Exhibit 10.18
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FROM CD-451 U.S. DEPARTMENT OF COMMERCE [_] GRANT [X] COOPERATIVE
(REV.10-93) AGREEMENT
DAO 203-26 ------------------------------------------
AMENDMENT TO FINANCIAL ASSISTANCE AWARD ACCOUNTING CODE
**SEE BELOW
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RECIPIENT NAME AWARD NUMBER
CURAGEN CORPORATION 70NANB7H3004
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STREET ADDRESS AMENDMENT NUMBER
LONG WHARF MARITIME CENTER, 000 XXXX XXXXX XXXXX, 00XX FLOOR 01
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CITY, STATE, ZIP CODE EFFECTIVE DATE
XXX XXXXX, XX 00000 April 28, 1997
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EXTENDED WORK COMPLETION TO
N/A
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DEPARTMENT OF COMMERCE OPERATING UNIT
NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, XXXXXX XXXXXX
XXXXXXXX 000, XXXX X000, XXXXXXXXXXXX, XXXXXXXX 00000-0000
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COSTS ARE REVISED AS PREVIOUS ESTIMATED ADD DEDUCT TOTAL ESTIMATED COST
FOLLOWS: COSTS
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FEDERAL SHARE OF COST $2,000,000 $-0- $-0- $2,000,000
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RECIPIENT SHARE OF COST $-0- $-0- $-0- $-0-
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TOTAL ESTIMATED COST $2,000,000 $-0- $-0- $2,000,000
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REASON(S) FOR AMENDMENT
Project Title: Programmable Nonoscale Engines for Molecular Separation
This amendment is issued to change the Special Award Conditions as shown on the
attached page. Reference CuraGen Corporation's letter dated April 10, 1997.
ALL OTHER TERMS AND CONDITIONS REMAIN THE SAME.
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This Amendment approved by the Grants Officer is issued in triplicate and
constitutes an obligation of Federal funding. By signing the three documents,
the Recipient agrees to comply with the Amendment provisions checked below and
attached, as well as previous provisions incorporated into the Award. Upon
acceptance by the Recipient, two signed Amendment documents shall be returned to
the Grants Officer and the third document shall be retained by the Recipient. If
not signed and returned by the Recipient within 15 days of receipt, the Grants
Officer may declare this Amendment null and void.
[X] Special Award Conditions
[_] Line Item Budget
[_] Other(s):
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**ACCOUNTING CODE: 0-000-0000 Obj. Cl. 4110 Reg. No. 0-000-0000 $-0-
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B-AE93-N-C-F-N-A-09 00000 XXX: 00-0000000 470/S Xxxxxxxxxx
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SIGNATURE OF DEPARTMENT OF COMMERCE GRANT OFFICER TITLE DATE
/s/ Xxxxxx Xxxxxx Grants Officer 4/28/97
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TYPED NAME AND SIGNATURE OF AUTHORIZED RECIPIENT OFFICIAL TITLE DATE
/s/ Xxxxxxxxx X. Xxxxxxxx Director of Fund Mgmt. 5/6/97
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SPECIAL AWARD CONDITIONS
ADVANCED TECHNOLOGY PROGRAM - SINGLE RECIPIENT
COOPERATIVE AGREEMENT NO. 70NANB7H3004, Amendment #01
The following Special Award Conditions placed in the original award document
have been amended and are earmarked as such in "bold" print as follows:
1. RECIPIENT CONTACT
The recipient Contact's name, address, and telephone number are:
(Technical) Xxxx X. Xxxxx, Ph.d.
Telephone: (000)000-0000, Ext. 236
CuraGen Corporation
Long Wharf Maritime Center
000 Xxxx Xxxxx Xxxxx, 00xx Xxxxx
Xxx Xxxxx, XX 00000
(Administrative) Xxxxxxxxx X. Xxxxxxxx, C.P.A.
Telephone: (000)000-0000, Ext. 224
Fax: (000)000-0000
Curagen Corporation
Long Wharf Maritime Center
000 Xxxx Xxxxx Xxxxx, 00xx Xxxxx
Xxx Xxxxx, XX 00000
2. GRANTS OFFICER
The Grants Officer's name and address are:
Xxxxxx Xxxxxx
National Institute of Standards and Xxxxxxxxxx
Xxxx. 000, Xxxx X000
Xxxxxxxxxxxx, XX 00000-0000
3. GRANTS SPECIALIST
The Grants Specialist's name, address, and telephone number are:
Xxxxxxx Xxxxxxxxx
National Institute of Standards and Technology
Xxxx. 000, Xxxx X000
Xxxxxxxxxxxx, XX 00000-0000
(000)000-0000
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FROM CD-450 U.S. DEPARTMENT OF COMMERCE [_] GRANT [X] COOPERATIVE
(REV.10-93) AGREEMENT
DAO 203-26 ------------------------------------------
FINANCIAL ASSISTANCE AWARD ACCOUNTING CODE
**SEE BELOW
------------------------------------------------------------------------------------------------------------------------------
RECIPIENT NAME AWARD NUMBER
CURAGEN CORPORATION 70NANB7H3004
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STREET ADDRESS FEDERAL SHARE OF COST
LONG WHARF MARITIME CENTER, 000 XXXX XXXXX XXXXX, 00XX XXXXX 2,000,000
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CITY, STATE, ZIP CODE RECIPIENT SHARE OF COST
XXX XXXXX, XX 00000 -0-
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AWARD PERIOD TOTAL ESTIMATED COST
April 1, 1997 - March 31, 1999 2,000,000
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DEPARTMENT OF COMMERCE OPERATING UNIT
NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, XXXXXX XXXXXX
XXXXXXXX 000, XXXX X000, XXXXXXXXXXXX, XXXXXXXX 00000-0000
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AUTHORITY
Authorized by Section 5131 of P.L. 100-418, codified at 15 USC 278n as modified by P.L. 102-245 the Final Rule 15 CFR Part
295, and Program Announcement 96-01.
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PROJECT TITLE
Programmable Nanoscale Engines for Molecular Separation
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This Award approved by the Grants Officer is issued in triplicate and
constitutes an obligation of Federal funding. By signing the three documents,
the Recipient agrees to comply with the Award provisions checked below and
attached. Upon acceptance by the Recipient, two signed Award documents shall be
returned to the Grants Officer and the third document shall be retained by the
Recipient. If not signed and returned by the Recipient within 15 days of
receipt, the Grants Officer may declare this Award null and void.
[X] Department of Commerce Financial Assistance Standard Terms and Conditions
[X] Special Award Conditions
[X] Line Item Budget
[_] OMB Circular A-21, Cost Principles for Educational Institutions
[_] OMB Circular A-87, Cost Principles for State and Local Governments
[X] OMB Circular A-110, Grants and Agreements with Institutions of Higher
Education, Hospitals, and Other Nonprofit Organizations Uniform
Administrative Requirements
[_] OMB Circular A-122, Cost Principles of Nonprofit Organizations
[_] 15 CFR Part 24, Uniform Administrative Requirements for Grants and
Cooperative Agreements to State and Local Governments
[_] 15 CFR Part 29a, Audit Requirements for State and Local Governments
[_] 15 CFR Part 29b, Audit Requirements for Institutions of Higher Education
and Nonprofit Organizations
[X] 48 CFR Part 31, Contract Cost Principles and Procedures
[X] Other(s): General Terms and Conditions-Advanced Technology Program-Single
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Recipient - 3/97 Program Specific Audit Guidelines for Advanced Technology
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Program-Single Recipient - 11/96
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**ACCOUNTING CODE: CC: 0-000-0000 Obj. Class 4110 Req. No. 7470-2104 $1,000,000
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B-AE93-N-C-F-N-A-09 00000 XXX: 00-0000000 470/S Xxxxxxxxxx
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SIGNATURE OF DEPARTMENT OF COMMERCE GRANT OFFICER TITLE DATE
/s/ Xxxxxx Xxxxxx Grants Officer 4/28/97
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TYPED NAME AND SIGNATURE OF AUTHORIZED RECIPIENT OFFICIAL TITLE DATE
/s/ Xxxxxxxxx X. Xxxxxxxx Director of Fund Mgmt. 5/6/97
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SPECIAL AWARD CONDITIONS
ADVANCED TECHNOLOGY PROGRAM - SINGLE RECIPIENT
CuraGen, Corporation
COOPERATIVE AGREEMENT NO. 70NANB7H3004
1. RECIPIENT CONTACT
The Recipient Contact's name, address, and telephone number are:
(Technical) Xxxx X. Xxxxx, Ph.d.
(000)000-0000 Ext. 236
CuraGen, Corporation
Long Wharf Maritime Center
000 Xxxx Xxxxx Xxxxx, 00xx Xxxxx
Xxx Xxxxx, Xxxxxxxxxxx 00000
(Administrative) Xxxxxxxxx X. Xxxxxxxx, CPA
(000)000-0000 Ext. 224
CuraGen, Corporation
000 Xxxx Xxxx Xxxxxx
Xxxxxxxx, Xxxxxxxxxxx 00000
2. GRANTS OFFICER
The Grants Officer's name and address are:
Xxxxxx X. Xxxxxx
National Institute of Standards and Xxxxxxxxxx
Xxxx. 000, Xxxx X000
Xxxxxxxxxxxx, XX 00000-0000
3. GRANTS SPECIALIST
Xxxxxxx Xxxxxxxxx
National Institute of Standards and Xxxxxxxxxx
Xxxx. 000, Xxxx X000
Xxxxxxxxxxxx, XX 00000-0000
(000)000-0000
4. PROJECT MANAGEMENT
a. The Technical Project Manager's name, address, and telephone number are:
Xxxxxxx Xxxxxxxxxx
National Institute of Standards and Xxxxxxxxxx
Xxxx. 000, Xxxx X000
Xxxxxxxxxxxx, XX 00000-0000
(000)000-0000
b. The Business Project Manager's name, address, and telephone number are:
Xxxxx Xxxx
National Institute of Standards and Xxxxxxxxxx
Xxxx. 000, Xxxx X000
Xxxxxxxxxxxx, XX 00000-0000
(000)000-0000
The structure of the ATP Project Management Team is subject to change.
5. PROJECT DESCRIPTION
All research shall be conducted in accordance with the Recipient's proposal
dated September 17, 1996.
6. FUNDING LIMITATIONS
The scope of work and budget incorporated into this award covers a two-year
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period (referred to as the "project period") for a total amount of $2,000,000 in
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Federal funds. However, Federal funding available at this time is limited to
$1,000,000 for the first year period (referred to as the "budget period").
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Receipt of any additional funding up to the level projected under this award is
contingent upon the availability of funds from Congress, satisfactory
performance, and will be at the sole discretion of the Agency. The Recipient may
not obligate, incur any expenditures, nor engage in any commitments which
involve any amount in excess of the Federal amount presently available. No legal
liability will exist or result on the part of the Federal Government for payment
of any portion of the remaining funds which have not been made available under
the award. Should additional funds not be made available, expenses incurred
related to closeout activities must be funded from the amount included on this
award. The notice of availability or non-availability of additional funding for
the Second and Final year(s) will be made in writing only by the Grants Officer.
------ ----- --------------------------
This written notification shall be made prior to or no later than 30 days after
the expiration of each year's activities.
Proposed Future Funding:
Year Funds Budget Period
Yr 2 $1,000,000 04-01-98 - 03-31-99
7. VERTEBRATE ANIMALS
If this project involves the use of vertebrate animals, the Recipient is
required to comply, as applicable, with the Animal Welfare Act as amended, and
implementing regulations (7 USC 2131 et seq., 9 CFR parts 1, 2, and 3), and
other Federal Statutes and regulations relating to animals.
If vertebrate animals are involved, the Principal Investigator shall submit to
the ATP Program Manager:
(1) A completed Extramural Animal Study Proposal Form (NIST-1258), with singed
approvals by the International Animal Care and Use Committee (IACUC).
(2) Copies of other governmental approvals for Recipient's animal care and use
procedures and showing the current status of Recipient's assurance by the Public
Health Service/National Institutes of Health (PHS/NIH), and copies of animal
care facility accreditation.
(3) Certification that the Principal Investigator and other personnel involved
in the care and use of the animals are trained as required by NIST and the
PHS/NIH Guide for the Care and Use of Laboratory Animals.
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The Recipient must inform the ATP Program Manager in writing of any proposed
deviation from procedures involving animals described Form NIST-1258, any change
in personnel and their training, and change in the status of their PHS/NIH
assurance or other government inspecting bodies; and the results of any
inspections of their animal care facilities that take place during the course of
the award.
8. HUMAN SUBJECTS
If this project involves human subjects, the Department of Commerce Regulations,
15 CFR Part 27, require that recipients whose research involves human subjects
maintain appropriate policies and procedures for the protection of human
subjects. These regulations are available from the NIST Grants Office upon
request.
No research involving human subjects is permitted under this award until NIST
has reviewed and approved those activities.
9. CONTINGENCY
Recipient must conduct a separations demonstration in the middle of the second
year. The demonstration should show the experimental ability using the proposed
technology to separate two DNA samples having at least 100 oligoners that differ
by three bases. Continuation of research efforts and funding is contingent upon
the satisfactory demonstration of the above requirement and approval by the
ATP/NIST Program Manager and NIST Grants Officer.
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ESTIMATED MULTI-YEAR BUDGET-SINGLE COMPA_____
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YEAR ONE YEAR TWO YEAR THREE YEAR FOUR
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1. OBJECT CLASS CATEGORY
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A. Technical Personnel Salaries/Wages $544,000 $544,000 $1,088,000
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B. Technical Personnel Fringe Benefits 79,097 79,097 158,194
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C. Administrative Support Salaries/Wages 74,000 74,000 148,000
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D. Administrative Support Fringe Benefits 10,760 10,760 21,520
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E. Travel 18,000 18,000 36,000
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F. Equipment 75,143 75,143 150,266
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G. Materials/Supplies 134,000 134,000 268,000
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H. Subcontracts 60,000 60,000 120,000
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I. Other 5,000 5,000 10,000
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J. Total Direct Costs (Line A thru I) 1,000,000 1,000,000 2,000,000
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K. Total Direct Costs Requested From ATP 1,000,000 1,000,000 2,000,000
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L. Total Direct Costs Shared by Proposer 0 0 0
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M. Total Indirect Costs Absorbed by Proposer 715,410 715,410 1,430,820
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N. Total Costs (Lines K, L, and M) 1,1715,410 1,715,410 3,430,820
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2. SOURCES OF FUNDS
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A. ATP (Same as Line K) $1,000,000 $1,000,000 $2,000,000
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B. Company Funds 715,410 715,410 1,430,820
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C.
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D.
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E.
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F.
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G. Total Sources of Funds (Same as Line N) $1,715,410 $1,715,410 $3,430,820
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3. TASKS
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A. Separation Device $961,913 $965,913 $1,923,626
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B. Real-Time ImageEnhancement 320,637 320,637 641,274
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C. Biological Separations 432,860 432,860 865,720
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D.
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E.
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F.
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G. Total Costs of All Tasks (Same as Line N) $1,715,410 $1,715,410 $3,430,820
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