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EXHIBIT 10.2
LICENSE AGREEMENT BETWEEN
XXXXXX XXXXXXXX COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
AND
PAIN THERAPEUTICS, INC.
TABLE OF CONTENTS
ARTICLE I
DEFINITIONS ............................................................... 2
1.1 "AFFILIATE" ................................................... 2
1.2 "AGENCY" ...................................................... 2
1.3 "CALENDAR QUARTER" ............................................ 2
1.4 "CALENDAR YEAR" ............................................... 3
1.5 "CONFIDENTIAL INFORMATION" .................................... 3
1.6 "DEVELOPMENT SCHEDULE" ........................................ 3
1.7 "FIRST COMMERCIAL SALE" ....................................... 3
1.8 "IND" ......................................................... 3
1.9 "KNOW-HOW" .................................................... 3
1.10 "LICENSED PRODUCT" ............................................ 4
1.11 "MAJOR COUNTRIES" ............................................. 4
1.12 "NDA" ......................................................... 4
1.13 "NET SALES" ................................................... 4
1.14 "NET PROCEEDS" ................................................ 5
1.15 "PATENT RIGHTS" ............................................... 5
1.16 "SUBLICENSEE" ................................................. 6
1.17 "TERRITORY" ................................................... 6
1.18 "VALID PATENT CLAIM" .......................................... 6
ARTICLE II
PATENT RIGHTS AND KNOW-HOW .................................................6
ARTICLE III
PAYMENTS ...................................................................8
Table I ...................................................................10
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ARTICLE IV
ROYALTIES AND REPORTS .................................................... 11
ARTICLE V
DEVELOPMENT AND COMMERCIALIZATION ........................................ 17
ARTICLE VI
CONFIDENTIALITY AND PUBLICATION .......................................... 18
ARTICLE VII
PATENTS .................................................................. 21
ARTICLE VIII
TERM AND TERMINATION ..................................................... 24
ARTICLE IX
INDEMNIFICATION .......................................................... 26
ARTICLE X
MISCELLANEOUS ............................................................ 28
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LICENSE AGREEMENT
THIS AGREEMENT, effective as of the date of last signature by a party
hereto (the "Effective Date"), is entered into by and between Xxxxxx Xxxxxxxx
College of Medicine of Yeshiva University, a division of Yeshiva University, a
corporation existing under the laws of the State of New York, having an office
and place of business at 0000 Xxxxxx Xxxx Xxxxxx, Xxxxx, Xxx Xxxx 00000
("UNIVERSITY") and Pain Therapeutics, Inc., a corporation organized and existing
under the laws of Delaware and having its principal office at 0000 Xxxxxxx
Xxxxxx, Xxx Xxxxxxxxx, XX 00000 ("LICENSEE").
WITNESSETH
WHEREAS, in the course of research conducted under UNIVERSITY auspices
by Xx. Xxxxxxx X. Xxxxx and Dr. Ke-Xxx Xxxx in the Department of Neuroscience of
UNIVERSITY certain Know-How and Patent Rights have been developed;
WHEREAS, pursuant to assignments by Xx. Xxxxx and Xx. Xxxx to
UNIVERSITY, which assignments have been recorded in the U.S. Patent and
Trademark Office, UNIVERSITY is the owner of the Know-How and Patent Rights, and
has the right to grant licenses under the Know-How and Patent Rights;
WHEREAS, UNIVERSITY desires to have the Patent Rights utilized in the
public interest and is willing to grant a license to its interest thereunder,
WHEREAS, LICENSEE desires to obtain a license under the Patent Rights
and Know-How in accordance with the terms and conditions set forth herein, to
commercially develop and exploit the Patent Rights and Know-How;
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NOW, THEREFORE, in consideration of the mutual covenants and agreements
of the parties herein contained, the parties hereto, intending to be legally
bound, do hereby agree as follows.
ARTICLE I
DEFINITIONS
The terms in this Agreement with initial letters capitalized, whether
used in the singular or plural, shall have the meaning designated below or, if
not designated below, the meaning as designated in places throughout this
Agreement.
1.1 "AFFILIATE" means any corporation or other entity which controls, is
controlled by, or is under common control with a party to this Agreement. A
corporation or other entity shall be regarded as in control of another
corporation or entity if it owns or directly or indirectly controls more
than fifty percent (50%) of the voting stock or other ownership interest of
the other corporation or entity, or if it possesses, directly or
indirectly, the power to direct or cause the direction of the management
and policies of the corporation or other entity or the power to elect or
appoint more than fifty percent (50%) of the members of the governing body
of the corporation or other entity.
1.2 "AGENCY" means any governmental regulatory authority responsible for
granting health or pricing approvals, registrations, import permits, and
other approvals required before Licensed Product may be tested or marketed
in any country.
1.3 "CALENDAR QUARTER" means the respective periods of three (3) consecutive
calendar months ending on March 31, June 30, September 30 and December 31.
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1.4 "CALENDAR YEAR" means each successive period of twelve (12) months
commencing on January 1 and ending on December 31.
1.5 "CONFIDENTIAL INFORMATION" means and includes, without limitation,
information and data of one party supplied to the other, know-how, and all
other scientific, clinical, regulatory, marketing, financial and commercial
information or data, whether communicated in writing or orally or by other
means, which is provided by one party to the other party in connection with
this Agreement, and which is designated confidential by the disclosing
party.
1.6 "DEVELOPMENT SCHEDULE"' shall have the meaning set forth in Section 5.2
hereof.
1.7 "FIRST COMMERCIAL SALE" means, with respect to a Licensed Product, the
first sale for use or consumption by the public of such Licensed Product in
a country after all required approvals, including marketing and pricing
approvals, have been granted by the governing health authority of such
country.
1.8 "IND" means Investigational New Drug application, or the like, as defined
in the applicable laws and regulations of the governmental drug regulatory
agencies in each country.
1.9 "KNOW-HOW" means all information and materials, including but not limited
to, technology, experience, discoveries, improvements, processes, formulae,
data (including but not limited to all preclinical, clinical,
toxicological, and pharmacological data) and inventions, trade secrets,
patentable or otherwise, developed by UNIVERSITY through Drs. Xxxxx and
Shen, which on the Effective Date of this Agreement are in UNIVERSITY's
possession and control, are not generally known and are necessary or useful
for LICENSEE in the research,
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development, manufacture, marketing, use or sale of compositions or methods
for the attenuation of opioid tolerance and dependence and the enhancement
of opioid analgesic potency. Know-How shall also include any Know-How and
improvements or modifications to the Know-How which are developed by
UNIVERSITY through Drs. Xxxxx, Xxxx and their staff after the Effective
Date of this Agreement as a result of any research funding provided by
LICENSEE to UNIVERSITY pursuant to this Agreement.
1.10 "LICENSED PRODUCT" means any and all formulations for human pharmaceutical
or animal health use, the manufacture, importation use or sale of which
would (a) infringe a Valid Patent Claim but for the license provided under
Article II hereof or (b) involve the use of Know-How.
1.11 "MAJOR COUNTRIES" means the following countries: United States, Canada,
Japan and collectively the European Community.
1.12 "NDA" means a New Drug Application in the U.S. or the corresponding
application for authorization for marketing of Licensed Product in any
other country, as defined in the applicable laws and regulations and filed
with the Agency of a given country.
1.13 "NET SALES" means the aggregate gross invoice price of Licensed Product
sold by LICENSEE, its Affiliates and Sublicensees to an independent third
party, including without limitation distributors, after deducting (to the
extent not already deducted in the amount invoiced):
(i) trade and quantity discounts given;
(ii) returns and allowances;
(iii) rebates, chargebacks and other amounts paid, credited or
accrued;
(iv) retroactive price reductions;
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(v) sales commissions paid to distributors and/or selling
agents;
(vi) a fixed amount equal to five percent (5%) for U.S. sales
and ten percent (10%) for sales outside the U.S., of the
amount invoiced to cover bad debt, custom duties,
surcharges, sales or excise taxes, cash discounts,
transportation and insurance charges; and
(vii) as agreed by the parties, any other specifically
identifiable amounts included in gross sales that were or
ultimately will be credited and that are substantially
similar to those listed above.
1.14 "NET PROCEEDS" shall mean the total consideration. in any form (including,
but not limited to, license signing and maintenance fees, minimum payments,
research and development funds, and payments for equity of Licensee in
excess of fair market value. etc.), received by LICENSEE from any third
party or parties in connection with the grant to said third party or
parties of a sublicense to make and sell (or otherwise dispose of) Licensed
Products. Net Proceeds do not include royalties based on Net Sales of a
sublicensee, nor payments made to Licensee that are specifically earmarked
for and actually used to conduct clinical trials for Licensed Products.
1.15 "PATENT RIGHTS" means the patents and patent applications listed on
Attachment A and any and all divisions, continuations,
continuations-in-part, reissues, renewals, extensions or the like of any
such patents and patent applications and all foreign equivalents thereof
and any and all patents and patent applications owned by UNIVERSITY which
contain one or more claims directed to compositions or methods for the
attenuation of opioid tolerance and dependence and the enhancement of
opioid analgesic potency and which result from the research funding
provided by LICENSEE to UNIVERSITY pursuant to this Agreement, and any and
all divisions, continuations, continuations-in-part,
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reissues, renewals, extensions or the like of any such patents and patent
applications and all foreign equivalents thereof.
1.16 "SUBLICENSEE" means a business entity which is sublicensed by LICENSEE
under this Agreement.
1.17 "TERRITORY" means the entire world.
1.18 "VALID PATENT CLAIM"' means a claim of an issued and unexpired patent
included within the Patent Rights which has not been revoked or held
unenforceable or invalid by a decision of a court or other governmental
agency of competent jurisdiction, unappealable or unappealed within the
time allowed for appeal, or which has not been disclaimed, denied or
admitted to be invalid or unenforceable through reissue or disclaimer or
otherwise.
ARTICLE 11
PATENT RIGHTS AND KNOW-HOW
2.1 Subject to paragraph 2.4, UNIVERSITY hereby grants to LICENSEE an exclusive
license, with right to grant sublicenses, under the Patent Rights and
Know-How to make, have made, use, sell, offer for sale and import Licensed
Products in the Territory. LICENSEE shall require all of its sublicensees
to expressly agree to indemnify UNIVERSITY in the same manner as LICENSEE
is required to indemnify UNIVERSITY pursuant to this Agreement. For each
sublicense agreement into which LICENSEE proposes to enter, LICENSEE shall
notify UNIVERSITY of the name and address of the sublicensee and provide to
UNIVERSITY a copy of the proposed agreement with such sublicensee. Within
thirty days of receipt of the proposed agreement and name and address,
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UNIVERSITY shall have the right to reject a proposed Sublicensee if such
sublicensee:
1. Has, within the past 2 years, engaged in illegal activities;
2. Has an unusually high debt burden or liability (as compared with similar
businesses in the same country); and
3. Has, within the past 2 years, been censured by the U.S. Securities and
Exchange Commission or, if not a U.S. company, by the securities
regulators of its country.
4. Has, within the past 2 years, engaged in a boycott or Israel.
A true and complete copy of all sublicense agreements shall be promptly
provided to UNIVERSITY.
2.2 Within thirty (30) days following the Effective Date of this License
Agreement, UNIVERSITY shall provide to LICENSEE Know-How not already
provided to LICENSEE. Throughout the term of this Agreement, UNIVERSITY
will provide additional Know-How to LICENSEE promptly as it is developed.
2.3 LICENSEE's Right of Negotiation. It is recognized that during the term of
this Agreement discoveries and inventions may be made as a result of the
research funding provided by LICENSEE to UNIVERSITY pursuant to this
Agreement that have utility in the pharmaceutical or animal fields which
are outside the scope of the license granted under Section 2.1 hereof. Such
discoveries and inventions may be made solely by UNIVERSITY or jointly by
UNIVERSITY and LICENSEE (said discoveries and inventions referred to herein
collectively as "Subject Inventions"). In consideration of this Agreement,
UNIVERSITY hereby grants to LICENSEE the fight to require, at LICENSEE's
election, that UNIVERSITY negotiate in good faith with LICENSEE with
respect to the grant to LICENSEE of an exclusive world-wide license, with
right to grant sublicenses, to make, have
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made, use, sell, offer for sale and import under UNIVERSITY's rights in any
and all Subject Inventions and any patent or patent application claiming
such Subject Inventions. The terms and Conditions of such license will be
determined giving consideration to product sales, the license scope and
rates conventionally granted for inventions with reasonably similar
commercial potential and the relative contributions of the parties to the
invention, the relative contribution of such invention to the product
commercialized, and the cost of subsequent research and development needed
to bring the product into the marketplace.
2.4 UNIVERSITY has and will perform research sponsored in part by the United
States Government and related to Licensed Products. As a result of this
government sponsorship of the aforementioned research, the United States
Government retains certain rights in such research as set forth in 35
U.S.C. Section 200 et. seq. and applicable regulations. The continuation
of such government sponsored research by UNIVERSITY during the term of this
Agreement will not constitute a breach of this Agreement. All rights
reserved to the U.S. Government under 35 U.S.C. Section 200 et. seq. and
applicable regulations shall remain so reserved and shall in no way be
affected by this Agreement. UNIVERSITY is not obligated under this
Agreement to take any action which would conflict in any respect with their
past, current or future obligations to the U.S. Government as to work
already performed and to be performed in the future.
ARTICLE III
PAYMENTS
3.1 LICENSE FEE. In consideration for the rights and licenses granted
hereunder, LICENSEE shall pay to UNIVERSITY a one time license fee payment
of one hundred thousand dollars ($100,000) which shall be due within thirty
(30) days of
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the Effective Date. This payment is non-returnable and not creditable
against any other payment due under this Agreement.
3.2 RESEARCH FUNDING. In consideration of the license grant and with the
understanding that the following payments will be used to fund research at
UNIVERSITY in the laboratory of Drs. Xxxxx and Xxxx, LICENSEE shall pay
UNIVERSITY a total of six hundred thousand dollars ($600,000) as follows:
(a) FIRST PAYMENT: one hundred thousand dollars ($100,000) paid
in the first year of this Agreement, which shall be due
within thirty (30) days of the Effective Date;
(b) SECOND PAYMENT: one hundred thousand dollars ($100,000) paid
in the first year of this Agreement, which shall be due
within thirty (30) days of the sixth (6) month anniversary of
the Effective Date;
(c) THIRD PAYMENT: two hundred thousand dollars ($200,000), paid
in the second year of this Agreement, which shall be due
within thirty (30) days of the one year anniversary of the
Effective Date; and
(d) FOURTH PAYMENT: two hundred thousand dollars ($200,000), paid
in the third year of this Agreement, which shall be due
within thirty (30) days of the two year anniversary of the
Effective Date.
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The parties acknowledge and agree that in the event LICENSEE terminates
this Agreement as provided under Article VIII hereinbelow, then LICENSEE
shall not be obligated to make any payment under this Section 3.2 that,
becomes due after such termination. Thus, e.g., if LICENSEE terminates this
Agreement on the six month anniversary of the Effective Date, then LICENSEE
shall not be obligated to make the payments of Sections 3.2(a) and (b).
3.3 MILESTONES: MILESTONE PAYMENTS. In further consideration of the rights and
licenses granted to LICENSEE hereunder, LICENSEE shall make lump sum
milestone payments to UNIVERSITY upon the first achievement of the
Milestone Events, as set forth in Table I hereinbelow, with respect to
Licensed Product.
TABLE 1
MILESTONE EVENT MILESTONE PAYMENT MILESTONE DATE
----------------------------- ----------------- -----------------------
Initiation of first Phase III $200,000 4 years from Effective
studies in the U.S. Date
First NDA filing in the U.S. $300,000 8 years from Effective
Date
First NDA approval in the U.S. $3,000,000 1O Years from Effective
Date
First approval to market in $500,000
each Major Country, other than
the U.S.
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LICENSEE shall notify UNIVERSITY in writing within thirty (30) days upon
the achievement of each Milestone Event and such Milestone Payment shall be paid
no later than thirty (30) days following achievement of the Milestone Event. All
Milestone Payments under this Agreement shall be made in United States dollars.
Notwithstanding anything to the contrary, LICENSEE shall be deemed to
have met a Milestone obligation upon timely payment of the Milestone Payment,
regardless of whether the Milestone Event has actually been achieved. Moreover,
in the event LICENSEE meets a Milestone by timely payment of the Milestone
Payment, and then achieves the Milestone Event some time after the Milestone
Date, then the remaining Milestone Dates shall be adjusted into the future by
the same amount of time, up to one year, that it took to achieve the Milestone
Event. For example, if LICENSEE tendered the Milestone Payment associated with
the initiation of first Phase III Studies in the U.S. on the Milestone Date, and
achieved this Milestone Event 4.5 years from the Effective Date, then remaining
Milestone Dates would be adjusted forward as follows: First NDA filing in the
U.S., 8.5 years from Effective Date; First NDA approval in the U.S., 10.5
years. However, if LICENSEE tendered the Milestone Payment associated with the
initiation of first Phase III Studies in the U.S. on the Milestone Date, and
achieved this Milestone Event 5.5 years from the Effective Date, then remaining
Milestone Dates would be adjusted forward as follows: First NDA filing in the
U.S., 9 years from Effective Date; First NDA approval in the U.S., 11 years.
ARTICLE IV
ROYALTIES AND REPORTS
4.1 In consideration of the license rights granted to LICENSEE by UNIVERSITY
hereunder, LICENSEE shall pay to UNIVERSITY annual royalties for each
Calendar Year on Net Sales of Licensed Product(s) by LICENSEE, its
Affiliates and Sublicensees in the Territory. Such royalty shall be payable
based upon the
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worldwide annual aggregate Net Sales in a Calendar Year of Licensed
Product(s) at the rates and in the amounts set forth below:
(a) four percent (4%) of the total aggregate Net Sales of
Licensed Product(s) in all countries in the Territory in
which the sale of the Licensed Product is covered in whole or
in part by a Valid Patent Claim;
or, in the event that the Licensed Product is not covered by a
Valid Patent Claim,
(b) a royalty of two percent (2%) as a Know-How royalty, for each
country in the Territory in which the sale of the Licensed
product is not covered in whole or in part by a Valid Patent
Claim but involves the use of Know-How.
For each country, royalties on Licensed Product(s) at the rate set forth above
shall be payable to UNIVERSITY effective as of the date of First Commercial Sale
in the country. The royalty payable under Section 4.1(a) shall be payable until
the date of expiration of the last applicable Patent Right containing a Valid
Patent Claim in each such country. The royalty payable under Section 4.1(b)
shall be payable for a period of ten (10) years from the date of First
Commercial Sale.
The royalties payable hereunder shall be subject to the following
conditions:
(i) that only one royalty shall be due with respect to the
same unit of Licensed Product;
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(ii) that no royalties shall be due upon the sale or other
transfer between LICENSEE and its Affiliates;
(iii) no royalties shall accrue on the disposition of Licensed
Product in reasonable quantities by LICENSEE, Affiliates
or its Sublicensees as bona fide samples or as donations
to nonprofit institutions or government agencies for
non-commercial purposes; and
(iv) notwithstanding the above royalty rates, upon LICENSEE's
request. the parties agree to discuss in good faith a
reduction of such royalty rate in any given country in the
event the level of development, patent protection or
general commercial environment affects the commercial
viability of the Licensed Product under such royalty rate.
4.2 If LICENSEE grants a sublicense under Patent Rights and/or Know-How prior
to the completion of a Phase 11 clinical trial in support of approval to
sell the first Licensed Product in the U.S.A., then LICENSEE shall pay to
UNIVERSITY fifty percent (50%) of Net Proceeds in addition to payments due
to UNIVERSITY pursuant to Paragraph 4.1 with respect to Net Sales of such
Sublicensee. If LICENSEE grants a sublicense under Patent Rights and/or
Know-How after the completion of a Phase II clinical trial in support of
approval to sell the first Licensed Product in the U.S.A., then LICENSEE
shall be obligated to make payments to UNIVERSITY pursuant to Paragraph 4.1
with respect to Net Sales of such Sublicensee, but will not be obligated to
make additional payments to UNIVERSITY based on Net Proceeds.
4.3 COMPULSORY LICENSES. If a compulsory license is granted with respect to
Licensed Product in any country in the Territory with a royalty rate lower
than the
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royalty rate provided by Section 4.1., then the royalty rate to be paid by
LICENSEE on Net Sales in that country under Section 4.1 shall be reduced to
be equal to the rate paid by the compulsory licensee.
4.4 THIRD PARTY PATENTS. If LICENSEE, in its reasonable judgment, is required
to obtain a license from any third party under any patent in order to
import, manufacture, use or sell the Licensed Product, and to pay a royalty
under such license, and the infringement of such patent cannot reasonably
be avoided by LICENSEE, LICENSEE's obligation to pay royalties under
Section 4.1 hereof shall be reduced by one-half of the amount of the
royalty paid to such third party, provided, however, that the royalties
payable under Section 4.1 hereof shall not be reduced in any such event
below one-half (1/2) of the amounts set forth in Sections 4.1(a)-(b) above.
In addition, if LICENSEE is required to pay up-front payments or milestone
payments to such third party in consideration for such license, then the
milestone payments under Section 3.3 shall be reduced by one-half of the
amount of such up-front payments or milestone payments paid to such third
party, provided, however, that the milestone payments payable under Section
3.3 hereof shall not be reduced in any such event below one-half (1/2) of
the amounts set forth in Section 3.3.
4.5 ROYALTY DURING INFRINGEMENT. If there is substantial infringement of the
Patent Rights by a third party or parties and LICENSEE has commenced
litigation to xxxxx such infringement, LICENSEE may discontinue payment of
up to one half of the royalty with respect to sales in the country where
the infringement occurs, until the infringement ends, after which the
royalty rate will return to its previous level. Upon successful completion
of the litigation and receipt by LICENSEE of a monetary award therefor,
LICENSEE shall reimburse UNIVERSITY those royalties withheld under this
paragraph 4.5. For the purpose of this paragraph 4.5 "substantial
infringement" means unit sales which equal at least 10% of
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LICENSEE's unit sales in the country over any three (3) month period, as
reported by IMS America Ltd. or another reputable, independent market
research firm reasonably acceptable to both parties.
4.6 PAID-UP LICENSE. For each country, upon expiration of LICENSEE's obligation
to pay royalties pursuant to Section 4.1, LICENSEE shall have a fully
paid-up, non-exclusive license under any Know-How, to make, have made, use
and sell Licensed Product in that country.
4.7 REPORTS: PAYMENT OF ROYALTY. During the term of the Agreement following the
First Commercial Sale of a Licensed Product, LICENSEE shall furnish to
UNIVERSITY a quarterly written report for the Calendar Quarter showing the
sales of all Licensed Product(s) subject to royalty payments sold by
LICENSEE, its Affiliates and its Sublicensees in the Territory during the
reporting period and the royalties payable under this Agreement. Reports
shall be due on the ninetieth (90) day following the close of each Calendar
Quarter. Royalties shown to have accrued by each royalty report shall be
due and payable on the date such royalty report is due. LICENSEE shall keep
complete and accurate records in sufficient detail to enable the royalties
payable hereunder to be determined.
4.8 AUDITS.
(a) Upon the written request of UNIVERSITY and not more than once in each
Calendar Year, LICENSEE shall permit an independent certified public
accounting firm of nationally recognized standing selected by
UNIVERSITY and reasonably acceptable to LICENSEE, at UNIVERSITY's
expense, to have access during normal business hours to such records
of LICENSEE as may be reasonably necessary to verify the accuracy of
the royalty reports hereunder for any Calendar Year ending not more
than twenty-four (24) months prior to the date of such request.
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These rights with respect to any Calendar Year shall terminate two (2)
years after the end of any such Calendar Year.
(b) If such accounting firm correctly concludes that additional royalties
were owed during such period, LICENSEE shall pay the additional
royalties within thirty (30) days of the date UNIVERSITY delivers to
LICENSEE such accounting firm's written report so correctly
concluding. The fees charged by such accounting firm shall be paid by
UNIVERSITY unless the audit discloses that the payments payable by
LICENSEE for the audited period are more than one hundred ten percent
(110%) of the payments actually made for such period, in which case
LICENSEE shall pay the reasonable fees and expenses charged by the
accounting firm.
(c) LICENSEE shall include in each sublicense granted by it pursuant to
this Agreement a provision requiring the Sublicensee to make reports
to LICENSEE, to keep and maintain records of sales made pursuant to
such sublicense and to grant access to such records by UNIVERSITY's
independent accountant to the same extent required of LICENSEE under
this Agreement.
(d) UNIVERSITY shall treat all financial information and other LICENSEE
information subject to review under this Section 4.8 or under any
sublicense agreement in accordance with the confidentiality provisions
of this Agreement, and shall cause its accounting firm to enter into a
confidentiality agreement with LICENSEE obligating it to retain all
such financial information in confidence pursuant to such
confidentiality agreement.
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4.9 PAYMENT AND EXCHANGE RATE. All payments to be made by LICENSEE to
UNIVERSITY under this Agreement shall be made in United States dollars and
shall be paid by bank wire transfer in immediately available funds to such
bank account in the United States designated in writing by UNIVERSITY from
time to time. In the case of sales outside the United States by LICENSEE,
the rate of exchange to be used in computing the amount of currency
equivalent in United States dollars due UNIVERSITY shall be the month-end
exchange rate applicable for the month in which the sales are recorded.
Such month-end exchange rate is the exchange rate utilized by LICENSEE in
its worldwide accounting system and reflects the average exchange rate for
each month.
4.10 INTEREST ON LATE PAYMENTS. UNIVERSITY reserves the right to charge and
LICENSEE hereby agrees to pay interest on any overdue amounts owing from
LICENSEE which are overdue through the fault of LICENSEE, at the rate of
one-half percent (0.5%) per month calculated from the date any payment was
due and payable.
ARTICLE V
DEVELOPMENT AND COMMERCIALIZATION
5.1 LICENSEE shall use its good faith efforts, to safely and appropriately
manage at its own cost all scientific, medical and business activities that
lead to regulatory approval, manufacturing, marketing and sale of Licensed
Products worldwide.
5.2 Within ninety (90) days of the Effective Date of this Agreement, LICENSEE
shall provide to UNIVERSITY a proposed schedule for the development of the
Licensed Product (the "Development Schedule"). LICENSEE shall provide to
UNIVERSITY an updated Development Schedule on an annual basis during the
development of Licensed Product.
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ARTICLE VI
CONFIDENTIALITY AND PUBLICATION
6.1 The parties hereby agree to not disclose and to use all reasonable efforts
to maintain the secrecy of any and all Confidential Information disclosed
by one party to the other under the terms of this Agreement without the
express, written consent of the disclosing party, with the exception of the
following:
(a) information which, at the time of disclosure, is available to the
public;
(b) information which, after disclosure, becomes available to the public
by publication or otherwise, other than by breach of this Agreement by
the receiving party;
(c) information that the receiving party can establish by prior record was
already known to it or was in its possession or in the possession of
an Affiliate (as such term is defined below) at the time of disclosure
and was not acquired, directly or indirectly, from the disclosing
party;
(d) information that the receiving party obtains from a third party;
provided however, that such information was not obtained by said third
party, directly or indirectly, from the disclosing party under an
obligation of confidentiality toward the disclosing party;
(e) information that the receiving party can establish was independently
developed by persons in its employ or otherwise who had no contact
with and were not aware of the content of the Confidential
Information; and
(f) information that the receiving party is compelled to disclose by a
court or other tribunal of competent jurisdiction, provided however,
that in such case the receiving party shall immediately give notice
to the providing party so that the providing party may seek a
protective order or other remedy from said court or tribunal. In any
event, the receiving party shall
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disclose only that portion of the Confidential Information that,
in the opinion of its legal counsel, is legally required to be
disclosed and will exercise reasonable efforts to ensure that any
such information so disclosed will be accorded confidential
treatment by said court or tribunal.
6.2 The receiving party will not disclose any such Confidential Information
to any person other than to Rs directors, officers or employees, or to,
directors, officers or employees of an Affiliate and sublicensees, and
only then if they have a clear need to know such Confidential
Information in connection with the performance of their professional
responsibilities.
6.3 The receiving party shall take all reasonable steps, including, but not
limited to, those steps taken to protect its own information, data or
other tangible or intangible property that it regards as proprietary or
confidential, to insure that the Confidential Information is not
disclosed or duplicated for the use of any third party, and shall take
all reasonable steps to prevent its officers and employees, or any
others having access to the Confidential Information, from disclosing or
making unauthorized use of any Confidential Information, or from
committing any acts or omissions that may result in a violation of this
Agreement.
6.4 Title to, and all rights emanating from the ownership of, all
Confidential Information disclosed under this Agreement shall remain
vested in the disclosing party. Nothing herein shall be construed as
granting any license or other right to use the Confidential Information
other than as specifically agreed upon by the parties.
6.5 Upon written request of the disclosing party, the receiving party shall
return promptly to the disclosing party all written materials and
documents, as well as any computer software or other media, made
available or supplied by the
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disclosing party to the receiving party that contains Confidential
Information, together with any copies thereof, except that the receiving
party may retain one copy of each such document or other media for
archival purposes, subject to protection and non-disclosure in
accordance with the terms of this Agreement
6.6 The receiving party agrees that the disclosure of Confidential
Information without the express written consent of the disclosing party
will cause irreparable harm to the disclosing party, and that any breach
or threatened breach of this Agreement by the receiving party will
entitle the disclosing party to injunctive relieve, in addition to any
other legal remedies available to it, in any court of competent
jurisdiction.
6.7 USE OF CONFIDENTIAL IN INFORMATION. Both parties agree that the
Confidential Information shall only be used in connection with the
parties' respective rights and obligations under this Agreement.
6.8 PUBLICATION. During the term of this Agreement, LICENSEE and UNIVERSITY
each acknowledge the other party's interest in publishing its results to
obtain recognition within the scientific community and to advance the
state of scientific knowledge. Each party also recognizes the mutual
interest in obtaining valid patent protection and in protecting business
interests and trade secret information. Consequently, either party, its
employees or consultants wishing to make a publication of the research
funded by LICENSEE pursuant to this Agreement shall deliver to the other
party a copy of the proposed written publication or an outline of an
oral disclosure at least thirty (30) days prior to submission for
publication or presentation. The reviewing party shall have the right
(i) to propose modifications to the publication for patent reasons,
trade secret reasons or business reasons or (ii) to request a reasonable
delay in publication or presentation in order to protect patentable
information. If the
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reviewing party requests a delay, the publishing party shall delay
submission or presentation for a period of sixty (60) days to enable
patent applications protecting each party's rights in such information
to be filed. Upon expiration of such sixty (60) days, the publishing
party shall be free to proceed with the publication or presentation. If
the reviewing party requests modifications to the publication, the
publishing party shall edit such publication to prevent disclosure or
trade secret or proprietary business information prior to submission of
the publication or presentation. In addition, the contributions of the
parties to the research shall be expressly noted in such publications or
other public disclosures by acknowledgment or co-authorship, whichever
is appropriate.
ARTICLE VII
PATENTS
7.1 FILING, PROSECUTION AND MAINTENANCE OF PATENTS. The parties shall
diligently take all commercially reasonable steps required to maintain
the Patent Rights in full force and effect, UNIVERSITY shall be
responsible for the day-to-day activities associated with filing,
prosecuting and maintaining the Patent Rights. UNIVERSITY agrees to
consult with and cooperate with LICENSEE to promptly file, prosecute and
maintain the Patent Rights in the Territory. All filing, prosecution,
and maintenance decisions with respect to the Patent Rights, including
without limitation decisions about reexaminations and reissue
proceedings, shall be made by LICENSEE with the approval of UNIVERSITY,
such approval not to be unreasonably withheld. All such filing,
prosecution, and maintenance of the Patent Rights shall be carried out
by outside patent counsel selected by LICENSEE with the approval of
UNIVERSITY, such approval not to be unreasonably withheld. Such outside
patent counsel shall at all times during the term of this Agreement keep
LICENSEE and UNIVERSITY advised of the status of patent filings and upon
request of either party shall provide copies of
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any papers relating to the filing, prosecution or maintenance of such
Patent Rights. During the term of this Agreement the parties shall
cooperate in providing information to assist the outside counsel with
the patent prosecution of the Patent Rights.
7.2 PATENT COSTS. In consideration of this Agreement, during the term of
this Agreement LICENSEE shall reimburse UNIVERSITY for the documented
filing, prosecution, and maintaining costs with respect to the Patent
Rights which are invoiced by such outside patent counsel (the "Patent
Costs"). Outside patent counsel shall provide LICENSEE with detailed
invoices, reasonably satisfactory to LICENSEE, for the Patent Costs.
LICENSEE shall pay outside patent counsel within thirty (30) days of
receipt of such invoices. UNIVERSITY shall promptly give notice to
LICENSEE of the grant, lapse, revocation, surrender, invalidation, or
abandonment of any Patent Rights licensed to LICENSEE for which
UNIVERSITY is responsible for the filing, prosecution and maintenance.
In the event that UNIVERSITY desires to discontinue maintenance or
prosecution of the Patent Rights, UNIVERSITY shall first agree to assign
such Patent Rights to LICENSEE at no cost.
7.3 PATENT TERM RESTORATION. The parties hereto shall cooperate with each
other in obtaining patent term restoration or supplemental protection
certificates or their equivalents in any country in the Territory where
applicable to Patent Rights. In the event that elections with respect to
obtaining such patent term restoration, supplemental protection
certificates or their equivalents are to be made, LICENSEE shall have
the right to make the election and UNIVERSITY agrees to abide by such
election.
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7.4 INFRINGEMENT.
(a) UNIVERSITY and LICENSEE each shall immediately give notice to
the other of any potential infringement or infringement by a
third party of any Patent Rights of which they become aware or
of any certification of which they become aware filed under the
United States "Drug Price Competition and Patent Term
Restoration Act of 1984" claiming that Patent Rights covering
the Licensed Product are invalid or unenforceable or that
infringement will not arise from the manufacture, use or sale of
Licensed Product by a third party.
(b) LICENSEE as exclusive licensee will have the right to settle
with the infringer or to bring suit or other proceeding at its
expense against the infringer in its own name or in the name of
UNIVERSITY where necessary, after consultation with UNIVERSITY.
UNIVERSITY shall be kept advised at all times of such suit or
proceedings brought by LICENSEE. UNIVERSITY may, in its
discretion, join LICENSEE as party to the suit or other
proceeding, provided that LICENSEE shall retain control of the
prosecution of such suit or proceedings in such event.
UNIVERSITY agrees to cooperate with LICENSEE in its efforts to
protect Patent Rights, including joining as a party where
necessary.
(c) If LICENSEE does not settle with the infringer or bring suit or
other proceeding against the infringer, UNIVERSITY may in its
discretion, bring suit or other proceeding at its expense
against the infringer, provided however, that UNIVERSITY shall
first consult with LICENSEE as to whether such act(s) by a third
party reasonably constitute infringement and whether it is
commercially advisable to bring such suit or proceeding, as
reasonably determined by LICENSEE. LICENSEE shall be kept
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advised at all times of such suit or proceedings brought by
UNIVERSITY. LICENSEE may, in its discretion, join LICENSEE as
party to the suit or other proceeding, provided that UNIVERSITY
shall retain control of the prosecution of such suit or
proceedings in such event. LICENSEE agrees to cooperate with
UNIVERSITY in its efforts to protect Patent Rights, including
joining as a party where necessary.
(d) Each party will bear its own expenses with respect to any suit
or other proceeding against an infringer. Any recovery in
connection with such suit or proceeding will first be applied to
reimburse UNIVERSITY and LICENSEE for their out-of-pocket
expenses, including attorney's fees. The party controlling the
suit will retain the balance of any recovery. However, if the
damages awarded LICENSEE include an amount based on lost sales
or profit, then LICENSEE shall pay to UNIVERSITY four percent
(4%) of the award after first subtracting from the award those
amounts not based on lost sales or profit (such as punitive
damages including treble damages, e.g.). If the damages awarded
LICENSEE include an amount based on a reasonable royalty then,
LICENSEE shall pay to UNIVERSITY twenty percent (20%) of the
award after first subtracting from the award those amounts not
based on a reasonable royalty (such as punitive damages
including treble damages, e.g.).
ARTICLE VIII
TERM AND TERMINATION
8.1 TERM AND EXPIRATION. This Agreement shall be effective as of the
Effective Date and unless terminated earlier pursuant to Section 8.2,
8.3 or 8.4 below, the terms of this Agreement shall continue in effect
on a country-by-country basis until expiration date of the last
obligation of LICENSEE to pay royalty to
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UNIVERSITY for the sale of a Licensed Product in that country. Upon
expiration of this Agreement as to any country due to the expiration of
the obligation of LICENSEE to pay royalty to UNIVERSITY for the sale of
a Licensed Product in that country, the licenses hereunder with respect
to Licensed Product shall become fully paid-up, perpetual licenses.
8.2 TERMINATION FOR CAUSE. This Agreement may be terminated by notice by
either party at any time during the term of this Agreement:
(a) if it is shown by credible evidence that the other party is in
breach of its material obligations hereunder (including all
obligations of Licensee to make payments to UNIVERSITY
hereunder) by causes and reasons within its control and has not
cured such breach within ninety (90) days after written notice
requesting cure of the breach; or
(b) upon the filing or institution of bankruptcy, liquidation or
receivership proceedings, or upon an assignment of a substantial
portion of the assets for the benefit of creditors by the other
party; provided, however, in the case of any involuntary
bankruptcy proceeding such right to terminate shall only become
effective if the party consents to the involuntary bankruptcy or
such proceeding is not dismissed within ninety (90) days after
the filing thereof.
8.3 TERMINATION WITHOUT CAUSE. This Agreement may be terminated by LICENSEE
at any time on fifteen (15) days written notice. Upon such termination
all right, title and interest in the Patent Rights, Know-How and all
preclinical and clinical data shall revert to UNIVERSITY and LICENSEE
shall have no further obligations under this Agreement.
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8.4 TERMINATION by UNIVERSITY. If LICENSEE has not initiated a Phase III
clinical trial in the U.S.A. for a Licensed Product before the fourth
anniversary of the Effective Date, then UNIVERSITY may terminate and the
licenses granted hereunder by giving notice to LICENSEE FIFTEEN (15)
days prior to such termination. Upon such termination all right, title
and interest in the Patent Rights, Know-how and all preclinical data
shall revert to UNIVERSITY and LICENSEE shall have no further
obligations under this Agreement.
8.5 EFFECT OF TERMINATION. Expiration or termination of the Agreement shall
not relieve the parties of any obligation accruing prior to such
expiration or termination. Any expiration or early termination of this
Agreement shall be without prejudice to the rights of either party
against the other accrued or accruing under this Agreement prior to
termination, including the obligation to pay royalties for Licensed
Product sold prior to such termination.
ARTICLE IX
INDEMNIFICATION
9.1 INDEMNIFICATION BY LICENSEE. LICENSEE shall at all times during the term
of this Agreement and thereafter, indemnify, defend and hold harmless
UNIVERSITY, its trustees, officers, employees and affiliates, from and
against any and all claim, loss, damage, liability, injury, cost or
expense, including without limitation expenses of litigation and
reasonable attorneys' fees, in connection with any claims made or suits
brought against LICENSEE relating to this Agreement: (i) arising from
the negligence, willful misconduct, or material breach of this Agreement
by LICENSEE, its Affiliates, subcontractors, sublicensees, or agents or
(ii)
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arising out of the death of or injury to any person or persons or out of
any damage to property and resulting from the production, manufacture,
sale, use, lease, consumption or advertisement of Licensed Product;
provided however that LICENSEE shall not be obligated to provide
indemnification hereunder to the extent that any such claim, loss,
damage, liability, injury, cost or expense results form the gross
negligence, willful misconduct, or material breach of this Agreement by
UNIVERSITY.
9.2 INSURANCE. LICENSEE represents and warrants that prior to any clinical
trials of Licensed Product, LICENSEE shall have liability protection,
the nature and extent of which is commensurate with usual and customary
industry practices.
9.3 PROCEDURE. Should UNIVERSITY or any of its officers, agents, parent
companies, affiliates, or employees (the "Indemnitee") intend to claim
indemnification under this Article 9, such Indemnitee shall promptly
notify LICENSEE (the "Indemnitor") in writing of any loss, claim,
damage, liability or action in respect of which the Indemnitee intends
to claim such indemnification, and the Indemnitor shall be entitled to
assume the defense thereof with counsel selected by the Indemnitor and
approved by the Indemnitee, such approval not to be unreasonably
withheld; provided, however, that if representation of Indemnitee by
such counsel first selected by the Indemnitor would be inappropriate due
to a conflict of interest between such Indemnitee and any other party
represented by such counsel, then Indemnitor shall select other counsel
for the defense of Indemnitee, with the fees and expenses to be paid by
the Indemnitor, such other counsel to be approved by Indemnitee and such
approval not to be
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unreasonably withheld. The indemnity agreement in this Article 9 shall
not apply to amounts paid in settlement of any loss, claim, damage,
liability or action if such settlement is effected without the consent
of the Indemnitor, which consent shall not be withheld unreasonably. The
failure to deliver notice to the Indemnitor within a reasonable time
after the commencement of any such action, prejudicial to its ability to
defend such action, shall relieve such Indemnitor of any liability to
the Indemnitee under this Article 9, but the omission so to deliver
notice to the Indemnitor will not relieve it of any liability that it
may have to any Indemnitee otherwise than under this Article 9. The
Indemnities under this Article 9, its employees and agents, shall
cooperate fully with the Indemnitor and its legal representatives in the
investigation of any action, claim or liability covered by this
indemnification.
9.4 Except as otherwise expressly set forth in this Agreement, UNIVERSITY
MAKES NO REPRESENTATIONS AND EXTENDS NO WARRANTIES OF ANY KIND, EITHER
EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE NON-INFRINGEMENT OF
THIRD PARTY RIGHTS, AND VALIDITY OF PATENT RIGHTS CLAIMS, ISSUED OR
PENDING.
ARTICLE X
MISCELLANEOUS
10.1 FORCE MAJEURE. Neither party shall be held liable or responsible to the
other party nor be deemed to have defaulted under or breached the
Agreement for failure or delay in fulfilling or performing any term of
the
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Agreement when such failure or delay is caused by or results from causes
beyond the reasonable control of the affected party including, but not
limited to, fire, floods, embargoes, war, acts of war (whether war be
declared or not), insurrections, riots, civil commotions, strikes,
lockouts of other labor disturbances, acts of God or acts, omissions or
delays in acting by any governmental authority or the other party.
10.2 ASSIGNMENT. This Agreement may not be assigned or otherwise transferred
by either party without the consent of the other party; provided,
however, that LICENSEE may, without such consent, assign this Agreement
and its rights and obligations hereunder to its Affiliates or in
connection with the transfer or sale of all or substantially all of its
business, or in the event of its merger or consolidation or change in
control or similar transaction. Any purported assignment in violation of
the preceding sentences shall be void. Any permitted assignee shall
assume all obligations of its assignor under this Agreement.
10.3 SEVERABILITY. In the event any one or more of the provisions contained
in this Agreement should be held invalid, illegal or unenforceable in
any respect, the validity, legality and enforceability of the remaining
provisions contained herein shall not in any way be affected or impaired
thereby, unless the absence of the invalidated provision(s) adversely
affect the substantive rights of the parties. The parties shall in such
an instance use their best efforts to replace the invalid, illegal or
unenforceable provision(s) with valid, legal and enforceable
provision(s) which, insofar as practical, implement the purposes of this
Agreement.
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10.4 NOTICES. Any payment, notice or other communication pursuant to this
Agreement shall be sufficiently made or given on the date of mailing if
sent to such party by facsimile on such date, with paper copy being sent
by certified first class mail, postage prepaid, or by next day express
delivery service, addressed to it at is address below (or such address
as it shall designate by written notice given to the other party).
In the case of LICENSEE:
Pain Therapeutics, Inc.
0000 Xxxxxxx Xxxxxx
Xxx Xxxxxxxxx, XX 00000
Attn: Xx. Xxxx Xxxxxxx
In the case of UNIVERSITY:
Office of Industrial Liaison
Xxxxxx Xxxxxxxx College of Medicine of Yeshiva University
Xxxx and Xxxxx Xxxxxxx Campus
0000 Xxxxxx Xxxx Xxxxxx
Xxxxx, XX 00000
Telephone No. (000) 000-0000
Fax No. (000) 000-0000
With copy to:
Xxxxxxx X. Xxxxxx, Esq.
XXXXXX, XXXXXXXXX & XXXXXXXXX
00 Xxxx Xxxxxx
Xxx Xxxx, XX 00000
Telephone No. (000) 000-0000
Fax No. (000) 000-0000
10.5 APPLICABLE LAW/JURISDICTION. This Agreement is acknowledged to have been
made in and shall be construed, governed, interpreted and applied in
accordance with the laws of the State of New York, without giving effect
to
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its conflict of laws provisions. The parties shall attempt in good faith
to amicably resolve any disputes under this Agreement. LICENSEE and
UNIVERSITY agree to negotiate in good faith a resolution of any dispute
between them regarding this Agreement. In this regard, the President and
CEO of LICENSEE and the Director of the Office of Industrial Liaison of
UNIVERSITY shall meet in person for at least two continuous hours to
attempt in good faith to resolve the dispute. With respect to such
disputes, any litigation instituted by LICENSEE shall be brought in a
state or federal court located in New York, and any litigation
instituted by UNIVERSITY shall be brought in a state or federal court
located in New York. Each party hereby irrevocably consents to the
personal and exclusive jurisdiction and venue of such courts.
10.6 ENTIRE AGREEMENT. This Agreement sets forth the entire agreement and
understanding of the parties as to the subject matter hereof. This
Agreement may be amended only by a written instrument duly executed by
both parties hereto.
10.7 HEADINGS. The captions to the Articles and Sections hereof are not a
part of the Agreement, but are merely guides or labels to assist in
locating and reading the Articles and Sections hereof.
10.8 INDEPENDENT CONTRACTORS. It is expressly agreed that UNIVERSITY and
LICENSEE shall be independent contractors with respect to this Agreement
and that the relationship between the two parties created by this
Agreement shall not constitute a partnership, joint venture or agency.
Neither UNIVERSITY nor LICENSEE shall have the authority to make any
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statements, representations or commitments of any kind, or to take any
action, which shall be binding on the other, without the prior consent
of the party to do so.
10.9 WAIVER. The waiver by either party hereto of any right hereunder or the
failure to perform or of a breach by the other party shall not be deemed
a waiver of any other right hereunder or of any other breach or failure
by said other party whether of a similar nature or otherwise.
10.10 COUNTERPARTS. The Agreement may be executed in two or more counterparts,
each of which shall be deemed an original, but all of which together
shall constitute one and the same instrument.
10.11 REPRESENTATIONS AND WARRANTIES. UNIVERSITY hereby represents and
warrants that: (1) it has the right to enter into this Agreement and to
grant the licenses contained herein and owns the Patent Rights and
Know-How licensed hereunder by virtue of assignments from Drs. Xxxxx and
Shen and (2) no other person or organization presently has any effective
option or license from UNIVERSITY to manufacture, use, sell or import
Licensed Product or is presently authorized by UNIVERSITY to use the
Know-How. Each party warrants and represents to the other that it has
the full eight and authority to enter into this Agreement, and that it
is not aware of any impediment, including any charge of infringement of
patents, which would inhibit its ability to perform the terms and
conditions imposed on it by such Agreement.
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10.12 Nothing in this Agreement is or shall be construed as:
(a) A warranty or representation by UNIVERSITY that anything made or
used by LICENSEE under any license granted in this Agreement is
or will be free from infringement of patents, copyrights, and
other rights of third parties; or
(b) Granting by implication, estoppel, or otherwise any license,
right or interest other than as expressly set forth herein.
10.13 As of the Effective Date, to the best of UNIVERSITY's knowledge and
belief, it has advised Licensee in writing of any conditions that may:
(a) materially affect pre-clinical/clinical development, regulatory
approval or commercialization of Licensed Products, or
(b) raise reasonable doubts about the safety or utility of Licensed
Products, including serious or unexpected side effects, toxicity
or sensitivity reactions related to the clinical use or
administration of the Licensed Products.
10.14 PUBLICITY. Each party agrees not to issue any press release or other
public statement, whether oral or written, disclosing the existence of
this Agreement or any information relating to this Agreement without the
prior written consent of the other party, provided however, that neither
party will be prevented from complying with any duty of disclosure it
may have pursuant to law or government regulation.
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10.15 USE OF NAMES. Neither party will, without prior written consent of the
other party, use the name or any trademark or trade name owned by the
other party, or, owned by an affiliate or parent corporation of the
other party, in any publication, publicity, advertising, or otherwise.
10.16 NON-SOLICITATION. Except in the event of an initial public offering,
LICENSEE will not directly or indirectly solicit the general public, or
UNIVERSITY, its employees, directors, affiliates and all other parties
related to UNIVERSITY, for any fund raising purposes whatsoever.
IN WITNESS WHEREOF, the parties intending to be bound have caused
this Agreement to be executed by their duly authorized representatives,
Effective as of the Effective Date.
XXXXXX XXXXXXXX COLLEGE OF MEDICINE
OF YESHIVA UNIVERSITY
BY: /s/ XXXXXXX XXXX
-----------------------------------------
XXXXXXX XXXX
ASSOCIATE XXXX FOR BUSINESS AFFAIRS
DATE: 5/5/98
---------------------------------------
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PAIN THERAPEUTICS, INC.
BY: /s/ XXXX XXXXXXX
----------------------------------------
TITLE: President & CEO
-------------------------------------
DATE:
--------------------------------------
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APPENDIX A
[*]
[*] Confidential Treatment Requested
36
