Strike Price: USD 73.6708 17.1860 Premium: USD 2,719,500 36,000,000.00 Premium Payment Date: February 7June 18, 2020 2013 Exchange: The NASDAQ Global Select Market Related Exchange(s): All Exchanges Excluded Provisions: Section 14.04(h14.04(g) and Section 14.03 of the Indenture.

Trade Date. February 5January 24, 2020 2019 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTCNMD”). Number of Options: 75,000300,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 20% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.573911.2608. Strike Price: USD 73.6708 88.8036 Premium: USD 2,719,500 8,904,000.00 Premium Payment Date: February 7January 29, 2020 2019 Exchange: The NASDAQ Global Select Market Related Exchange(s): All Exchanges Excluded Provisions: Section 14.03 and Section 14.04(h) and Section 14.03 of the Indenture.

Trade Date. February 5June 6, 2020 2018 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTAVYA”). Number of Options: 75,000300,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 20% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.573936.0295. Strike Price: USD 73.6708 27.76 Premium: USD 2,719,500 14,460,000 Premium Payment Date: February 7June 11, 2020 2018 Exchange: The NASDAQ Global Select Market New York Stock Exchange Related Exchange(s): All Exchanges Excluded Provisions: Section 14.04(h) 14.03 and Section 14.03 14.04(i) of the Indenture.

Trade Date. February 54, 2020 Effective Date: The second Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IART”). Number of Options: 75,000500,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 2040% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.5739. Strike Price: USD 73.6708 Premium: USD 2,719,500 36,260,000 Premium Payment Date: February 7, 2020 Exchange: The NASDAQ Global Select Market Related Exchange(s): All Exchanges Excluded Provisions: Section 14.04(h) and Section 14.03 of the Indenture.

Trade Date. February 5June 2, 2020 2015 Effective Date: The second third Exchange Business Day immediately prior to the Premium Payment Date Option Style: “Modified American”, as described under “Procedures for Exercise” below Option Type: Call Buyer: Counterparty Seller: Dealer Shares: The common stock of Counterparty, par value USD 0.01 per share (Exchange symbol “IARTON”). Number of Options: 75,000600,000. For the avoidance of doubt, the Number of Options shall be reduced by any Options exercised by Counterparty. In no event will the Number of Options be less than zero. Applicable Percentage: 20[ ]% Option Entitlement: A number equal to the product of the Applicable Percentage and 13.573954.0643. Strike Price: USD 73.6708 18.4965 Premium: USD 2,719,500 [ ] Premium Payment Date: February 7June 8, 2020 2015 Exchange: The NASDAQ Global Select Market Related Exchange(s): All Exchanges Excluded Provisions: Section 14.04(h) and Section 14.03 of the Indenture.