AMENDMENT TO EMPLOYMENT AGREEMENT TO INCREASE ANNUAL SALARY

Exhibit 10.6

AMENDMENT TO EMPLOYMENT AGREEMENT

TO INCREASE ANNUAL SALARY

Re: EMPLOYMENT AGREEMENT entered into as of January 20, 2011, by and between Cancer Prevention Pharmaceuticals, Inc., a Delaware Company (“CCP”) and Xxxxxxx Xxxxx (“Employee”).

Effective September 2, 2013 (the “Amendment Effective Date”), Employee and CPP hereby agree to amend section 1 Salary; Equity Awards of the above stated agreement to increase the annual salary to $310,000.00.

Except as expressly provided above, all other terms and conditions of this agreement remain in full force and effect unchanged.

If the foregoing is acceptable, please so indicate by signing where indicated below.

Xxxxxxx Xxxxx (Employee)

/s/ Xxxxxxx Xxxxx

Signature

Date: 9-2-13

Cancer Prevention Pharmaceuticals, Inc. (CPP)

/s/ Xxxxxx Xxxxxx

Xxxxxx Xxxxxx, CSO

Date: 9-2-13