January 25, 2001 Ms. Anna Hall Director of Business Development Genentech, Inc.

Exhibit 10.9

January 25, 2001

Ms. Xxxx Xxxx

Director of Business Development

Genentech, Inc.

0 XXX Xxx

Xxxxx Xxx Xxxxxxxxx

XX 00000-0000

RE: AMENDMENT NO. 5 TO THE INTERMUNE/GENENTECH LICENSE AGREEMENT

Dear Xx. Xxxx:

Please consider this document as Amendment No. 5 to that certain License Agreement for Interferon Gamma, dated May 5, 1998; as amended on December 26, 1998; January 15, 1999; April 27, 1999; and June 23, 2000 (collectively, the “Agreement”), between INTERMUNE PHARMACEUTICALS, INC. and GENENTECH, INC. (collectively, the “Parties”).

1. The Parties agree that the first sentence of Section 2.2(b) of the Agreement is hereby terminated in its entirety and amended and superseded as follows:

“(b) Use of the Xxxx. In using the Actimmune xxxx, InterMune shall display said xxxx with either the first letter in uppercase (i.e., Actimmune) or all letters in uppercase (i.e., ACTIMMUNE).”

2. All other sections and exhibits of the Agreement remain unchanged.

3. This Amendment No. 5 to the Agreement is made effective as of January 25, 2001.

IN WITNESS THEREOF, the parties have executed this Amendment No. 5 to the Agreement as of the date set forth below.

INTERMUNE PHARMACEUTICALS, INC.  GENENTECH, INC.

By /s/ Xxxx Xxxx By /s/ Xxxxxx X. XxXxxxxxx

Xxxx Xxxx       Print Name: Xxxxxx X. XxXxxxxxx

Xx. Vice President of Corporate Development  Title: VP Business Development

Date January 25, 2001   Date: 4/5/01