ACCESSION AGREEMENT CLASS B SHAREHOLDERS AGREEMENT

Exhibit 4.5

Execution Copy

ACCESSION AGREEMENT CLASS B SHAREHOLDERS AGREEMENT

This Accession Agreement (the “Agreement”) is made on 25 May 2012 and made between

(1) COÖPERATIEVE AAC LS U.A., a coöperative (coöperatie) incorporated under the laws of the Netherlands with its corporate seat in Amsterdam, and its business address at Xxxxxxxx 0 00, 0000 XX Xxxxxxx, xxx Xxxxxxxxxxx and registered with the Commercial Register of Gooi-, Eem- en Flevoland under number 34256402 (the “Existing Investor I”);

(2) FORBION CO-INVESTMENT COÖPERATIEF U.A., a coöperative (coöperatie) incorporated under the laws of the Netherlands with its registered office in Naarden, and its business address at Xxxxxxxx 0 00, 0000 XX Xxxxxxx, xxx Xxxxxxxxxxx and registered with the Commercial Register of Gooi-, Eem- en Flevoland under number 32142360 (the “Existing Investor II”);

(3) FORBION CO-INVESTMENT II COÖPERATIEF U.A., a coöperative (coöperatie) incorporated under the laws of the Netherlands with its registered office in Naarden, and its business address at Xxxxxxxx 0 00, 0000 XX Xxxxxxx, xxx Xxxxxxxxxxx and registered with the Commercial Register of Gooi-, Eem- en Flevoland under number 53958713 (the “New Investor I”);

(4) COÖPERATIEVE GILDE HEALTHCARE II U.A., a coöperative (coöperatie) incorporated under the laws of the Netherlands with its corporate seat in Utrecht, and its business address at Xxxxxxxxxx 00 (0000 XX), xxx Xxxxxxxxxxx and registered with the Commercial Register of Midden-Nederland under number 30216414 (the “New Investor II”);

(5) STICHTING ADMINISTRATIEKANTOOR UNIQURE B.V., a foundation organised under the laws of the Netherlands, having its registered office in Amsterdam, at Xxxxxxxxxxxx 00, 0000 XX Xxxxxxxxx Zuidoost, the Netherlands and registered with the Commercial Register of Amsterdam under number 55055036 (the “Trust Foundation”);

(6) UNIQURE B.V., a private company with limited liability (besloten vennootschap met beperkte aansprakelijkheid), incorporated under the laws of the Netherlands with its registered office in Amsterdam, and its business address at Xxxxxxxxxxxx 00, 0000 XX Xxxxxxxxx Zuidoost, the Netherlands and registered with the Commercial Register of Amsterdam under number 54385229 (the “Company”);

(7) S.J.H. VAN DEVENTER C.V., a Dutch limited partnership (commanditaire vennootschap), having its registered address at 1411 DC Naarden, Gooimeer 2 35, registered in the trade register under number 32158843 (the “New Shareholder 1”);

(8) CREDIT LYONNAIS INNOVATION 6, a French venture capital fund (Fonds Commun de Placement dans l’Innovation), having its business location at 000 Xxxxxxxxx xx Xxxxxxxxxxxx, 00000 Xxxxx, Xxxxxx (the “New Shareholder 2”), which is represented by its managing company the French limited liability company (société anonyme à directoire et conseil de surveillance) OMNES Capital, incorporated and existing under the laws of France, having its registered address at 000 Xxxxxxxxx xx Xxxxxxxxxxxx, 00000 Xxxxx, Xxxxxx and registered with the French Registry of Commerce and Companies under number 428 711 196 TCS Paris (“OMNES Capital”);

(9) LCL INNOVATION 1, a French venture capital fund (Fonds commun de placement dans l’innovation), having its business location at 000 Xxxxxxxxx xx Xxxxxxxxxxxx, 00000 Xxxxx, Xxxxxx (the “New Shareholder 3”), which is represented by OMNES Capital;

(10) CLVC, a French corporation (Société anonyme), incorporated and existing under the laws of France, having its registered office at 000 Xxxxxxxxx xx Xxxxxxxxxxxx, 00000 Xxxxx, Xxxxxx, and registered with the French Registry of Commerce and Companies under number 434.465.514 RCS Paris, France (the “New Shareholder 4”), which is represented by OMNES Capital;

(11) CLV 1, a French Fonds Commun de Placement à Risques,  having its business location at 000 Xxxxxxxxx xx Xxxxxxxxxxxx, 00000 Xxxxx, Xxxxxx (the “New Shareholder 5”), which is represented by OMNES Capital;

(12) ADVENT PRIVATE EQUITY FUND IV, an English partnership, incorporated and existing under the laws of the United Kingdom, having its registered address at 00 Xxxxxxxxxx Xxxx, Xxxxxx, XX0X 0XX, Xxxxxx Xxxxxxx and registered in England and Wales under number LP10002 (the “New Shareholder 6”);

(13) ADVENT MANAGEMENT IV LP, a Scottish limited partnership, incorporated and existing under the laws of Scotland, having its registered address at 00 Xxxxxxx Xxxx, Xxxxxxxx Xxxxxx, Xxxxxxxxx, XX0 0XX, Xxxxxx Xxxxxxx and registered in Scotland under number SL005366 (the “New Shareholder 7”);

(14) TIVERINA INVERSIONES S.L., a Spanish private company with limited liability, having its place of business at Xxxxx Xxxxxxx xx00 0x, Xxxxxx, Xxxxx, with Tax Identification Number B-85381960 (the “New Shareholder 8”);

(15) ABADAI INVERSIONES S.L., a Spanish private company with limited liability, having its place of business at Xxxxx Xxxxxxx xx00 0x, Xxxxxx, Xxxxx, with Tax Identification Number B-85383511 (the “New Shareholder 9”);

(16) SURRIC INVERSIONES S.L., a Spanish private company with limited liability, having its place of business at Xxxxx Xxxxxxx xx00 0x, Xxxxxx, Xxxxx, with Tax Identification Number B-85381507 (the “New Shareholder 10”);

(17) HILOS Y POLO S.L., a Spanish private company with limited liability, having its place of business at Xxxxx Xxxxxxx xx00 0x, Xxxxxx, Xxxxx, with Tax Identification Number B-83914481 (the “New Shareholder 11”);

(18) XXXXX XXXX-XXXXXXXX XXXX-XXXXXXXX, with professional domicile at Madrid, Calle Zurbano nº76 6ª and holder of a National Identity Card with number  31.241.827-F (the “New Shareholder 12”);

(19) ACTIVOS Y TENENCIAS 85 S.L., a Spanish private company with limited liability, having its place of business at Xxxxx Xxx Xxxxxx 00 X, Xxxxxx Xxxxx, with Tax identification number B-84366111 (the “New Shareholder 13”);

(20) FUNDACION PARA EL DESARROLLO Y LA COOPERACION INTERNACIONAL, having its place of business at Xxxxx Xxxx Xxxxxxx xx00 0x, Xxxxxx, Xxxxx, with Tax identification number G-80787161 (the “New Shareholder 14”);

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(21) FUNDACION UNIVERSITARIA XX XXXXXXX, having its place of business at Avd. Xxx XXX 00 0x, Xxxxxxxx, Xxxxx, with Tax Identification Number G-31469125 (the “New Shareholder 15”);

(22) XXXX XXXX XXXXXXX PLAZA, with professional domicile at Madrid, Calle del Pastor 4 and holder of a National Identity Card with number 02.153.208-V (the “New Shareholder 16”);

(23) LUPUS ALPHA MICRO CHAMPIONS, a Sub Fund of Lupus alpha Fonds, a Fonds Commun de placement under Luxembourg law, for which and on behalf wherof Lupus alpha Investment S.A., 69, route x’Xxxx, X-0000 Xxxxxxxxxx, R.C.S. Luxembourg B-79272 (Management Company) acts  (the “New Shareholder 17”); and

(24) LUPUS ALPHA ALL OPPORTUNITIES FUND, a Sub Fund of Lupus alpha Fonds, a Fonds Commun de placement under Luxembourg law, for which and on behalf wherof Lupus alpha Investment S.A., 69, route x’Xxxx, X-0000 Xxxxxxxxxx, R.C.S. Luxembourg B-79272 (Management Company) acts (the “New Shareholder 18”),

The parties to this Agreement are hereinafter collectively referred to as the “Parties” and individually as a “Party”. The New Shareholders 1 up to and including 18 collectively referred to as the “New Shareholders” and individually as a “New Shareholder”.

RECITALS:

(A) By an issue of new Ordinary Shares Class A pursuant to conversion of Ordinary Shares Class B following the Exchange Offer:

(i) The Existing Investor I will acquire 4,193,568 Ordinary Shares Class A;

(ii) The Existing Investor II will acquire 1,794,117 Ordinary Shares Class A;

(iii) The New Investor II will acquire 6,081,803 Ordinary Shares Class A;

(iv) The New Shareholder 1  will acquire 49,298 Ordinary Shares Class A;

(v) The New Shareholder 2 will acquire 576,520 Ordinary Shares Class A;

(vi) the New Shareholder 3 will acquire 512,462 Ordinary Shares Class A;

(vii) the New Shareholder 4 will acquire 401,320 Ordinary Shares Class A;

(viii) the New Shareholder 5 will acquire 69,716 Ordinary Shares Class A;

(ix) the New Shareholder 6 will acquire 3,724,371 Ordinary Shares Class A;

(x) the New Shareholder 7 will acquire 37,241 Ordinary Shares Class A;

(xi) the New Shareholder 8 will acquire 478,084 Ordinary Shares Class A;

(xii) the New Shareholder 9 will acquire 210,824 Ordinary Shares Class A;

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(xiii) the New Shareholder 10 will acquire 210,824 Ordinary Shares Class A;

(xiv) the New Shareholder 11 will acquire 66,000 Ordinary Shares Class A;

(xv) the New Shareholder 12 will acquire 48,000 Ordinary Shares Class A;

(xvi) the New Shareholder 13 will acquire 31,764 Ordinary Shares Class A;

(xvii) the New Shareholder 14 will acquire 269,768 Ordinary Shares Class A;

(xviii) the New Shareholder 15 will acquire 230,631 Ordinary Shares Class A;

(xix) the New Shareholder 16 will acquire 10,000 Ordinary Shares Class A;

(xx) the New Shareholder 17 will acquire 1,560,000 Ordinary Shares Class A; and

(xxi) the New Shareholder 18 will acquire 850,000 Ordinary Shares Class A.

(B) This Agreement is entered into in compliance with the terms of the class B shareholders agreement dated 19 April 2012 between the Existing Investors, the New Investors, the Trust Foundation and the Company (all as defined therein) (which agreement is referred to in this Agreement as the “Class B Shareholders Agreement”).

The New Shareholder 1 up to and including the New Shareholder 18 collectively referred to as the “New Shareholders” and individually as a “New Shareholder”.

IT IS AGREED as follows:

(1) Definitions used in this Agreement have the same meaning as given to them in the Class B Shareholders Agreement unless stated otherwise and the provisions of Clause 1 (Interpretation) of the Class B Shareholders Agreement shall apply to this Agreement.

(2) With effect from the date of this Agreement, the New Shareholder becomes a Party to and will be bound by the terms of the Class B Shareholders Agreement in all respects as an Investor, under the condition precedent (opschortende voorwaarde) that the New Shareholder has acquired the Ordinary Shares Class A pursuant to the execution of the Exchange Offer as referred to in Recital A above.

(3) SCHEDULE A (Parties) to the Class B Shareholders Agreement shall be updated to properly reflect the relevant changes in the ownership of the Shares.

(4) The provisions of the Clauses 7.4, 7.5, 7.6, 7.7, 7.8, 7.12, 7.13 and 7.14 of the Class B Shareholders Agreement shall apply mutatis mutandis to this Agreement.

THUS AGREED AND SIGNED ON 25 May 2012

[signature pages to follow]

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This Agreement has been entered into on the date first above written.

Coöperatieve AAC LS U.A.			Coöperatieve AAC LS U.A.
/s/ H. A. Slootweg			/s/ M. A. van Osch
By: Forbion 1 Management B.V.			By: Forbion 1 Management B.V.
Title: Director			Title: Director
By:	H. A. Slootweg		By:	M. A. van Osch
Title:	Director		Title:	Director
Forbion Co-Investment Coöperatief U.A.			Forbion Co-Investment Coöperatief U.A.
/s/ H. A. Slootweg			/s/ M. A. van Osch
By: Forbion 1 Management B.V.			By: Forbion 1 Management B.V.
Title: Director			Title: Director
By:	H. A. Slootweg		By:	M. A. van Osch
Title:	Director		Title:	Director
Forbion Co-Investment II Coöperatief U.A.			Forbion Co-Investment II Coöperatief U.A.
/s/ H. A. Slootweg			/s/ M. A. van Osch
By: Forbion 1 Co II Management B.V.			By: Forbion 1 Co II Management B.V.
Title: Director			Title: Director
By:	H. A. Slootweg		By:	M. A. van Osch
Title:	Director		Title:	Director
Coöperatieve Gilde Healthcare II U.A.
/s/ Xxxxx xx Xxxx
By: Gilde Healthcare II Management B.V.
Title: Director
By:	Xxxxx xx Xxxx
Title:	Managing Partner
Stichting Administratiekantoor uniQure B.V.			Stichting Administratiekantoor uniQure B.V.
/s/ H. A. Slootweg			/s/ M. A. van Osch
By: Forbion 1 Co II Management B.V.			By: Forbion 1 Co II Management B.V.
Title: Director			Title: Director
By:	H. A. Slootweg		By:	M. A. van Osch
Title:	Director		Title:	Director
uniQure B.V.			uniQure B.V.
/s/ Xxxxx			/s/ X. X. Xxxxxx
By: XXXXX			By: X. X. Xxxxxx
Title: Director			Title: Director

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This Agreement has been entered into on the date first above written.

S.J.H. Van Deventer C.V.			S.J.H. Van Deventer C.V.
/s/ H. A. Slootweg			/s/ M. A. van Osch
By: Forbion Capital Partners Management Services B.V.			By: Forbion Capital Partners Management Services B.V.
Title: General Partner			Title: General Partner
By:	H. A. Slootweg		By:	M. A. van Osch
Title:	Director		Title:	Director

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This Agreement has been entered into on the date first above written.

Credit Lyonnais Innovation 6
/s/ Xxxxxx Xxxxxxx
By: OMNES capital
Title: Managing company
By:				Xxxxxx Xxxxxxx
Title:				Illegible
LCL Innovation 1
/s/ Xxxxxx Xxxxxxx
By: OMNES capital
Title: Managing company
By:			Xxxxxx Xxxxxxx
Title:			Illegible
CLVC
/s/ Xxxxxx Xxxxxxx
By:	Xxxxxx Xxxxxxx
Title:	Illegible
CLV 1
/s/ Xxxxxx Xxxxxxx
By: OMNES capital
Title: Managing company
By:		Xxxxxx Xxxxxxx
Title:		Illegible

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This Agreement has been entered into on the date first above written.

Advent Private Equity Fund IV LP				Advent Private Equity Fund IV LP
/s/ Signature Illegible				/s/ Signature Illegible
By: Advent Management IV Limited Partnership acting as General Partner by Advent Venture Partners LLP acting as Manager				By: Advent Management IV Limited Partnership acting as General Partner by Advent Venture Partners LLP acting as Manager
By:	Name Illegible			By:	Name Illegible
Title:	Partner			Title:	Partner
Advent Management IV Limited Partnership				Advent Management IV Limited Partnership
/s/ Signature Illegible				/s/ Signature Illegible
By: Advent Venture Partners LLP				By: Advent Venture Partners LLP
By:		Name Illegible		By:		Name Illegible
Title:		Partner		Title:		Partner

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This Agreement has been entered into on the date first above written.

Tiverina Inversiones S.L						Tiverina Inversiones S.L
/s/ Signature Illegible						N/A
By: Name Illegible						By:
Title: Director						Title: Director
By:						By:
Title:						Title:
Abadai Inversiones S.L						Abadai Inversiones S.L
/s/ Signature Illegible						N/A
By: Name Illegible						By:
Title: Director						Title: Director
By:						By:
Title:						Title:
Surric Inversiones S.L						Surric Inversiones S.L
/s/ Signature Illegible						N/A
By: Name Illegible						By:
Title: Director						Title: Director
By:						By:
Title:						Title:
Hilos y Polo S.L						Hilos y Polo S.L
/s/ Signature Illegible						N/A
By: Name Illegible						By:
Title: Director						Title: Director
By:						By:
Title:						Title:

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This Agreement has been entered into on the date first above written.

Xxxxx Xxxx-Xxxxxxxx Xxxx-Xxxxxxxx			Xxxx Xxxx Xxxxxxx Plaza
/s/ Signature Illegible			/s/ Signature Illegible
Activos y Tenencias 85 S.L			Acitvos y Tenencias 85 S.L
/s/ Signature Illegible			N/A
By: Name Illegible			By:
Title: Director			Title: Director
By:			By:	N/A
Title:			Title:
Fundacion para el			Fundacion para el
Desarrollo y la Cooperación Internacional			Desarrollo y la Cooperación Internacional
/s/ Signature Illegible			/s/ Signature Illegible
By: Name Illegible			By: Name Illegible
Title: Director			Title: Director
By:			By:
Title:			Title:
Fundacion Universitaria xx Xxxxxxx			Fundacion Universitaria xx Xxxxxxx
/s/ Signature Illegible			/s/ Signature Illegible
By:			By:
Title: Director			Title: Director
By:	Name Illegible		By:	Name Illegible
Title:	Director		Title:	CEO

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This Agreement has been entered into on the date first above written.

Lupus Alpha Micro Champions				Lupus Alpha Micro Champions
/s/ Signature Illegible		/s/ Signature Illegible		/s/ Signature Illegible		/s/ Signature Illegible
By: Lupus alpha Investment S.A.				By: Lupus alpha Investment S.A.
Title: Management Company				Title: Management Company
By:	Name Illegible	Name Illegible		By:	Name Illegible	Name Illegible
Title:	MD	MD		Title:	MD	MD
Lupus Alpha All Opportunities Fund				Lupus Alpha All Opportunities Fund
/s/ Signature Illegible		/s/ Signature Illegible		/s/ Signature Illegible		/s/ Signature Illegible
By: Lupus alpha Investment S.A.				By: Lupus alpha Investment S.A.
Title: Management Company				Title: Management Company
By:	Name Illegible	Name Illegible		By:	Name Illegible	Name Illegible
Title:	MD	MD		Title:	MD	MD

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