Amendment #3
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By this Amendment, Duke University ("DUKE") and CISTRON
Biotechnology, Inc. ("SPONSOR") agree to amend the terms of the Clinical
Study and Research Agreement entered into by the parties effective
September 1, 1998 ("Agreement"), and amended on December 18, 1999 and in
March, 1999 as follows:
1. The parties agree that Article 1, Statement of Work, shall be
further expanded to include the research described in an additional
Statement of Work, a copy of which is attached to this Agreement as
Exhibit G. The parties also agree that the SPONSOR shall provide
additional compensation to DUKE for the research set forth in
Exhibit G in accordance with the terms described in the supplemental
budget attached to this Agreement as Exhibit H.
2. The parties agree that SPONSOR shall compensate DUKE as follows:
$20,719.16 shall be paid to DUKE no later that September 15, 1999.
The remaining balance of $20,719.16 shall be paid to DUKE on
completion of the Research and receipt by CISTRON of a final report
as detailed in the Agreement.
3. The parties agree that the terms of the Clinical Study and
Research Agreement shall be extended through March 31, 2000 and may be
extended beyond that date by mutual agreement of both parties.
4. All other terms of the Agreement are unchanged and remain in
full force and effect.
AGREED:
DUKE UNIVERSITY CISTRON BIOTECHNOLOGY, INC.
By: /s/XXXXX XXXXXXXXX, M.D. By: /s/XXXXXXX X.XXXXXXX
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Xxxxx Xxxxxxxxx, M.D. Name: Xxxxxxx X. Xxxxxxx
Chancellor for Health Affairs Title: Vice President - Operations
and New Product Development
Date: 9/8/99 Date: September 1, 1999
Acknowledged:
By: /s/XXXXXX X. XXXXXX, Ph.D.
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Xxxxxx Xxxxxx, Ph.D.
Principal Investigator
