Exhibit 10.25
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FORM CD-450 U.S. DEPARTMENT OF COMMERCE
(REV 10/98)
[_] GRANT [X] COOPERATIVE
FINANCIAL ASSISTANCE AWARD AGREEMENT
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ACCOUNTING CODE
0/473-1341 Obj. Class: 4110
Req. No. 0/473-3403 $666,666.00
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RECIPIENT NAME AWARD NUMBER
Curis, Inc. (Formally Reprogenesis, Inc.) 70NANB0H3010
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STREET ADDRESS FEDERAL SHARE OF COST
00 Xxxx Xxxxxx $666,666.00
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CITY, STATE, ZIP CODE RECIPIENT SHARE OF COST
Xxxxxxxxx, XX 00000 $302,511.00
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AWARD PERIOD TOTAL ESTIMATED COST
11/01/00-10/31/03 (project period)* $969,177.00*
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AUTHORITY
P.L. 100-418, Section 5131 (Codified at 15 USC 278n) as modified by P.L. 102-245
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CFDA NO. 11.612, Advanced Technology Program (ATP), Proposal 00-00-4109
PROJECT TITLE: Biomaterials for Minimally Invasive Therapies
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This Award approved by the Grants Officer is issued in triplicate and constitutes an obligation of Federal funding. By signing the
three documents, the Recipient agrees to comply with the Award provisions checked below and attached. Upon acceptance by the
Recipient, two signed Award documents shall be returned to the Grants Officer and the third document shall be retained by the
Recipient. IF not signed and returned without modification by the Recipient within 30 days of receipt, the Grants Officer may
unilaterally terminate this Award.
[X] Department of Commerce Financial Assistance Standard Terms and Conditions
[X] Special Award Conditions
[X] Line Item Budget
[X] 15 CFR Part 14, Uniform Administrative Requirements for Grants and Agreements with Institutions of Higher Education, Hospitals
Other Non-Profit, and Commercial Organizations
[_] 15 CFR Part, 24, Uniform Administrative Requirements for Grants and agreements to State and Local Governments
[_] OMB Circular A-21, Cost Principles for Educational Institutions
[_] OMB Circular A-87, Cost Principles for State, Local, and Indian Tribal Governments
[_] OMB Circular A-122, Cost Principles for Nonprofit Organizations
[X] 48 CFR Part 31, Contract Cost Principles and Procedures
[_] OMB Circular A-133, Audits of States, Local Governments, and Non-Profit Organizations
[X] Other(s) General Terms and Conditions, Advanced Technology Program (ATP)(9/00); Program Specific
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Audit Guidelines for ATP Cooperative Agreements with Single Companies (9/99)
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* Multi-year Project. See Special Award Condition #6.
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B-AE93-N-C-F-N-A-2-11000 EIN: 00-0000000 473/X. Xxxxxxxxx
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SIGNATURE OF DEPARTMENT OF COMMERCE GRANTS OFFICER TITLE DATE
Xxxxxx Xxxxxx Grants Officer 9/29/00
/s/Xxxxxx Xxxxxx
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TYPED NAME AND SIGNATURE OF AUTHORIZED RECIPIENT OFFICIAL TITLE DATE
/s/ Xxxxxxx X. Xxxx Controller 10/8/00
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SPECIAL AWARD CONDITIONS
ADVANCED TECHNOLOGY PROGRAM - SINGLE RECIPIENT
Curis, Inc. (Formally Reprogenesis, Inc.)
COOPERATIVE AGREEMENT NO. 70NANB0H3010
1. RECIPIENT ADMINISTRATOR CONTACT
The Recipient Administrator Contact's name, title, address, and telephone number
are:
(Technical) Xx. Xxxxx X. Xxxx
Curis, Inc.
00 Xxxx Xxxxxx
Xxxxxxxxx, XX 00000
Ph (617) 499-2928 x180
Fax (000) 000-0000
(Administrative) Xxxxxxx X. Xxxx
Ph (000) 000-0000 x000
Fax (000) 000-0000
2. GRANTS OFFICER
The Grants Officer's name, address, and telephone number are:
Xxxxxx Xxxxxx
National Institute of Standards and Technology
000 Xxxxxx Xxxxx, Xxxx. 000, Xxxx 143-A,
Mail Stop 3576
Xxxxxxxxxxxx, XX 00000-0000
(000) 000-0000
3. GRANTS SPECIALIST
The Grant Specialist's name, address, and telephone number are:
Xxxxxx Xxxxxxxx
National Institute of Standards and Technology
000 Xxxxxx Xxxxx, Xxxx. 000, Xxxx 143-A,
Mail Stop 3576
Xxxxxxxxxxxx, XX 00000-0000
(000) 000-0000
4. PROGRAM OFFICERS
a. The Project Manager's name, address, and telephone number are:
Xxxxx Xxxxxxxxx
National Institute of Standards and Technology
000 Xxxxxx Xxxxx, Xxxx. 000, Mail Stop 4730
Xxxxxxxxxxxx, XX 00000-0000
(000) 000-0000
b. The Business Specialist's name, address, and telephone number are:
Xxxx Xxxxx
National Institute of Standards and Technology
000 Xxxxxx Xxxxx, Xxxx. 000, Mail Stop 4730
Xxxxxxxxxxxx, XX 00000-0000
(000) 000-0000
5. PROJECT DESCRIPTION
All research shall be conducted in accordance with Reprogenesis Inc.'s proposal
dated March 7, 2000, revision dated June 21, 29, 2000, August 1, 4, 8, 9, 2000
and revised budget dated August 8, 2000.
6. funding limitations
The scope of work and budget incorporated into this award cover a three-year
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period (referred to as the "project period") for a total amount of $2,000,000.00
in Federal funds. However, Federal funding available at this time is limited to
$666,666.00 for the first year period from 11/01/00 through 10/31/01 (referred
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to as the "budget period"). The Grants Officer may require additional
clarification to support the budget. If that results in changes to the budget
or budget narrative, the Recipient shall submit, in writing, a revised budget
and/or budget narrative to the Grants Officer for approval. Receipt of any
funding beyond the first year up to the level projected under this award is
contingent upon the availability of funds from Congress, satisfactory
performance, and will be at the sole discretion of the National Institute of
Standards and Technology (NIST). The Recipient may not obligate, incur any
expenditure, nor engage in any commitments which involve any amount in excess of
the Federal amount presently available. No legal liability exists or will
result on the part of the Federal Government for payment of any portion of the
remaining funds, which have not been made available under the award. If
additional funds are not made available, any expenses incurred related to
closeout activities must be funded from the amount already made available under
this award. The notice of availability or non-availability of additional
funding for the second and third years will be made in writing by the Grants
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Officer. Only the Grants Officer is authorized to obligate funds. No other
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verbal
or written notice should be relied upon by the Recipient. In the absence of a
written notice of additional funding, no assumption should be made by the
Recipient that the funds will be forth coming, and no costs should be incurred
in excess of funding already provided.
Projected budget amounts and periods:
Year 2: $ 666,667 (From 11/01/01 to 10/31/02)
Year 3: $ 666,667 (From 11/01/02 to 10/31/03)
7. COST SHARE
For the first year period, the cost sharing ratio (direct cost only) applicable
to this award is the Recipient's contribution of 31.22% ($302,511.00) and NIST's
contribution of 68.78% ($666,666.00).
8. RESTRICTION ON USE OF VERTEBRATE ANIMALS
Based upon materials submitted by the Recipient and reviewed by the appropriate
NIST officials, NIST has determined that the proposed research complies, as
applicable, with the Animal Welfare Act as amended, (7 USC 2131 et seq.,
implementing regulations 9 CFR parts 1, 2, and 3), and other Federal statutes
and regulations relating to vertebrate animals. Therefore, the proposed
research involving vertebrate animals is approved for
Facility 1: Xxxxx University (Sheep)
Facility 2: The Center for Blood Research (Mouse/Rat)
Which are the only facilities authorized to conduct research involving
vertebrate animals under this award.
In order to continue research involving vertebrate animals, the Recipient must
maintain the following valid, current approvals, and certifications.
Facility 1: Xxxxx University
Protocol # 53-00, Titles: Host response to injection of autologous Chondrocyte
hydrogel suspension injected into sheep bladder.
Species: Sheep
Expiration date 5/26/01
Animal Welfare Assurance # A 3284-01 Expiration date not given.
USDA # 15-R-0003 Expiration date 10/27/02
Facility 2: The Center for Blood Research
Protocol # 14M1199 Titles: Tissue formation in cell-containing hydrogels
Species: Mouse/Rat
Expiration date 12/21/02
Animal Welfare Assurance # A 3251 Expiration date not given.
The Recipient shall provide documentation in evidence of the renewal of all
approvals and certifications upon receipt from the IACUC and/or the cognizant
certifying body, but in any case, no later than the expiration date shown above.
The Recipient shall provide to the NIST Grants Officer documentation of
continuing review of the ASP as it occurs.
The Recipient shall immediately inform the ATP Project Manager and NIST Grants
Officer in writing of any proposed deviation from the procedures involving
vertebrate animals approved by NIST during the project period, and submit
documentation evidencing approval of the revised animal study proposal by the
IACUC for NIST review.
