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Exhibit 10.29(a)

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Wednesday, December 18, 2002

Xx. Xxx Xxxxxxxx

President

Reliant Pharmaceuticals, LLC

000 Xxxxx Xxxx

Liberty Corner, NJ 07938, USA

Dear Xx. Xxxxxxxx:

Upon acceptance by Reliant Pharmaceuticals, LLC, (“Reliant”), this letter will constitute an amendment of the “Development, License and Supply Agreement”, dated May 7, 2001, between Ethypharm and Reliant. The parties agree as follows:

1. Reimbursement of Expenses: Reliant shall [***] Ethypharm for the expenses incurred for [***], in order to [***]. Such expenses, totaling [***], shall be invoiced to Reliant by a single separate and itemized invoice by [***] and be payable to Ethypharm by [***].

2. Credit to Reliant: By [***], Ethypharm will provide Reliant with a [***], dated [***].

3. Amendment to Paragraph 4.2[b]: The first sentence of paragraph 4.2[b] is hereby amended by deleting [***] in the first sentence and substituting [***] in lieu thereof. Paragraph 4.2[b][i] is hereby amended by deleting [***] in the first sentence and substituting [***] in lieu thereof.

4. Miscellaneous: Except as expressly provided herein, all terms contained in the License Agreement shall remain in full force in effect.

If this letter accurately sets forth our agreement, please execute a copy of this letter and return it to me.

Sincerely,

Xxxxxx Xxxxx

Chief Operation Officer Ethypharm S.A.

Accepted by Reliant Pharmaceuticals, LLC:

Name: 

Title: 

[***]: Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted portions.