EXHIBIT 10.46 Mr. Steven J. Lee 112 Farm Road Sherborn, MA 01770 Re: AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT Dear Steve, This letter agreement serves to further amend the Amended Executive Employment Agreement dated as of April 1, 2001, by and...

                                                                   EXHIBIT 10.46


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                 Re: AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT

Dear Xxxxx,

This letter agreement serves to further amend the Amended Executive Employment
Agreement dated as of April 1, 2001, by and between you and PolyMedica
Corporation (the "Company") as amended on June 8, 2001 and September 25, 2001
(together, the "Executive Employment Agreement").

         SALARY. The Base Salary, as defined in Section 3.1 of the Amended
         Executive Employment Agreement, shall be increased to $610,000
         effective April 1, 2002.

If the foregoing is acceptable to you, please indicate your agreement by signing
a copy of this letter agreement and returning it to the undersigned.

                                                 Very truly yours,


                                                 /s/ Xxxxxx X. Xxxxxxxxx
                                                 -----------------------------
                                                 Xxxxxx X. Xxxxxxxxx
                                                 President

ACCEPTED AND AGREED TO:



/s/ Xxxxxx X. Xxx
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Xxxxxx X. Xxx