EXHIBIT I Agreement of Joint Filing Pursuant to Rule 13d-1(k)(1)(iii) of Regulation 13D-G of the General Rules and Regulations of the Securities and Exchange Commission under the Securities Exchange Act of 1934, as amended, the undersigned agree that...

                                                                       EXHIBIT I

Agreement of Joint Filing

                        Pursuant to Rule 13d-1(k)(1)(iii) of Regulation 13D-G of
                        the General Rules and Regulations of the Securities and
                        Exchange Commission under the Securities Exchange Act of
                        1934, as amended, the undersigned agree that the
                        statement to which this exhibit is attached is filed on
                        behalf of each of them in the capacities set forth
                        below.

Date: October 11, 2002
                                            XXXXX & NEPHEW PLC


                                            By: /s/ Xxxx Xxxxxxxx
                                                -----------------
                                               Name: Xxxx Xxxxxxxx
                                               Title: Company Secretary

                                            XXXXX & NEPHEW HOLDINGS, INC.


                                            By: /s/ Xxxxx X. Xxxxxxx
                                                --------------------
                                               Name: Xxxxx X. Xxxxxxx
                                               Title: President

                                            XXXXX & NEPHEW SNATS, INC.


                                            By: /s/ Xxxxx X. Xxxxxxx
                                                ---------------------
                                               Name: Xxxxx X. Xxxxxxx
                                               Title: Vice President & Treasurer