AMENDMENT TO WARRANT TO PURCHASE SERIES D PREFERRED STOCK OF ARTES MEDICAL, INC. (Issued in Connection with Interim Credit Facility 2005)

EXHIBIT 4.17

AMENDMENT TO
WARRANT TO PURCHASE SERIES D PREFERRED STOCK
OF ARTES MEDICAL, INC.
(Issued in Connection with Interim Credit Facility 2005)

     This Amendment dated as of June 23, 2006 (this “Amendment”), to each of the Warrants to Purchase Series D Preferred Stock (each, a “Warrant” and collectively, the “Warrants”) for the purchase of shares of Series D Preferred Stock of Artes Medical, Inc. (the “Company”), is made by and between the Company and each of the holders of one or more Warrants listed on Exhibit A (each, a “Holder” and collectively, the “Holders”).

RECITALS

     Whereas, pursuant to the Preamble of each Warrant, each of the Warrants expires and ceases to be exercisable on the earlier of (i) 5:00 P.M. Pacific Standard Time, on the date set forth under “Original Expiration Date” on Exhibit A hereto or (ii) the closing of (a) a Corporate Transaction (as defined in the Warrant) or (b) the initial underwritten public offering of the Company’s common stock pursuant to a registration statement filed under the Securities Act of 1933, as amended;

     Whereas, pursuant to Section 3 of each Warrant, each Holder is entitled to exercise such Holder’s Warrant through a “cashless exercise” feature by converting the Warrant into Warrant Shares (as defined in each of the Warrants) at any time or from time to time during the exercise period, the number of Warrant Shares to be computed using the Net Issuance formula provided in Section 3.1 of the Warrant; and

     Whereas, the Company and each of the Holders desire to amend the Warrants held by the Holders as set forth below.

AGREEMENT

     NOW, THEREFORE, IT IS HEREBY AGREED AS FOLLOWS:

     1. Amendment to Preamble. The first paragraph of the Preamble of each of the Warrants is hereby amended and restated in its entirety to read as follows:

     “Artes Medical USA, Inc., a Delaware corporation (the “Company”), hereby certifies that, for value received, ___(including any successors and assigns, “Holder”), is entitled, subject to the terms set forth below, to purchase from the Company at any time or from time to time before the earlier of (i) 5:00 P.M. Pacific Standard Time, on the date set forth with respect to this Warrant under “Original Expiration Date” on Exhibit A of this Amendment or (ii) the closing of a Corporate Transaction (the earlier to occur of (i) or (ii) the “Expiration Date”), fully paid and nonassessable shares of the Company’s Series D Preferred Stock (the “Warrant Shares”) under the terms set forth herein:”

     2. Amendment to Section 3. Section 3 of each of the Warrants is hereby deleted in its entirety.

     3. Governing Law. This Amendment shall be governed by and construed in accordance with the laws of the State of California as applied to agreements among California residents, entered into and to be performed entirely within California.

     4. Successors and Assigns. This Amendment shall be binding upon, and inure to the benefit of, the parties hereto, their respective successors and legal representatives and their permitted assigns.

     5. Warrant Terms to Remain in Effect. Except as specifically otherwise modified herein, each Warrant as previously executed remains in full force and effect.

     6. Effectiveness; No Amendment to Other Warrants. This Amendment shall become effective as to each of the Warrants upon the execution and delivery by each Holder of a Warrant Holder Election Form in the form provided by the Company to the Holder with respect to the applicable Warrant, indicating such Holder’s agreement to be bound by this Amendment. Notwithstanding Section 8.5 of each Warrant, this Amendment shall be effective only as to each Warrant that the applicable Holder has elected to amend as set forth in this Section 6, and shall not be effective as to any other warrant. Each Warrant so amended by this Amendment shall be listed on Exhibit A.

     7. Counterparts. This Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

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2

Acknowledged and agreed:		ARTES MEDICAL, INC.,
		a Delaware corporation
		By:
		Name:
		Title:

[Signature Page to Amendment to Warrant to Purchase Series D Preferred Stock]

EXHIBIT A

WARRANT HOLDERS

Number of

Shares

Underlying

Original

Name of Warrant Holder

Warrant

Exercise Price

Expiration Date

Xxxxxxx X. Xxxxx

75,000

$

2.00

05/10/10

IC-1, LLC

145,500

$

2.00

05/13/10

First Roseland Pension & Profit Sharing Plan

75,000

$

2.00

05/18/10