RECITALS

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EXHIBIT 10.7

ADDENDUM TO AGREEMENT OF JUNE 11, 1998

This agreement is an addendum to the Agreement dated as of June 11, 1998
between GEN-PROBE INCORPORATED, a Delaware corporation, and CHIRON CORPORATION,
a Delaware corporation ("Chiron").

RECITALS

WHEREAS, Chiron and Gen-Probe signed an agreement on June 11, 1998 with
respect to Products for the Blood Screening Field and Clinical Diagnostic Field.

WHEREAS, Chiron and Gen-Probe attached a brief agreement in lieu of
Schedules B and C (the "Agreement In Lieu of Schedules") to their June 11, 1998
Agreement.

WHEREAS, Chiron and Gen-Probe now desire to complete the June 11, 1998
Agreement by approving Schedules B and C thereto and to amend the language of
Article 9 of the Agreement in certain respects.

NOW, THEREFORE, in consideration of the foregoing premises and the mutual
covenants set forth below, the parties hereby agree as follows:

1. The first sentence of Section 9.1.6 of the June 11, 1998 Agreement is
amended to read as follows:

A Disclosing Party shall have the exclusive option to acquire, on
Commercially Reasonable Terms, all right, title and interest in any
Derivative Invention which represents an improvement to, and as to
which any substantial use would infringe a Valid Claim for, that Core
Technology of the Disclosing Party which was the subject of the
Confidential Information through or with which the Derivative
Invention was made and without which it would not have been made.

2. Section 9.1.1(b) of the June 11, 1998 Agreement is amended to add, at
the end thereof, the following provision:

(iii) Such use or application of a Joint Invention resulting
from application of Section 9.1.6 (d) or (e) is made in connection
with any product which competes directly with a nucleic acid
probe-based assay product of the other party which has been sold as of
the Effective Date of this Agreement.

3. Section 9.1.1 of the June 11, 1998 Agreement is amended to add, at the
end thereof, the following provisions:

(c) Notwithstanding any other provision of this Agreement, the
parties agree that a Derivative Invention (as defined in section
9.1.4, below) as to which any substantial use would infringe a claim
of [***], shall be owned jointly by the parties and considered a Joint
Invention. Gen-Probe waives any and all rights in any such Derivative
Invention to the extent (and only to the extent) that such Derivative
Invention is used in connection with immunoassays or protein binding
assays and such use would infringe [***]. Gen-Probe agrees that Chiron
shall have exclusive rights with respect to such uses. Chiron waives
any and all rights in any such Derivative Invention to the extent (and
only to the extent) that such Derivative Invention is used in
connection with nucleic acid hybridization assays and such use would
infringe [***]. Chiron agrees that Gen-Probe shall have exclusive
rights with respect to such uses.

(d) Notwithstanding any other provision of this Agreement, the
parties agree that a Derivative Invention (as defined in section
9.1.4, below) made by Chiron as to which any substantial use would
infringe a Valid Claim of [***], shall be owned jointly by the parties
and considered a Joint Invention. Gen-Probe waives any and all rights
in any

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such Derivative-Invention to the extent (and only to the extent) that
any such Derivative Invention made by Chiron is used in connection
with immunoassays or protein binding assays, provided however that
nothing contained herein shall constitute a license to Chiron of any
rights under [***]. Chiron waives any and all rights in any such
Derivative Invention to the extent (and only to the extent) that such
Derivative Invention is used in connection with nucleic acid
hybridization assays. Chiron agrees that Gen-Probe shall have
exclusive rights with respect to such uses.

(e) Notwithstanding any other provision of this Agreement, the
parties agree that a Derivative Invention (as defined in section
9.1.4, below) made by Chiron as to which any substantial use would
infringe a Valid Claim which issues from [***], shall be owned jointly
by the parties and considered a Joint Invention. Gen-Probe waives any
and all rights in any such Derivative Invention to the extent (and
only to the extent) that any such Derivative Invention made by Chiron
is used in connection with immunoassays or protein binding assays,
provided however that nothing contained herein shall constitute a
license to Chiron of any rights under the [***]. Chiron waives any and
all rights in any such Derivative Invention to the extent (and only to
the extent) that such Derivative Invention is used in connection with
nucleic acid hybridization assays. Chiron agrees that Gen-Probe shall
have exclusive rights with respect to such uses. This subsection (e)
shall apply only to claims of the [***] when such claims have issued.

(f) Any party granting a license of a Joint Invention shall
require as a term of the license that the licensee agree to the
restrictions set forth in Sections 9.1.1(b), 9.1.1(c), 9.1.1(d) and
9.1.1(e) and to include such restrictions in any further

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licenses or sublicenses.

4. Section 9.1.6 of the June 11, 1998 Agreement is amended to add, at
the end thereof, the following provisions:

(d) Notwithstanding any other provision of this Section 9.1.6, the
parties agree that if substantial uses of a Derivative Invention would
infringe a Valid Claim for Core Technology of both parties, then such
Derivative Invention shall be considered as a Joint Invention under Section
9.1.1, provided, however, that this subsection (d) shall not apply to:

(i) a Derivative Invention as to which any substantial use would
infringe any Valid Claim to the same or substantially the same
subject matter claimed in the patents and patent applications
identified on Schedule "C" as items A1 through A11, A16, B1
through B3, B5 through B6, C1 through C6, or D1; or

(ii) a Derivative Invention as to which any substantial use would
infringe any Valid Claim which issues from the patent
applications identified on Schedule "C" as items A13 or A15,
effective immediately upon issuance or approval of such claim as
to Derivative Inventions made after that date. (Any license of a
Derivative Invention shall include such limitation.)

(e) The parties agree, solely for purposes of the use
restriction of Sections 9.1.6.(a) and (b)(ii) and Sections 9.1.7(a)(i) and
9.1.7(b)(ii), that the term "Valid Claim" shall not include unissued claims
set forth in pending patent applications pertaining to the Core Technology
of the Disclosing Party identified on Schedules B and C, respectively;
provided, however, that the term "Valid Claim" shall include a claim of
such a patent application immediately upon issuance or approval of the
claim and that any license of a Derivative Invention shall include such
limitation. This subsection (e) shall not apply to exempt from the use
restrictions referenced above a Derivative Invention as to which any
substantial use would infringe any Valid Claim to the same or substantially
the same subject matter claimed in the patent applications identified on
Schedule "C" as items A9 through A11, B6, C5 or C6.

5. The parties approve the schedules attached to this First Amendment and
agree that such schedules shall serve for all purposes as Schedules B and C to
the June 11, 1998 Agreement. The parties agree that all conditions of the
Agreement In Lieu of Schedules have been satisfied and waive the ten day
limitation set forth therein.

7. Section 1.57 of the June 11, 1998 Agreement is amended to read as
follows:

"TMA Assay" shall mean an in vitro diagnostic assay based on or
utilizing transcription-based nucleic acid amplification, but excluding the
"Teknika Version" of transcription-based amplification (as that term is
defined in Schedule E).

8. Article 9 of the June 11, 1998 Agreement is amended to add at the end
thereof the following provisions:

9.7 Stanford Agreement. The patent rights designated as "Selective
Amplification", U.S. Patent No. 5,537,990 (Item A.2 on Schedule C) Application
No. 080,479 with a filing date of July 31, 1987 are sublicensed to Chiron by
Gen-Probe under the terms of a co-exclusive license agreement (the "Stanford
Agreement") effective April 27, 1997 between Gen-Probe and The Board of
Trustees of the Xxxxxx Xxxxxxxx Junior University, Palo Alto, California
("Stanford"). Under the terms of the Stanford Agreement, certain provisions as
set forth in Schedule D attached hereto are incorporated into this Agreement by
reference.

9.8 Teknika Agreement. Gen-Probe is a party to a non-assertion
agreement effective February 7, 1997 (the "Teknika Agreement") with Organon
Teknika B.V., having a place of business at Xxxxxxx 00, 0000 XX Xxxxxx, Xxx
Xxxxxxxxxxx ("Teknika"), which agreement grants certain rights and imposes
certain conditions with respect to the transcription-based amplification patent
rights set forth in Schedule C. Chiron agrees, at the request of Teknika, to
permit and to cooperate fully with an annual review of its manufacturing
records (and such other records as may be required) by an impartial,
technically qualified third party to verify compliance with the provisions of
Section 3.3 of the Teknika Agreement. Selection of such third party shall be
subject to the approval of Chiron, such approval to be not unreasonably
withheld. The results of such a review as provided to Teknika will consist
solely of a finding of compliance or non-compliance. The cost of such review
shall be born by Teknika and shall not be unreasonably burdensome for Chiron.

9.9 Continuation of Rights. In the event the Stanford Agreement or
Teknika Agreement is terminated for any reason, the rights under such
agreements which are granted by Gen-Probe to Chiron under this Agreement,
as applicable, may be continued with Stanford and/or Teknika, as
applicable, provided that certain conditions precedent, as set forth in
Exhibit D, shall have been fulfilled.

9. The parties hereby ratify and reaffirm the June 11, 1998 Agreement in
all respects, nunc pro tunc, except as the Agreement is expressly amended by
this Addendum.

By the signatures of their respective officers below, the parties adopt
this Addendum as of June 26, 1998.

CHIRON CORPORATION GEN-PROBE INCORPORATED

By /s/ Xxxx X. Xxxxx By /s/ Xxxxx X. Xxxxxxxx
------------------------------ -----------------------------
Xxxx X. Xxxxx Xxxxx X. Xxxxxxxx
President and President and
Chief Executive Officer Chief Executive Officer

[APPROVED LEGAL DEPT. SEAL]

CHIRON CORPORATION
CORE TECHNOLOGIES

Chiron Core Technology means (1) technology claimed in Valid Claims of the
following patents and (2) technology claimed in Valid Claims of patent
applications pending before the United States Patent & Trademark Office to the
extent that such applications are substantially equivalent to the claims in the
patent applications listed below, both (1) and (2) together with any unlisted
patents and U.S. patent applications from which any of the listed patents claim
priority and any and all patents which have issued or in the future issue from
the listed patents and applications and all divisionals, continuations,
continuations in-part, reissues, renewals, re-examinations, extensions or
additions thereof (all only to the extent that the claims thereof are to the
same or substantially the same subject matter claimed in the listed patents or
patent applications.

1. Human Immunodeficiency Virus (HIV)

------------------------------------------------------------------------------------------------
Title of Invention Patent/Pub. Issue/Pub. Priority
No. Date Date
------------------------------------------------------------------------------------------------
[ *** ]

2. Hepatitis C Virus (HCV)

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3. [***]
-------------------------------

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TITLE OF INVENTION PATENT/PUB. ISSUE/PUB. PRIORITY
NO. NO. DATE
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TITLE OF INVENTION PATENT/PUB. ISSUE/PUB. PRIORITY
NO. NO. DATE
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4. [***]

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SCHEDULE C

GEN-PROBE INCORPORATED
CORE TECHNOLOGIES
---- ------------

Gen-Probe Core Technologies means (1) technology claimed in Valid Claims
of the following patents and (2) technology claimed in Valid Claims of patent
applications pending before the United States Patent & Trademark Office to the
extent that such applications are substantially equivalent to the claims in the
patent applications listed below, both (1) and (2) together with any unlisted
patents and U.S. patent applications from which any of the listed patents claim
priority and any and all patents which have issued or in the future issue from
the listed patents and applications and all divisionals, continuations,
continuations-in-part, reissues, renewals, re-examinations, extensions, or
additions thereof (all only to the extent that the claims thereof are to the
same or substantially the same subject matter claimed in the listed patents or
patent applications).

A. [***]

Issue/Pub.
Title of Invention Issue/Xxx.Xx. Date Priority Date

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B. [***]

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C. [***]

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D. [***]

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E. [***]

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F. [***]

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SCHEDULE D

ADDITIONAL CLAUSES RELATING TO THE STANFORD AGREEMENT AND THE TEKNIKA AGREEMENT

STANFORD LICENSE

The Stanford Agreement sets forth the following terms and conditions
relating to required provisions in any sublicense and to the continuation of
sublicenses following termination of the Stanford Agreement.

4.3.2 Any such sublicense shall also expressly include the provisions of
Articles 7, 8, and 9 for the benefit of STANFORD.

4.3.3 Upon termination of this Agreement for any cause, any sublicense
granted hereunder shall continue with STANFORD provided the sublicensee agrees
to thereafter assume the obligations of GEN-PROBE insofar as they correspond to
the scope of the sublicense.

7. REPORTS, PAYMENTS, AND ACCOUNTING

7.1 Quarterly Royalty Payment and Report. GEN-PROBE shall make written
reports and royalty payments to STANFORD within ninety (90) days after the end
of each calendar quarter. This report shall state the number, description, and
aggregate Net Sales of Licensed Product(s) during such completed calendar
quarter, and resulting calculation pursuant to Paragraph 6.2 of earned royalty
payment due STANFORD for such completed calendar quarter. Concurrent with the
making of each such report, GEN-PROBE shall include payment due STANFORD of
royalties for the calendar quarter covered by such report.

7.2 Accounting. GEN-PROBE agrees to keep records for a period of three
(3) years showing the manufacturing, sales, use, and other disposition of
products sold or otherwise disposed of under the license herein granted in
sufficient detail to enable the royalties payable hereunder by GEN-PROBE to be
determined, and further agrees to permit its books and records to be examined to
the extent necessary to verify reports provided for in Paragraph 7.1 by an
independent certified public accountant, provided that such audits occur no more
than one (1) time per calendar year and provided further that accountant shall
report to STANFORD only errors regarding calculation of royalties. Such
examination is to be made by STANFORD, at the expense of STANFORD, except in the
event that the results of the audit reveal a discrepancy in GEN-PROBE'S favor of
ten percent (10%) or more, then the audit fees shall be paid by GEN-PROBE.

8. WARRANTY AND NEGATION OF WARRANTIES

8.1 Nothing in this Agreement is or shall be construed as:

(a) A warranty or representation by STANFORD as to the validity or scope
of any Licensed Patent(s);

(b) A warranty or representation that anything made, used, sold, or
otherwise disposed of under any license granted in this Agreement is or will be
free from of patents, copyrights, and other rights of third parties;

(c) An obligation to bring or prosecute actions or suits against third
parties for infringement, except to the extent and in the circumstances
described in Article 12; or

(d) Granting by implication, estoppel, or otherwise any licenses under
patents of STANFORD or other persons other than Licensed Patent(s), regardless
of whether such patents are dominant or subordinate to any Licensed Patent(s)

8.2 EXCEPT AS EXPRESSLY SET FORTH IN THIS AGREEMENT, STANFORD MAKES NO
REPRESENTATIONS AND EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR
IMPLIED. THERE ARE NO EXPRESS OR IMPLIED WARRANTIES OF MERCHANTABILITY OR
FITNESS FOR A PARTICULAR PURPOSE, OR THAT THE USE OF THE LICENSED PRODUCT(S)
WILL NOT INFRINGE ANY PATENT, COPYRIGHT, TRADEMARK, OR OTHER RIGHTS OF THIRD
PARTIES.

9. INDEMNITY

9.1 GEN-PROBE agrees to indemnify, hold harmless, and defend STANFORD and
its trustees, officers, employees, students, and agents against any and all
claims for death, illness, personal injury, property damage, and improper
business practices arising out of the manufacture, use, sale, or other
disposition of Invention, Licensed Patent(s), or Licensed Product(s) by
GEN-PROBE, its sublicenses or their customers.

9.2 GEN-PROBE shall at all times comply, through insurance or
self-insurance, with all statutory workers' compensation and employers'
liability requirements covering any and all employees with respect to activities
performed under this Agreement.

9.3 GEN-PROBE shall maintain, beginning on the first day GEN-PROBE or any
GEN-PROBE sublicensee ships a therapeutics product manufactured by the licensed
process, commercial general liability insurance, including products liability
insurance, with minimum limits of liability of $5 million with reputable and

financially secure insurance carrier(s) to cover the activities of GEN-PROBE and
its sublicensee(s). Any and all such policies of insurance described in the
previous sentence shall include as additional named insureds STANFORD, Stanford
Health Services, their trustees, directors, officers, employees, students and
agents, and shall provide that such policies may not, without 30 days prior
written notice to STANFORD, be canceled or changed to materially adversely
affect any such additional named insured's coverage. Such insurance shall be
written to cover liability of such additional named insureds incurred beginning
on the first day GEN-PROBE or any GEN-PROBE sublicensee ships a therapeutics
product.

Teknika Agreement

The Teknika Agreement sets forth the following terms and conditions
relating to rights of Gen-Probe's Licensees should a breach by Gen-Probe
terminate its rights under the Teknika Agreement:

10.3 Upon termination of this Agreement, as permitted by Section 10.2, the
non-breaching party shall grant direct immunity from legal action to Licensees
of the breaching party, under the terms and conditions set forth in this
Agreement, provided that:

(a) the non-breaching party shall have received express written notice of
the license granted to such Licensee prior to the effective termination date of
this Agreement;

(b) the Licensee expressly agreed in writing on or before the ninetieth
(90th) day prior to the effective termination date of this Agreement to be
bound by the terms and conditions of this Agreement.

EXHIBIT E

TRANSCRIPTION-BASED AMPLIFICATION VERSIONS

"GEN-PROBE Version" shall mean transcription-based nucleic acid
amplification using reverse transcriptase, RNA polymerase and [***] wherein

(a) the reverse transcriptase and RNase H activities are provided by
a [***]

(b) said protein has a minimal reverse transcriptase activity of
[***] (where the unit definition and assay conditions are equivalent to those
set forth below; and,

"TEKNIKA Version" shall mean transcription-based nucleic acid amplification
using reverse transcriptase, RNA polymerase and [***] wherein:

(a) [***]

(b) [***] and

ENZYME ASSAYS

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Equivalent unit definitions and assay conditions may be substituted as long as
they produce results that may be quantitatively converted by established valid
procedures (e.g., multiplication by a conversion factor or by reference to a
standard curve) to the assay conditions and unit definitions set forth above.

For example, [***]

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[***]

Data supporting equivalence of any substitutions must be made available for
inspection as set forth in Section 3.3 of this Agreement.

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