AMENDMENT LETTER TO EXCLUSIVE PATENT AND KNOW HOW LICENCE Beijing Med-Pharm Corporation 600 West Germantown Pike Suite 400 Plymouth Meeting PA 19462 USA Dear Sirs

AMENDMENT LETTER TO EXCLUSIVE PATENT
AND KNOW HOW LICENCE

19 January 2006

Beijing Med-Pharm Corporation
000 Xxxx Xxxxxxxxxx Xxxx
Xxxxx 000
Xxxxxxxx Xxxxxxx
XX 00000
XXX

Dear Sirs

Re: Exclusive Patent and Know How Licence Agreement between pSiOncology Pte Limited (“Licensor”), Beijing Med-Pharm Corporation (“Licensee”) and pSiMedica Limited (“pSiMedica”) dated 26th October 2005 (“the Licence”)

The parties wish to amend the Licence as follows:

1. Clause 1 — Definitions

Sub-clause 1.15
Delete the words “its Associates” after the words “invoiced by the Licensee”.

Sub-clause 1.22
Delete the words “its Associates” after the words “sales between or among Licensee”.

2. Clause 3.2 — Condition Precedent and Clause 6 Milestone Payments

The time period of 90 calendar days referred to twice in clause 3.2 (Condition Precedent) and once in clause 6 (Milestone Payments) shall be extended to 180 calendar days.

3. Clause 23.9 — Entire Agreement

Insert the following wording after the words “confidentiality agreement dated 11 July 2005,”:

“the letter dated 26^th October 2005 from pSiMedica addressed to Xxxxxx Xxxxxxxxx of Beijing Med-Pharm Corporation, referring to Clauses 14.1.2 and 14.1.3 and disclosing patent searches in its appendix,”

Save for the amendments referred to above, all other provisions of the Licence shall remain unaltered. The amendments provided in this letter shall take immediate effect.

Please confirm your agreement by signing, dating and returning the counterpart of this letter.

Yours faithfully

XXXXX XXXXXXXXXXXX

Xx. Xxxxx Xxxxxxxxxxxx
Chairman
pSiMedica Limited

Agreed by and on behalf of Beijing Med-Pharm Corporation

Signed: XXXXXX XXXXXXXXX

Authorized Signatory

Name: M.D. Greenacre

Dated: Jan. 20 06