EXHIBIT 10.3 Stephen F. Brandon 200 North Oak Street Roanoke, Texas 76262 (817) 491-2770 November 22, 1996 Niche Pharmaceuticals, Inc. 200 North Oak Street P.O. Box 449 Roanoke, Texas 76262 Dear Sirs: I hereby agree to extend the due date of my loan...

                                                                 EXHIBIT 10.3

                               Xxxxxxx X. Xxxxxxx
                              000 Xxxxx Xxx Xxxxxx
                              Xxxxxxx, Xxxxx 00000
                                 (000) 000-0000


November 22, 1996


Niche Pharmaceuticals, Inc.
000 Xxxxx Xxx Xxxxxx
P.O. Box 449
Roanoke, Texas 76262

Dear Sirs:

I hereby agree to extend the due date of my loan to Niche Pharmaceuticals, Inc.,
originally dated January 11, 1991, in the original  principal amount of $500,000
(of which a principal balance of $295,487 remains outstanding as of the due date
hereof), from January 11, 1997 to January 11, 1998.

Sincerely,

/s/ Xxxxxxx X. Xxxxxxx
Xxxxxxx X. Xxxxxxx

READ AND AGREED
NICHE PHARMACEUTICALS, INC.

BY:/s/   Xxxxxxx X. Xxxxxxx, President