JOINT FILING AGREEMENT

EXHIBIT 99.1

JOINT FILING AGREEMENT

The undersigned hereby agree that a single Schedule 13D (or any amendment thereto) relating to the Common Stock of Skye Bioscience, Inc. shall be filed on behalf of each of the undersigned and that this Joint Filing Agreement shall be filed as an exhibit to such Schedule 13D.

Dated: December 19, 2024

5AM Ventures VII, L.P. By: 5AM Partners VII, LLC its General Partner By: /s/ Xxxxxx X. Xxxxxx Name: Xxxxxx X. Xxxxxx Title: Managing Member	5AM Partners VII, LLC By: /s/ Xxxxxx X. Xxxxxx Name: Xxxxxx X. Xxxxxx Title: Managing Member
5AM Ventures II, L.P. By: 5AM Partners II, LLC its General Partner By: /s/ Xxxxxx X. Xxxxxx Name: Xxxxxx X. Xxxxxx Title: Managing Member 5AM Co-Investors II, L.P. By: 5AM Partners II, LLC its General Partner By: /s/ Xxxxxx X. Xxxxxx Name: Xxxxxx X. Xxxxxx Title: Managing Member	5AM Partners II, LLC By: /s/ Xxxxxx X. Xxxxxx Name: Xxxxxx X. Xxxxxx Title: Managing Member
/s/ Xxxxxx X. Xxxxxx Xxxxxx X. Xxxxxx /s/ Xx. Xxxx Xxxxxx Xx. Xxxx Xxxxxx /s/ Xx. Xxxx X. Xxxxxxx Xx. Xxxx X. Xxxxxxx /s/ Xx. Xxxxx X. Xxxxxxxx Xx. Xxxxx X. Xxxxxxxx