EXHIBIT 1
JOINT FILING AGREEMENT
By this Agreement, the undersigned agree that this Statement on Schedule
13G being filed on or about this date, and any subsequent amendments thereto
filed by any of us, with respect to the securities of Orexigen Therapeutics,
Inc. is being filed on behalf of each of us.
July 12, 2010
XXXXX XXXXX
/s/ Xxxxxxxx Xxxxx
----------------------------
By: Xxxxxxxx Xxxxx*
Title: Attorney-in-fact
X. XXXXX (1999) LTD.
/s/ Xxxxxxxx Xxxxx
----------------------------
By: Xxxxxxxx Xxxxx**
Title: Attorney-in-fact for Xxxxx Xxxxx,
Chairman of X. Xxxxx (1999) Ltd.
SPHERA FUNDS MANAGEMENT LTD.
/s/ Xxx Senator
----------------------------
By: Xxx Senator***
Title: Director
/s/ Xxxxx Xxxxx
----------------------------
By: Xxxxx Xxxxx***
Title: Director
/s/ Israel Mor
----------------------------
Israel Mor
/s/ Xxxxx Xxxxx
----------------------------
Xxxxx Xxxxx
/s/ Xxx Senator
----------------------------
Xxx Senator
* Duly authorized under Special Power of Attorney appointing Xxxxxxxx Xxxxx
attorney-in-fact, dated February 9, 2010 by and on behalf of Xxxxx Xxxxx
(incorporated herein by reference to Exhibit 2 to the Schedule 13G filed on
February 9, 2010).
** Duly authorized under Special Power of Attorney appointing Xxxxxxxx Xxxxx
attorney-in-fact, dated February 9, 2010 by and on behalf of Xxxxx Xxxxx as
Chairman of X. Xxxxx (1999) Ltd. (incorporated herein by reference to Exhibit 3
to the Schedule 13G filed on February 9, 2010).
*** Duly authorized by Unanimous Written Consent of the Board of Directors of
Sphera Funds Management Ltd. allowing Xxx Senator, Xxxxx Xxxxx, and Israel Mor,
any two of whom acting together, to bind Sphera Funds Management Ltd. for any
and all matters, dated July 1, 2010, attached hereto as Exhibit 4.
2
