JOINT FILING AGREEMENT
Exhibit 1
The undersigned hereby agree that the Statement on Schedule 13G, dated October 28, 2009, with
respect to the shares of A.P. Pharma, Inc.’s Common Stock, par value $0.01 per share, is, and any
amendments thereto executed by each of us shall be, filed on behalf of each of us pursuant to and
in accordance with the provisions of Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as
amended, and that this Agreement shall be included as an Exhibit to the Schedule 13G and each such
amendment. Each of the undersigned agrees to be responsible for the timely filing of the Schedule
13G and any amendments thereto, and for the completeness and accuracy of the information concerning
itself contained therein. This Agreement may be executed in any number of counterparts, all of
which taken together shall constitute one and the same instrument.
IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the 28th day of
October, 2009.
| BOXER CAPITAL, LLC |
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| By: | /s/ Xxxxxxxxxxx Xxxxxxxxx | |||
| Name: | Xxxxxxxxxxx Xxxxxxxxx | |||
| Title: | Authorized Signatory | |||
| BOXER ASSET MANAGEMENT INC. |
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| By: | /s/ Xxxxxxxxx X. Xxxx | |||
| Name: | Xxxxxxxxx X. Xxxx | |||
| Title: | Director | |||
| XXXX XXXXXXXXXX |
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| By: | /s/ Xxxx Xxxxxxxxxx | |||
| Xxxx Xxxxxxxxxx, Individually | ||||
| XXXXXX XXXXX |
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| By: | /s/ Xxxxxx Xxxxx | |||
| Xxxxxx Xxxxx, Individually | ||||
