Agreement of Joint Filing

Exhibit 1

Agreement of Joint Filing

Pursuant to 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, the undersigned persons hereby agree to file with the Securities and Exchange Commission the Statement on Schedule 13D (the “Statement”) to which this Agreement is attached as an exhibit, and agree that such Statement, as so filed, is filed on behalf of each of them.

IN WITNESS WHEREOF, the undersigned have executed this Agreement.

Dated: July 13, 2016

QVT FINANCIAL LP				QVT FUND V LP
By:		QVT Financial GP LLC, its General Partner		By:		QVT Associates GP LLC, its General Partner
By:		/s/ Xxxxxxxx Xxxxx		By:		/s/ Xxxxxxxx Xxxxx
Name:		Xxxxxxxx Xxxxx		Name:		Xxxxxxxx Xxxxx
Title:		Managing Member		Title:		Managing Member
By:		/s/ Xxxxx Xx		By:		/s/ Xxxxx Xx
Name:		Xxxxx Xx		Name:		Xxxxx Xx
Title:		Managing Member		Title:		Managing Member
QVT FINANCIAL GP LLC				QVT ASSOCIATES GP LLC
By:		/s/ Xxxxxxxx Xxxxx		By:		/s/ Xxxxxxxx Xxxxx
Name:		Xxxxxxxx Xxxxx		Name:		Xxxxxxxx Xxxxx
Title:		Managing Member		Title:		Managing Member
By:		/s/ Xxxxx Xx		By:		/s/ Xxxxx Xx
Name:		Xxxxx Xx		Name:		Xxxxx Xx
Title:		Managing Member		Title:		Managing Member

Page 10 of 11 pages

Appendix A

Covered Persons

Name of Covered Person		Principal Business Address		Principal Occupation
Xxxxxx Xxxx		QVT Financial LP 1177 Avenue of the Xxxxxxxx, 0xx Xxxxx Xxx Xxxx, Xxx Xxxx 00000		Investment Management
Xxxxxxxx Xxxxx		QVT Financial LP 1177 Avenue of the Xxxxxxxx, 0xx Xxxxx Xxx Xxxx, Xxx Xxxx 00000		Investment Management
Xxxxxx Xxx		QVT Financial LP 1177 Avenue of the Xxxxxxxx, 0xx Xxxxx Xxx Xxxx, Xxx Xxxx 00000		Investment Management
Xxxxx Xx		QVT Financial LP 1177 Avenue of the Xxxxxxxx, 0xx Xxxxx Xxx Xxxx, Xxx Xxxx 00000		Investment Management

Page 11 of 11 pages