Agreement of Joint Filing

Exhibit 1

Agreement of Joint Filing

Pursuant to 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, the undersigned persons hereby agree to file with the Securities and Exchange Commission the Statement on Schedule 13D (the “Statement”) to which this Agreement is attached as an exhibit, and agree that such Statement, as so filed, is filed on behalf of each of them.

IN WITNESS WHEREOF, the undersigned have executed this Agreement.

Dated: July 13, 2016

QVT FINANCIAL LP						QVT FUND V LP
By:		QVT Financial GP LLC, its General Partner				By:		QVT Associates GP LLC, its General Partner
By:		/s/ Xxxxxxxx Xxxxx				By:		/s/ Xxxxxxxx Xxxxx
Name:		Xxxxxxxx Xxxxx				Name:		Xxxxxxxx Xxxxx
Title:		Managing Member				Title:		Managing Member
By:		/s/ Xxxxx Xx				By:		/s/ Xxxxx Xx
Name:		Xxxxx Xx				Name:		Xxxxx Xx
Title:		Managing Member				Title:		Managing Member
QVT FINANCIAL GP LLC						QVT ASSOCIATES GP LLC
By:		/s/ Xxxxxxxx Xxxxx				By:		/s/ Xxxxxxxx Xxxxx
Name:		Xxxxxxxx Xxxxx				Name:		Xxxxxxxx Xxxxx
Title:		Managing Member				Title:		Managing Member
By:		/s/ Xxxxx Xx				By:		/s/ Xxxxx Xx
Name:		Xxxxx Xx				Name:		Xxxxx Xx
Title:		Managing Member				Title:		Managing Member

Page 10 of 11 pages

Appendix A

Covered Persons

Name of Covered Person		Principal Business Address		Principal Occupation
Xxxxxx Xxxx		QVT Financial LP 1177 Avenue of the Xxxxxxxx, 0xx Xxxxx Xxx Xxxx, Xxx Xxxx 00000		Investment Management
Xxxxxxxx Xxxxx		QVT Financial LP 1177 Avenue of the Xxxxxxxx, 0xx Xxxxx Xxx Xxxx, Xxx Xxxx 00000		Investment Management
Xxxxxx Xxx		QVT Financial LP 1177 Avenue of the Xxxxxxxx, 0xx Xxxxx Xxx Xxxx, Xxx Xxxx 00000		Investment Management
Xxxxx Xx		QVT Financial LP 1177 Avenue of the Xxxxxxxx, 0xx Xxxxx Xxx Xxxx, Xxx Xxxx 00000		Investment Management

Page 11 of 11 pages