CUSIP NO. 00000X000 Schedule 13G Page 20 of 24
EXHIBIT 1
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JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)(1)
The undersigned acknowledge and agree that the foregoing
statement on Schedule 13G is filed on behalf of each of the undersigned and that
all subsequent amendments to this statement on Schedule 13G shall be filed on
behalf of each of the undersigned without the necessity of filing additional
joint filing statements. The undersigned acknowledge that each shall be
responsible for the timely filing of such amendments, and for the completeness
and accuracy of the information concerning him, her or it contained herein, but
shall not be responsible for the completeness and accuracy of the information
concerning the other entities or persons, except to the extent that he, she or
it knows or has reason to believe that such information is inaccurate.
Dated as of May 21, 2003
PERSEUS-XXXXX BIOPHARMACEUTICAL FUND, LP
By: Perseus-Xxxxx Partners, LLC, Its General Partner
By: SFM Participation, L.P., Its Managing Member
By: SFM AH, LLC, Its General Partner
By: Xxxxx Private Funds Management LLC, Its Managing
Member
/s/ Xxxxx Xxxxxxxxx
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By: Xxxxx Xxxxxxxxx
Title: Attorney-in-Fact
PERSEUS-XXXXX PARTNERS, LLC
By: SFM Participation, L.P., Its Managing Member
By: SFM AH, LLC, Its General Partner
By: Xxxxx Private Funds Management LLC, Its Managing
Member
/s/ Xxxxx Xxxxxxxxx
----------------------------------------------------
By: Xxxxx Xxxxxxxxx
Title: Attorney-in-Fact
CUSIP NO. 00000X000 Schedule 13G Page 21 of 24
PERSEUS BIOTECH FUND PARTNERS, LLC
By: Perseuspur EC, L.L.C., Managing Member
By: Perseuspur, LLC, Member
/s/ Xxxx Xxxxxxx
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By: Xxxx Xxxxxxx
Title: Secretary and Treasurer
PERSEUS EC, L.L.C.
By: Perseuspur, LLC, Member
/s/ Xxxx Xxxxxxx
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By: Xxxx Xxxxxxx
Title: Secretary and Treasurer
PERSEUSPUR, LLC
/s/ Xxxx Xxxxxxx
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By: Xxxx Xxxxxxx
Title: Secretary and Treasurer
XX. XXXXX X. XXXXX
/s/ Xxxx Xxxxxxx
----------------------------------------------------
By: Xxxx Xxxxxxx
Title: Attorney-in-Fact
CUSIP NO. 00000X000 Schedule 13G Page 22 of 24
SFM PARTICIPATION, LP
By: SFM AH, LLC, Its General Partner
By: Xxxxx Private Funds Management LLC, Its Managing
Member
/s/ Xxxxx Xxxxxxxxx
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By: Xxxxx Xxxxxxxxx
Title: Attorney-in-Fact
SFM AH, LLC
By: Xxxxx Private Funds Management LLC, Its Managing
Member
/s/ Xxxxx Xxxxxxxxx
----------------------------------------------------
By: Xxxxx Xxxxxxxxx
Title: Attorney-in-Fact
XXXXX FUND MANAGEMENT LLC
/s/ Xxxxx Xxxxxxxxx
----------------------------------------------------
By: Xxxxx Xxxxxxxxx
Title: Assistant Counsel
MR. XXXXXX XXXXX
/s/ Xxxxx Xxxxxxxxx
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By: Xxxxx Xxxxxxxxx
Title: Attorney-in-Fact
